Zinlirvimab / 6udj

A4DAB308_6udj_A_R | Source PDB: 6udj | Chains: A, R | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.5565
Max Score
2.4457
Min Score
-3.8414
Total Score
-131.88
Score CDR
-0.3662
Score non-CDR
-0.6239

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSALSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) A (Heavy), R (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.8414
Maximum Score 2.4457
Average Score -0.5565
Total Score -131.8843

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q A -1.7391 Soluble
2 V A -1.4781 Soluble
3 Q A -2.0119 Soluble
4 L A -1.4144 Soluble
5 Q A -1.8713 Soluble
6 E A 0.0000 Buried
7 S A -0.6401 Soluble
8 G A -0.3512 Soluble
9 P A 0.0154 Aggregation-prone
11 G A 0.5002 Aggregation-prone
12 L A 1.0868 Aggregation-prone
13 V A -0.3229 Soluble
14 K A -1.8567 Soluble
15 P A -1.6648 Soluble
16 S A -1.8497 Soluble
17 E A -2.8153 Soluble
18 T A -2.1031 Soluble
19 L A 0.0000 Buried
20 S A -0.8066 Soluble
21 V A 0.0000 Buried
22 T A -0.6786 Soluble
23 C A 0.0000 Buried
24 S A -1.1707 Soluble
25 V A 0.0000 Buried
26 S A -1.8381 Soluble
27 G A -2.0443 Soluble
28 D A -2.7478 Soluble
29 S A -1.9681 Soluble
30 M A 0.0000 Buried
35 N A -2.3897 Soluble
36 N A -2.1952 Soluble
37 Y A -1.2642 Soluble
38 Y A -1.1822 Soluble
39 W A 0.0000 Buried
40 T A 0.0000 Buried
41 W A 0.0000 Buried
42 I A 0.0000 Buried
43 R A -0.5031 Soluble
44 Q A -0.9842 Soluble
45 S A 0.0000 Buried
46 P A -1.1014 Soluble
47 G A -1.5014 Soluble
48 K A -2.3240 Soluble
49 G A -1.6127 Soluble
50 L A 0.0000 Buried
51 E A -1.1135 Soluble
52 W A 0.0000 Buried
53 I A 0.0000 Buried
54 G A 0.0000 Buried
55 Y A -0.0220 Soluble
56 I A 0.0000 Buried
57 S A -2.2925 Soluble
58 D A -3.8414 Soluble
59 R A -3.6438 Soluble
63 E A -3.6429 Soluble
64 S A -2.0052 Soluble
65 A A -0.4928 Soluble
66 T A 0.0151 Aggregation-prone
67 Y A 0.1399 Aggregation-prone
68 N A 0.0000 Buried
69 P A -0.6008 Soluble
70 S A -0.6943 Soluble
71 L A -0.8571 Soluble
72 N A -1.7243 Soluble
74 S A -1.0151 Soluble
75 R A -1.3575 Soluble
76 V A 0.0000 Buried
77 V A 0.9050 Aggregation-prone
78 I A 0.0000 Buried
79 S A -0.7526 Soluble
80 R A -2.1728 Soluble
81 D A -3.0641 Soluble
82 T A -2.0641 Soluble
83 S A -1.8155 Soluble
84 K A -2.6085 Soluble
85 N A -2.2374 Soluble
86 Q A -1.8658 Soluble
87 L A 0.0000 Buried
88 S A -0.5054 Soluble
89 L A 0.0000 Buried
90 K A -1.1631 Soluble
91 L A 0.0000 Buried
92 N A -2.2879 Soluble
93 S A -1.7457 Soluble
94 V A 0.0000 Buried
95 T A -0.9872 Soluble
96 P A -0.6626 Soluble
97 A A -0.2495 Soluble
98 D A -0.3938 Soluble
99 T A -0.0678 Soluble
100 A A 0.0000 Buried
101 V A -0.2663 Soluble
102 Y A 0.0000 Buried
103 Y A 0.0000 Buried
104 C A 0.0000 Buried
105 A A 0.0000 Buried
106 T A 0.0000 Buried
107 A A 0.0000 Buried
108 R A -1.5163 Soluble
109 R A -1.7717 Soluble
110 G A -1.0432 Soluble
111 Q A -0.5199 Soluble
111A R A -0.0125 Soluble
111B I A 1.4019 Aggregation-prone
111C Y A 1.0570 Aggregation-prone
111D G A 1.2411 Aggregation-prone
111E V A 2.2691 Aggregation-prone
111F V A 2.4457 Aggregation-prone
112G S A 1.5174 Aggregation-prone
112F F A 2.2530 Aggregation-prone
112E G A 1.1928 Aggregation-prone
112D E A 1.0608 Aggregation-prone
112C F A 1.2511 Aggregation-prone
112B F A 0.4439 Aggregation-prone
112A Y A 0.2813 Aggregation-prone
112 Y A 0.0000 Buried
113 Y A 0.0000 Buried
114 S A 0.0000 Buried
115 M A 0.0000 Buried
116 D A -0.0895 Soluble
117 V A 0.1797 Aggregation-prone
118 W A 0.0000 Buried
119 G A 0.0000 Buried
120 K A -2.2126 Soluble
121 G A 0.0000 Buried
122 T A -0.6218 Soluble
123 T A -0.0967 Soluble
124 V A 0.0000 Buried
125 T A 0.1587 Aggregation-prone
126 V A 0.0000 Buried
127 S A -0.5575 Soluble
128 S A -0.6852 Soluble
129 A A -0.1613 Soluble
11 L R 0.7703 Aggregation-prone
12 S R 0.6153 Aggregation-prone
13 V R 0.5676 Aggregation-prone
14 A R 0.4751 Aggregation-prone
15 L R 0.4939 Aggregation-prone
16 G R -0.8788 Soluble
17 E R -1.5090 Soluble
18 T R -1.3202 Soluble
19 A R 0.0000 Buried
20 R R -1.8450 Soluble
21 I R 0.0000 Buried
22 S R -1.2429 Soluble
23 C R -1.2943 Soluble
24 G R -1.3633 Soluble
25 R R -1.5193 Soluble
26 Q R -1.7158 Soluble
27 A R -0.5105 Soluble
28 L R 0.8101 Aggregation-prone
29 G R 0.3173 Aggregation-prone
36 S R 0.6458 Aggregation-prone
37 R R 0.0000 Buried
38 A R 0.0000 Buried
39 V R 0.0000 Buried
40 Q R 0.0000 Buried
41 W R 0.0000 Buried
42 Y R 0.0000 Buried
43 Q R -0.3905 Soluble
44 H R 0.0000 Buried
45 R R -1.4931 Soluble
46 P R -1.1522 Soluble
47 G R -1.4997 Soluble
48 Q R -1.8926 Soluble
49 A R -1.1778 Soluble
50 P R 0.0000 Buried
51 I R 0.4773 Aggregation-prone
52 L R 0.0000 Buried
53 L R 0.0000 Buried
54 I R 0.0000 Buried
55 Y R -0.5786 Soluble
56 N R -1.0160 Soluble
57 N R 0.0000 Buried
65 Q R -1.5113 Soluble
66 D R -1.3366 Soluble
67 R R -1.6189 Soluble
68 P R -0.7734 Soluble
69 S R -0.8058 Soluble
70 G R -0.8079 Soluble
71 I R -0.7046 Soluble
72 P R -1.3071 Soluble
74 E R -2.2596 Soluble
75 R R -1.4796 Soluble
76 F R 0.0000 Buried
77 S R -1.2724 Soluble
78 G R -1.1435 Soluble
79 T R -0.6384 Soluble
80 P R -0.2938 Soluble
81 D R 0.2236 Aggregation-prone
81A I R 1.6819 Aggregation-prone
82 N R 0.4306 Aggregation-prone
83 F R 1.5127 Aggregation-prone
84 G R 0.0392 Aggregation-prone
85 T R -0.7046 Soluble
86 R R -2.1703 Soluble
87 A R 0.0000 Buried
88 T R 0.0000 Buried
89 L R 0.0000 Buried
90 T R -0.9311 Soluble
91 I R 0.0000 Buried
92 S R -1.3932 Soluble
93 G R -1.1184 Soluble
94 V R 0.0000 Buried
95 E R -1.8573 Soluble
96 A R -0.8332 Soluble
97 G R -1.2483 Soluble
98 D R 0.0000 Buried
99 E R -1.5261 Soluble
100 A R 0.0000 Buried
101 D R 0.0000 Buried
102 Y R 0.0000 Buried
103 Y R 0.0000 Buried
104 C R 0.0000 Buried
105 H R 0.0000 Buried
106 M R 0.0000 Buried
107 W R 0.0000 Buried
108 D R 0.0000 Buried
109 S R -0.4379 Soluble
110 R R -1.5730 Soluble
112 S R -0.8906 Soluble
113 G R -0.5970 Soluble
114 F R 0.3925 Aggregation-prone
115 S R 0.0000 Buried
116 W R 0.0413 Aggregation-prone
117 S R -0.3073 Soluble
118 F R 0.0000 Buried
119 G R -0.7385 Soluble
120 G R -1.1873 Soluble
121 A R -1.0408 Soluble
122 T R -0.8192 Soluble
123 R R -1.6936 Soluble
124 L R 0.0000 Buried
125 T R 0.2108 Aggregation-prone
126 V R 0.5444 Aggregation-prone
127 L R 1.3988 Aggregation-prone
128 G R 0.4039 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.4249 4.4406 CSV PDB
4.5 -0.4625 4.4123 CSV PDB
5.0 -0.5099 4.3707 CSV PDB
5.5 -0.5593 4.3227 CSV PDB
6.0 -0.6024 4.2757 CSV PDB
6.5 -0.6325 4.2539 CSV PDB
7.0 -0.647 4.2369 CSV PDB
7.5 -0.6491 4.2207 CSV PDB
8.0 -0.6435 4.2064 CSV PDB
8.5 -0.632 4.1975 CSV PDB
9.0 -0.6151 4.197 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH