Sonavibart / 5jw3

A4DAB244_5jw3_H_L | Source PDB: 5jw3 | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6565
Max Score
2.3554
Min Score
-3.3032
Total Score
-280.98
Score CDR
-0.0107
Score non-CDR
-0.7439

Calculation Parameters

Chain Sequence(s) QVQLQQSGPGLVKPSQTLSLTCAISGDSVSSYNAVWNWIRQSPSRGLEWLGRTYYRSGWYNDYAESVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARSGHITVFGVNVDAFDMWGQGTMVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPMTQSPSSLSASVGDRVTITCRTSQSLSSYTHWYQQKPGKAPKLLIYAASSRGSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.3032
Maximum Score 2.3554
Average Score -0.6565
Total Score -280.9801

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.5249 Soluble
2 V H -1.3035 Soluble
3 Q H -1.9446 Soluble
4 L H 0.0000 Buried
5 Q H -1.8441 Soluble
6 Q H 0.0000 Buried
7 S H -0.8565 Soluble
8 G H -0.4833 Soluble
9 P H -0.5659 Soluble
11 G H -0.2694 Soluble
12 L H -0.1820 Soluble
13 V H 0.0000 Buried
14 K H -2.0345 Soluble
15 P H -1.6460 Soluble
16 S H -1.4707 Soluble
17 Q H -2.0261 Soluble
18 T H -1.4108 Soluble
19 L H 0.0000 Buried
20 S H -0.7150 Soluble
21 L H 0.0000 Buried
22 T H -0.7448 Soluble
23 C H 0.0000 Buried
24 A H -1.2244 Soluble
25 I H 0.0000 Buried
26 S H -1.2237 Soluble
27 G H -1.2124 Soluble
28 D H -1.1357 Soluble
29 S H -0.4509 Soluble
30 V H 0.0000 Buried
31 S H -0.0672 Soluble
34 S H 0.0003 Aggregation-prone
35 Y H 0.5323 Aggregation-prone
36 N H -0.9468 Soluble
37 A H 0.0000 Buried
38 V H 0.0000 Buried
39 W H 0.0000 Buried
40 N H 0.0000 Buried
41 W H 0.0000 Buried
42 I H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.5985 Soluble
45 S H -1.0664 Soluble
46 P H -0.8951 Soluble
47 S H -1.6309 Soluble
48 R H -2.5407 Soluble
49 G H -1.5709 Soluble
50 L H 0.0000 Buried
51 E H -0.8450 Soluble
52 W H 0.0000 Buried
53 L H 0.0000 Buried
54 G H 0.0000 Buried
55 R H -0.6060 Soluble
56 T H 0.0000 Buried
57 Y H 0.1804 Aggregation-prone
58 Y H 0.5429 Aggregation-prone
59 R H 0.0582 Aggregation-prone
60 S H -0.0188 Soluble
62 G H 0.1058 Aggregation-prone
63 W H 0.4905 Aggregation-prone
64 Y H 0.3598 Aggregation-prone
65 N H -0.6597 Soluble
66 D H -1.2986 Soluble
67 Y H -1.4004 Soluble
68 A H -1.6883 Soluble
69 E H -2.5385 Soluble
70 S H -1.5558 Soluble
71 V H 0.0000 Buried
72 K H -2.6016 Soluble
74 S H -1.5903 Soluble
75 R H -1.2988 Soluble
76 I H 0.0000 Buried
77 T H -1.1619 Soluble
78 I H 0.0000 Buried
79 N H -1.5100 Soluble
80 P H -1.1842 Soluble
81 D H -1.5820 Soluble
82 T H -1.2711 Soluble
83 S H -1.3617 Soluble
84 K H -2.1903 Soluble
85 N H -1.5859 Soluble
86 Q H -1.4979 Soluble
87 F H 0.0000 Buried
88 S H -0.8413 Soluble
89 L H 0.0000 Buried
90 Q H -0.9689 Soluble
91 L H 0.0000 Buried
92 N H -1.3384 Soluble
93 S H -1.3191 Soluble
94 V H 0.0000 Buried
95 T H -1.3727 Soluble
96 P H -1.3929 Soluble
97 E H -2.2263 Soluble
98 D H 0.0000 Buried
99 T H -0.5727 Soluble
100 A H 0.0000 Buried
101 V H 0.2558 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H 0.0000 Buried
107 S H 0.0000 Buried
108 G H 0.0000 Buried
109 H H -0.6543 Soluble
110 I H 0.2244 Aggregation-prone
111 T H 0.8645 Aggregation-prone
111A V H 1.7114 Aggregation-prone
111B F H 2.3554 Aggregation-prone
112C G H 1.0969 Aggregation-prone
112B V H 1.8836 Aggregation-prone
112A N H 0.5094 Aggregation-prone
112 V H 0.0000 Buried
113 D H 0.0000 Buried
114 A H 0.0000 Buried
115 F H 0.0000 Buried
116 D H -0.4679 Soluble
117 M H -0.5804 Soluble
118 W H 0.0000 Buried
119 G H 0.0000 Buried
120 Q H -1.9987 Soluble
121 G H -1.0262 Soluble
122 T H -0.2620 Soluble
123 M H 0.3246 Aggregation-prone
124 V H 0.0000 Buried
125 T H -0.3306 Soluble
126 V H 0.0000 Buried
127 S H -0.7181 Soluble
128 S H -0.7921 Soluble
129 A H -0.5409 Soluble
130 S H -0.6375 Soluble
131 T H -0.8076 Soluble
132 K H -1.4575 Soluble
133 G H -1.5917 Soluble
134 P H 0.0000 Buried
135 S H -0.4061 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.2451 Soluble
139 L H 0.0000 Buried
140 A H -0.8225 Soluble
141 P H 0.0000 Buried
142 S H -0.4104 Soluble
143 G H -0.6408 Soluble
144 T H -0.4669 Soluble
145 A H -0.2622 Soluble
146 A H 0.0000 Buried
147 L H 0.0000 Buried
148 G H 0.0000 Buried
149 C H 0.0000 Buried
150 L H 0.0000 Buried
151 V H 0.0000 Buried
152 K H 0.0000 Buried
153 D H -0.5690 Soluble
154 Y H 0.0000 Buried
155 F H -0.2204 Soluble
156 P H 0.0000 Buried
157 E H -0.1662 Soluble
158 P H -0.4659 Soluble
159 V H -0.5356 Soluble
160 T H -0.5438 Soluble
161 V H -0.3239 Soluble
162 S H -0.3516 Soluble
163 W H 0.0000 Buried
164 N H -0.6853 Soluble
165 S H -0.5918 Soluble
166 G H -0.5849 Soluble
167 A H -0.2555 Soluble
168 L H -0.0315 Soluble
169 T H -0.2047 Soluble
170 S H -0.2195 Soluble
171 G H -0.2611 Soluble
172 V H 0.1008 Aggregation-prone
173 H H -0.1664 Soluble
174 T H 0.0078 Aggregation-prone
175 F H 0.0000 Buried
176 P H -0.1511 Soluble
177 A H 0.3547 Aggregation-prone
178 V H 0.6835 Aggregation-prone
179 L H 1.3105 Aggregation-prone
180 Q H 0.3076 Aggregation-prone
181 S H -0.0586 Soluble
182 S H -0.2451 Soluble
183 G H 0.0187 Aggregation-prone
184 L H 0.1656 Aggregation-prone
185 Y H 0.5203 Aggregation-prone
186 S H 0.0000 Buried
187 L H 0.0000 Buried
188 S H 0.0000 Buried
189 S H 0.0000 Buried
190 V H 0.0000 Buried
191 V H 0.0000 Buried
192 T H -0.1564 Soluble
193 V H 0.0000 Buried
194 P H -0.4887 Soluble
195 S H -0.5311 Soluble
196 S H -0.6120 Soluble
197 S H -0.5733 Soluble
198 L H -0.7765 Soluble
199 G H -0.9233 Soluble
200 T H -0.6715 Soluble
201 Q H -1.0904 Soluble
202 T H -1.0381 Soluble
203 Y H 0.0000 Buried
204 I H -1.1468 Soluble
205 C H 0.0000 Buried
206 N H -1.3310 Soluble
207 V H 0.0000 Buried
208 N H -1.8522 Soluble
209 H H 0.0000 Buried
210 K H -2.7828 Soluble
211 P H -1.6151 Soluble
212 S H -1.9083 Soluble
213 N H -2.6242 Soluble
214 T H -2.1895 Soluble
215 K H -2.5881 Soluble
216 V H -1.4202 Soluble
217 D H -2.0361 Soluble
218 K H -1.9682 Soluble
219 K H -2.5177 Soluble
220 V H 0.0000 Buried
221 E H -2.4865 Soluble
222 P H -1.1909 Soluble
4 M L -1.0396 Soluble
5 T L -1.1423 Soluble
6 Q L 0.0000 Buried
7 S L -0.8287 Soluble
8 P L -0.5174 Soluble
9 S L -0.8537 Soluble
10 S L -0.7669 Soluble
11 L L -0.5875 Soluble
12 S L -0.9262 Soluble
13 A L -1.1212 Soluble
14 S L -1.0731 Soluble
15 V L -0.2275 Soluble
16 G L -0.8693 Soluble
17 D L -1.8900 Soluble
18 R L -2.3079 Soluble
19 V L 0.0000 Buried
20 T L -0.6367 Soluble
21 I L 0.0000 Buried
22 T L -0.7954 Soluble
23 C L 0.0000 Buried
24 R L -2.3624 Soluble
25 T L 0.0000 Buried
26 S L -1.2032 Soluble
27 Q L -1.6096 Soluble
28 S L -1.0394 Soluble
29 L L 0.0383 Aggregation-prone
36 S L -0.2484 Soluble
37 S L 0.3811 Aggregation-prone
38 Y L 0.3130 Aggregation-prone
39 T L 0.0000 Buried
40 H L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L -1.2660 Soluble
45 K L -1.5433 Soluble
46 P L -1.3107 Soluble
47 G L -1.6461 Soluble
48 K L -2.5676 Soluble
49 A L -1.6328 Soluble
50 P L 0.0000 Buried
51 K L -1.4990 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.1091 Soluble
56 A L 0.0318 Aggregation-prone
57 A L 0.0000 Buried
65 S L -0.7103 Soluble
66 S L -0.8444 Soluble
67 R L -1.6354 Soluble
68 G L 0.0000 Buried
69 S L -0.9372 Soluble
70 G L -0.8359 Soluble
71 V L 0.0000 Buried
72 P L -0.6920 Soluble
74 S L -0.7660 Soluble
75 R L -0.8246 Soluble
76 F L 0.0000 Buried
77 S L -0.7681 Soluble
78 G L -0.5887 Soluble
79 S L -0.6131 Soluble
80 G L -0.7958 Soluble
83 S L -0.8046 Soluble
84 G L -1.1848 Soluble
85 T L -1.4963 Soluble
86 D L -1.7488 Soluble
87 F L 0.0000 Buried
88 T L -0.6700 Soluble
89 L L 0.0000 Buried
90 T L -0.6096 Soluble
91 I L 0.0000 Buried
92 S L -1.3287 Soluble
93 S L -1.2099 Soluble
94 L L 0.0000 Buried
95 Q L -0.7861 Soluble
96 P L -1.3549 Soluble
97 E L -1.3754 Soluble
98 D L 0.0000 Buried
99 F L -0.9664 Soluble
100 A L 0.0000 Buried
101 T L -0.8853 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 S L -0.5063 Soluble
116 R L -1.1543 Soluble
117 T L -0.7651 Soluble
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 Q L -1.7041 Soluble
121 G L -1.0567 Soluble
122 T L 0.0000 Buried
123 K L -1.4685 Soluble
124 V L 0.0000 Buried
125 E L -1.2173 Soluble
126 I L 0.0000 Buried
127 K L -1.7825 Soluble
128 R L -1.0281 Soluble
129 T L -0.1250 Soluble
130 V L 0.4947 Aggregation-prone
131 A L 0.2425 Aggregation-prone
132 A L -0.0475 Soluble
133 P L 0.0000 Buried
134 S L -0.1435 Soluble
135 V L 0.0000 Buried
136 F L 0.1891 Aggregation-prone
137 I L 0.1566 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.7231 Soluble
140 P L -0.8820 Soluble
141 S L -1.7339 Soluble
142 D L -3.1076 Soluble
143 E L -3.2468 Soluble
144 Q L 0.0000 Buried
145 L L -2.2483 Soluble
146 K L -2.8870 Soluble
147 S L -1.8030 Soluble
148 G L -1.4602 Soluble
149 T L -1.0862 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.7724 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.4867 Soluble
162 R L -2.3638 Soluble
163 E L -2.9379 Soluble
164 A L -2.1695 Soluble
165 K L -2.3108 Soluble
166 V L -0.9765 Soluble
167 Q L -0.5476 Soluble
168 W L 0.0000 Buried
169 K L -0.5836 Soluble
170 V L 0.0000 Buried
171 D L -2.0749 Soluble
172 N L -1.6474 Soluble
173 A L -0.3319 Soluble
174 L L 0.6373 Aggregation-prone
175 Q L -0.3501 Soluble
176 S L -0.6753 Soluble
177 G L -1.2599 Soluble
178 N L -1.5577 Soluble
179 S L -1.3473 Soluble
180 Q L -1.2094 Soluble
181 E L -1.3729 Soluble
182 S L -0.5572 Soluble
183 V L -0.4192 Soluble
184 T L -0.6895 Soluble
185 E L -1.3507 Soluble
186 Q L 0.0000 Buried
187 D L -1.6368 Soluble
188 S L -1.8849 Soluble
189 K L -2.5014 Soluble
190 D L -2.0084 Soluble
191 S L 0.0000 Buried
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.6293 Soluble
199 L L 0.0000 Buried
200 T L -0.6427 Soluble
201 L L -0.7530 Soluble
202 S L -1.1588 Soluble
203 K L -1.8898 Soluble
204 A L -1.6703 Soluble
205 D L -2.3878 Soluble
206 Y L 0.0000 Buried
207 E L -2.6879 Soluble
208 K L -3.3032 Soluble
209 H L -3.0359 Soluble
210 K L -3.2633 Soluble
211 V L -1.5767 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.7749 Soluble
216 V L 0.0000 Buried
217 T L -1.2278 Soluble
218 H L 0.0000 Buried
219 Q L -1.6504 Soluble
220 G L -0.3582 Soluble
221 L L -0.1709 Soluble
222 S L -0.4295 Soluble
223 S L -0.4643 Soluble
224 P L -0.5876 Soluble
225 V L -0.0580 Soluble
226 T L -0.4199 Soluble
227 K L -0.5427 Soluble
228 S L -0.5022 Soluble
229 F L -0.9919 Soluble
230 N L -2.0281 Soluble
231 R L -2.6853 Soluble
232 G L -2.3767 Soluble
233 E L -2.5740 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.775 4.8028 CSV PDB
4.5 -0.808 4.8028 CSV PDB
5.0 -0.8455 4.8028 CSV PDB
5.5 -0.879 4.8028 CSV PDB
6.0 -0.8983 4.8028 CSV PDB
6.5 -0.8959 4.8028 CSV PDB
7.0 -0.8723 4.8028 CSV PDB
7.5 -0.8351 4.8028 CSV PDB
8.0 -0.7905 4.8028 CSV PDB
8.5 -0.7408 4.8028 CSV PDB
9.0 -0.6861 4.8028 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH