Zinlirvimab / 7ugq

A4DAB308_7ugq_O_R | Source PDB: 7ugq | Chains: O, R | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.5353
Max Score
2.4466
Min Score
-3.5425
Total Score
-126.87
Score CDR
-0.3109
Score non-CDR
-0.6148

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSALSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) O (Heavy), R (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.5425
Maximum Score 2.4466
Average Score -0.5353
Total Score -126.8653

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q O -1.7103 Soluble
2 V O 0.0000 Buried
3 Q O -1.9130 Soluble
4 L O 0.0000 Buried
5 Q O -2.0323 Soluble
6 E O -1.3873 Soluble
7 S O -0.8711 Soluble
8 G O -0.5515 Soluble
9 P O -0.2582 Soluble
11 G O 0.1528 Aggregation-prone
12 L O 0.6761 Aggregation-prone
13 V O 0.0000 Buried
14 K O -1.1494 Soluble
15 P O -1.0684 Soluble
16 S O -1.2153 Soluble
17 E O -1.7455 Soluble
18 T O -1.3474 Soluble
19 L O 0.0000 Buried
20 S O -0.9504 Soluble
21 V O 0.0000 Buried
22 T O -0.7377 Soluble
23 C O 0.0000 Buried
24 S O -1.2468 Soluble
25 V O 0.0000 Buried
26 S O -1.5780 Soluble
27 G O -1.6979 Soluble
28 D O -2.2208 Soluble
29 S O -1.5023 Soluble
30 M O 0.0000 Buried
35 N O -2.3104 Soluble
36 N O -2.3940 Soluble
37 Y O -1.3407 Soluble
38 Y O -0.8927 Soluble
39 W O 0.0000 Buried
40 T O 0.0000 Buried
41 W O 0.0000 Buried
42 I O 0.0000 Buried
43 R O -0.5632 Soluble
44 Q O 0.0000 Buried
45 S O -0.9875 Soluble
46 P O -1.1402 Soluble
47 G O -1.4758 Soluble
48 K O -2.1965 Soluble
49 G O -1.3538 Soluble
50 L O 0.0000 Buried
51 E O -0.8404 Soluble
52 W O 0.0000 Buried
53 I O 0.0000 Buried
54 G O 0.0000 Buried
55 Y O 0.0541 Aggregation-prone
56 I O 0.0000 Buried
57 S O 0.0000 Buried
58 D O -3.5425 Soluble
59 R O -3.5261 Soluble
63 E O -3.2808 Soluble
64 S O -1.7575 Soluble
65 A O -0.5767 Soluble
66 T O -0.2707 Soluble
67 Y O -0.2730 Soluble
68 N O 0.0000 Buried
69 P O -0.8170 Soluble
70 S O -0.7985 Soluble
71 L O 0.0000 Buried
72 N O -1.7041 Soluble
74 S O -1.0257 Soluble
75 R O -1.3658 Soluble
76 V O 0.0000 Buried
77 V O -0.0783 Soluble
78 I O 0.0000 Buried
79 S O -0.7253 Soluble
80 R O -1.4757 Soluble
81 D O -1.6344 Soluble
82 T O -1.6507 Soluble
83 S O -1.5024 Soluble
84 K O -2.2969 Soluble
85 N O -1.8588 Soluble
86 Q O -1.4411 Soluble
87 L O 0.0000 Buried
88 S O -0.6612 Soluble
89 L O 0.0000 Buried
90 K O -1.3613 Soluble
91 L O 0.0000 Buried
92 N O -1.4795 Soluble
93 S O -1.1897 Soluble
94 V O 0.0000 Buried
95 T O -0.6043 Soluble
96 P O -0.5307 Soluble
97 A O -0.0430 Soluble
98 D O 0.0000 Buried
99 T O 0.0656 Aggregation-prone
100 A O 0.0000 Buried
101 V O -0.2516 Soluble
102 Y O 0.0000 Buried
103 Y O 0.0000 Buried
104 C O 0.0000 Buried
105 A O 0.0000 Buried
106 T O 0.0000 Buried
107 A O 0.0000 Buried
108 R O -1.8362 Soluble
109 R O -1.9976 Soluble
110 G O -1.1928 Soluble
111 Q O -0.5124 Soluble
111A R O 0.1995 Aggregation-prone
111B I O 1.7985 Aggregation-prone
111C Y O 1.5739 Aggregation-prone
111D G O 1.3513 Aggregation-prone
111E V O 2.1873 Aggregation-prone
111F V O 2.4466 Aggregation-prone
112G S O 1.4486 Aggregation-prone
112F F O 2.1374 Aggregation-prone
112E G O 1.1789 Aggregation-prone
112D E O 1.0460 Aggregation-prone
112C F O 1.4030 Aggregation-prone
112B F O 0.4296 Aggregation-prone
112A Y O 0.0906 Aggregation-prone
112 Y O -0.2560 Soluble
113 Y O 0.0000 Buried
114 S O 0.0000 Buried
115 M O 0.0000 Buried
116 D O -0.2371 Soluble
117 V O 0.1024 Aggregation-prone
118 W O 0.0000 Buried
119 G O 0.0000 Buried
120 K O -2.3645 Soluble
121 G O 0.0000 Buried
122 T O -0.7827 Soluble
123 T O -0.2591 Soluble
124 V O 0.0000 Buried
125 T O 0.1779 Aggregation-prone
126 V O 0.0829 Aggregation-prone
127 S O -0.1070 Soluble
128 S O -0.2599 Soluble
129 A O -0.0633 Soluble
11 L R 1.0248 Aggregation-prone
12 S R 0.6888 Aggregation-prone
13 V R 0.0000 Buried
14 A R 0.2200 Aggregation-prone
15 L R 0.0467 Aggregation-prone
16 G R -1.2072 Soluble
17 E R -1.7548 Soluble
18 T R -1.3701 Soluble
19 A R 0.0000 Buried
20 R R -1.7560 Soluble
21 I R 0.0000 Buried
22 S R -1.0604 Soluble
23 C R -0.8701 Soluble
24 G R -1.1639 Soluble
25 R R -1.4956 Soluble
26 Q R -1.6710 Soluble
27 A R -0.7255 Soluble
28 L R 0.1801 Aggregation-prone
29 G R 0.1192 Aggregation-prone
36 S R 0.6415 Aggregation-prone
37 R R 0.0000 Buried
38 A R 0.0000 Buried
39 V R 0.0000 Buried
40 Q R 0.0000 Buried
41 W R 0.0000 Buried
42 Y R 0.0000 Buried
43 Q R -0.5174 Soluble
44 H R 0.0000 Buried
45 R R -2.3780 Soluble
46 P R -1.9879 Soluble
47 G R -1.7946 Soluble
48 Q R -2.2889 Soluble
49 A R -1.4077 Soluble
50 P R 0.0000 Buried
51 I R 0.5929 Aggregation-prone
52 L R 0.0000 Buried
53 L R 0.0000 Buried
54 I R 0.0000 Buried
55 Y R -0.8560 Soluble
56 N R -1.2283 Soluble
57 N R 0.0000 Buried
65 Q R -2.0806 Soluble
66 D R -2.1465 Soluble
67 R R -1.7822 Soluble
68 P R -0.8577 Soluble
69 S R -0.6181 Soluble
70 G R -0.4983 Soluble
71 I R -0.8040 Soluble
72 P R -1.3468 Soluble
74 E R -2.1365 Soluble
75 R R -1.5546 Soluble
76 F R 0.0000 Buried
77 S R -1.4370 Soluble
78 G R -1.2747 Soluble
79 T R -0.7314 Soluble
80 P R -0.4549 Soluble
81 D R 0.1860 Aggregation-prone
81A I R 1.6672 Aggregation-prone
82 N R 0.3979 Aggregation-prone
83 F R 1.4360 Aggregation-prone
84 G R 0.1407 Aggregation-prone
85 T R -0.5421 Soluble
86 R R -1.6955 Soluble
87 A R 0.0000 Buried
88 T R -0.9599 Soluble
89 L R 0.0000 Buried
90 T R -0.9765 Soluble
91 I R 0.0000 Buried
92 S R -1.5927 Soluble
93 G R -1.3567 Soluble
94 V R 0.0000 Buried
95 E R -2.2963 Soluble
96 A R -1.1613 Soluble
97 G R -1.4746 Soluble
98 D R 0.0000 Buried
99 E R -2.7478 Soluble
100 A R 0.0000 Buried
101 D R 0.0000 Buried
102 Y R 0.0000 Buried
103 Y R 0.0000 Buried
104 C R 0.0000 Buried
105 H R 0.0000 Buried
106 M R 0.0000 Buried
107 W R 0.0000 Buried
108 D R 0.0000 Buried
109 S R -0.4173 Soluble
110 R R -1.6935 Soluble
112 S R -0.9049 Soluble
113 G R -0.4691 Soluble
114 F R 0.7435 Aggregation-prone
115 S R 0.3610 Aggregation-prone
116 W R 0.1501 Aggregation-prone
117 S R -0.2710 Soluble
118 F R 0.0000 Buried
119 G R -0.6857 Soluble
120 G R -1.1189 Soluble
121 A R -0.9985 Soluble
122 T R -0.8675 Soluble
123 R R -2.0708 Soluble
124 L R 0.0000 Buried
125 T R -0.2334 Soluble
126 V R 0.0965 Aggregation-prone
127 L R 1.4565 Aggregation-prone
128 G R 0.4437 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.3792 4.3355 CSV PDB
4.5 -0.4125 4.3126 CSV PDB
5.0 -0.4546 4.277 CSV PDB
5.5 -0.4983 4.2419 CSV PDB
6.0 -0.5357 4.2174 CSV PDB
6.5 -0.5608 4.1931 CSV PDB
7.0 -0.5716 4.1692 CSV PDB
7.5 -0.572 4.1465 CSV PDB
8.0 -0.5663 4.127 CSV PDB
8.5 -0.5565 4.1141 CSV PDB
9.0 -0.5428 4.1136 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH