Zinlirvimab / 6orn

A4DAB308_6orn_A_B | Source PDB: 6orn | Chains: A, B | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6157
Max Score
2.7538
Min Score
-3.2675
Total Score
-145.92
Score CDR
-0.4809
Score non-CDR
-0.6634

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSALSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) A (Heavy), B (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.2675
Maximum Score 2.7538
Average Score -0.6157
Total Score -145.9184

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q A -2.0786 Soluble
2 V A 0.0000 Buried
3 Q A -2.1846 Soluble
4 L A -1.2891 Soluble
5 Q A -1.6650 Soluble
6 E A -1.1295 Soluble
7 S A -0.8118 Soluble
8 G A -0.5630 Soluble
9 P A -0.1265 Soluble
11 G A 0.4030 Aggregation-prone
12 L A 1.0333 Aggregation-prone
13 V A -0.2226 Soluble
14 K A -1.6547 Soluble
15 P A -1.2422 Soluble
16 S A -1.3862 Soluble
17 E A -1.7696 Soluble
18 T A -1.4103 Soluble
19 L A 0.0000 Buried
20 S A -0.7775 Soluble
21 V A 0.0000 Buried
22 T A -0.7392 Soluble
23 C A 0.0000 Buried
24 S A -1.2090 Soluble
25 V A 0.0000 Buried
26 S A -1.9063 Soluble
27 G A -2.1575 Soluble
28 D A -2.9048 Soluble
29 S A -1.9828 Soluble
30 M A -1.7536 Soluble
35 N A -2.1137 Soluble
36 N A -2.0184 Soluble
37 Y A -1.3438 Soluble
38 Y A -1.0616 Soluble
39 W A 0.0000 Buried
40 T A 0.0000 Buried
41 W A 0.0000 Buried
42 I A 0.0000 Buried
43 R A -0.4685 Soluble
44 Q A -0.8286 Soluble
45 S A -0.9321 Soluble
46 P A -1.0769 Soluble
47 G A -1.4969 Soluble
48 K A -2.2223 Soluble
49 G A -1.4243 Soluble
50 L A -0.7604 Soluble
51 E A -0.7213 Soluble
52 W A 0.0000 Buried
53 I A 0.0000 Buried
54 G A 0.0000 Buried
55 Y A 0.0172 Aggregation-prone
56 I A 0.0000 Buried
57 S A -2.1935 Soluble
58 D A -2.9709 Soluble
59 R A -3.2675 Soluble
63 E A -3.1898 Soluble
64 S A -1.6784 Soluble
65 A A -0.4804 Soluble
66 T A -0.0235 Soluble
67 Y A 0.1276 Aggregation-prone
68 N A 0.0000 Buried
69 P A -0.5993 Soluble
70 S A -0.5774 Soluble
71 L A -0.7937 Soluble
72 N A -1.6005 Soluble
74 S A -1.0727 Soluble
75 R A -1.4615 Soluble
76 V A -0.4823 Soluble
77 V A 0.4417 Aggregation-prone
78 I A 0.1536 Aggregation-prone
79 S A -0.7032 Soluble
80 R A -1.8850 Soluble
81 D A -2.2390 Soluble
82 T A -1.9697 Soluble
83 S A -1.7774 Soluble
84 K A -2.7573 Soluble
85 N A -2.7791 Soluble
86 Q A -1.9458 Soluble
87 L A 0.0000 Buried
88 S A -0.5797 Soluble
89 L A 0.0000 Buried
90 K A -0.8700 Soluble
91 L A -1.0732 Soluble
92 N A -1.8891 Soluble
93 S A -1.2987 Soluble
94 V A 0.0000 Buried
95 T A -0.7465 Soluble
96 P A -0.6522 Soluble
97 A A -0.1834 Soluble
98 D A -0.3179 Soluble
99 T A -0.0687 Soluble
100 A A 0.0000 Buried
101 V A -0.2217 Soluble
102 Y A 0.0000 Buried
103 Y A 0.0000 Buried
104 C A 0.0000 Buried
105 A A 0.0000 Buried
106 T A 0.0000 Buried
107 A A 0.0000 Buried
108 R A -2.0288 Soluble
109 R A -2.1717 Soluble
110 G A -1.7953 Soluble
111 Q A -1.4133 Soluble
111A R A -1.0103 Soluble
111B I A 1.1242 Aggregation-prone
111C Y A 1.3188 Aggregation-prone
111D G A 1.1283 Aggregation-prone
111E V A 2.2068 Aggregation-prone
111F V A 2.7538 Aggregation-prone
112G S A 1.6048 Aggregation-prone
112F F A 2.2036 Aggregation-prone
112E G A 1.1367 Aggregation-prone
112D E A 1.0283 Aggregation-prone
112C F A 1.1829 Aggregation-prone
112B F A 0.3267 Aggregation-prone
112A Y A 0.1607 Aggregation-prone
112 Y A 0.0000 Buried
113 Y A 0.0000 Buried
114 S A -0.8675 Soluble
115 M A 0.0000 Buried
116 D A -0.5259 Soluble
117 V A -0.0828 Soluble
118 W A -0.2564 Soluble
119 G A 0.0000 Buried
120 K A -2.3166 Soluble
121 G A -1.3237 Soluble
122 T A -0.6883 Soluble
123 T A 0.0255 Aggregation-prone
124 V A 0.0000 Buried
125 T A 0.1711 Aggregation-prone
126 V A 0.0000 Buried
127 S A -0.4439 Soluble
128 S A -0.6817 Soluble
129 A A -0.3727 Soluble
11 L B 0.7921 Aggregation-prone
12 S B 0.6886 Aggregation-prone
13 V B 0.0000 Buried
14 A B 0.6007 Aggregation-prone
15 L B 0.7792 Aggregation-prone
16 G B -0.8008 Soluble
17 E B -1.4228 Soluble
18 T B -1.2779 Soluble
19 A B 0.0000 Buried
20 R B -1.6790 Soluble
21 I B -0.5769 Soluble
22 S B -0.9545 Soluble
23 C B -0.9626 Soluble
24 G B -1.5917 Soluble
25 R B -2.0930 Soluble
26 Q B -1.9325 Soluble
27 A B -0.9742 Soluble
28 L B -0.0545 Soluble
29 G B -0.0034 Soluble
36 S B 0.0735 Aggregation-prone
37 R B 0.0000 Buried
38 A B 0.0000 Buried
39 V B 0.0000 Buried
40 Q B 0.0000 Buried
41 W B 0.0000 Buried
42 Y B 0.0000 Buried
43 Q B -0.3307 Soluble
44 H B 0.0000 Buried
45 R B -1.6336 Soluble
46 P B -1.3850 Soluble
47 G B -1.6091 Soluble
48 Q B -2.0728 Soluble
49 A B -1.1605 Soluble
50 P B 0.0000 Buried
51 I B 0.5108 Aggregation-prone
52 L B 0.0000 Buried
53 L B 0.0000 Buried
54 I B 0.0000 Buried
55 Y B -0.8765 Soluble
56 N B -1.4841 Soluble
57 N B 0.0000 Buried
65 Q B -2.2951 Soluble
66 D B -2.3381 Soluble
67 R B -1.7486 Soluble
68 P B -0.8200 Soluble
69 S B -0.6476 Soluble
70 G B -0.7090 Soluble
71 I B -0.6607 Soluble
72 P B -1.3400 Soluble
74 E B -2.3853 Soluble
75 R B -1.8820 Soluble
76 F B 0.0000 Buried
77 S B -1.2873 Soluble
78 G B -1.0415 Soluble
79 T B -0.7369 Soluble
80 P B -0.7430 Soluble
81 D B -0.3913 Soluble
81A I B 1.3956 Aggregation-prone
82 N B 0.3012 Aggregation-prone
83 F B 1.3121 Aggregation-prone
84 G B 0.0421 Aggregation-prone
85 T B -0.5984 Soluble
86 R B -2.0724 Soluble
87 A B -1.4225 Soluble
88 T B -0.9710 Soluble
89 L B 0.0000 Buried
90 T B -1.0066 Soluble
91 I B 0.0000 Buried
92 S B -1.6543 Soluble
93 G B -1.0892 Soluble
94 V B 0.0000 Buried
95 E B -1.0766 Soluble
96 A B -0.3533 Soluble
97 G B -0.8797 Soluble
98 D B -1.1576 Soluble
99 E B -1.6520 Soluble
100 A B 0.0000 Buried
101 D B 0.0000 Buried
102 Y B 0.0000 Buried
103 Y B 0.0000 Buried
104 C B 0.0000 Buried
105 H B 0.0000 Buried
106 M B -0.2188 Soluble
107 W B 0.0000 Buried
108 D B 0.0000 Buried
109 S B -0.6059 Soluble
110 R B -1.7830 Soluble
112 S B -0.9256 Soluble
113 G B -0.3483 Soluble
114 F B 0.9603 Aggregation-prone
115 S B 0.5292 Aggregation-prone
116 W B 0.2572 Aggregation-prone
117 S B -0.1087 Soluble
118 F B -0.2936 Soluble
119 G B -0.7920 Soluble
120 G B -1.2727 Soluble
121 A B -1.0321 Soluble
122 T B -0.7560 Soluble
123 R B -1.6955 Soluble
124 L B 0.0000 Buried
125 T B -0.0049 Soluble
126 V B 0.6293 Aggregation-prone
127 L B 1.5047 Aggregation-prone
128 G B 0.5907 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5225 4.4805 CSV PDB
4.5 -0.5583 4.4496 CSV PDB
5.0 -0.6024 4.4041 CSV PDB
5.5 -0.6472 4.3516 CSV PDB
6.0 -0.6844 4.3003 CSV PDB
6.5 -0.7079 4.2585 CSV PDB
7.0 -0.717 4.2325 CSV PDB
7.5 -0.716 4.2206 CSV PDB
8.0 -0.7092 4.2162 CSV PDB
8.5 -0.6982 4.2147 CSV PDB
9.0 -0.6829 4.2142 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH