Zinlirvimab / 8dok

A4DAB308_8dok_Q_R | Source PDB: 8dok | Chains: Q, R | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.4756
Max Score
2.9617
Min Score
-3.0343
Total Score
-111.77
Score CDR
-0.1665
Score non-CDR
-0.5864

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) Q (Heavy), R (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.0343
Maximum Score 2.9617
Average Score -0.4756
Total Score -111.767

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q Q -1.3789 Soluble
2 V Q -0.8166 Soluble
3 Q Q -1.2154 Soluble
4 L Q 0.0000 Buried
5 Q Q -1.7812 Soluble
6 E Q 0.0000 Buried
7 S Q -0.8836 Soluble
8 G Q -0.7967 Soluble
9 P Q -0.3730 Soluble
11 G Q -0.1028 Soluble
12 L Q 0.3730 Aggregation-prone
13 V Q 0.0000 Buried
14 K Q -2.0027 Soluble
15 P Q -1.5631 Soluble
16 S Q -1.7423 Soluble
17 E Q -2.7041 Soluble
18 T Q -1.5707 Soluble
19 L Q 0.0000 Buried
20 S Q -0.7120 Soluble
21 V Q 0.0000 Buried
22 T Q 0.0000 Buried
23 C Q 0.0000 Buried
24 S Q -1.3653 Soluble
25 V Q 0.0000 Buried
26 S Q -1.2005 Soluble
27 G Q -1.0696 Soluble
28 D Q -1.0433 Soluble
29 S Q -0.9258 Soluble
30 M Q -0.8405 Soluble
35 N Q -1.4637 Soluble
36 N Q -2.1011 Soluble
37 Y Q -1.1981 Soluble
38 Y Q 0.0000 Buried
39 W Q 0.0000 Buried
40 T Q 0.0000 Buried
41 W Q 0.0000 Buried
42 I Q 0.0000 Buried
43 R Q 0.0000 Buried
44 Q Q -0.9514 Soluble
45 S Q -1.0307 Soluble
46 P Q -1.1265 Soluble
47 G Q -1.5395 Soluble
48 K Q -2.3849 Soluble
49 G Q -1.7024 Soluble
50 L Q 0.0000 Buried
51 E Q -0.9634 Soluble
52 W Q 0.0000 Buried
53 I Q 0.0000 Buried
54 G Q 0.1021 Aggregation-prone
55 Y Q 0.1528 Aggregation-prone
56 I Q 0.0000 Buried
57 S Q 0.0000 Buried
58 D Q -2.0815 Soluble
59 R Q -3.0343 Soluble
63 E Q -2.9208 Soluble
64 S Q -1.6568 Soluble
65 A Q -0.5156 Soluble
66 T Q 0.0021 Aggregation-prone
67 Y Q 0.0597 Aggregation-prone
68 N Q -0.4907 Soluble
69 P Q -0.8415 Soluble
70 S Q -0.8448 Soluble
71 L Q 0.0000 Buried
72 N Q -1.6662 Soluble
74 S Q -0.9279 Soluble
75 R Q -1.0233 Soluble
76 V Q 0.0000 Buried
77 V Q 0.7679 Aggregation-prone
78 I Q 0.1144 Aggregation-prone
79 S Q -0.5680 Soluble
80 R Q -1.2471 Soluble
81 D Q -1.4445 Soluble
82 T Q -1.1892 Soluble
83 S Q -1.4050 Soluble
84 K Q -2.2589 Soluble
85 N Q -1.6992 Soluble
86 Q Q -1.4731 Soluble
87 L Q 0.0000 Buried
88 S Q 0.0000 Buried
89 L Q 0.0000 Buried
90 K Q -0.7297 Soluble
91 L Q 0.0000 Buried
92 N Q -1.3473 Soluble
93 S Q -1.3940 Soluble
94 V Q 0.0000 Buried
95 T Q -0.6913 Soluble
96 P Q -0.4170 Soluble
97 A Q -0.0787 Soluble
98 D Q 0.0000 Buried
99 T Q 0.0000 Buried
100 A Q 0.0000 Buried
101 V Q -0.2785 Soluble
102 Y Q 0.0000 Buried
103 Y Q 0.0000 Buried
104 C Q 0.0000 Buried
105 A Q 0.0000 Buried
106 T Q 0.0000 Buried
107 A Q 0.0000 Buried
108 R Q -2.4865 Soluble
109 R Q -1.6967 Soluble
110 G Q -0.8273 Soluble
111 Q Q -0.2058 Soluble
111A R Q 0.3881 Aggregation-prone
111B I Q 2.0982 Aggregation-prone
111C Y Q 1.5478 Aggregation-prone
111D G Q 1.5953 Aggregation-prone
111E V Q 2.6723 Aggregation-prone
111F V Q 2.9617 Aggregation-prone
112G S Q 1.7516 Aggregation-prone
112F F Q 2.5375 Aggregation-prone
112E G Q 1.7438 Aggregation-prone
112D E Q 1.7035 Aggregation-prone
112C F Q 2.1644 Aggregation-prone
112B F Q 0.7696 Aggregation-prone
112A Y Q 0.4795 Aggregation-prone
112 Y Q -0.0770 Soluble
113 Y Q 0.0000 Buried
114 S Q -1.0496 Soluble
115 M Q 0.0000 Buried
116 D Q -1.7242 Soluble
117 V Q -0.8190 Soluble
118 W Q 0.0000 Buried
119 G Q 0.0000 Buried
120 K Q -2.2113 Soluble
121 G Q -1.3904 Soluble
122 T Q 0.0000 Buried
123 T Q -0.1677 Soluble
124 V Q 0.0000 Buried
125 T Q 0.0154 Aggregation-prone
126 V Q -0.3484 Soluble
127 S Q -0.4250 Soluble
11 L R 0.8636 Aggregation-prone
12 S R 0.6148 Aggregation-prone
13 V R 0.0000 Buried
14 A R 0.9015 Aggregation-prone
15 L R 1.0560 Aggregation-prone
16 G R -0.4389 Soluble
17 E R -0.9591 Soluble
18 T R -1.1934 Soluble
19 A R -1.3273 Soluble
20 R R -2.1041 Soluble
21 I R 0.0000 Buried
22 S R -1.0388 Soluble
23 C R 0.0000 Buried
24 G R -1.3038 Soluble
25 R R -1.6926 Soluble
26 Q R -1.6783 Soluble
27 A R 0.0000 Buried
28 L R 0.0376 Aggregation-prone
29 G R -0.0751 Soluble
36 S R 0.4957 Aggregation-prone
37 R R 0.0000 Buried
38 A R 0.0000 Buried
39 V R 0.0000 Buried
40 Q R 0.0000 Buried
41 W R 0.0000 Buried
42 Y R 0.0000 Buried
43 Q R 0.0000 Buried
44 H R 0.0000 Buried
45 R R -1.1779 Soluble
46 P R -1.4113 Soluble
47 G R -1.5505 Soluble
48 Q R -1.9880 Soluble
49 A R -1.0049 Soluble
50 P R 0.0000 Buried
51 I R 0.6454 Aggregation-prone
52 L R 0.0000 Buried
53 L R 0.0000 Buried
54 I R 0.0000 Buried
55 Y R -0.6670 Soluble
56 N R -0.8119 Soluble
57 N R 0.0000 Buried
65 Q R -1.4667 Soluble
66 D R -1.5415 Soluble
67 R R -1.7322 Soluble
68 P R -1.0280 Soluble
69 S R -0.6985 Soluble
70 G R -0.8302 Soluble
71 I R -0.8821 Soluble
72 P R -1.7179 Soluble
74 E R -2.8839 Soluble
75 R R -2.9882 Soluble
76 F R 0.0000 Buried
77 S R -1.6799 Soluble
78 G R -1.2130 Soluble
79 T R -0.3461 Soluble
80 P R -0.3505 Soluble
81 D R 0.3924 Aggregation-prone
81A I R 1.6039 Aggregation-prone
82 N R 0.4365 Aggregation-prone
83 F R 1.5263 Aggregation-prone
84 G R 0.2042 Aggregation-prone
85 T R -0.0524 Soluble
86 R R -0.7898 Soluble
87 A R 0.0000 Buried
88 T R -0.7939 Soluble
89 L R 0.0000 Buried
90 T R -1.6092 Soluble
91 I R 0.0000 Buried
92 S R -1.5707 Soluble
93 G R -0.9665 Soluble
94 V R -0.7315 Soluble
95 E R -1.6633 Soluble
96 A R -1.2821 Soluble
97 G R 0.0000 Buried
98 D R 0.0000 Buried
99 E R -2.4888 Soluble
100 A R -1.7407 Soluble
101 D R -1.3777 Soluble
102 Y R 0.0000 Buried
103 Y R 0.0000 Buried
104 C R 0.0000 Buried
105 H R 0.0000 Buried
106 M R 0.0000 Buried
107 W R 0.0000 Buried
108 D R 0.0000 Buried
109 S R -0.4470 Soluble
110 R R -1.7425 Soluble
112 S R -0.9147 Soluble
113 G R -0.4633 Soluble
114 F R 0.4937 Aggregation-prone
115 S R 0.0000 Buried
116 W R 0.1808 Aggregation-prone
117 S R -0.2876 Soluble
118 F R 0.0000 Buried
119 G R -0.8023 Soluble
120 G R -1.3058 Soluble
121 A R -0.9784 Soluble
122 T R -0.8389 Soluble
123 R R -1.8131 Soluble
124 L R 0.0000 Buried
125 T R 0.1086 Aggregation-prone
126 V R 0.9019 Aggregation-prone
127 L R 1.7864 Aggregation-prone
128 G R 0.6284 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.3507 4.739 CSV PDB
4.5 -0.377 4.7182 CSV PDB
5.0 -0.4136 4.6897 CSV PDB
5.5 -0.4532 4.6584 CSV PDB
6.0 -0.4878 4.629 CSV PDB
6.5 -0.5106 4.6065 CSV PDB
7.0 -0.5187 4.5936 CSV PDB
7.5 -0.5152 4.5881 CSV PDB
8.0 -0.5054 4.5861 CSV PDB
8.5 -0.4929 4.5854 CSV PDB
9.0 -0.4789 4.5852 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH