Cosfroviximab / 5ken

A4DAB073_5ken_Q_P | Source PDB: 5ken | Chains: Q, P | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.5948
Max Score
1.3155
Min Score
-2.921
Total Score
-135.61
Score CDR
-0.4814
Score non-CDR
-0.6258

Calculation Parameters

Chain Sequence(s) DVKLLESGGGLVQPGGSLKLSCAASGFSLSTSGVGVGWFRQPSGKGLEWLALIWWDDDKYYNPSLKSQLSISKDFSRNQVFLKISNVDIADTATYYCARRDPFGYDNAMGYWGQGTSVTVSDIVMTQSPLSLSTSVGDRVSLTCKASQNVGTAVAWYQQKPGQSPKLLIYSASNRYTGVPDRFTGSGSGTDFTLTISNMQSEDLADYFCQQYSSYPLTFGAGTKLELR input.pdb
Selected Chain(s) Q (Heavy), P (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -2.921
Maximum Score 1.3155
Average Score -0.5948
Total Score -135.6137

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 D Q -2.2639 Soluble
2 V Q 0.0000 Buried
3 K Q -2.3467 Soluble
4 L Q 0.0000 Buried
5 L Q -0.5943 Soluble
6 E Q -0.7200 Soluble
7 S Q -0.7953 Soluble
8 G Q -0.9089 Soluble
9 G Q -0.4783 Soluble
11 G Q 0.0888 Aggregation-prone
12 L Q 1.0648 Aggregation-prone
13 V Q 0.2830 Aggregation-prone
14 Q Q -0.9401 Soluble
15 P Q -0.7685 Soluble
16 G Q -1.2708 Soluble
17 G Q -1.3609 Soluble
18 S Q -1.5534 Soluble
19 L Q -1.4598 Soluble
20 K Q -2.0754 Soluble
21 L Q 0.0000 Buried
22 S Q -0.6336 Soluble
23 C Q 0.0000 Buried
24 A Q -0.7517 Soluble
25 A Q 0.0000 Buried
26 S Q -1.3704 Soluble
27 G Q -1.4841 Soluble
28 F Q -0.6764 Soluble
29 S Q -0.3277 Soluble
30 L Q 0.0000 Buried
31 S Q -0.1961 Soluble
34 T Q -0.4156 Soluble
35 S Q -0.8004 Soluble
36 G Q -0.7004 Soluble
37 V Q 0.0000 Buried
38 G Q 0.0000 Buried
39 V Q 0.0000 Buried
40 G Q 0.0000 Buried
41 W Q 0.0000 Buried
42 F Q 0.1542 Aggregation-prone
43 R Q 0.0000 Buried
44 Q Q 0.0000 Buried
45 P Q 0.0000 Buried
46 S Q -0.9877 Soluble
47 G Q -1.5592 Soluble
48 K Q -2.0132 Soluble
49 G Q -1.0423 Soluble
50 L Q 0.0000 Buried
51 E Q -0.4445 Soluble
52 W Q 0.0000 Buried
53 L Q 0.0000 Buried
54 A Q 0.0000 Buried
55 L Q -0.0573 Soluble
56 I Q 0.0000 Buried
57 W Q -1.3039 Soluble
58 W Q -1.2598 Soluble
59 D Q -2.3126 Soluble
63 D Q -2.9210 Soluble
64 D Q -2.2965 Soluble
65 K Q -1.6628 Soluble
66 Y Q -0.2348 Soluble
67 Y Q -0.2113 Soluble
68 N Q -0.5056 Soluble
69 P Q -0.9913 Soluble
70 S Q -0.8730 Soluble
71 L Q -0.7669 Soluble
72 K Q -1.5307 Soluble
74 S Q -1.1565 Soluble
75 Q Q -1.2882 Soluble
76 L Q 0.0000 Buried
77 S Q -1.0174 Soluble
78 I Q 0.0000 Buried
79 S Q -0.7101 Soluble
80 K Q -0.9779 Soluble
81 D Q -1.0402 Soluble
82 F Q 0.0230 Aggregation-prone
83 S Q -0.8620 Soluble
84 R Q -2.0170 Soluble
85 N Q -1.1561 Soluble
86 Q Q -0.9912 Soluble
87 V Q 0.0000 Buried
88 F Q -0.6385 Soluble
89 L Q 0.0000 Buried
90 K Q -1.7093 Soluble
91 I Q 0.0000 Buried
92 S Q -1.6313 Soluble
93 N Q -1.7200 Soluble
94 V Q 0.0000 Buried
95 D Q -0.4844 Soluble
96 I Q 1.3155 Aggregation-prone
97 A Q 0.8123 Aggregation-prone
98 D Q 0.0000 Buried
99 T Q 0.6264 Aggregation-prone
100 A Q 0.0000 Buried
101 T Q -0.4551 Soluble
102 Y Q 0.0000 Buried
103 Y Q 0.0000 Buried
104 C Q 0.0000 Buried
105 A Q 0.0000 Buried
106 R Q -0.0829 Soluble
107 R Q 0.0000 Buried
108 D Q -0.2492 Soluble
109 P Q 0.0809 Aggregation-prone
110 F Q 0.2535 Aggregation-prone
111 G Q 0.0635 Aggregation-prone
112A Y Q 0.7755 Aggregation-prone
112 D Q -0.1781 Soluble
113 N Q -0.3078 Soluble
114 A Q 0.0000 Buried
115 M Q 0.0000 Buried
116 G Q -0.1061 Soluble
117 Y Q -0.1411 Soluble
118 W Q -0.3998 Soluble
119 G Q 0.0000 Buried
120 Q Q -1.5930 Soluble
121 G Q -1.0239 Soluble
122 T Q -0.6364 Soluble
123 S Q -0.2596 Soluble
124 V Q 0.0000 Buried
125 T Q 0.5086 Aggregation-prone
126 V Q 0.0000 Buried
127 S Q 0.0305 Aggregation-prone
1 D P -0.9159 Soluble
2 I P 0.2363 Aggregation-prone
3 V P 1.1660 Aggregation-prone
4 M P 0.0000 Buried
5 T P 0.2136 Aggregation-prone
6 Q P 0.0000 Buried
7 S P 0.0505 Aggregation-prone
8 P P 0.3490 Aggregation-prone
9 L P 1.0281 Aggregation-prone
10 S P -0.2195 Soluble
11 L P -0.3130 Soluble
12 S P -1.2151 Soluble
13 T P 0.0000 Buried
14 S P -0.5141 Soluble
15 V P 0.2132 Aggregation-prone
16 G P -1.1543 Soluble
17 D P -1.8029 Soluble
18 R P -2.5971 Soluble
19 V P 0.0000 Buried
20 S P -0.7693 Soluble
21 L P 0.0000 Buried
22 T P -0.6253 Soluble
23 C P 0.0000 Buried
24 K P -1.7585 Soluble
25 A P 0.0000 Buried
26 S P -0.9252 Soluble
27 Q P -1.8123 Soluble
28 N P -2.4439 Soluble
29 V P 0.0000 Buried
36 G P -1.4377 Soluble
37 T P -0.9752 Soluble
38 A P -0.4725 Soluble
39 V P 0.0000 Buried
40 A P 0.0000 Buried
41 W P 0.0000 Buried
42 Y P 0.0000 Buried
43 Q P -1.0669 Soluble
44 Q P -1.5501 Soluble
45 K P -1.8408 Soluble
46 P P -1.4044 Soluble
47 G P -1.3911 Soluble
48 Q P -2.0413 Soluble
49 S P -1.2680 Soluble
50 P P 0.0000 Buried
51 K P -0.8484 Soluble
52 L P 0.0000 Buried
53 L P 0.0000 Buried
54 I P 0.0000 Buried
55 Y P -0.4729 Soluble
56 S P -0.5222 Soluble
57 A P 0.0000 Buried
65 S P -1.0688 Soluble
66 N P -1.5709 Soluble
67 R P -1.5509 Soluble
68 Y P -0.8816 Soluble
69 T P -0.7614 Soluble
70 G P -0.8086 Soluble
71 V P 0.0000 Buried
72 P P -1.2986 Soluble
74 D P -2.3057 Soluble
75 R P -1.9597 Soluble
76 F P 0.0000 Buried
77 T P -0.9996 Soluble
78 G P -0.6630 Soluble
79 S P -0.8984 Soluble
80 G P -1.1043 Soluble
83 S P -1.3407 Soluble
84 G P -1.8709 Soluble
85 T P -2.2724 Soluble
86 D P -2.7011 Soluble
87 F P 0.0000 Buried
88 T P -0.8032 Soluble
89 L P 0.0000 Buried
90 T P -0.8863 Soluble
91 I P 0.0000 Buried
92 S P -1.9728 Soluble
93 N P -2.2819 Soluble
94 M P 0.0000 Buried
95 Q P -1.2828 Soluble
96 S P -1.0713 Soluble
97 E P -1.7437 Soluble
98 D P 0.0000 Buried
99 L P -1.3249 Soluble
100 A P 0.0000 Buried
101 D P -1.7125 Soluble
102 Y P 0.0000 Buried
103 F P 0.0000 Buried
104 C P 0.0000 Buried
105 Q P 0.0000 Buried
106 Q P 0.0000 Buried
107 Y P 0.0000 Buried
108 S P -0.4614 Soluble
109 S P 0.0644 Aggregation-prone
114 Y P 1.0103 Aggregation-prone
115 P P 0.3461 Aggregation-prone
116 L P 0.4327 Aggregation-prone
117 T P 0.0000 Buried
118 F P 0.4892 Aggregation-prone
119 G P 0.0000 Buried
120 A P 0.3105 Aggregation-prone
121 G P 0.0000 Buried
122 T P 0.0000 Buried
123 K P -1.9769 Soluble
124 L P 0.0000 Buried
125 E P -2.0361 Soluble
126 L P -1.0997 Soluble
127 R P -1.8359 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5366 3.1604 CSV PDB
4.5 -0.5809 3.0947 CSV PDB
5.0 -0.6304 3.0234 CSV PDB
5.5 -0.6781 2.9502 CSV PDB
6.0 -0.7165 2.8765 CSV PDB
6.5 -0.7398 2.8027 CSV PDB
7.0 -0.749 2.7294 CSV PDB
7.5 -0.7491 2.6579 CSV PDB
8.0 -0.7429 2.5915 CSV PDB
8.5 -0.7292 2.5371 CSV PDB
9.0 -0.7053 2.5021 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH