Cosfroviximab / 5kel

A4DAB073_5kel_M_O | Source PDB: 5kel | Chains: M, O | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6247
Max Score
1.2685
Min Score
-3.3559
Total Score
-142.44
Score CDR
-0.4936
Score non-CDR
-0.6607

Calculation Parameters

Chain Sequence(s) DVKLLESGGGLVQPGGSLKLSCAASGFSLSTSGVGVGWFRQPSGKGLEWLALIWWDDDKYYNPSLKSQLSISKDFSRNQVFLKISNVDIADTATYYCARRDPFGYDNAMGYWGQGTSVTVSDIVMTQSPLSLSTSVGDRVSLTCKASQNVGTAVAWYQQKPGQSPKLLIYSASNRYTGVPDRFTGSGSGTDFTLTISNMQSEDLADYFCQQYSSYPLTFGAGTKLELR input.pdb
Selected Chain(s) M (Heavy), O (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.3559
Maximum Score 1.2685
Average Score -0.6247
Total Score -142.442

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 D M -2.1490 Soluble
2 V M -1.5738 Soluble
3 K M -2.1716 Soluble
4 L M -1.0881 Soluble
5 L M -0.4706 Soluble
6 E M -0.7172 Soluble
7 S M -0.7988 Soluble
8 G M -1.0384 Soluble
9 G M -0.8232 Soluble
11 G M -0.0930 Soluble
12 L M 0.9801 Aggregation-prone
13 V M 0.1374 Aggregation-prone
14 Q M -1.0880 Soluble
15 P M -0.8487 Soluble
16 G M -1.3589 Soluble
17 G M -1.0397 Soluble
18 S M -1.6054 Soluble
19 L M 0.0000 Buried
20 K M -2.0803 Soluble
21 L M 0.0000 Buried
22 S M -0.7427 Soluble
23 C M 0.0000 Buried
24 A M -0.6889 Soluble
25 A M 0.0000 Buried
26 S M -1.2485 Soluble
27 G M -1.3276 Soluble
28 F M -0.5453 Soluble
29 S M -0.3189 Soluble
30 L M -0.0850 Soluble
31 S M -0.2180 Soluble
34 T M -0.2670 Soluble
35 S M -0.9027 Soluble
36 G M -0.9376 Soluble
37 V M 0.0000 Buried
38 G M 0.0000 Buried
39 V M 0.1724 Aggregation-prone
40 G M 0.0000 Buried
41 W M 0.0000 Buried
42 F M 0.0000 Buried
43 R M 0.0000 Buried
44 Q M 0.0000 Buried
45 P M -0.9438 Soluble
46 S M -1.0184 Soluble
47 G M -1.4500 Soluble
48 K M -2.1187 Soluble
49 G M -1.1442 Soluble
50 L M 0.0000 Buried
51 E M -0.7216 Soluble
52 W M 0.0000 Buried
53 L M 0.0000 Buried
54 A M 0.0000 Buried
55 L M 0.0000 Buried
56 I M 0.0000 Buried
57 W M -1.6066 Soluble
58 W M -1.4496 Soluble
59 D M -2.9398 Soluble
63 D M -3.3559 Soluble
64 D M -2.7975 Soluble
65 K M -1.9679 Soluble
66 Y M -0.4152 Soluble
67 Y M -0.3673 Soluble
68 N M -0.6759 Soluble
69 P M -1.0341 Soluble
70 S M -1.0004 Soluble
71 L M -0.8957 Soluble
72 K M -1.7686 Soluble
74 S M -1.2843 Soluble
75 Q M -1.4093 Soluble
76 L M 0.0000 Buried
77 S M -1.0422 Soluble
78 I M 0.0000 Buried
79 S M -0.6024 Soluble
80 K M -1.0163 Soluble
81 D M -0.9283 Soluble
82 F M -0.4056 Soluble
83 S M -1.0298 Soluble
84 R M -2.0792 Soluble
85 N M -1.2326 Soluble
86 Q M -0.9602 Soluble
87 V M 0.0000 Buried
88 F M -0.6676 Soluble
89 L M 0.0000 Buried
90 K M -1.7748 Soluble
91 I M 0.0000 Buried
92 S M -1.6865 Soluble
93 N M -1.9072 Soluble
94 V M 0.0000 Buried
95 D M -0.5679 Soluble
96 I M 1.2685 Aggregation-prone
97 A M 0.7804 Aggregation-prone
98 D M 0.0000 Buried
99 T M 0.5537 Aggregation-prone
100 A M 0.0000 Buried
101 T M -0.5112 Soluble
102 Y M 0.0000 Buried
103 Y M 0.0000 Buried
104 C M 0.0000 Buried
105 A M 0.0000 Buried
106 R M 0.0406 Aggregation-prone
107 R M 0.0000 Buried
108 D M -0.1392 Soluble
109 P M 0.2521 Aggregation-prone
110 F M 0.5166 Aggregation-prone
111 G M 0.2392 Aggregation-prone
112A Y M 0.9421 Aggregation-prone
112 D M 0.0798 Aggregation-prone
113 N M -0.0390 Soluble
114 A M 0.0000 Buried
115 M M 0.0000 Buried
116 G M 0.0000 Buried
117 Y M -0.2339 Soluble
118 W M -0.6098 Soluble
119 G M 0.0000 Buried
120 Q M -1.6662 Soluble
121 G M -1.0492 Soluble
122 T M -0.5975 Soluble
123 S M -0.3169 Soluble
124 V M 0.0000 Buried
125 T M 0.3935 Aggregation-prone
126 V M 0.0000 Buried
127 S M -0.1456 Soluble
1 D O -1.0652 Soluble
2 I O 0.2399 Aggregation-prone
3 V O 1.1118 Aggregation-prone
4 M O 0.3939 Aggregation-prone
5 T O 0.2748 Aggregation-prone
6 Q O 0.0000 Buried
7 S O 0.0281 Aggregation-prone
8 P O 0.3092 Aggregation-prone
9 L O 1.0064 Aggregation-prone
10 S O -0.3509 Soluble
11 L O -0.4469 Soluble
12 S O -1.3004 Soluble
13 T O 0.0000 Buried
14 S O -0.5804 Soluble
15 V O 0.2831 Aggregation-prone
16 G O -1.1131 Soluble
17 D O -1.8006 Soluble
18 R O -2.5951 Soluble
19 V O 0.0000 Buried
20 S O -0.7771 Soluble
21 L O 0.0000 Buried
22 T O -0.5885 Soluble
23 C O 0.0000 Buried
24 K O -1.6343 Soluble
25 A O 0.0000 Buried
26 S O -0.8857 Soluble
27 Q O -1.7744 Soluble
28 N O -2.4505 Soluble
29 V O 0.0000 Buried
36 G O -1.3884 Soluble
37 T O -0.9005 Soluble
38 A O -0.3548 Soluble
39 V O 0.0000 Buried
40 A O 0.0000 Buried
41 W O 0.0000 Buried
42 Y O 0.0000 Buried
43 Q O 0.0000 Buried
44 Q O -1.4202 Soluble
45 K O -1.5508 Soluble
46 P O -1.2318 Soluble
47 G O -1.4347 Soluble
48 Q O -2.0522 Soluble
49 S O -1.5269 Soluble
50 P O 0.0000 Buried
51 K O -1.6553 Soluble
52 L O 0.0000 Buried
53 L O 0.0000 Buried
54 I O 0.0000 Buried
55 Y O -0.6018 Soluble
56 S O -0.4834 Soluble
57 A O 0.0000 Buried
65 S O -1.1480 Soluble
66 N O -1.7491 Soluble
67 R O -1.9042 Soluble
68 Y O -1.0729 Soluble
69 T O -0.7767 Soluble
70 G O -0.8380 Soluble
71 V O 0.0000 Buried
72 P O -1.3630 Soluble
74 D O -2.3674 Soluble
75 R O -1.9756 Soluble
76 F O 0.0000 Buried
77 T O -1.1528 Soluble
78 G O -0.7243 Soluble
79 S O -0.8531 Soluble
80 G O -1.1135 Soluble
83 S O -1.2952 Soluble
84 G O -1.8380 Soluble
85 T O -2.1527 Soluble
86 D O -2.4585 Soluble
87 F O 0.0000 Buried
88 T O -0.7778 Soluble
89 L O 0.0000 Buried
90 T O -0.8795 Soluble
91 I O 0.0000 Buried
92 S O -2.1851 Soluble
93 N O -2.2717 Soluble
94 M O 0.0000 Buried
95 Q O -1.1318 Soluble
96 S O -1.2738 Soluble
97 E O -1.6698 Soluble
98 D O 0.0000 Buried
99 L O -1.0870 Soluble
100 A O 0.0000 Buried
101 D O -1.1217 Soluble
102 Y O 0.0000 Buried
103 F O 0.0000 Buried
104 C O 0.0000 Buried
105 Q O 0.0000 Buried
106 Q O 0.0000 Buried
107 Y O 0.1487 Aggregation-prone
108 S O -0.3766 Soluble
109 S O 0.0320 Aggregation-prone
114 Y O 0.9026 Aggregation-prone
115 P O 0.3110 Aggregation-prone
116 L O 0.3579 Aggregation-prone
117 T O 0.0000 Buried
118 F O 0.5506 Aggregation-prone
119 G O 0.0000 Buried
120 A O 0.2192 Aggregation-prone
121 G O -0.3662 Soluble
122 T O 0.0000 Buried
123 K O -1.8665 Soluble
124 L O 0.0000 Buried
125 E O -2.3623 Soluble
126 L O -1.1672 Soluble
127 R O -1.8829 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.606 3.2088 CSV PDB
4.5 -0.6537 3.1385 CSV PDB
5.0 -0.7064 3.0602 CSV PDB
5.5 -0.7566 2.9788 CSV PDB
6.0 -0.796 2.8964 CSV PDB
6.5 -0.8181 2.8139 CSV PDB
7.0 -0.8235 2.7317 CSV PDB
7.5 -0.8176 2.651 CSV PDB
8.0 -0.804 2.5744 CSV PDB
8.5 -0.7816 2.5086 CSV PDB
9.0 -0.7488 2.4625 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH