Zinlirvimab / 8g6u

A4DAB308_8g6u_O_P | Source PDB: 8g6u | Chains: O, P | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6048
Max Score
2.4534
Min Score
-3.239
Total Score
-142.13
Score CDR
-0.3003
Score non-CDR
-0.7139

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) O (Heavy), P (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.239
Maximum Score 2.4534
Average Score -0.6048
Total Score -142.1251

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q O -1.6039 Soluble
2 V O -1.0022 Soluble
3 Q O -1.7706 Soluble
4 L O -1.3086 Soluble
5 Q O -1.9189 Soluble
6 E O -1.2207 Soluble
7 S O -0.7006 Soluble
8 G O -0.2659 Soluble
9 P O 0.0821 Aggregation-prone
11 G O 0.6086 Aggregation-prone
12 L O 1.1754 Aggregation-prone
13 V O -0.1697 Soluble
14 K O -1.6791 Soluble
15 P O -1.3728 Soluble
16 S O -1.5112 Soluble
17 E O -2.2297 Soluble
18 T O -1.6867 Soluble
19 L O 0.0000 Buried
20 S O -0.7658 Soluble
21 V O 0.0000 Buried
22 T O -0.7625 Soluble
23 C O 0.0000 Buried
24 S O -1.1514 Soluble
25 V O -1.2618 Soluble
26 S O -1.4843 Soluble
27 G O -1.4078 Soluble
28 D O -1.5956 Soluble
29 S O -0.9220 Soluble
30 M O -0.5233 Soluble
35 N O -1.8577 Soluble
36 N O -1.6898 Soluble
37 Y O 0.0000 Buried
38 Y O -1.2484 Soluble
39 W O 0.0000 Buried
40 T O 0.0000 Buried
41 W O 0.0000 Buried
42 I O 0.0000 Buried
43 R O -0.9133 Soluble
44 Q O -1.3051 Soluble
45 S O -1.0464 Soluble
46 P O -1.1789 Soluble
47 G O -1.5751 Soluble
48 K O -2.3036 Soluble
49 G O -1.5430 Soluble
50 L O -0.9805 Soluble
51 E O -1.0779 Soluble
52 W O 0.0000 Buried
53 I O 0.0000 Buried
54 G O 0.0000 Buried
55 Y O -0.0831 Soluble
56 I O 0.0000 Buried
57 S O -1.7369 Soluble
58 D O -2.5461 Soluble
59 R O -3.2186 Soluble
63 E O -3.2390 Soluble
64 S O -1.5886 Soluble
65 A O -0.2821 Soluble
66 T O 0.0017 Aggregation-prone
67 Y O 0.0179 Aggregation-prone
68 N O 0.0000 Buried
69 P O -0.7288 Soluble
70 S O -0.6646 Soluble
71 L O -0.8897 Soluble
72 N O -1.7198 Soluble
74 S O -1.0807 Soluble
75 R O -1.5812 Soluble
76 V O 0.0000 Buried
77 V O 0.8489 Aggregation-prone
78 I O 0.0000 Buried
79 S O 0.0000 Buried
80 R O -2.0733 Soluble
81 D O -2.8139 Soluble
82 T O -1.8637 Soluble
83 S O -1.8881 Soluble
84 K O -2.4966 Soluble
85 N O -2.1806 Soluble
86 Q O -1.8668 Soluble
87 L O 0.0000 Buried
88 S O -0.8573 Soluble
89 L O 0.0000 Buried
90 K O -1.1892 Soluble
91 L O -1.0395 Soluble
92 N O -1.8754 Soluble
93 S O -1.4520 Soluble
94 V O -1.2221 Soluble
95 T O -0.8778 Soluble
96 P O -0.6876 Soluble
97 A O -0.4821 Soluble
98 D O -0.8640 Soluble
99 T O -0.4480 Soluble
100 A O -0.3234 Soluble
101 V O -0.2082 Soluble
102 Y O -0.2055 Soluble
103 Y O 0.0000 Buried
104 C O 0.0000 Buried
105 A O 0.0000 Buried
106 T O 0.0000 Buried
107 A O 0.0000 Buried
108 R O -2.1457 Soluble
109 R O -2.2736 Soluble
110 G O -1.4107 Soluble
111 Q O -0.7824 Soluble
111A R O 0.3135 Aggregation-prone
111B I O 1.8530 Aggregation-prone
111C Y O 1.8621 Aggregation-prone
111D G O 1.4196 Aggregation-prone
111E V O 2.3418 Aggregation-prone
111F V O 2.4534 Aggregation-prone
112G S O 1.4256 Aggregation-prone
112F F O 2.1176 Aggregation-prone
112E G O 0.8005 Aggregation-prone
112D E O 0.5940 Aggregation-prone
112C F O 1.3976 Aggregation-prone
112B F O 0.7466 Aggregation-prone
112A Y O 0.9807 Aggregation-prone
112 Y O -0.0099 Soluble
113 Y O -0.8630 Soluble
114 S O -0.7822 Soluble
115 M O 0.0000 Buried
116 D O -0.0782 Soluble
117 V O 0.4680 Aggregation-prone
118 W O 0.0000 Buried
119 G O 0.0000 Buried
120 K O -2.4814 Soluble
121 G O 0.0000 Buried
122 T O -0.6308 Soluble
123 T O -0.0360 Soluble
124 V O 0.0000 Buried
125 T O 0.1949 Aggregation-prone
126 V O -0.0282 Soluble
127 S O -0.2926 Soluble
11 L P 1.1461 Aggregation-prone
12 S P 0.2039 Aggregation-prone
13 V P 0.1563 Aggregation-prone
14 A P 0.8308 Aggregation-prone
15 L P 1.1832 Aggregation-prone
16 G P -0.7732 Soluble
17 E P -1.4916 Soluble
18 T P -1.0428 Soluble
19 A P -1.1959 Soluble
20 R P -1.7035 Soluble
21 I P -0.6644 Soluble
22 S P -1.0501 Soluble
23 C P -1.1296 Soluble
24 G P -1.8246 Soluble
25 R P -2.6562 Soluble
26 Q P -2.3334 Soluble
27 A P -1.0020 Soluble
28 L P -0.2961 Soluble
29 G P -0.0983 Soluble
36 S P 0.2692 Aggregation-prone
37 R P 0.0000 Buried
38 A P 0.0000 Buried
39 V P 0.0000 Buried
40 Q P 0.0000 Buried
41 W P 0.0000 Buried
42 Y P 0.0000 Buried
43 Q P 0.0000 Buried
44 H P 0.0000 Buried
45 R P -0.9056 Soluble
46 P P -1.0637 Soluble
47 G P -1.5478 Soluble
48 Q P -2.0185 Soluble
49 A P -0.9437 Soluble
50 P P 0.0000 Buried
51 I P 0.8059 Aggregation-prone
52 L P 0.0000 Buried
53 L P 0.0000 Buried
54 I P 0.0000 Buried
55 Y P -0.8039 Soluble
56 N P -1.3583 Soluble
57 N P 0.0000 Buried
65 Q P -2.0533 Soluble
66 D P -2.6432 Soluble
67 R P -2.9677 Soluble
68 P P -1.3803 Soluble
69 S P -1.0354 Soluble
70 G P -0.9562 Soluble
71 I P -1.0320 Soluble
72 P P -1.7441 Soluble
74 E P -2.9227 Soluble
75 R P -2.5785 Soluble
76 F P -1.5915 Soluble
77 S P -1.7224 Soluble
78 G P -1.0201 Soluble
79 T P -0.5224 Soluble
80 P P -0.2692 Soluble
81 D P -0.0387 Soluble
81A I P 1.5285 Aggregation-prone
82 N P 0.3432 Aggregation-prone
83 F P 1.3116 Aggregation-prone
84 G P -0.1408 Soluble
85 T P -0.7395 Soluble
86 R P -2.2318 Soluble
87 A P -1.4998 Soluble
88 T P -0.9201 Soluble
89 L P 0.0000 Buried
90 T P -1.2445 Soluble
91 I P 0.0000 Buried
92 S P -1.2162 Soluble
93 G P -1.0551 Soluble
94 V P -0.8160 Soluble
95 E P -1.9282 Soluble
96 A P -1.2278 Soluble
97 G P 0.0000 Buried
98 D P 0.0000 Buried
99 E P -1.6889 Soluble
100 A P 0.0000 Buried
101 D P 0.0000 Buried
102 Y P 0.0000 Buried
103 Y P 0.0000 Buried
104 C P 0.0000 Buried
105 H P 0.0000 Buried
106 M P 0.0000 Buried
107 W P 0.0000 Buried
108 D P 0.0000 Buried
109 S P -0.4841 Soluble
110 R P -1.8446 Soluble
112 S P -0.9338 Soluble
113 G P -0.3929 Soluble
114 F P 0.6992 Aggregation-prone
115 S P 0.1629 Aggregation-prone
116 W P 0.2901 Aggregation-prone
117 S P -0.1505 Soluble
118 F P 0.0000 Buried
119 G P -0.6779 Soluble
120 G P -1.0839 Soluble
121 A P -0.7144 Soluble
122 T P -0.6530 Soluble
123 R P -1.5641 Soluble
124 L P -0.4185 Soluble
125 T P 0.4683 Aggregation-prone
126 V P 1.2341 Aggregation-prone
127 L P 1.8952 Aggregation-prone
128 G P 0.7740 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5027 4.4142 CSV PDB
4.5 -0.5419 4.3632 CSV PDB
5.0 -0.5918 4.2943 CSV PDB
5.5 -0.6441 4.219 CSV PDB
6.0 -0.689 4.1572 CSV PDB
6.5 -0.7194 4.1119 CSV PDB
7.0 -0.7331 4.0669 CSV PDB
7.5 -0.7335 4.0527 CSV PDB
8.0 -0.7256 4.0482 CSV PDB
8.5 -0.7117 4.0467 CSV PDB
9.0 -0.6923 4.0462 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH