Motavizumab / 4zyp

A4DAB172_4zyp_N_O | Source PDB: 4zyp | Chains: N, O | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6667
Max Score
2.6006
Min Score
-3.3137
Total Score
-282.67
Score CDR
-0.251
Score non-CDR
-0.7173

Calculation Parameters

Chain Sequence(s) QVTLRESGPALVKPTQTLTLTCTFSGFSLSTAGMSVGWIRQPPGKALEWLADIWWDDKKHYNPSLKDRLTISKDTSKNQVVLKVTNMDPADTATYYCARDMIFNFYFDVWGQGTTVTVSSASTKGPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPDIQMTQSPSTLSASVGDRVTITCSASSRVGYMHWYQQKPGKAPKLLIYDTSKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCFQGSGYPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG input.pdb
Selected Chain(s) N (Heavy), O (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.3137
Maximum Score 2.6006
Average Score -0.6667
Total Score -282.6749

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q N -1.2451 Soluble
2 V N -0.6724 Soluble
3 T N -0.6957 Soluble
4 L N 0.0000 Buried
5 R N -1.1819 Soluble
6 E N 0.0000 Buried
7 S N -0.5092 Soluble
8 G N -0.4233 Soluble
9 P N -0.2639 Soluble
11 A N -0.3867 Soluble
12 L N -0.2515 Soluble
13 V N 0.0000 Buried
14 K N -2.1088 Soluble
15 P N -1.9290 Soluble
16 T N -1.8376 Soluble
17 Q N -1.9127 Soluble
18 T N -1.3503 Soluble
19 L N 0.0000 Buried
20 T N -0.5702 Soluble
21 L N 0.0000 Buried
22 T N -0.3736 Soluble
23 C N 0.0000 Buried
24 T N -0.7787 Soluble
25 F N 0.0000 Buried
26 S N -0.6825 Soluble
27 G N -0.7802 Soluble
28 F N -0.3499 Soluble
29 S N -0.2422 Soluble
30 L N 0.0000 Buried
31 S N -0.5801 Soluble
34 T N -0.1537 Soluble
35 A N 0.0637 Aggregation-prone
36 G N 0.0000 Buried
37 M N 0.0000 Buried
38 S N 0.0000 Buried
39 V N 0.0000 Buried
40 G N 0.0000 Buried
41 W N 0.0000 Buried
42 I N 0.0000 Buried
43 R N 0.0000 Buried
44 Q N -0.8960 Soluble
45 P N 0.0000 Buried
46 P N -1.0613 Soluble
47 G N -1.4500 Soluble
48 K N -2.1869 Soluble
49 A N -1.2523 Soluble
50 L N 0.0000 Buried
51 E N -0.6901 Soluble
52 W N 0.0000 Buried
53 L N 0.0000 Buried
54 A N 0.0000 Buried
55 D N 0.0000 Buried
56 I N 0.0000 Buried
57 W N 0.0000 Buried
58 W N -1.1228 Soluble
59 D N -2.1956 Soluble
63 D N -3.0223 Soluble
64 K N -2.8527 Soluble
65 K N -2.2719 Soluble
66 H N -1.0195 Soluble
67 Y N -0.5548 Soluble
68 N N 0.0000 Buried
69 P N -1.0474 Soluble
70 S N -0.7626 Soluble
71 L N -0.8611 Soluble
72 K N -1.8818 Soluble
74 D N -2.3573 Soluble
75 R N -1.9398 Soluble
76 L N 0.0000 Buried
77 T N -0.9822 Soluble
78 I N 0.0000 Buried
79 S N -1.0606 Soluble
80 K N -1.2085 Soluble
81 D N -1.5568 Soluble
82 T N -1.2787 Soluble
83 S N -1.4962 Soluble
84 K N -2.2715 Soluble
85 N N -1.5990 Soluble
86 Q N -1.2935 Soluble
87 V N 0.0000 Buried
88 V N -0.1872 Soluble
89 L N 0.0000 Buried
90 K N -1.0791 Soluble
91 V N 0.0000 Buried
92 T N -1.7619 Soluble
93 N N -2.2046 Soluble
94 M N 0.0000 Buried
95 D N -2.1522 Soluble
96 P N -1.1433 Soluble
97 A N -0.5638 Soluble
98 D N 0.0000 Buried
99 T N -0.3927 Soluble
100 A N 0.0000 Buried
101 T N -0.3329 Soluble
102 Y N 0.0000 Buried
103 Y N 0.0000 Buried
104 C N 0.0000 Buried
105 A N 0.0000 Buried
106 R N -0.0912 Soluble
107 D N 0.0000 Buried
108 M N 1.4205 Aggregation-prone
109 I N 2.3011 Aggregation-prone
110 F N 2.6006 Aggregation-prone
112 N N 1.3483 Aggregation-prone
113 F N 1.2779 Aggregation-prone
114 Y N 0.0000 Buried
115 F N 0.0000 Buried
116 D N -0.6471 Soluble
117 V N -0.5447 Soluble
118 W N -0.6016 Soluble
119 G N 0.0000 Buried
120 Q N -1.8011 Soluble
121 G N -1.1637 Soluble
122 T N -0.5450 Soluble
123 T N -0.2490 Soluble
124 V N 0.0000 Buried
125 T N 0.0000 Buried
126 V N 0.0000 Buried
127 S N -0.8729 Soluble
128 S N -0.7506 Soluble
129 A N -0.5780 Soluble
130 S N -0.7486 Soluble
131 T N -0.9357 Soluble
132 K N -1.7463 Soluble
133 G N -1.7222 Soluble
134 P N -0.8283 Soluble
135 S N -0.4372 Soluble
136 V N 0.0000 Buried
137 F N 0.0000 Buried
138 P N -1.1486 Soluble
139 L N 0.0000 Buried
140 A N -0.7911 Soluble
141 P N 0.0000 Buried
142 S N -0.1858 Soluble
143 T N -0.2907 Soluble
144 A N 0.0000 Buried
145 A N 0.0000 Buried
146 L N 0.0000 Buried
147 G N 0.0000 Buried
148 C N 0.0000 Buried
149 L N 0.0000 Buried
150 V N 0.0000 Buried
151 K N -0.3784 Soluble
152 D N -0.6679 Soluble
153 Y N 0.0000 Buried
154 F N 0.0000 Buried
155 P N 0.0000 Buried
156 E N -0.6338 Soluble
157 P N -0.6882 Soluble
158 V N -0.6297 Soluble
159 T N -0.5184 Soluble
160 V N -0.3329 Soluble
161 S N -0.3760 Soluble
162 W N 0.0000 Buried
163 N N -0.8412 Soluble
164 S N -0.6689 Soluble
165 G N -0.4282 Soluble
166 A N -0.2058 Soluble
167 L N 0.0333 Aggregation-prone
168 T N -0.1364 Soluble
169 S N -0.1667 Soluble
170 G N -0.1841 Soluble
171 V N 0.1734 Aggregation-prone
172 H N -0.2103 Soluble
173 T N -0.0695 Soluble
174 F N 0.0000 Buried
175 P N -0.2193 Soluble
176 A N 0.2829 Aggregation-prone
177 V N 0.5767 Aggregation-prone
178 L N 1.3914 Aggregation-prone
179 Q N 0.2285 Aggregation-prone
180 S N -0.0842 Soluble
181 S N -0.2522 Soluble
182 G N -0.0290 Soluble
183 L N -0.0043 Soluble
184 Y N 0.5692 Aggregation-prone
185 S N 0.0000 Buried
186 L N 0.0000 Buried
187 S N 0.0000 Buried
188 S N 0.0000 Buried
189 V N 0.0000 Buried
190 V N 0.0000 Buried
191 T N -0.1360 Soluble
192 V N 0.0000 Buried
193 P N -0.5236 Soluble
194 S N -0.4837 Soluble
195 S N -0.5618 Soluble
196 S N -0.6401 Soluble
197 L N -0.9163 Soluble
198 G N -1.2406 Soluble
199 T N -0.9796 Soluble
200 Q N -1.3782 Soluble
201 T N -1.2416 Soluble
202 Y N 0.0000 Buried
203 I N -1.2310 Soluble
204 C N 0.0000 Buried
205 N N -1.4327 Soluble
206 V N 0.0000 Buried
207 N N -1.7176 Soluble
208 H N 0.0000 Buried
209 K N -2.7452 Soluble
210 P N -1.6329 Soluble
211 S N -1.9366 Soluble
212 N N -2.5413 Soluble
213 T N -2.1134 Soluble
214 K N -2.5916 Soluble
215 V N -1.3512 Soluble
216 D N -2.4755 Soluble
217 K N -1.8987 Soluble
218 K N -2.5277 Soluble
219 V N 0.0000 Buried
220 E N -2.4943 Soluble
221 P N -1.2160 Soluble
1 D O -1.9229 Soluble
2 I O -1.5111 Soluble
3 Q O -1.6665 Soluble
4 M O 0.0000 Buried
5 T O -0.7837 Soluble
6 Q O 0.0000 Buried
7 S O -0.5097 Soluble
8 P O -0.5157 Soluble
9 S O -0.6997 Soluble
10 T O -0.6272 Soluble
11 L O -0.3117 Soluble
12 S O -0.6805 Soluble
13 A O -0.9677 Soluble
14 S O -1.0093 Soluble
15 V O -0.2631 Soluble
16 G O -0.9220 Soluble
17 D O -1.8752 Soluble
18 R O -2.2686 Soluble
19 V O 0.0000 Buried
20 T O -0.6130 Soluble
21 I O 0.0000 Buried
22 T O -0.5638 Soluble
23 C O 0.0000 Buried
24 S O -1.2617 Soluble
25 A O 0.0000 Buried
26 S O -1.4743 Soluble
27 S O -1.7560 Soluble
28 R O -2.2214 Soluble
29 V O 0.0000 Buried
37 G O -0.4547 Soluble
38 Y O 0.6156 Aggregation-prone
39 M O 0.0000 Buried
40 H O 0.0000 Buried
41 W O 0.0000 Buried
42 Y O 0.0000 Buried
43 Q O 0.0000 Buried
44 Q O 0.0000 Buried
45 K O -1.5133 Soluble
46 P O -1.2387 Soluble
47 G O -1.5758 Soluble
48 K O -2.4997 Soluble
49 A O -1.6767 Soluble
50 P O 0.0000 Buried
51 K O -1.7009 Soluble
52 L O 0.0000 Buried
53 L O 0.0000 Buried
54 I O 0.0000 Buried
55 Y O -0.2253 Soluble
56 D O -0.3967 Soluble
57 T O 0.0000 Buried
65 S O -0.7976 Soluble
66 K O -1.3135 Soluble
67 L O -0.3037 Soluble
68 A O -0.5026 Soluble
69 S O -0.4600 Soluble
70 G O -0.4420 Soluble
71 V O -0.2797 Soluble
72 P O -0.3379 Soluble
74 S O -0.3893 Soluble
75 R O -0.5861 Soluble
76 F O 0.0000 Buried
77 S O -0.5877 Soluble
78 G O -0.6249 Soluble
79 S O -0.8562 Soluble
80 G O -0.9786 Soluble
83 S O -1.1199 Soluble
84 G O -1.4257 Soluble
85 T O -1.7136 Soluble
86 E O -2.3676 Soluble
87 F O 0.0000 Buried
88 T O -0.6947 Soluble
89 L O 0.0000 Buried
90 T O -0.6217 Soluble
91 I O 0.0000 Buried
92 S O -1.1891 Soluble
93 S O -1.1402 Soluble
94 L O 0.0000 Buried
95 Q O -1.3243 Soluble
96 P O -2.0033 Soluble
97 D O -2.5628 Soluble
98 D O 0.0000 Buried
99 F O 0.0000 Buried
100 A O 0.0000 Buried
101 T O -0.6025 Soluble
102 Y O 0.0000 Buried
103 Y O 0.0000 Buried
104 C O 0.0000 Buried
105 F O 0.0000 Buried
106 Q O 0.0000 Buried
107 G O 0.2426 Aggregation-prone
108 S O -0.1435 Soluble
109 G O -0.2441 Soluble
114 Y O 0.0373 Aggregation-prone
115 P O 0.0000 Buried
116 F O 0.0000 Buried
117 T O -0.5863 Soluble
118 F O 0.0000 Buried
119 G O 0.0000 Buried
120 G O -1.0000 Soluble
121 G O -0.9044 Soluble
122 T O 0.0000 Buried
123 K O -1.2413 Soluble
124 V O 0.0000 Buried
125 E O -0.9373 Soluble
126 I O 0.0000 Buried
127 K O -1.4598 Soluble
128 R O -0.9935 Soluble
129 T O -0.1138 Soluble
130 V O 0.3616 Aggregation-prone
131 A O 0.1461 Aggregation-prone
132 A O -0.0905 Soluble
133 P O 0.0000 Buried
134 S O -0.1169 Soluble
135 V O 0.0000 Buried
136 F O 0.0916 Aggregation-prone
137 I O 0.0924 Aggregation-prone
138 F O 0.0000 Buried
139 P O -0.5709 Soluble
140 P O 0.0000 Buried
141 S O -1.5294 Soluble
142 D O -2.7987 Soluble
143 E O -2.7030 Soluble
144 Q O 0.0000 Buried
145 L O -2.1555 Soluble
146 K O -2.7680 Soluble
147 S O -1.7387 Soluble
148 G O -1.2633 Soluble
149 T O -0.9999 Soluble
150 A O 0.0000 Buried
151 S O 0.0000 Buried
152 V O 0.0000 Buried
153 V O 0.0000 Buried
154 C O 0.0000 Buried
155 L O 0.0000 Buried
156 L O 0.0000 Buried
157 N O 0.0000 Buried
158 N O -0.8938 Soluble
159 F O 0.0000 Buried
160 Y O 0.0000 Buried
161 P O -1.7551 Soluble
162 R O -2.8298 Soluble
163 E O -3.2017 Soluble
164 A O -2.2859 Soluble
165 K O -2.5423 Soluble
166 V O -1.2199 Soluble
167 Q O -0.8127 Soluble
168 W O 0.0000 Buried
169 K O -0.6689 Soluble
170 V O 0.0000 Buried
171 D O -1.8369 Soluble
172 N O -1.3989 Soluble
173 A O -0.3601 Soluble
174 L O 0.5553 Aggregation-prone
175 Q O -0.1650 Soluble
176 S O -0.5660 Soluble
177 G O -0.9665 Soluble
178 N O -0.8893 Soluble
179 S O -1.4287 Soluble
180 Q O -1.9700 Soluble
181 E O -2.3369 Soluble
182 S O -0.9434 Soluble
183 V O -0.3556 Soluble
184 T O -0.5941 Soluble
185 E O -1.3054 Soluble
186 Q O 0.0000 Buried
187 D O -1.9282 Soluble
188 S O -2.2674 Soluble
189 K O -2.8310 Soluble
190 D O -2.3805 Soluble
191 S O 0.0000 Buried
192 T O 0.0000 Buried
193 Y O 0.0000 Buried
194 S O 0.0000 Buried
195 L O 0.0000 Buried
196 S O 0.0000 Buried
197 S O 0.0000 Buried
198 T O -0.8217 Soluble
199 L O 0.0000 Buried
200 T O -0.4583 Soluble
201 L O -0.5428 Soluble
202 S O -0.9500 Soluble
203 K O -1.9670 Soluble
204 A O -1.6257 Soluble
205 D O -2.2192 Soluble
206 Y O 0.0000 Buried
207 E O -3.1994 Soluble
208 K O -3.3137 Soluble
209 H O -2.8701 Soluble
210 K O -3.0685 Soluble
211 V O -1.7060 Soluble
212 Y O 0.0000 Buried
213 A O 0.0000 Buried
214 C O 0.0000 Buried
215 E O -0.8852 Soluble
216 V O 0.0000 Buried
217 T O -1.2363 Soluble
218 H O 0.0000 Buried
219 Q O -1.5247 Soluble
220 G O -0.3864 Soluble
221 L O -0.2287 Soluble
222 S O -0.4493 Soluble
223 S O -0.4076 Soluble
224 P O -0.5086 Soluble
225 V O -0.0171 Soluble
226 T O -0.5659 Soluble
227 K O -0.8502 Soluble
228 S O -0.7464 Soluble
229 F O -0.9575 Soluble
230 N O -2.0817 Soluble
231 R O -2.3569 Soluble
232 G O -1.4333 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6703 5.3031 CSV PDB
4.5 -0.7133 5.3031 CSV PDB
5.0 -0.7612 5.3031 CSV PDB
5.5 -0.805 5.3031 CSV PDB
6.0 -0.834 5.3031 CSV PDB
6.5 -0.8401 5.3031 CSV PDB
7.0 -0.8237 5.3031 CSV PDB
7.5 -0.7922 5.3031 CSV PDB
8.0 -0.7519 5.3031 CSV PDB
8.5 -0.704 5.3031 CSV PDB
9.0 -0.6478 5.3031 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH