Zinlirvimab / 6udk

A4DAB308_6udk_O_P | Source PDB: 6udk | Chains: O, P | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6212
Max Score
2.92
Min Score
-3.7922
Total Score
-147.22
Score CDR
-0.4133
Score non-CDR
-0.6948

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSALSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) O (Heavy), P (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.7922
Maximum Score 2.92
Average Score -0.6212
Total Score -147.2177

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q O -1.9378 Soluble
2 V O 0.0000 Buried
3 Q O -1.9044 Soluble
4 L O -1.3313 Soluble
5 Q O -1.8946 Soluble
6 E O -1.4123 Soluble
7 S O -0.8216 Soluble
8 G O -0.4248 Soluble
9 P O -0.0398 Soluble
11 G O 0.2970 Aggregation-prone
12 L O 1.0299 Aggregation-prone
13 V O -0.4328 Soluble
14 K O -1.8802 Soluble
15 P O -1.6790 Soluble
16 S O -1.9602 Soluble
17 E O -2.9186 Soluble
18 T O -2.0236 Soluble
19 L O 0.0000 Buried
20 S O -0.9404 Soluble
21 V O 0.0000 Buried
22 T O -0.7248 Soluble
23 C O 0.0000 Buried
24 S O -1.2638 Soluble
25 V O 0.0000 Buried
26 S O -1.6045 Soluble
27 G O -1.9303 Soluble
28 D O -2.4171 Soluble
29 S O -1.7272 Soluble
30 M O -1.6823 Soluble
35 N O -2.3836 Soluble
36 N O -2.5343 Soluble
37 Y O -1.6606 Soluble
38 Y O 0.0000 Buried
39 W O 0.0000 Buried
40 T O 0.0000 Buried
41 W O 0.0000 Buried
42 I O 0.0000 Buried
43 R O -0.5583 Soluble
44 Q O -0.9506 Soluble
45 S O -1.0388 Soluble
46 P O -1.0989 Soluble
47 G O -1.5024 Soluble
48 K O -2.2780 Soluble
49 G O -1.5588 Soluble
50 L O 0.0000 Buried
51 E O -0.9960 Soluble
52 W O 0.0000 Buried
53 I O 0.0000 Buried
54 G O 0.0000 Buried
55 Y O -0.0129 Soluble
56 I O 0.0000 Buried
57 S O -2.6678 Soluble
58 D O -3.7922 Soluble
59 R O -3.6365 Soluble
63 E O -3.4317 Soluble
64 S O -1.9045 Soluble
65 A O -0.5536 Soluble
66 T O -0.0561 Soluble
67 Y O 0.0432 Aggregation-prone
68 N O 0.0000 Buried
69 P O -0.7696 Soluble
70 S O -0.7977 Soluble
71 L O 0.0000 Buried
72 N O -1.7317 Soluble
74 S O -1.2591 Soluble
75 R O -1.7057 Soluble
76 V O 0.0000 Buried
77 V O -0.0204 Soluble
78 I O 0.0000 Buried
79 S O -0.7216 Soluble
80 R O -1.3976 Soluble
81 D O -1.5375 Soluble
82 T O -1.4834 Soluble
83 S O -1.4654 Soluble
84 K O -2.3711 Soluble
85 N O -1.8804 Soluble
86 Q O -1.5763 Soluble
87 L O 0.0000 Buried
88 S O -0.5529 Soluble
89 L O 0.0000 Buried
90 K O -1.4727 Soluble
91 L O 0.0000 Buried
92 N O -2.4223 Soluble
93 S O -1.6672 Soluble
94 V O 0.0000 Buried
95 T O -0.9178 Soluble
96 P O -0.6860 Soluble
97 A O -0.2170 Soluble
98 D O -0.3732 Soluble
99 T O -0.1161 Soluble
100 A O 0.0000 Buried
101 V O -0.3399 Soluble
102 Y O 0.0000 Buried
103 Y O 0.0000 Buried
104 C O 0.0000 Buried
105 A O 0.0000 Buried
106 T O 0.0000 Buried
107 A O 0.0000 Buried
108 R O -2.2383 Soluble
109 R O -2.1237 Soluble
110 G O -1.4716 Soluble
111 Q O -1.0969 Soluble
111A R O -0.1080 Soluble
111B I O 1.6334 Aggregation-prone
111C Y O 1.6019 Aggregation-prone
111D G O 1.5089 Aggregation-prone
111E V O 2.4984 Aggregation-prone
111F V O 2.9200 Aggregation-prone
112G S O 1.7357 Aggregation-prone
112F F O 2.3302 Aggregation-prone
112E G O 1.4714 Aggregation-prone
112D E O 1.2638 Aggregation-prone
112C F O 1.6075 Aggregation-prone
112B F O 0.8187 Aggregation-prone
112A Y O 0.1819 Aggregation-prone
112 Y O 0.0000 Buried
113 Y O 0.0000 Buried
114 S O 0.0000 Buried
115 M O 0.0000 Buried
116 D O -0.2671 Soluble
117 V O 0.1023 Aggregation-prone
118 W O 0.0000 Buried
119 G O 0.0000 Buried
120 K O -2.3268 Soluble
121 G O -1.4862 Soluble
122 T O -0.7755 Soluble
123 T O -0.2337 Soluble
124 V O 0.0000 Buried
125 T O 0.0516 Aggregation-prone
126 V O 0.0000 Buried
127 S O -0.4933 Soluble
128 S O -0.6428 Soluble
129 A O -0.1595 Soluble
11 L P 0.9330 Aggregation-prone
12 S P 0.6746 Aggregation-prone
13 V P 0.0000 Buried
14 A P 0.3354 Aggregation-prone
15 L P 0.1899 Aggregation-prone
16 G P -1.2003 Soluble
17 E P -2.0724 Soluble
18 T P -1.4452 Soluble
19 A P -1.2302 Soluble
20 R P -1.9371 Soluble
21 I P 0.0000 Buried
22 S P -1.1246 Soluble
23 C P -1.0015 Soluble
24 G P -1.3314 Soluble
25 R P -1.6551 Soluble
26 Q P -1.7689 Soluble
27 A P -0.6699 Soluble
28 L P 0.0322 Aggregation-prone
29 G P -0.1808 Soluble
36 S P 0.5705 Aggregation-prone
37 R P 0.0000 Buried
38 A P 0.0000 Buried
39 V P 0.0000 Buried
40 Q P 0.0000 Buried
41 W P 0.0000 Buried
42 Y P 0.0000 Buried
43 Q P 0.0000 Buried
44 H P 0.0000 Buried
45 R P -2.0629 Soluble
46 P P -1.5981 Soluble
47 G P -1.7007 Soluble
48 Q P -2.1918 Soluble
49 A P -1.2985 Soluble
50 P P 0.0000 Buried
51 I P 0.2607 Aggregation-prone
52 L P 0.0000 Buried
53 L P 0.0000 Buried
54 I P 0.0000 Buried
55 Y P -1.0355 Soluble
56 N P -1.7060 Soluble
57 N P 0.0000 Buried
65 Q P -2.3414 Soluble
66 D P -2.4608 Soluble
67 R P -1.8242 Soluble
68 P P -0.7052 Soluble
69 S P -0.5382 Soluble
70 G P -0.7638 Soluble
71 I P -0.6406 Soluble
72 P P -1.2818 Soluble
74 E P -2.2259 Soluble
75 R P -1.5614 Soluble
76 F P 0.0000 Buried
77 S P -1.4421 Soluble
78 G P -1.3702 Soluble
79 T P -0.5445 Soluble
80 P P -0.2218 Soluble
81 D P 0.3638 Aggregation-prone
81A I P 1.7697 Aggregation-prone
82 N P 0.4457 Aggregation-prone
83 F P 1.4576 Aggregation-prone
84 G P 0.1382 Aggregation-prone
85 T P -0.4088 Soluble
86 R P -1.5302 Soluble
87 A P 0.0000 Buried
88 T P -1.0615 Soluble
89 L P 0.0000 Buried
90 T P -0.9980 Soluble
91 I P 0.0000 Buried
92 S P -1.6452 Soluble
93 G P -1.4437 Soluble
94 V P 0.0000 Buried
95 E P -1.9443 Soluble
96 A P -0.8963 Soluble
97 G P -1.2395 Soluble
98 D P -1.4333 Soluble
99 E P -2.1977 Soluble
100 A P 0.0000 Buried
101 D P -1.4494 Soluble
102 Y P 0.0000 Buried
103 Y P 0.0000 Buried
104 C P 0.0000 Buried
105 H P 0.0000 Buried
106 M P 0.0000 Buried
107 W P 0.0000 Buried
108 D P 0.0000 Buried
109 S P -0.6000 Soluble
110 R P -1.8794 Soluble
112 S P -0.9613 Soluble
113 G P -0.4333 Soluble
114 F P 0.5627 Aggregation-prone
115 S P 0.2557 Aggregation-prone
116 W P 0.0529 Aggregation-prone
117 S P -0.3708 Soluble
118 F P 0.0000 Buried
119 G P -0.9101 Soluble
120 G P -1.3513 Soluble
121 A P -1.1477 Soluble
122 T P -0.8406 Soluble
123 R P -1.8525 Soluble
124 L P 0.0000 Buried
125 T P -0.1507 Soluble
126 V P 0.5277 Aggregation-prone
127 L P 1.2058 Aggregation-prone
128 G P 0.2618 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
Load structure to view sequence…
Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.4789 4.558 CSV PDB
4.5 -0.5195 4.5447 CSV PDB
5.0 -0.5685 4.5307 CSV PDB
5.5 -0.6178 4.5166 CSV PDB
6.0 -0.6591 4.5025 CSV PDB
6.5 -0.6855 4.4884 CSV PDB
7.0 -0.6955 4.4745 CSV PDB
7.5 -0.6934 4.4613 CSV PDB
8.0 -0.6838 4.4498 CSV PDB
8.5 -0.6688 4.4416 CSV PDB
9.0 -0.6495 4.4373 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH