Tixagevimab / 7mlz

A4DAB270_7mlz_H_L | Source PDB: 7mlz | Chains: H, L | Done
95.26
Yes
10 Å
Yes
Avg A4D Score
-0.7047
Max Score
1.6333
Min Score
-3.5553
Total Score
-301.62
Score CDR
-0.3684
Score non-CDR
-0.7502

Calculation Parameters

Chain Sequence(s) MQLVQSGPEVKKPGTSVKVSCKASGFTFTSSAVQWVRQARGQRLEWIGWIVVGSGNTNYAQKFQERVTITRDMSTSTAYMELSSLRSEDTAVYYCAAPYCSGGSCFDGFDIWGQGTMVTVSSASTKGPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGFPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGNSPWTFGQGTKVEIRRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.5553
Maximum Score 1.6333
Average Score -0.7047
Total Score -301.6185

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 M H 0.2818 Aggregation-prone
3 Q H -0.8702 Soluble
4 L H 0.0000 Buried
5 V H -0.2749 Soluble
6 Q H -0.5167 Soluble
7 S H -0.7870 Soluble
8 G H -0.5157 Soluble
9 P H -0.4404 Soluble
11 E H -0.5333 Soluble
12 V H 0.4379 Aggregation-prone
13 K H -0.7342 Soluble
14 K H -1.8158 Soluble
15 P H -1.6518 Soluble
16 G H -1.3557 Soluble
17 T H -0.9623 Soluble
18 S H -1.2652 Soluble
19 V H 0.0000 Buried
20 K H -1.8088 Soluble
21 V H 0.0000 Buried
22 S H -0.5896 Soluble
23 C H 0.0000 Buried
24 K H -1.4868 Soluble
25 A H 0.0000 Buried
26 S H -0.7833 Soluble
27 G H -0.3691 Soluble
28 F H 0.0000 Buried
29 T H -0.3306 Soluble
30 F H 0.0000 Buried
35 T H -0.3372 Soluble
36 S H -0.5329 Soluble
37 S H -0.0793 Soluble
38 A H 0.1518 Aggregation-prone
39 V H 0.0000 Buried
40 Q H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H -0.7524 Soluble
44 Q H -1.1539 Soluble
45 A H -1.5952 Soluble
46 R H -1.9065 Soluble
47 G H -2.1997 Soluble
48 Q H -2.7492 Soluble
49 R H -3.0744 Soluble
50 L H 0.0000 Buried
51 E H -1.1261 Soluble
52 W H 0.0000 Buried
53 I H 0.0000 Buried
54 G H 0.0000 Buried
55 W H -0.0767 Soluble
56 I H 0.0000 Buried
57 V H -0.2856 Soluble
58 V H 0.0000 Buried
59 G H -0.5165 Soluble
62 S H -0.6904 Soluble
63 G H -0.9101 Soluble
64 N H -1.5292 Soluble
65 T H -0.9184 Soluble
66 N H -1.3284 Soluble
67 Y H -1.4845 Soluble
68 A H 0.0000 Buried
69 Q H -2.6755 Soluble
70 K H -3.0079 Soluble
71 F H 0.0000 Buried
72 Q H -3.0785 Soluble
74 E H -3.0679 Soluble
75 R H -1.9621 Soluble
76 V H 0.0000 Buried
77 T H -0.9514 Soluble
78 I H -0.6975 Soluble
79 T H -0.7582 Soluble
80 R H -1.0684 Soluble
81 D H -1.1468 Soluble
82 M H -0.3182 Soluble
83 S H -0.3902 Soluble
84 T H -0.5632 Soluble
85 S H -0.7518 Soluble
86 T H 0.0000 Buried
87 A H 0.0000 Buried
88 Y H -0.7914 Soluble
89 M H 0.0000 Buried
90 E H -1.6281 Soluble
91 L H 0.0000 Buried
92 S H -1.2800 Soluble
93 S H -1.2256 Soluble
94 L H 0.0000 Buried
95 R H -2.4017 Soluble
96 S H -2.0692 Soluble
97 E H -2.3518 Soluble
98 D H 0.0000 Buried
99 T H -0.7144 Soluble
100 A H 0.0000 Buried
101 V H 0.0297 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 A H 0.0000 Buried
107 P H 0.0000 Buried
108 Y H 0.5554 Aggregation-prone
109 C H 0.0000 Buried
110 S H -0.4182 Soluble
111 G H -0.8377 Soluble
111A G H -0.8316 Soluble
112B S H -0.5262 Soluble
112A C H -0.0990 Soluble
112 F H -0.3026 Soluble
113 D H -1.3005 Soluble
114 G H 0.0000 Buried
115 F H 0.0000 Buried
116 D H -0.6011 Soluble
117 I H 0.0000 Buried
118 W H -0.2885 Soluble
119 G H -0.8852 Soluble
120 Q H -1.0471 Soluble
121 G H -0.5384 Soluble
122 T H 0.0000 Buried
123 M H 0.0258 Aggregation-prone
124 V H 0.0000 Buried
125 T H 0.0000 Buried
126 V H 0.0000 Buried
127 S H -0.7050 Soluble
128 S H -0.6213 Soluble
129 A H -0.5468 Soluble
130 S H -0.7729 Soluble
131 T H -1.0072 Soluble
132 K H -1.7537 Soluble
133 G H -1.5028 Soluble
134 P H -0.7471 Soluble
135 S H -0.4433 Soluble
136 V H 0.0000 Buried
137 F H 0.2159 Aggregation-prone
138 P H -0.4909 Soluble
139 L H 0.0000 Buried
140 A H -0.7984 Soluble
141 P H -0.4182 Soluble
142 S H -0.0893 Soluble
143 T H -0.0254 Soluble
144 A H 0.0341 Aggregation-prone
145 A H 0.0000 Buried
146 L H 0.0000 Buried
147 G H 0.0000 Buried
148 C H 0.0000 Buried
149 L H 0.3511 Aggregation-prone
150 V H 0.0000 Buried
151 K H -0.2126 Soluble
152 D H -0.8582 Soluble
153 Y H 0.0000 Buried
154 F H 0.0000 Buried
155 P H 0.0000 Buried
156 E H -0.5754 Soluble
157 P H -0.6198 Soluble
158 V H -0.3907 Soluble
159 T H -0.3679 Soluble
160 V H 0.0549 Aggregation-prone
161 S H -0.5186 Soluble
162 W H 0.0000 Buried
163 N H -1.1726 Soluble
164 S H -0.7358 Soluble
165 G H -0.7399 Soluble
166 A H -0.3403 Soluble
167 L H -0.0029 Soluble
168 T H -0.0742 Soluble
169 S H -0.1126 Soluble
170 G H -0.0236 Soluble
171 V H 0.3140 Aggregation-prone
172 H H 0.0540 Aggregation-prone
173 T H 0.0766 Aggregation-prone
174 F H 0.0000 Buried
175 P H -0.3384 Soluble
176 A H 0.2327 Aggregation-prone
177 V H 0.4783 Aggregation-prone
178 L H 0.8326 Aggregation-prone
179 Q H -0.1918 Soluble
180 S H -0.2852 Soluble
181 S H -0.3981 Soluble
182 G H -0.1502 Soluble
183 L H -0.2157 Soluble
184 Y H 0.0000 Buried
185 S H 0.0000 Buried
186 L H 0.1048 Aggregation-prone
187 S H 0.1905 Aggregation-prone
188 S H 0.0000 Buried
189 V H 0.0000 Buried
190 V H 0.0000 Buried
191 T H -0.0284 Soluble
192 V H 0.1072 Aggregation-prone
193 P H -0.3440 Soluble
194 S H -0.2565 Soluble
195 S H -0.1627 Soluble
196 S H -0.1679 Soluble
197 L H 0.0791 Aggregation-prone
198 G H -0.6071 Soluble
199 T H -0.8949 Soluble
200 Q H -1.4610 Soluble
201 T H -1.3630 Soluble
202 Y H 0.0000 Buried
203 I H -1.1501 Soluble
204 C H 0.0000 Buried
205 N H -1.5070 Soluble
206 V H 0.0000 Buried
207 N H -2.3395 Soluble
208 H H 0.0000 Buried
209 K H -2.7077 Soluble
210 P H -1.6007 Soluble
211 S H -1.9468 Soluble
212 N H -2.5168 Soluble
213 T H -2.2404 Soluble
214 K H -2.8101 Soluble
215 V H -1.4854 Soluble
216 D H -2.2684 Soluble
217 K H -2.0274 Soluble
218 K H -2.6133 Soluble
219 V H 0.0000 Buried
220 E H -2.4686 Soluble
221 P H -1.0898 Soluble
1 E L -0.7872 Soluble
2 I L 1.5009 Aggregation-prone
3 V L 1.6333 Aggregation-prone
4 L L 0.0000 Buried
5 T L -0.1691 Soluble
6 Q L 0.0000 Buried
7 S L -0.8481 Soluble
8 P L -0.5330 Soluble
9 G L -0.9104 Soluble
10 T L -0.6898 Soluble
11 L L -0.1941 Soluble
12 S L -0.4935 Soluble
13 L L -0.5390 Soluble
14 S L -1.0832 Soluble
15 P L -1.6322 Soluble
16 G L -1.7379 Soluble
17 E L 0.0000 Buried
18 R L -2.4228 Soluble
19 A L -1.1788 Soluble
20 T L -0.4957 Soluble
21 L L 0.0000 Buried
22 S L -0.7327 Soluble
23 C L 0.0000 Buried
24 R L -1.6506 Soluble
25 A L -0.9332 Soluble
26 S L -0.6561 Soluble
27 Q L -1.4981 Soluble
28 S L -1.1175 Soluble
29 V L -0.4175 Soluble
30 S L -0.1409 Soluble
36 S L 0.0315 Aggregation-prone
37 S L 0.0573 Aggregation-prone
38 Y L 0.6715 Aggregation-prone
39 L L 0.0000 Buried
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L -0.9529 Soluble
45 K L -1.2847 Soluble
46 P L -1.4466 Soluble
47 G L -1.5359 Soluble
48 Q L -1.9180 Soluble
49 A L -1.2145 Soluble
50 P L -0.9171 Soluble
51 R L -0.6288 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.1315 Soluble
56 G L 0.0000 Buried
57 A L 0.0000 Buried
65 S L -0.4448 Soluble
66 S L -0.4167 Soluble
67 R L -0.6472 Soluble
68 A L 0.0000 Buried
69 T L -0.2391 Soluble
70 G L -0.4971 Soluble
71 F L -0.3245 Soluble
72 P L -1.4215 Soluble
74 D L -2.8302 Soluble
75 R L -3.1360 Soluble
76 F L -1.8982 Soluble
77 S L -0.9095 Soluble
78 G L -0.2647 Soluble
79 S L -0.4775 Soluble
80 G L -0.7722 Soluble
83 S L -0.8207 Soluble
84 G L -0.9984 Soluble
85 T L -1.3412 Soluble
86 D L -1.4718 Soluble
87 F L 0.0000 Buried
88 T L -0.6633 Soluble
89 L L -0.0720 Soluble
90 T L -0.7906 Soluble
91 I L 0.0000 Buried
92 S L -2.6950 Soluble
93 R L -3.5553 Soluble
94 L L 0.0000 Buried
95 E L -3.3285 Soluble
96 P L -2.2324 Soluble
97 E L -2.6553 Soluble
98 D L -1.7211 Soluble
99 F L 0.0000 Buried
100 A L 0.0000 Buried
101 V L -0.4357 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 Y L 0.0000 Buried
108 G L -0.7894 Soluble
109 N L -1.5962 Soluble
114 S L -1.1898 Soluble
115 P L -1.0541 Soluble
116 W L -0.5894 Soluble
117 T L 0.0000 Buried
118 F L 0.0000 Buried
119 G L -0.5311 Soluble
120 Q L -1.3613 Soluble
121 G L -1.2926 Soluble
122 T L 0.0000 Buried
123 K L -1.2177 Soluble
124 V L -0.3560 Soluble
125 E L -0.5844 Soluble
126 I L -0.8416 Soluble
127 R L -1.8312 Soluble
128 R L -1.3303 Soluble
129 T L -0.4004 Soluble
130 V L 0.1947 Aggregation-prone
131 A L 0.1888 Aggregation-prone
132 A L -0.0975 Soluble
133 P L -0.0853 Soluble
134 S L -0.0231 Soluble
135 V L 0.5854 Aggregation-prone
136 F L 0.0000 Buried
137 I L 0.0000 Buried
138 F L 0.0000 Buried
139 P L -0.1937 Soluble
140 P L -0.7390 Soluble
141 S L -1.5313 Soluble
142 D L -2.8348 Soluble
143 E L -2.8743 Soluble
144 Q L 0.0000 Buried
145 L L -0.9051 Soluble
146 K L -2.0795 Soluble
147 S L -1.4501 Soluble
148 G L -0.8300 Soluble
149 T L -0.2748 Soluble
150 A L 0.0000 Buried
151 S L -0.1756 Soluble
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L -0.3427 Soluble
158 N L -0.5808 Soluble
159 F L 0.0000 Buried
160 Y L -0.8776 Soluble
161 P L -1.5496 Soluble
162 R L -2.8235 Soluble
163 E L -3.0896 Soluble
164 A L -1.8752 Soluble
165 K L -2.2984 Soluble
166 V L -0.9889 Soluble
167 Q L -1.5684 Soluble
168 W L -1.1166 Soluble
169 K L -2.1705 Soluble
170 V L 0.0000 Buried
171 D L -2.0155 Soluble
172 N L -2.0074 Soluble
173 A L -0.9776 Soluble
174 L L 0.2604 Aggregation-prone
175 Q L -0.9758 Soluble
176 S L -1.3473 Soluble
177 G L -1.3690 Soluble
178 N L -1.8767 Soluble
179 S L -1.5388 Soluble
180 Q L -1.5585 Soluble
181 E L -1.6435 Soluble
182 S L -0.4624 Soluble
183 V L 0.0873 Aggregation-prone
184 T L -0.7138 Soluble
185 E L -2.1343 Soluble
186 Q L -2.1463 Soluble
187 D L -2.5601 Soluble
188 S L -2.4412 Soluble
189 K L -2.6948 Soluble
190 D L -2.5848 Soluble
191 S L -2.1868 Soluble
192 T L 0.0000 Buried
193 Y L -0.9624 Soluble
194 S L 0.0000 Buried
195 L L -0.1272 Soluble
196 S L 0.0000 Buried
197 S L -0.6784 Soluble
198 T L -0.5858 Soluble
199 L L 0.0000 Buried
200 T L -0.5952 Soluble
201 L L -0.6439 Soluble
202 S L -0.6709 Soluble
203 K L -0.7554 Soluble
204 A L -0.6599 Soluble
205 D L -1.3697 Soluble
206 Y L -1.3685 Soluble
207 E L -3.0633 Soluble
208 K L -3.0831 Soluble
209 H L 0.0000 Buried
210 K L -1.4253 Soluble
211 V L -1.0875 Soluble
212 Y L 0.0000 Buried
213 A L -1.1037 Soluble
214 C L 0.0000 Buried
215 E L -0.7959 Soluble
216 V L 0.0000 Buried
217 T L -1.1903 Soluble
218 H L -1.3816 Soluble
219 Q L -1.5090 Soluble
220 G L -0.9191 Soluble
221 L L -0.5274 Soluble
222 S L -0.7703 Soluble
223 S L -0.1978 Soluble
224 P L 0.6496 Aggregation-prone
225 V L 1.2575 Aggregation-prone
226 T L 0.2536 Aggregation-prone
227 K L -1.2574 Soluble
228 S L -0.0310 Soluble
229 F L 0.8181 Aggregation-prone
230 N L -0.8100 Soluble
231 R L -0.9640 Soluble
232 G L -1.1365 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7041 2.7438 CSV PDB
4.5 -0.7486 2.7457 CSV PDB
5.0 -0.802 2.7515 CSV PDB
5.5 -0.8534 2.768 CSV PDB
6.0 -0.8909 2.8077 CSV PDB
6.5 -0.9054 2.8808 CSV PDB
7.0 -0.8966 2.9814 CSV PDB
7.5 -0.8724 3.0963 CSV PDB
8.0 -0.8401 3.2164 CSV PDB
8.5 -0.8024 3.3381 CSV PDB
9.0 -0.7597 3.4594 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH