Zinlirvimab / 7ugp

A4DAB308_7ugp_N_Q | Source PDB: 7ugp | Chains: N, Q | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.506
Max Score
2.8877
Min Score
-3.6549
Total Score
-119.91
Score CDR
-0.3492
Score non-CDR
-0.5615

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSALSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) N (Heavy), Q (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6549
Maximum Score 2.8877
Average Score -0.506
Total Score -119.911

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q N -1.7983 Soluble
2 V N -1.2853 Soluble
3 Q N -1.8738 Soluble
4 L N 0.0000 Buried
5 Q N -1.6389 Soluble
6 E N -1.3579 Soluble
7 S N -0.7006 Soluble
8 G N -0.4147 Soluble
9 P N -0.0137 Soluble
11 G N 0.4583 Aggregation-prone
12 L N 1.1183 Aggregation-prone
13 V N 0.0000 Buried
14 K N -0.9507 Soluble
15 P N -1.2111 Soluble
16 S N -1.2459 Soluble
17 E N -1.6442 Soluble
18 T N -1.1652 Soluble
19 L N 0.0000 Buried
20 S N -0.6639 Soluble
21 V N 0.0000 Buried
22 T N -0.6459 Soluble
23 C N 0.0000 Buried
24 S N -1.2879 Soluble
25 V N 0.0000 Buried
26 S N -1.4465 Soluble
27 G N -1.6893 Soluble
28 D N -2.2232 Soluble
29 S N -1.1707 Soluble
30 M N -0.5824 Soluble
35 N N -1.9215 Soluble
36 N N -2.3206 Soluble
37 Y N -1.1924 Soluble
38 Y N -0.9132 Soluble
39 W N 0.0000 Buried
40 T N 0.0000 Buried
41 W N 0.0000 Buried
42 I N 0.0000 Buried
43 R N 0.0000 Buried
44 Q N -0.6028 Soluble
45 S N 0.0000 Buried
46 P N -0.8592 Soluble
47 G N -1.2014 Soluble
48 K N -1.5368 Soluble
49 G N -1.1904 Soluble
50 L N 0.0000 Buried
51 E N 0.0000 Buried
52 W N 0.0000 Buried
53 I N 0.0000 Buried
54 G N 0.0000 Buried
55 Y N 0.0803 Aggregation-prone
56 I N 0.0000 Buried
57 S N 0.0000 Buried
58 D N -3.6549 Soluble
59 R N -3.6488 Soluble
63 E N -3.4119 Soluble
64 S N -1.9152 Soluble
65 A N -0.6739 Soluble
66 T N -0.1534 Soluble
67 Y N 0.2136 Aggregation-prone
68 N N 0.0000 Buried
69 P N -0.7490 Soluble
70 S N -0.7819 Soluble
71 L N 0.0000 Buried
72 N N -1.6017 Soluble
74 S N -0.8886 Soluble
75 R N -1.0806 Soluble
76 V N 0.0000 Buried
77 V N 1.3190 Aggregation-prone
78 I N 0.5684 Aggregation-prone
79 S N -0.5124 Soluble
80 R N -1.9947 Soluble
81 D N -2.2954 Soluble
82 T N -1.7188 Soluble
83 S N -1.8527 Soluble
84 K N -2.7648 Soluble
85 N N -2.5560 Soluble
86 Q N -1.8836 Soluble
87 L N 0.0000 Buried
88 S N -0.4101 Soluble
89 L N 0.0000 Buried
90 K N -0.7329 Soluble
91 L N 0.0000 Buried
92 N N -1.7362 Soluble
93 S N -1.3585 Soluble
94 V N 0.0000 Buried
95 T N -0.5090 Soluble
96 P N -0.4008 Soluble
97 A N -0.1911 Soluble
98 D N 0.0000 Buried
99 T N 0.1231 Aggregation-prone
100 A N 0.0000 Buried
101 V N -0.0979 Soluble
102 Y N 0.0000 Buried
103 Y N 0.0000 Buried
104 C N 0.0000 Buried
105 A N 0.0000 Buried
106 T N 0.0000 Buried
107 A N 0.0000 Buried
108 R N -2.2050 Soluble
109 R N -1.9752 Soluble
110 G N -1.3097 Soluble
111 Q N -0.7345 Soluble
111A R N 0.1382 Aggregation-prone
111B I N 1.6936 Aggregation-prone
111C Y N 1.5162 Aggregation-prone
111D G N 1.5508 Aggregation-prone
111E V N 2.5470 Aggregation-prone
111F V N 2.8877 Aggregation-prone
112G S N 1.6973 Aggregation-prone
112F F N 2.3488 Aggregation-prone
112E G N 1.2984 Aggregation-prone
112D E N 1.2156 Aggregation-prone
112C F N 1.4424 Aggregation-prone
112B F N 0.3749 Aggregation-prone
112A Y N -0.0786 Soluble
112 Y N -0.4307 Soluble
113 Y N 0.0000 Buried
114 S N 0.0000 Buried
115 M N 0.0000 Buried
116 D N -0.2032 Soluble
117 V N 0.2231 Aggregation-prone
118 W N -0.1008 Soluble
119 G N -1.2529 Soluble
120 K N -2.3050 Soluble
121 G N -1.3247 Soluble
122 T N -0.6585 Soluble
123 T N 0.1185 Aggregation-prone
124 V N 0.0000 Buried
125 T N 0.3713 Aggregation-prone
126 V N 0.2266 Aggregation-prone
127 S N -0.0347 Soluble
128 S N -0.3523 Soluble
129 A N -0.2788 Soluble
11 L Q 0.7015 Aggregation-prone
12 S Q 0.6564 Aggregation-prone
13 V Q 0.3260 Aggregation-prone
14 A Q 0.3734 Aggregation-prone
15 L Q 0.5870 Aggregation-prone
16 G Q -1.0244 Soluble
17 E Q -1.8866 Soluble
18 T Q -1.4830 Soluble
19 A Q 0.0000 Buried
20 R Q -1.9558 Soluble
21 I Q 0.0000 Buried
22 S Q -0.7990 Soluble
23 C Q -1.1308 Soluble
24 G Q -1.2414 Soluble
25 R Q -1.5014 Soluble
26 Q Q -1.8294 Soluble
27 A Q -1.1525 Soluble
28 L Q -0.5119 Soluble
29 G Q -0.2901 Soluble
36 S Q 0.4536 Aggregation-prone
37 R Q 0.0000 Buried
38 A Q 0.0000 Buried
39 V Q 0.0000 Buried
40 Q Q 0.0000 Buried
41 W Q 0.0000 Buried
42 Y Q 0.0000 Buried
43 Q Q 0.0000 Buried
44 H Q 0.0000 Buried
45 R Q -1.3478 Soluble
46 P Q -1.2507 Soluble
47 G Q -1.3159 Soluble
48 Q Q -1.9328 Soluble
49 A Q -1.0758 Soluble
50 P Q 0.0000 Buried
51 I Q 0.5392 Aggregation-prone
52 L Q 0.0000 Buried
53 L Q 0.0000 Buried
54 I Q 0.0000 Buried
55 Y Q -0.5818 Soluble
56 N Q -0.9430 Soluble
57 N Q 0.0000 Buried
65 Q Q -1.7526 Soluble
66 D Q -1.6004 Soluble
67 R Q -1.6888 Soluble
68 P Q -0.6528 Soluble
69 S Q -0.6182 Soluble
70 G Q -0.5062 Soluble
71 I Q -0.6605 Soluble
72 P Q -1.3198 Soluble
74 E Q -2.1739 Soluble
75 R Q -1.4066 Soluble
76 F Q 0.0000 Buried
77 S Q -1.3075 Soluble
78 G Q -0.9611 Soluble
79 T Q -0.5420 Soluble
80 P Q -0.3784 Soluble
81 D Q 0.2537 Aggregation-prone
81A I Q 1.6823 Aggregation-prone
82 N Q 0.3129 Aggregation-prone
83 F Q 1.0981 Aggregation-prone
84 G Q -0.1367 Soluble
85 T Q -0.6463 Soluble
86 R Q -1.9825 Soluble
87 A Q 0.0000 Buried
88 T Q -1.0457 Soluble
89 L Q 0.0000 Buried
90 T Q -0.9927 Soluble
91 I Q 0.0000 Buried
92 S Q -1.5343 Soluble
93 G Q -1.1994 Soluble
94 V Q 0.0000 Buried
95 E Q -1.8238 Soluble
96 A Q -0.8270 Soluble
97 G Q -1.1214 Soluble
98 D Q -1.3614 Soluble
99 E Q -1.6251 Soluble
100 A Q 0.0000 Buried
101 D Q 0.0000 Buried
102 Y Q 0.0000 Buried
103 Y Q 0.0000 Buried
104 C Q 0.0000 Buried
105 H Q 0.0000 Buried
106 M Q 0.0000 Buried
107 W Q 0.0000 Buried
108 D Q 0.0000 Buried
109 S Q -0.8257 Soluble
110 R Q -1.9293 Soluble
112 S Q -1.0478 Soluble
113 G Q -0.6117 Soluble
114 F Q 0.3867 Aggregation-prone
115 S Q 0.0000 Buried
116 W Q 0.1852 Aggregation-prone
117 S Q -0.2916 Soluble
118 F Q 0.0000 Buried
119 G Q -1.0133 Soluble
120 G Q -1.1699 Soluble
121 A Q -0.8846 Soluble
122 T Q -0.8057 Soluble
123 R Q -1.6494 Soluble
124 L Q 0.0000 Buried
125 T Q -0.0369 Soluble
126 V Q 0.0000 Buried
127 L Q 1.5475 Aggregation-prone
128 G Q 0.4070 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.348 4.5487 CSV PDB
4.5 -0.3809 4.5188 CSV PDB
5.0 -0.4218 4.4748 CSV PDB
5.5 -0.4635 4.4241 CSV PDB
6.0 -0.4989 4.3746 CSV PDB
6.5 -0.5229 4.3342 CSV PDB
7.0 -0.5345 4.3091 CSV PDB
7.5 -0.5372 4.2976 CSV PDB
8.0 -0.5348 4.2933 CSV PDB
8.5 -0.5285 4.2919 CSV PDB
9.0 -0.5184 4.2914 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH