Timcevibart / 7b3o

A4DAB267_7b3o_H_L | Source PDB: 7b3o | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6086
Max Score
1.7453
Min Score
-3.1492
Total Score
-256.21
Score CDR
-0.0427
Score non-CDR
-0.673

Calculation Parameters

Chain Sequence(s) QVQLVESGGGLVQPGGSLRLSCAASGLTVSSNYMSWVRQAPGKGLEWVSVIYSGGSTYYADSVKGRFTISRDDSKNTLYLQMNSLRAEDTAVYYCARDVADAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDIVMTQSPSFLSASVGDRVTITCRASQGISSYLAWYQQKPGKAPKLLIYAASTLQSGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCQQLNSYPPFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLRSPVTKSFNRGEC input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.1492
Maximum Score 1.7453
Average Score -0.6086
Total Score -256.2132

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -0.8534 Soluble
2 V H 0.2831 Aggregation-prone
3 Q H -0.6017 Soluble
4 L H 0.0000 Buried
5 V H 0.3728 Aggregation-prone
6 E H 0.0000 Buried
7 S H -0.5091 Soluble
8 G H -0.7633 Soluble
9 G H -0.2861 Soluble
11 G H 0.2026 Aggregation-prone
12 L H 0.8067 Aggregation-prone
13 V H 0.0000 Buried
14 Q H -1.5096 Soluble
15 P H -1.7639 Soluble
16 G H -1.5055 Soluble
17 G H -1.1331 Soluble
18 S H -1.4815 Soluble
19 L H -1.3637 Soluble
20 R H -2.4658 Soluble
21 L H 0.0000 Buried
23 C H 0.0000 Buried
24 A H -0.3319 Soluble
25 A H 0.0000 Buried
26 S H -0.3290 Soluble
27 G H -0.4042 Soluble
28 L H -0.2029 Soluble
29 T H -0.5608 Soluble
30 V H 0.0000 Buried
35 S H -0.9789 Soluble
36 S H -0.4879 Soluble
37 N H 0.2266 Aggregation-prone
38 Y H 0.7118 Aggregation-prone
39 M H 0.0000 Buried
40 S H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.7805 Soluble
45 A H -1.1456 Soluble
46 P H -0.9826 Soluble
47 G H -1.5120 Soluble
48 K H -2.2701 Soluble
49 G H -1.4133 Soluble
50 L H 0.0000 Buried
51 E H -0.9525 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 S H 0.0000 Buried
55 V H 0.0000 Buried
56 I H 0.0000 Buried
57 Y H 0.3031 Aggregation-prone
58 S H -0.2557 Soluble
59 G H -0.5534 Soluble
63 G H -0.5150 Soluble
64 S H -0.0178 Soluble
65 T H 0.4138 Aggregation-prone
66 Y H 0.5171 Aggregation-prone
67 Y H -0.4998 Soluble
68 A H -1.2849 Soluble
69 D H -2.3629 Soluble
70 S H -1.7554 Soluble
71 V H 0.0000 Buried
72 K H -2.3872 Soluble
74 G H -1.7154 Soluble
75 R H -1.4250 Soluble
76 F H -1.2651 Soluble
78 I H -0.2223 Soluble
79 S H -0.7856 Soluble
80 R H -1.5477 Soluble
81 D H -2.3644 Soluble
82 D H -3.0064 Soluble
83 S H -2.2463 Soluble
84 K H -2.7479 Soluble
85 N H -2.1667 Soluble
86 T H -1.3603 Soluble
87 L H 0.0000 Buried
88 Y H -0.7715 Soluble
89 L H 0.0000 Buried
90 Q H -2.0632 Soluble
91 M H 0.0000 Buried
92 N H -1.9202 Soluble
94 L H 0.0000 Buried
95 R H -2.4850 Soluble
96 A H -1.8221 Soluble
97 E H -2.2666 Soluble
98 D H 0.0000 Buried
99 T H -0.6071 Soluble
100 A H 0.0000 Buried
101 V H 0.3172 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H 0.2714 Aggregation-prone
107 D H 0.0000 Buried
108 V H 1.7453 Aggregation-prone
109 A H 0.8470 Aggregation-prone
113 D H 0.2722 Aggregation-prone
114 A H 0.0000 Buried
115 F H 0.0000 Buried
116 D H -0.2535 Soluble
117 I H 0.0425 Aggregation-prone
118 W H -0.4509 Soluble
119 G H 0.0000 Buried
120 Q H -1.4809 Soluble
121 G H -0.6498 Soluble
122 T H 0.0090 Aggregation-prone
123 M H 0.6343 Aggregation-prone
124 V H 0.0000 Buried
125 T H -0.1639 Soluble
126 V H 0.0000 Buried
127 S H -0.9002 Soluble
128 S H -0.8223 Soluble
129 A H -0.4616 Soluble
130 S H -0.6550 Soluble
131 T H -0.7239 Soluble
132 K H -1.1840 Soluble
133 G H -1.3976 Soluble
134 P H 0.0000 Buried
135 S H -0.2890 Soluble
136 V H 0.0000 Buried
137 F H -0.4969 Soluble
138 P H -1.1098 Soluble
139 L H 0.0000 Buried
140 A H -1.2324 Soluble
141 P H 0.0000 Buried
142 S H -1.1943 Soluble
143 S H -1.2870 Soluble
144 K H -1.7774 Soluble
145 G H -0.6462 Soluble
146 T H -0.4740 Soluble
147 A H -0.4337 Soluble
148 A H 0.0000 Buried
149 L H 0.0000 Buried
150 G H 0.0000 Buried
151 C H 0.0000 Buried
152 L H 0.0000 Buried
153 V H 0.0000 Buried
154 K H 0.0000 Buried
155 D H -0.3588 Soluble
156 Y H 0.0000 Buried
157 F H 0.0000 Buried
158 P H -0.7281 Soluble
159 E H -0.9287 Soluble
160 P H -1.0928 Soluble
161 V H -0.7244 Soluble
162 T H -0.7983 Soluble
163 V H -0.2948 Soluble
164 S H -0.4590 Soluble
165 W H 0.0000 Buried
166 N H -0.7494 Soluble
167 S H -0.6643 Soluble
168 G H -0.5626 Soluble
169 A H -0.2321 Soluble
170 L H 0.0168 Aggregation-prone
171 T H -0.1590 Soluble
172 S H -0.1685 Soluble
173 G H -0.2134 Soluble
174 V H 0.1627 Aggregation-prone
175 H H -0.2639 Soluble
176 T H 0.1074 Aggregation-prone
177 F H 0.0000 Buried
178 P H -0.1422 Soluble
179 A H 0.3263 Aggregation-prone
180 V H 0.7434 Aggregation-prone
181 L H 1.4928 Aggregation-prone
182 Q H 0.4868 Aggregation-prone
183 S H 0.0287 Aggregation-prone
184 S H -0.1475 Soluble
185 G H 0.1367 Aggregation-prone
186 L H 0.1199 Aggregation-prone
187 Y H 0.4876 Aggregation-prone
189 L H 0.4304 Aggregation-prone
190 S H 0.0000 Buried
191 S H 0.0000 Buried
192 V H 0.0000 Buried
193 V H 0.0000 Buried
194 T H -0.1459 Soluble
195 V H 0.0000 Buried
196 P H -0.5035 Soluble
197 S H -0.5625 Soluble
198 S H -0.6195 Soluble
199 S H -0.5950 Soluble
200 L H -0.7824 Soluble
201 G H -0.9526 Soluble
202 T H -0.7101 Soluble
203 Q H -1.1503 Soluble
204 T H -1.0870 Soluble
205 Y H 0.0000 Buried
206 I H -1.2662 Soluble
207 C H 0.0000 Buried
208 N H -1.5852 Soluble
209 V H 0.0000 Buried
210 N H -2.4575 Soluble
211 H H 0.0000 Buried
212 K H -2.9356 Soluble
213 P H -1.7490 Soluble
214 S H -1.8986 Soluble
215 N H -2.6907 Soluble
216 T H -2.2154 Soluble
217 K H -2.8955 Soluble
218 V H -1.7434 Soluble
219 D H -2.5976 Soluble
220 K H -1.9675 Soluble
221 K H -2.5083 Soluble
222 V H 0.0000 Buried
223 E H -2.8775 Soluble
224 P H -1.9259 Soluble
225 K H -2.3037 Soluble
226 S H -0.9002 Soluble
227 C H 0.1771 Aggregation-prone
1 D L -1.0270 Soluble
2 I L 0.1169 Aggregation-prone
3 V L 1.0466 Aggregation-prone
4 M L 0.0000 Buried
5 T L -0.5444 Soluble
6 Q L 0.0000 Buried
7 S L -0.4908 Soluble
8 P L -0.1090 Soluble
9 S L -0.0950 Soluble
10 F L 0.5828 Aggregation-prone
11 L L 0.2430 Aggregation-prone
12 S L -0.3199 Soluble
13 A L 0.0000 Buried
14 S L -0.2825 Soluble
15 V L 0.4063 Aggregation-prone
16 G L -0.6086 Soluble
17 D L -1.3349 Soluble
18 R L -2.1287 Soluble
19 V L 0.0000 Buried
20 T L -0.5995 Soluble
21 I L 0.0000 Buried
23 C L 0.0000 Buried
24 R L -2.5086 Soluble
25 A L 0.0000 Buried
26 S L -1.0285 Soluble
27 Q L -1.7826 Soluble
28 G L -1.4673 Soluble
29 I L 0.0000 Buried
36 S L -0.4394 Soluble
38 Y L 0.9237 Aggregation-prone
39 L L 0.0000 Buried
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 K L -1.6642 Soluble
46 P L -1.4924 Soluble
47 G L -1.6640 Soluble
48 K L -2.5533 Soluble
49 A L -1.5501 Soluble
50 P L 0.0000 Buried
51 K L -1.3996 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L 0.8354 Aggregation-prone
56 A L 0.5591 Aggregation-prone
57 A L 0.0000 Buried
65 S L -0.0448 Soluble
66 T L 0.1624 Aggregation-prone
67 L L 0.3000 Aggregation-prone
68 Q L -0.3114 Soluble
69 S L -0.4539 Soluble
70 G L -0.5205 Soluble
71 V L -0.3594 Soluble
72 P L -0.3390 Soluble
74 S L -0.4168 Soluble
75 R L -0.6938 Soluble
76 F L 0.0000 Buried
77 S L -0.3357 Soluble
78 G L -0.2229 Soluble
79 S L -0.7683 Soluble
80 G L -1.2556 Soluble
83 S L -0.8374 Soluble
84 G L -1.3390 Soluble
85 T L -2.2002 Soluble
86 E L -2.9224 Soluble
87 F L 0.0000 Buried
88 T L -0.9376 Soluble
89 L L 0.0000 Buried
90 T L -0.6168 Soluble
91 I L 0.0000 Buried
92 S L -1.2493 Soluble
93 S L -0.9992 Soluble
94 L L 0.0000 Buried
95 Q L -0.8464 Soluble
96 P L -0.8554 Soluble
97 E L -1.8851 Soluble
98 D L 0.0000 Buried
99 F L -0.3791 Soluble
100 A L 0.0000 Buried
101 T L -0.5155 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 L L 0.0000 Buried
108 N L -0.8136 Soluble
109 S L -0.0690 Soluble
113 Y L 0.5646 Aggregation-prone
114 P L -0.1849 Soluble
115 P L 0.0622 Aggregation-prone
116 F L 0.0000 Buried
117 T L 0.2527 Aggregation-prone
118 F L 0.1608 Aggregation-prone
119 G L 0.0000 Buried
120 P L -0.7218 Soluble
121 G L -0.6030 Soluble
122 T L 0.0000 Buried
123 K L -0.7664 Soluble
124 V L 0.0000 Buried
125 D L 0.0000 Buried
126 I L -0.0859 Soluble
127 K L -1.0357 Soluble
128 R L -1.0271 Soluble
129 T L -0.0068 Soluble
130 V L 0.8539 Aggregation-prone
131 A L 0.3097 Aggregation-prone
132 A L -0.1780 Soluble
133 P L -0.0156 Soluble
135 V L 0.1921 Aggregation-prone
136 F L 0.2826 Aggregation-prone
137 I L 0.1338 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.5319 Soluble
140 P L 0.0000 Buried
141 S L -1.5527 Soluble
142 D L -2.7553 Soluble
143 E L -2.1935 Soluble
144 Q L 0.0000 Buried
145 L L -1.9486 Soluble
146 K L -2.6580 Soluble
147 S L -1.7313 Soluble
148 G L -1.2317 Soluble
149 T L -0.8482 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L -0.3140 Soluble
158 N L -0.7768 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -0.8185 Soluble
163 E L -2.1841 Soluble
164 A L -1.4078 Soluble
165 K L -1.2769 Soluble
166 V L -0.5748 Soluble
167 Q L -0.2565 Soluble
168 W L 0.0000 Buried
169 K L -0.4423 Soluble
170 V L 0.0000 Buried
171 D L -1.7519 Soluble
172 N L -1.4236 Soluble
173 A L -0.1996 Soluble
174 L L 0.7609 Aggregation-prone
175 Q L -0.0758 Soluble
176 S L -0.3856 Soluble
177 G L -0.8724 Soluble
178 N L -0.7792 Soluble
179 S L -1.0298 Soluble
180 Q L -1.1320 Soluble
181 E L -1.7052 Soluble
182 S L -0.4600 Soluble
183 V L 0.0579 Aggregation-prone
184 T L -0.6704 Soluble
185 E L -1.8661 Soluble
186 Q L -1.4530 Soluble
187 D L -1.8632 Soluble
188 S L -1.6673 Soluble
189 K L -2.2429 Soluble
190 D L -1.7010 Soluble
191 S L -1.6248 Soluble
192 T L 0.0000 Buried
193 Y L -0.8197 Soluble
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.5780 Soluble
199 L L 0.0000 Buried
200 T L -0.2854 Soluble
201 L L -0.4431 Soluble
202 S L -0.8395 Soluble
203 K L -1.8445 Soluble
204 A L -1.3931 Soluble
206 Y L 0.0000 Buried
207 E L -3.1492 Soluble
208 K L -3.1403 Soluble
209 H L -2.5634 Soluble
210 K L -3.0177 Soluble
211 V L -1.3069 Soluble
212 Y L 0.0000 Buried
213 A L -0.7388 Soluble
214 C L 0.0000 Buried
215 E L -0.4127 Soluble
216 V L 0.0000 Buried
217 T L -1.0335 Soluble
218 H L 0.0000 Buried
219 Q L -1.6753 Soluble
220 G L -0.6212 Soluble
221 L L -0.9569 Soluble
222 R L -2.0629 Soluble
223 S L -1.1811 Soluble
224 P L -0.7226 Soluble
225 V L -0.0395 Soluble
226 T L -0.3546 Soluble
227 K L -0.6261 Soluble
228 S L -0.5521 Soluble
229 F L -0.8036 Soluble
230 N L -1.6634 Soluble
231 R L -2.3812 Soluble
232 G L -1.9628 Soluble
233 E L -2.0221 Soluble
234 C L -0.8037 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5775 2.9083 CSV PDB
4.5 -0.6181 2.7983 CSV PDB
5.0 -0.6659 2.6713 CSV PDB
5.5 -0.7115 2.537 CSV PDB
6.0 -0.7438 2.4002 CSV PDB
6.5 -0.7536 2.2628 CSV PDB
7.0 -0.7401 2.1346 CSV PDB
7.5 -0.7104 2.047 CSV PDB
8.0 -0.6715 1.9608 CSV PDB
8.5 -0.6258 1.9246 CSV PDB
9.0 -0.574 1.9154 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH