Vixticibart / 8tga

A4DAB296_8tga_H_L | Source PDB: 8tga | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6021
Max Score
1.9979
Min Score
-3.5351
Total Score
-257.1
Score CDR
-0.0485
Score non-CDR
-0.6755

Calculation Parameters

Chain Sequence(s) VQLVQSGAEVKKPGASVTVSCKASGYTFTDYYMHWVRQAPGQGLEWMGWIKPNSGGTNSAQRFQGRITMTWDTSISTAYMELSRLRSDDTAVYYCSRGGPVMNYYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVNIQMTQSPSSLSASVGDRVTITCRASQSIDSYLNWYQQKPGKAPKLLIYVASSLQSGVPSRFSGSGSGKDFTLTISSLQPEDFATYYCQQSYSIPTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.5351
Maximum Score 1.9979
Average Score -0.6021
Total Score -257.1017

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V H 1.0638 Aggregation-prone
3 Q H -0.3645 Soluble
4 L H 0.0000 Buried
5 V H 0.2901 Aggregation-prone
6 Q H -0.2175 Soluble
7 S H -0.6961 Soluble
8 G H -1.0414 Soluble
9 A H -0.9261 Soluble
11 E H -1.7044 Soluble
12 V H -0.9122 Soluble
13 K H -1.4782 Soluble
14 K H -2.1569 Soluble
15 P H -2.3215 Soluble
16 G H -2.1039 Soluble
17 A H -1.4867 Soluble
18 S H -1.0952 Soluble
19 V H 0.0000 Buried
20 T H -0.5519 Soluble
21 V H 0.0000 Buried
22 S H -0.1296 Soluble
23 C H 0.0000 Buried
24 K H -0.2598 Soluble
25 A H 0.0000 Buried
26 S H 0.0264 Aggregation-prone
27 G H -0.1844 Soluble
28 Y H 0.0818 Aggregation-prone
29 T H -0.1803 Soluble
30 F H 0.0000 Buried
35 T H -0.9615 Soluble
36 D H -0.9545 Soluble
37 Y H -0.0776 Soluble
38 Y H 0.0000 Buried
39 M H 0.0000 Buried
40 H H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.6059 Soluble
45 A H -1.0253 Soluble
46 P H -0.8019 Soluble
47 G H -1.2328 Soluble
48 Q H -1.8288 Soluble
49 G H -1.2852 Soluble
50 L H 0.0000 Buried
51 E H -0.5697 Soluble
52 W H 0.0000 Buried
53 M H 0.0000 Buried
54 G H 0.0000 Buried
55 W H -0.0182 Soluble
56 I H 0.0000 Buried
57 K H -0.8075 Soluble
58 P H 0.0000 Buried
59 N H -1.6421 Soluble
62 S H -1.1507 Soluble
63 G H -1.0951 Soluble
64 G H -0.8493 Soluble
65 T H -0.5284 Soluble
66 N H -0.7999 Soluble
67 S H -1.1755 Soluble
68 A H 0.0000 Buried
69 Q H -2.5590 Soluble
70 R H -2.9075 Soluble
71 F H 0.0000 Buried
72 Q H -2.4348 Soluble
74 G H -1.9987 Soluble
75 R H -1.5926 Soluble
76 I H -0.8753 Soluble
77 T H -0.4420 Soluble
78 M H 0.0539 Aggregation-prone
79 T H -0.0585 Soluble
80 W H 0.0702 Aggregation-prone
81 D H -0.1612 Soluble
82 T H 0.0121 Aggregation-prone
83 S H 0.4897 Aggregation-prone
84 I H 1.4821 Aggregation-prone
85 S H 0.4024 Aggregation-prone
86 T H 0.0000 Buried
87 A H 0.0000 Buried
88 Y H 0.0544 Aggregation-prone
89 M H 0.0000 Buried
90 E H -0.5777 Soluble
91 L H 0.0000 Buried
92 S H -1.5595 Soluble
93 R H -2.5629 Soluble
94 L H 0.0000 Buried
95 R H -3.0416 Soluble
96 S H -2.1304 Soluble
97 D H -2.4089 Soluble
98 D H 0.0000 Buried
99 T H -0.7638 Soluble
100 A H 0.0000 Buried
101 V H 0.0637 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 S H 0.0000 Buried
106 R H -0.2671 Soluble
107 G H 0.0000 Buried
108 G H 0.0000 Buried
109 P H 0.7222 Aggregation-prone
110 V H 0.6815 Aggregation-prone
111 M H 1.0144 Aggregation-prone
111A N H 1.0413 Aggregation-prone
111B Y H 1.9979 Aggregation-prone
112B Y H 1.8468 Aggregation-prone
112A Y H 1.9777 Aggregation-prone
112 Y H 1.7439 Aggregation-prone
113 Y H 1.2459 Aggregation-prone
114 G H 0.0000 Buried
115 M H 0.0000 Buried
116 D H -1.2437 Soluble
117 V H -0.3938 Soluble
118 W H -0.4777 Soluble
119 G H 0.0000 Buried
120 Q H -1.4205 Soluble
121 G H -0.7506 Soluble
122 T H 0.0000 Buried
123 T H -0.2943 Soluble
124 V H 0.0000 Buried
125 T H -1.0114 Soluble
126 V H 0.0000 Buried
127 S H -1.2301 Soluble
128 S H -0.9942 Soluble
129 A H -0.6938 Soluble
130 S H -0.8670 Soluble
131 T H -0.9308 Soluble
132 K H -1.5674 Soluble
133 G H -1.5742 Soluble
134 P H -0.7512 Soluble
135 S H -0.3344 Soluble
136 V H 0.0000 Buried
137 F H -0.5350 Soluble
138 P H -0.5507 Soluble
139 L H 0.0000 Buried
140 A H 0.2797 Aggregation-prone
141 P H 0.4529 Aggregation-prone
142 C H 0.6224 Aggregation-prone
143 T H -0.0823 Soluble
144 A H 0.3347 Aggregation-prone
145 A H 0.0000 Buried
146 L H 0.4382 Aggregation-prone
147 G H 0.0000 Buried
148 C H 0.0000 Buried
149 L H 0.0000 Buried
150 V H 0.0000 Buried
151 K H -0.3201 Soluble
152 D H -0.5364 Soluble
153 Y H 0.0000 Buried
154 F H 0.0000 Buried
155 P H -1.0935 Soluble
156 E H -1.5531 Soluble
157 P H -1.3152 Soluble
158 V H -0.2164 Soluble
159 T H 0.2390 Aggregation-prone
160 V H 1.4630 Aggregation-prone
161 S H 0.6669 Aggregation-prone
162 W H -0.1418 Soluble
163 N H -0.3514 Soluble
164 S H -0.0892 Soluble
165 G H -0.1934 Soluble
166 A H -0.1432 Soluble
167 L H 0.1765 Aggregation-prone
168 T H -0.1440 Soluble
169 S H -0.2718 Soluble
170 G H -0.5075 Soluble
171 V H 0.3473 Aggregation-prone
172 H H -0.2797 Soluble
173 T H 0.0636 Aggregation-prone
174 F H 0.0000 Buried
175 P H -0.1230 Soluble
176 A H 0.3051 Aggregation-prone
177 V H 0.8682 Aggregation-prone
178 L H 1.5457 Aggregation-prone
179 Q H 0.3829 Aggregation-prone
180 S H -0.0314 Soluble
181 S H -0.1883 Soluble
182 G H 0.0778 Aggregation-prone
183 L H 0.0047 Aggregation-prone
184 Y H 0.3301 Aggregation-prone
185 S H 0.0000 Buried
186 L H 0.3636 Aggregation-prone
187 S H -0.0077 Soluble
188 S H 0.0000 Buried
189 V H 0.0000 Buried
190 V H 0.5714 Aggregation-prone
191 T H 0.3890 Aggregation-prone
192 V H 0.2765 Aggregation-prone
193 P H -0.1840 Soluble
194 S H -0.2622 Soluble
195 S H -0.3069 Soluble
196 S H -0.3433 Soluble
197 L H 0.0277 Aggregation-prone
198 G H -0.5400 Soluble
199 T H -0.5833 Soluble
200 K H -0.8708 Soluble
201 T H -0.6642 Soluble
202 Y H -0.4123 Soluble
203 T H -1.1747 Soluble
204 C H 0.0000 Buried
205 N H -1.3774 Soluble
206 V H 0.0000 Buried
207 D H -2.0588 Soluble
208 H H 0.0000 Buried
209 K H -2.8755 Soluble
210 P H -1.8568 Soluble
211 S H -1.9818 Soluble
212 N H -2.7403 Soluble
213 T H -2.2362 Soluble
214 K H -2.8958 Soluble
215 V H -1.9235 Soluble
216 D H -2.7617 Soluble
217 K H -2.0826 Soluble
218 R H -1.9857 Soluble
219 V H -0.6815 Soluble
1 N L -1.5668 Soluble
2 I L -1.1884 Soluble
3 Q L -1.9134 Soluble
4 M L 0.0000 Buried
5 T L -1.3132 Soluble
6 Q L -0.9838 Soluble
7 S L -0.7354 Soluble
8 P L -0.5175 Soluble
9 S L -0.8576 Soluble
10 S L -0.7359 Soluble
11 L L -0.4053 Soluble
12 S L -0.7453 Soluble
13 A L 0.0000 Buried
14 S L -0.4848 Soluble
15 V L 0.6699 Aggregation-prone
16 G L -0.6356 Soluble
17 D L -1.5323 Soluble
18 R L -2.2203 Soluble
19 V L 0.0000 Buried
20 T L -0.5085 Soluble
21 I L 0.0000 Buried
22 T L -0.7927 Soluble
23 C L 0.0000 Buried
24 R L -2.5816 Soluble
25 A L 0.0000 Buried
26 S L -1.7803 Soluble
27 Q L -2.3595 Soluble
28 S L -1.8148 Soluble
29 I L 0.0000 Buried
36 D L -2.0086 Soluble
37 S L -0.7725 Soluble
38 Y L 0.2470 Aggregation-prone
39 L L 0.0000 Buried
40 N L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L -0.9023 Soluble
44 Q L 0.0000 Buried
45 K L -1.6369 Soluble
46 P L -1.4610 Soluble
47 G L -1.6705 Soluble
48 K L -2.6150 Soluble
49 A L -1.7093 Soluble
50 P L 0.0000 Buried
51 K L -2.1383 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L 0.7787 Aggregation-prone
56 V L 0.6643 Aggregation-prone
57 A L 0.0000 Buried
65 S L 0.0360 Aggregation-prone
66 S L 0.4028 Aggregation-prone
67 L L 0.6382 Aggregation-prone
68 Q L -0.0455 Soluble
69 S L -0.4430 Soluble
70 G L -0.4674 Soluble
71 V L -0.2951 Soluble
72 P L -0.2997 Soluble
74 S L -0.3687 Soluble
75 R L -0.6476 Soluble
76 F L 0.0000 Buried
77 S L -0.3108 Soluble
78 G L -0.1181 Soluble
79 S L -0.5591 Soluble
80 G L -1.3452 Soluble
83 S L -1.7040 Soluble
84 G L -2.0676 Soluble
85 K L -2.7068 Soluble
86 D L -2.5201 Soluble
87 F L 0.0000 Buried
88 T L -0.7226 Soluble
89 L L 0.0000 Buried
90 T L -0.6110 Soluble
91 I L 0.0000 Buried
92 S L -1.4690 Soluble
93 S L -1.1006 Soluble
94 L L 0.0000 Buried
95 Q L -0.8103 Soluble
96 P L -0.7436 Soluble
97 E L -1.5854 Soluble
98 D L 0.0000 Buried
99 F L -0.3697 Soluble
100 A L 0.0000 Buried
101 T L -0.7931 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 S L 0.0000 Buried
108 Y L 0.9323 Aggregation-prone
114 S L 0.5161 Aggregation-prone
115 I L 0.1820 Aggregation-prone
116 P L 0.2589 Aggregation-prone
117 T L -0.3226 Soluble
118 F L -0.3749 Soluble
119 G L -1.0193 Soluble
120 Q L -1.7696 Soluble
121 G L -1.2278 Soluble
122 T L 0.0000 Buried
123 R L -1.4195 Soluble
124 L L 0.0000 Buried
125 E L -0.7953 Soluble
126 I L -0.4180 Soluble
127 K L -1.5124 Soluble
128 R L -1.2392 Soluble
129 T L 0.0395 Aggregation-prone
130 V L 1.1705 Aggregation-prone
131 A L 0.4776 Aggregation-prone
132 A L 0.0822 Aggregation-prone
133 P L 0.0041 Aggregation-prone
134 S L -0.1213 Soluble
135 V L 0.1045 Aggregation-prone
136 F L 0.3559 Aggregation-prone
137 I L 0.4386 Aggregation-prone
138 F L 0.0000 Buried
139 P L 0.0000 Buried
140 P L -0.3504 Soluble
141 S L -1.2146 Soluble
142 D L -2.6156 Soluble
143 E L -2.4792 Soluble
144 Q L 0.0000 Buried
145 L L -2.0083 Soluble
146 K L -2.7480 Soluble
147 S L -1.7522 Soluble
148 G L -1.4888 Soluble
149 T L -1.1819 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.1370 Aggregation-prone
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L -0.4321 Soluble
158 N L -1.0812 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.5492 Soluble
162 R L -3.0429 Soluble
163 E L -2.9874 Soluble
164 A L -2.1758 Soluble
165 K L -2.3977 Soluble
166 V L -1.0403 Soluble
167 Q L -1.1258 Soluble
168 W L 0.0000 Buried
169 K L -0.9355 Soluble
170 V L 0.0000 Buried
171 D L -1.6115 Soluble
172 N L -1.3679 Soluble
173 A L -0.4064 Soluble
174 L L 0.5300 Aggregation-prone
175 Q L -0.3348 Soluble
176 S L -0.6511 Soluble
177 G L -1.0231 Soluble
178 N L -1.0144 Soluble
179 S L -1.1244 Soluble
180 Q L -0.9667 Soluble
181 E L -1.2307 Soluble
182 S L -0.5327 Soluble
183 V L -0.7194 Soluble
184 T L -1.1843 Soluble
185 E L -2.3400 Soluble
186 Q L -2.0884 Soluble
187 D L -2.3194 Soluble
188 S L -1.8620 Soluble
189 K L -2.4474 Soluble
190 D L -2.0162 Soluble
191 S L -1.9308 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L -0.2070 Soluble
197 S L 0.0000 Buried
198 T L -0.4435 Soluble
199 L L 0.0000 Buried
200 T L -0.2616 Soluble
201 L L -0.7037 Soluble
202 S L -1.3160 Soluble
203 K L -2.1802 Soluble
204 A L -2.0111 Soluble
205 D L -3.0328 Soluble
206 Y L -2.6851 Soluble
207 E L -3.5351 Soluble
208 K L -3.4227 Soluble
209 H L -2.9826 Soluble
210 K L -2.9779 Soluble
211 V L -1.2314 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.9835 Soluble
216 V L 0.0000 Buried
217 T L -1.2076 Soluble
218 H L 0.0000 Buried
219 Q L -1.6982 Soluble
220 G L -0.2792 Soluble
221 L L -0.1664 Soluble
222 S L -0.4742 Soluble
223 S L -0.4459 Soluble
224 P L -0.6102 Soluble
225 V L -0.0251 Soluble
226 T L -0.5742 Soluble
227 K L -0.7514 Soluble
228 S L -0.4951 Soluble
229 F L 0.0000 Buried
230 N L -1.2208 Soluble
231 R L -1.8041 Soluble
232 G L -1.8845 Soluble
233 E L -1.9679 Soluble
234 C L -0.5166 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6036 2.7768 CSV PDB
4.5 -0.648 2.7453 CSV PDB
5.0 -0.6975 2.6921 CSV PDB
5.5 -0.7422 2.6244 CSV PDB
6.0 -0.7724 2.5533 CSV PDB
6.5 -0.7813 2.4897 CSV PDB
7.0 -0.7711 2.4445 CSV PDB
7.5 -0.7497 2.4288 CSV PDB
8.0 -0.7221 2.4288 CSV PDB
8.5 -0.6891 2.4288 CSV PDB
9.0 -0.6494 2.4288 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH