Zinlirvimab / 9bew

A4DAB308_9bew_Q_R | Source PDB: 9bew | Chains: Q, R | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.5744
Max Score
2.8769
Min Score
-3.1626
Total Score
-136.12
Score CDR
-0.3633
Score non-CDR
-0.6491

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSALSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) Q (Heavy), R (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.1626
Maximum Score 2.8769
Average Score -0.5744
Total Score -136.1229

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q Q -1.7159 Soluble
2 V Q -1.3940 Soluble
3 Q Q -1.8735 Soluble
4 L Q -1.4049 Soluble
5 Q Q -2.0483 Soluble
6 E Q -1.3217 Soluble
7 S Q -0.9880 Soluble
8 G Q -0.2992 Soluble
9 P Q -0.0262 Soluble
11 G Q 0.3095 Aggregation-prone
12 L Q 1.1372 Aggregation-prone
13 V Q 0.0000 Buried
14 K Q -1.0721 Soluble
15 P Q -1.2584 Soluble
16 S Q -1.4385 Soluble
17 E Q -1.9363 Soluble
18 T Q -1.7159 Soluble
19 L Q 0.0000 Buried
20 S Q -1.0111 Soluble
21 V Q 0.0000 Buried
22 T Q -0.7231 Soluble
23 C Q 0.0000 Buried
24 S Q -1.1967 Soluble
25 V Q 0.0000 Buried
26 S Q -1.5697 Soluble
27 G Q -1.7655 Soluble
28 D Q -2.2649 Soluble
29 S Q -1.5175 Soluble
30 M Q -1.4989 Soluble
35 N Q -2.0961 Soluble
36 N Q -2.2637 Soluble
37 Y Q -1.2027 Soluble
38 Y Q -0.7323 Soluble
39 W Q 0.0000 Buried
40 T Q 0.0000 Buried
41 W Q 0.0000 Buried
42 I Q 0.0000 Buried
43 R Q -0.6227 Soluble
44 Q Q -1.0232 Soluble
45 S Q -1.0234 Soluble
46 P Q -1.0659 Soluble
47 G Q -1.4739 Soluble
48 K Q -2.2889 Soluble
49 G Q -1.6087 Soluble
50 L Q 0.0000 Buried
51 E Q -1.3524 Soluble
52 W Q 0.0000 Buried
53 I Q -0.0594 Soluble
54 G Q 0.0000 Buried
55 Y Q 0.3339 Aggregation-prone
56 I Q 0.0000 Buried
57 S Q -1.6652 Soluble
58 D Q -2.4897 Soluble
59 R Q -3.0640 Soluble
63 E Q -3.1626 Soluble
64 S Q -1.7686 Soluble
65 A Q -0.7109 Soluble
66 T Q -0.0504 Soluble
67 Y Q -0.0172 Soluble
68 N Q 0.0000 Buried
69 P Q -0.8209 Soluble
70 S Q -0.7262 Soluble
71 L Q -0.9036 Soluble
72 N Q -1.7629 Soluble
74 S Q -1.2120 Soluble
75 R Q -2.0603 Soluble
76 V Q 0.0000 Buried
77 V Q 0.0781 Aggregation-prone
78 I Q 0.0000 Buried
79 S Q -0.9043 Soluble
80 R Q -1.6716 Soluble
81 D Q -2.1316 Soluble
82 T Q -1.6550 Soluble
83 S Q -1.5922 Soluble
84 K Q -2.4984 Soluble
85 N Q -1.9862 Soluble
86 Q Q -1.5879 Soluble
87 L Q 0.0000 Buried
88 S Q -0.6632 Soluble
89 L Q 0.0000 Buried
90 K Q -1.9152 Soluble
91 L Q 0.0000 Buried
92 N Q -2.3114 Soluble
93 S Q -1.4953 Soluble
94 V Q 0.0000 Buried
95 T Q -0.5561 Soluble
96 P Q -0.4614 Soluble
97 A Q -0.0878 Soluble
98 D Q 0.0000 Buried
99 T Q -0.1003 Soluble
100 A Q 0.0000 Buried
101 V Q -0.2109 Soluble
102 Y Q 0.0000 Buried
103 Y Q 0.0000 Buried
104 C Q 0.0000 Buried
105 A Q 0.0000 Buried
106 T Q 0.0000 Buried
107 A Q 0.0000 Buried
108 R Q -1.8021 Soluble
109 R Q -2.3140 Soluble
110 G Q -1.3035 Soluble
111 Q Q -0.6662 Soluble
111A R Q 0.0252 Aggregation-prone
111B I Q 1.7997 Aggregation-prone
111C Y Q 1.6504 Aggregation-prone
111D G Q 1.5746 Aggregation-prone
111E V Q 2.4995 Aggregation-prone
111F V Q 2.8769 Aggregation-prone
112G S Q 1.6794 Aggregation-prone
112F F Q 2.3207 Aggregation-prone
112E G Q 1.2932 Aggregation-prone
112D E Q 1.1426 Aggregation-prone
112C F Q 1.4920 Aggregation-prone
112B F Q 0.4105 Aggregation-prone
112A Y Q 0.0302 Aggregation-prone
112 Y Q -0.3573 Soluble
113 Y Q 0.0000 Buried
114 S Q 0.0000 Buried
115 M Q 0.0000 Buried
116 D Q -0.8274 Soluble
117 V Q -0.2618 Soluble
118 W Q 0.0000 Buried
119 G Q 0.0000 Buried
120 K Q -2.3015 Soluble
121 G Q -1.4217 Soluble
122 T Q -0.7407 Soluble
123 T Q 0.0064 Aggregation-prone
124 V Q 0.0000 Buried
125 T Q 0.1706 Aggregation-prone
126 V Q 0.0571 Aggregation-prone
127 S Q -0.1457 Soluble
128 S Q -0.4442 Soluble
129 A Q -0.1894 Soluble
11 L R 0.5302 Aggregation-prone
12 S R 0.5242 Aggregation-prone
13 V R 0.0000 Buried
14 A R 0.5995 Aggregation-prone
15 L R 0.8715 Aggregation-prone
16 G R -0.5929 Soluble
17 E R -1.3381 Soluble
18 T R -1.1046 Soluble
19 A R 0.0000 Buried
20 R R -1.9136 Soluble
21 I R 0.0000 Buried
22 S R -1.2336 Soluble
23 C R -1.0700 Soluble
24 G R -1.5471 Soluble
25 R R -1.9742 Soluble
26 Q R -1.9780 Soluble
27 A R -0.9869 Soluble
28 L R -0.1268 Soluble
29 G R 0.0436 Aggregation-prone
36 S R 0.5614 Aggregation-prone
37 R R 0.0000 Buried
38 A R 0.0000 Buried
39 V R 0.0000 Buried
40 Q R 0.0000 Buried
41 W R 0.0000 Buried
42 Y R 0.0000 Buried
43 Q R 0.0000 Buried
44 H R 0.0000 Buried
45 R R -1.4383 Soluble
46 P R -1.1748 Soluble
47 G R -1.3964 Soluble
48 Q R -1.7120 Soluble
49 A R -1.0205 Soluble
50 P R 0.0000 Buried
51 I R 0.3463 Aggregation-prone
52 L R 0.0000 Buried
53 L R 0.0000 Buried
54 I R 0.0000 Buried
55 Y R -1.0322 Soluble
56 N R -1.4702 Soluble
57 N R 0.0000 Buried
65 Q R -2.0764 Soluble
66 D R -2.1766 Soluble
67 R R -1.7248 Soluble
68 P R -0.8805 Soluble
69 S R -0.7514 Soluble
70 G R -0.5025 Soluble
71 I R -0.6324 Soluble
72 P R -1.3190 Soluble
74 E R -2.1722 Soluble
75 R R -1.3767 Soluble
76 F R 0.0000 Buried
77 S R -1.1083 Soluble
78 G R -0.8678 Soluble
79 T R -0.5740 Soluble
80 P R -0.4063 Soluble
81 D R 0.2640 Aggregation-prone
81A I R 1.7214 Aggregation-prone
82 N R 0.4298 Aggregation-prone
83 F R 1.3674 Aggregation-prone
84 G R 0.0325 Aggregation-prone
85 T R -0.7664 Soluble
86 R R -2.1586 Soluble
87 A R -1.5590 Soluble
88 T R -1.0486 Soluble
89 L R 0.0000 Buried
90 T R -0.9271 Soluble
91 I R 0.0000 Buried
92 S R -1.4611 Soluble
93 G R -1.1573 Soluble
94 V R -0.9569 Soluble
95 E R -1.7995 Soluble
96 A R -0.8095 Soluble
97 G R -1.2433 Soluble
98 D R 0.0000 Buried
99 E R -1.9143 Soluble
100 A R 0.0000 Buried
101 D R 0.0000 Buried
102 Y R 0.0000 Buried
103 Y R 0.0000 Buried
104 C R 0.0000 Buried
105 H R 0.0000 Buried
106 M R 0.0000 Buried
107 W R 0.0000 Buried
108 D R 0.0000 Buried
109 S R -0.5214 Soluble
110 R R -1.7628 Soluble
112 S R -0.8983 Soluble
113 G R -0.5805 Soluble
114 F R 0.4809 Aggregation-prone
115 S R 0.2333 Aggregation-prone
116 W R -0.0009 Soluble
117 S R -0.4777 Soluble
118 F R 0.0000 Buried
119 G R -1.0640 Soluble
120 G R -1.3080 Soluble
121 A R -1.0283 Soluble
122 T R -0.6995 Soluble
123 R R -1.8238 Soluble
124 L R 0.0000 Buried
125 T R -0.0621 Soluble
126 V R 0.5214 Aggregation-prone
127 L R 1.4900 Aggregation-prone
128 G R 0.5524 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.4745 4.5359 CSV PDB
4.5 -0.5076 4.5088 CSV PDB
5.0 -0.5499 4.4657 CSV PDB
5.5 -0.5935 4.4133 CSV PDB
6.0 -0.6301 4.3599 CSV PDB
6.5 -0.6532 4.314 CSV PDB
7.0 -0.6615 4.2832 CSV PDB
7.5 -0.6594 4.2679 CSV PDB
8.0 -0.6516 4.262 CSV PDB
8.5 -0.6402 4.26 CSV PDB
9.0 -0.6255 4.2593 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH