Eltrekibart / 6wzm

A4DAB101_6wzm_C_D | Source PDB: 6wzm | Chains: C, D | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6975
Max Score
1.8259
Min Score
-3.3083
Total Score
-304.81
Score CDR
-0.4354
Score non-CDR
-0.7337

Calculation Parameters

Chain Sequence(s) QVQLVQSGAEVKKPGASVKVSCKASGYEFTSYWIHWVRQAPGQGLEWMGNISPNSGSANYNEKFKSRVTMTRDTSTSTVYMELSSLRSEDTAVYYCAREGPYSYYPSREYYGSDLWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVEIVLTQSPATLSLSPGERATLSCRASQSISNNLHWYQQKPGQAPRLLIYYTSRSVSGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCGQNNEWPEVFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) C (Heavy), D (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.3083
Maximum Score 1.8259
Average Score -0.6975
Total Score -304.8138

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q C -0.9286 Soluble
2 V C 0.1049 Aggregation-prone
3 Q C -0.3165 Soluble
4 L C 0.0000 Buried
5 V C 0.2223 Aggregation-prone
6 Q C 0.0000 Buried
7 S C -0.5379 Soluble
8 G C -0.5417 Soluble
9 A C 0.0076 Aggregation-prone
11 E C -0.2616 Soluble
12 V C 0.2204 Aggregation-prone
13 K C -1.3207 Soluble
14 K C -2.3193 Soluble
15 P C -2.1809 Soluble
16 G C -1.5213 Soluble
17 A C -1.1144 Soluble
18 S C -1.2495 Soluble
19 V C 0.0000 Buried
20 K C -1.8326 Soluble
21 V C 0.0000 Buried
22 S C -0.5104 Soluble
23 C C 0.0000 Buried
24 K C -0.7707 Soluble
25 A C 0.0000 Buried
26 S C -0.6418 Soluble
27 G C -0.7737 Soluble
28 Y C -0.8523 Soluble
29 E C -1.7336 Soluble
30 F C 0.0000 Buried
35 T C -1.0195 Soluble
36 S C -0.5082 Soluble
37 Y C -0.1871 Soluble
38 W C 0.1869 Aggregation-prone
39 I C 0.0000 Buried
40 H C 0.0000 Buried
41 W C 0.0000 Buried
42 V C 0.0000 Buried
43 R C 0.0000 Buried
44 Q C -0.5061 Soluble
45 A C -0.9119 Soluble
46 P C -0.7777 Soluble
47 G C -1.2155 Soluble
48 Q C -1.7371 Soluble
49 G C -1.0449 Soluble
50 L C 0.0000 Buried
51 E C -0.6008 Soluble
52 W C 0.0000 Buried
53 M C 0.0000 Buried
54 G C 0.0000 Buried
55 N C 0.0000 Buried
56 I C 0.0000 Buried
57 S C -0.6577 Soluble
58 P C 0.0000 Buried
59 N C -1.5892 Soluble
62 S C -1.0468 Soluble
63 G C -1.0400 Soluble
64 S C -0.7494 Soluble
65 A C -0.4150 Soluble
66 N C -0.9312 Soluble
67 Y C -1.3673 Soluble
68 N C -2.0290 Soluble
69 E C -3.2997 Soluble
70 K C -3.1285 Soluble
71 F C 0.0000 Buried
72 K C -3.0215 Soluble
74 S C -1.7679 Soluble
75 R C -1.2120 Soluble
76 V C 0.0000 Buried
77 T C -0.8120 Soluble
78 M C 0.0000 Buried
79 T C -0.4934 Soluble
80 R C -1.1895 Soluble
81 D C -1.2859 Soluble
82 T C -0.9554 Soluble
83 S C -0.5647 Soluble
84 T C -0.6473 Soluble
85 S C -1.0338 Soluble
86 T C 0.0000 Buried
87 V C 0.0000 Buried
88 Y C -0.5029 Soluble
89 M C 0.0000 Buried
90 E C -1.2456 Soluble
91 L C 0.0000 Buried
92 S C -0.9444 Soluble
93 S C -1.0187 Soluble
94 L C 0.0000 Buried
95 R C -2.6704 Soluble
96 S C -2.1891 Soluble
97 E C -2.3954 Soluble
98 D C 0.0000 Buried
99 T C -0.7621 Soluble
100 A C 0.0000 Buried
101 V C 0.4238 Aggregation-prone
102 Y C 0.0000 Buried
103 Y C 0.0000 Buried
104 C C 0.0000 Buried
105 A C 0.0000 Buried
106 R C 0.0000 Buried
107 E C 0.0000 Buried
108 G C 0.0000 Buried
109 P C -0.2021 Soluble
110 Y C 0.7129 Aggregation-prone
111 S C 0.9007 Aggregation-prone
111A Y C 1.8259 Aggregation-prone
111B Y C 1.7849 Aggregation-prone
111C P C 0.1444 Aggregation-prone
112C S C -1.0335 Soluble
112B R C -2.6076 Soluble
112A E C -2.1505 Soluble
112 Y C -0.6974 Soluble
113 Y C 0.1874 Aggregation-prone
114 G C 0.0000 Buried
115 S C 0.0000 Buried
116 D C -0.4695 Soluble
117 L C -0.2324 Soluble
118 W C 0.0000 Buried
119 G C 0.0000 Buried
120 Q C -1.3089 Soluble
121 G C -0.5703 Soluble
122 T C 0.0000 Buried
123 L C 0.4115 Aggregation-prone
124 V C 0.0000 Buried
125 T C 0.0000 Buried
126 V C 0.0000 Buried
127 S C -1.2906 Soluble
128 S C -1.1203 Soluble
129 A C -0.6222 Soluble
130 S C -0.6685 Soluble
131 T C -0.6220 Soluble
132 K C -1.1588 Soluble
133 G C -1.3788 Soluble
134 P C -0.6292 Soluble
135 S C -0.4316 Soluble
136 V C 0.0000 Buried
137 F C 0.0000 Buried
138 P C -0.7363 Soluble
139 L C 0.0000 Buried
140 A C -0.1910 Soluble
141 P C -0.4746 Soluble
142 C C -0.9443 Soluble
143 S C -1.3445 Soluble
144 R C -2.0240 Soluble
145 S C -1.4408 Soluble
146 T C -1.4650 Soluble
147 S C -1.4088 Soluble
148 E C -2.1455 Soluble
149 S C -1.2908 Soluble
150 T C -0.9019 Soluble
151 A C 0.0000 Buried
152 A C 0.0000 Buried
153 L C 0.0000 Buried
154 G C 0.0000 Buried
155 C C 0.0000 Buried
156 L C 0.0000 Buried
157 V C 0.0000 Buried
158 K C 0.0000 Buried
159 D C -0.4111 Soluble
160 Y C 0.0000 Buried
161 F C 0.0000 Buried
162 P C 0.0000 Buried
163 E C -0.3626 Soluble
164 P C -0.7927 Soluble
165 V C -0.7212 Soluble
166 T C -0.6175 Soluble
167 V C -0.2000 Soluble
168 S C -0.4707 Soluble
169 W C 0.0000 Buried
170 N C -1.0100 Soluble
171 S C -0.7664 Soluble
172 G C -0.5556 Soluble
173 A C -0.2364 Soluble
174 L C -0.0421 Soluble
175 T C -0.1662 Soluble
176 S C -0.1803 Soluble
177 G C -0.2150 Soluble
178 V C 0.1645 Aggregation-prone
179 H C -0.2991 Soluble
180 T C -0.0109 Soluble
181 F C 0.0000 Buried
182 P C -0.4844 Soluble
183 A C 0.1902 Aggregation-prone
184 V C 0.5521 Aggregation-prone
185 L C 1.1661 Aggregation-prone
186 Q C 0.2655 Aggregation-prone
187 S C -0.0623 Soluble
188 S C -0.2047 Soluble
189 G C -0.0001 Buried
190 L C 0.0817 Aggregation-prone
191 Y C 0.0000 Buried
192 S C 0.0000 Buried
193 L C 0.0000 Buried
194 S C 0.0000 Buried
195 S C 0.0000 Buried
196 V C 0.0000 Buried
197 V C 0.0000 Buried
198 T C -0.1388 Soluble
199 V C 0.0000 Buried
200 P C -0.7470 Soluble
201 S C -1.0205 Soluble
202 S C -0.7676 Soluble
203 S C -0.7868 Soluble
204 L C -0.8794 Soluble
205 G C -1.0981 Soluble
206 T C -1.0712 Soluble
207 K C -1.8604 Soluble
208 T C -1.2797 Soluble
209 Y C 0.0000 Buried
210 T C -1.5208 Soluble
211 C C 0.0000 Buried
212 N C -1.7510 Soluble
213 V C 0.0000 Buried
214 D C -2.0880 Soluble
215 H C 0.0000 Buried
216 K C -2.7877 Soluble
217 P C -1.5257 Soluble
218 S C -1.8226 Soluble
219 N C -2.6273 Soluble
220 T C -2.1646 Soluble
221 K C -2.8051 Soluble
222 V C -1.9260 Soluble
223 D C -2.8359 Soluble
224 K C -2.1771 Soluble
225 R C -2.3497 Soluble
226 V C -0.8002 Soluble
1 E D -1.6666 Soluble
2 I D -0.5552 Soluble
3 V D 0.2544 Aggregation-prone
4 L D 0.0000 Buried
5 T D -0.7187 Soluble
6 Q D -0.7293 Soluble
7 S D -0.6995 Soluble
8 P D -0.2928 Soluble
9 A D -0.2517 Soluble
10 T D -0.1712 Soluble
11 L D -0.0634 Soluble
12 S D -0.4832 Soluble
13 L D -1.0217 Soluble
14 S D -1.4996 Soluble
15 P D -1.8219 Soluble
16 G D -1.8647 Soluble
17 E D -2.4968 Soluble
18 R D -2.7246 Soluble
19 A D 0.0000 Buried
20 T D -0.6915 Soluble
21 L D 0.0000 Buried
22 S D -0.8137 Soluble
23 C D 0.0000 Buried
24 R D -2.3349 Soluble
25 A D 0.0000 Buried
26 S D -1.1433 Soluble
27 Q D -1.7052 Soluble
28 S D -1.3268 Soluble
29 I D 0.0000 Buried
36 S D -1.2803 Soluble
37 N D -1.1611 Soluble
38 N D 0.0000 Buried
39 L D 0.0000 Buried
40 H D 0.0000 Buried
41 W D 0.0000 Buried
42 Y D 0.0000 Buried
43 Q D 0.0000 Buried
44 Q D -0.9797 Soluble
45 K D -1.5267 Soluble
46 P D -1.3890 Soluble
47 G D -1.4410 Soluble
48 Q D -2.1331 Soluble
49 A D -1.3929 Soluble
50 P D 0.0000 Buried
51 R D -1.3177 Soluble
52 L D 0.0000 Buried
53 L D 0.0000 Buried
54 I D 0.0000 Buried
55 Y D -0.3766 Soluble
56 Y D -0.5487 Soluble
57 T D 0.0000 Buried
65 S D -1.0030 Soluble
66 R D -1.3429 Soluble
67 S D -0.8360 Soluble
68 V D -0.3604 Soluble
69 S D -0.3750 Soluble
70 G D -0.4265 Soluble
71 I D -0.1712 Soluble
72 P D -0.2307 Soluble
74 A D -0.1964 Soluble
75 R D -0.7039 Soluble
76 F D 0.0000 Buried
77 S D -0.6430 Soluble
78 G D -0.6163 Soluble
79 S D -0.7883 Soluble
80 G D -1.0892 Soluble
83 S D -1.0838 Soluble
84 G D -1.3719 Soluble
85 T D -1.6973 Soluble
86 D D -1.7525 Soluble
87 F D 0.0000 Buried
88 T D -0.7085 Soluble
89 L D 0.0000 Buried
90 T D -0.6308 Soluble
91 I D 0.0000 Buried
92 S D -1.3611 Soluble
93 S D -1.7748 Soluble
94 L D 0.0000 Buried
95 E D -2.3394 Soluble
96 P D -1.6952 Soluble
97 E D -2.3112 Soluble
98 D D 0.0000 Buried
99 F D -0.6378 Soluble
100 A D 0.0000 Buried
101 V D -0.0139 Soluble
102 Y D 0.0000 Buried
103 Y D 0.0000 Buried
104 C D 0.0000 Buried
105 G D 0.0000 Buried
106 Q D 0.0000 Buried
107 N D 0.0000 Buried
108 N D -1.1960 Soluble
109 E D -1.2247 Soluble
114 W D -0.5814 Soluble
115 P D -0.9119 Soluble
116 E D 0.0000 Buried
117 V D 0.0878 Aggregation-prone
118 F D 0.2411 Aggregation-prone
119 G D 0.0000 Buried
120 G D -0.6550 Soluble
121 G D -0.5501 Soluble
122 T D 0.0000 Buried
123 K D -0.4695 Soluble
124 V D 0.0000 Buried
125 E D 0.0000 Buried
126 I D -0.7363 Soluble
127 K D -1.4018 Soluble
128 R D -1.0714 Soluble
129 T D -0.0596 Soluble
130 V D 0.4944 Aggregation-prone
131 A D 0.0742 Aggregation-prone
132 A D -0.0582 Soluble
133 P D 0.0000 Buried
134 S D -0.1273 Soluble
135 V D 0.0000 Buried
136 F D -0.0066 Soluble
137 I D 0.0000 Buried
138 F D 0.0000 Buried
139 P D -0.6243 Soluble
140 P D -0.7505 Soluble
141 S D -1.6117 Soluble
142 D D -2.9703 Soluble
143 E D -3.0191 Soluble
144 Q D 0.0000 Buried
145 L D -2.2542 Soluble
146 K D -2.8601 Soluble
147 S D -1.7404 Soluble
148 G D -1.2981 Soluble
149 T D -0.9835 Soluble
150 A D 0.0000 Buried
151 S D 0.0000 Buried
152 V D 0.0000 Buried
153 V D 0.0000 Buried
154 C D 0.0000 Buried
155 L D 0.0000 Buried
156 L D 0.0000 Buried
157 N D 0.0000 Buried
158 N D -0.7717 Soluble
159 F D 0.0000 Buried
160 Y D 0.0000 Buried
161 P D -1.6013 Soluble
162 R D -2.7490 Soluble
163 E D -3.0985 Soluble
164 A D -2.2798 Soluble
165 K D -2.3730 Soluble
166 V D -0.9941 Soluble
167 Q D -0.5635 Soluble
168 W D 0.0000 Buried
169 K D -0.7209 Soluble
170 V D 0.0000 Buried
171 D D -1.7063 Soluble
172 N D -1.4514 Soluble
173 A D -0.4744 Soluble
174 L D 0.2937 Aggregation-prone
175 Q D -0.2552 Soluble
176 S D -0.5258 Soluble
177 G D -0.8713 Soluble
178 N D -0.7644 Soluble
179 S D -1.0301 Soluble
180 Q D -1.2866 Soluble
181 E D -1.7152 Soluble
182 S D -0.7535 Soluble
183 V D -0.8268 Soluble
184 T D -1.1596 Soluble
185 E D -2.2376 Soluble
186 Q D -1.7842 Soluble
187 D D -1.8745 Soluble
188 S D -1.6991 Soluble
189 K D -2.2107 Soluble
190 D D -1.6476 Soluble
191 S D -1.6312 Soluble
192 T D 0.0000 Buried
193 Y D 0.0000 Buried
194 S D 0.0000 Buried
195 L D 0.0000 Buried
196 S D 0.0000 Buried
197 S D 0.0000 Buried
198 T D -0.6221 Soluble
199 L D 0.0000 Buried
200 T D -0.4237 Soluble
201 L D -0.6033 Soluble
202 S D -0.9716 Soluble
203 K D -1.9438 Soluble
204 A D -1.7193 Soluble
205 D D -2.4533 Soluble
206 Y D 0.0000 Buried
207 E D -3.1041 Soluble
208 K D -3.3083 Soluble
209 H D -2.6855 Soluble
210 K D -2.4420 Soluble
211 V D -0.9878 Soluble
212 Y D 0.0000 Buried
213 A D 0.0000 Buried
214 C D 0.0000 Buried
215 E D -0.5802 Soluble
216 V D 0.0000 Buried
217 T D -1.1743 Soluble
218 H D 0.0000 Buried
219 Q D -1.6714 Soluble
220 G D -0.3465 Soluble
221 L D -0.1760 Soluble
222 S D -0.4470 Soluble
223 S D -0.3920 Soluble
224 P D -0.4535 Soluble
225 V D 0.1676 Aggregation-prone
226 T D -0.3135 Soluble
227 K D -0.5228 Soluble
228 S D -0.4246 Soluble
229 F D 0.0000 Buried
230 N D -1.6195 Soluble
231 R D -2.2251 Soluble
232 G D -2.0281 Soluble
233 E D -2.2537 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7582 2.5085 CSV PDB
4.5 -0.8008 2.5085 CSV PDB
5.0 -0.8536 2.5085 CSV PDB
5.5 -0.9055 2.5085 CSV PDB
6.0 -0.9444 2.5084 CSV PDB
6.5 -0.9594 2.5084 CSV PDB
7.0 -0.9484 2.5082 CSV PDB
7.5 -0.9189 2.5077 CSV PDB
8.0 -0.8798 2.5059 CSV PDB
8.5 -0.8352 2.5004 CSV PDB
9.0 -0.7864 2.4834 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH