Beludavimab / 6wpt

A4DAB038_6wpt_H_L | Source PDB: 6wpt | Chains: H, L | Done
99.57
Yes
10 Å
Yes
Avg A4D Score
-0.6601
Max Score
2.124
Min Score
-3.7223
Total Score
-146.54
Score CDR
-0.1004
Score non-CDR
-0.84

Calculation Parameters

Chain Sequence(s) VQLVQSGAEVKKPGASVKVSCKASGYPFTSYGISWVRQAPGQGLEWMGWISTYNGNTNYAQKFQGRVTMTTDTSTTTGYMELRRLRSDDTAVYYCARDYTRGAWFGESLIGGFDNWGQGTLVTIVLTQSLSLSPGERATLSCRASQTVSSTSLAWYQQKPGQAPRLLIYGASSRATGIRFSGSGSGTDFTLTISRLEPEDFAVYYCQQHDTSLTFGGGTKVE input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.7223
Maximum Score 2.124
Average Score -0.6601
Total Score -146.5411

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V H 0.6233 Aggregation-prone
3 Q H -0.6819 Soluble
4 L H 0.0000 Buried
5 V H 0.1350 Aggregation-prone
6 Q H -0.2232 Soluble
7 S H -0.7303 Soluble
8 G H -0.7379 Soluble
9 A H -0.3006 Soluble
11 E H -1.0164 Soluble
12 V H 0.4104 Aggregation-prone
13 K H -1.3835 Soluble
14 K H -2.4094 Soluble
15 P H -2.8076 Soluble
16 G H -2.2800 Soluble
17 A H -1.7805 Soluble
18 S H -2.0982 Soluble
19 V H 0.0000 Buried
20 K H -2.1175 Soluble
21 V H 0.0000 Buried
22 S H -0.6156 Soluble
23 C H 0.0000 Buried
24 K H -1.0897 Soluble
25 A H 0.0000 Buried
26 S H -0.4090 Soluble
27 G H -0.1371 Soluble
28 Y H 0.0074 Aggregation-prone
29 P H -0.3090 Soluble
30 F H 0.0000 Buried
35 T H 0.2616 Aggregation-prone
36 S H 0.4749 Aggregation-prone
37 Y H 0.6193 Aggregation-prone
38 G H 0.0000 Buried
39 I H 0.0000 Buried
40 S H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H -0.4780 Soluble
44 Q H -0.6616 Soluble
45 A H -0.9088 Soluble
46 P H -0.8079 Soluble
47 G H -1.2568 Soluble
48 Q H -1.7769 Soluble
49 G H -1.1726 Soluble
50 L H 0.0000 Buried
51 E H -0.8743 Soluble
52 W H 0.0000 Buried
53 M H 0.0000 Buried
54 G H 0.0000 Buried
55 W H 0.0000 Buried
56 I H 0.0000 Buried
57 S H 0.0000 Buried
58 T H 0.0000 Buried
59 Y H 0.5289 Aggregation-prone
62 N H -0.6829 Soluble
63 G H -1.3074 Soluble
64 N H -1.4846 Soluble
65 T H -1.1682 Soluble
66 N H -1.1942 Soluble
67 Y H -1.1034 Soluble
68 A H -1.5193 Soluble
69 Q H -2.5530 Soluble
70 K H -2.7182 Soluble
71 F H 0.0000 Buried
72 Q H -2.4166 Soluble
74 G H -1.6379 Soluble
75 R H -1.9064 Soluble
76 V H 0.0000 Buried
77 T H -0.7127 Soluble
78 M H 0.0000 Buried
79 T H -0.4467 Soluble
80 T H -0.4910 Soluble
81 D H -1.0009 Soluble
82 T H -0.4928 Soluble
83 S H -0.5386 Soluble
84 T H -0.6378 Soluble
85 T H -0.7446 Soluble
86 T H 0.0000 Buried
87 G H 0.0000 Buried
88 Y H -0.5103 Soluble
89 M H 0.0000 Buried
90 E H -1.4757 Soluble
91 L H 0.0000 Buried
92 R H -2.4905 Soluble
93 R H -3.1222 Soluble
94 L H 0.0000 Buried
95 R H -3.6722 Soluble
96 S H -2.4681 Soluble
97 D H -2.5916 Soluble
98 D H 0.0000 Buried
99 T H -0.7233 Soluble
100 A H 0.0000 Buried
101 V H 0.2733 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H -0.0896 Soluble
107 D H 0.0000 Buried
108 Y H 1.3180 Aggregation-prone
109 T H 0.0000 Buried
110 R H 0.1971 Aggregation-prone
111 G H 0.0000 Buried
111A A H 0.0000 Buried
111B W H 1.3298 Aggregation-prone
111C F H 1.5117 Aggregation-prone
112D G H -0.3647 Soluble
112C E H -1.3161 Soluble
112B S H -0.4558 Soluble
112A L H 0.7454 Aggregation-prone
112 I H 2.1240 Aggregation-prone
113 G H 0.0000 Buried
114 G H 0.0000 Buried
115 F H 0.0000 Buried
116 D H -0.5812 Soluble
117 N H -0.7668 Soluble
118 W H 0.0000 Buried
119 G H 0.0000 Buried
120 Q H -1.3462 Soluble
121 G H -0.5560 Soluble
122 T H 0.0000 Buried
123 L H 0.4083 Aggregation-prone
124 V H 0.0000 Buried
125 T H -0.5469 Soluble
2 I L 1.3668 Aggregation-prone
3 V L 1.6693 Aggregation-prone
4 L L 0.0000 Buried
5 T L -0.5435 Soluble
6 Q L -0.8848 Soluble
10 S L -0.7492 Soluble
11 L L -0.1944 Soluble
12 S L -0.6498 Soluble
13 L L -0.8566 Soluble
14 S L -1.5384 Soluble
15 P L -2.3398 Soluble
16 G L -2.5673 Soluble
17 E L -3.1765 Soluble
18 R L -3.4969 Soluble
19 A L 0.0000 Buried
20 T L -0.5334 Soluble
21 L L 0.0000 Buried
22 S L -0.9358 Soluble
23 C L 0.0000 Buried
24 R L -2.4260 Soluble
25 A L -1.0939 Soluble
26 S L -0.5451 Soluble
27 Q L -1.1817 Soluble
28 T L -1.2697 Soluble
29 V L 0.0000 Buried
30 S L -0.5459 Soluble
36 S L -0.4264 Soluble
37 T L 0.2993 Aggregation-prone
38 S L 0.0000 Buried
39 L L 0.0000 Buried
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L -1.2065 Soluble
44 Q L 0.0000 Buried
45 K L -2.8810 Soluble
46 P L -1.6408 Soluble
47 G L -1.7700 Soluble
48 Q L -2.4768 Soluble
49 A L -1.6853 Soluble
50 P L 0.0000 Buried
51 R L -1.4895 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L 0.1026 Aggregation-prone
56 G L 0.3112 Aggregation-prone
57 A L -0.2711 Soluble
65 S L -0.8202 Soluble
66 S L -0.8594 Soluble
67 R L -1.8579 Soluble
68 A L 0.0000 Buried
69 T L -0.6801 Soluble
70 G L -0.5458 Soluble
71 I L -0.4584 Soluble
72 R L -1.7051 Soluble
76 F L -0.9656 Soluble
77 S L -0.8076 Soluble
78 G L -0.6401 Soluble
79 S L -0.7535 Soluble
80 G L -1.0301 Soluble
83 S L -0.9896 Soluble
84 G L -1.2884 Soluble
85 T L -1.9369 Soluble
86 D L -2.6179 Soluble
87 F L 0.0000 Buried
88 T L -0.8794 Soluble
89 L L 0.0000 Buried
90 T L -0.8772 Soluble
91 I L 0.0000 Buried
92 S L -2.4225 Soluble
93 R L -3.7223 Soluble
94 L L 0.0000 Buried
95 E L -3.1118 Soluble
96 P L -1.9628 Soluble
97 E L -2.6666 Soluble
98 D L 0.0000 Buried
99 F L -1.7449 Soluble
100 A L 0.0000 Buried
101 V L 0.0000 Buried
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 H L 0.0000 Buried
108 D L -1.1228 Soluble
114 T L -0.5778 Soluble
115 S L -0.5849 Soluble
116 L L 0.0000 Buried
117 T L 0.3131 Aggregation-prone
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 G L -0.9805 Soluble
121 G L -1.0838 Soluble
122 T L -1.1760 Soluble
123 K L -2.1746 Soluble
124 V L 0.0000 Buried
125 E L -2.2525 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.662 4.977 CSV PDB
4.5 -0.6989 4.8861 CSV PDB
5.0 -0.7433 4.7623 CSV PDB
5.5 -0.7864 4.6267 CSV PDB
6.0 -0.8195 4.5 CSV PDB
6.5 -0.8362 4.4034 CSV PDB
7.0 -0.8356 4.3484 CSV PDB
7.5 -0.8231 4.3248 CSV PDB
8.0 -0.8039 4.3164 CSV PDB
8.5 -0.7801 4.3136 CSV PDB
9.0 -0.7524 4.3126 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH