Zinlirvimab / 7ucg

A4DAB308_7ucg_H_L | Source PDB: 7ucg | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.4876
Max Score
2.8039
Min Score
-3.1806
Total Score
-112.15
Score CDR
-0.3036
Score non-CDR
-0.5555

Calculation Parameters

Chain Sequence(s) VQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTV input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.1806
Maximum Score 2.8039
Average Score -0.4876
Total Score -112.1537

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V H 0.6818 Aggregation-prone
3 Q H -0.7608 Soluble
4 L H 0.0000 Buried
5 Q H -1.6910 Soluble
6 E H -1.1352 Soluble
7 S H -0.7895 Soluble
8 G H -0.4640 Soluble
9 P H -0.0275 Soluble
11 G H 0.4235 Aggregation-prone
12 L H 1.0619 Aggregation-prone
13 V H -0.0542 Soluble
14 K H -1.5518 Soluble
15 P H -1.2873 Soluble
16 S H -1.3203 Soluble
17 E H -1.5555 Soluble
18 T H -1.2138 Soluble
19 L H 0.0000 Buried
20 S H -0.8644 Soluble
21 V H 0.0000 Buried
22 T H -0.7330 Soluble
23 C H 0.0000 Buried
24 S H -1.2570 Soluble
25 V H -1.0759 Soluble
26 S H -1.0726 Soluble
27 G H -1.1228 Soluble
28 D H -2.1099 Soluble
29 S H -1.8168 Soluble
30 M H -1.5127 Soluble
35 N H -2.2599 Soluble
36 N H -2.0239 Soluble
37 Y H -1.0587 Soluble
38 Y H -0.5251 Soluble
39 W H 0.0000 Buried
40 T H 0.0000 Buried
41 W H 0.0000 Buried
42 I H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.9696 Soluble
45 S H 0.0000 Buried
46 P H -1.0771 Soluble
47 G H -1.4730 Soluble
48 K H -2.3363 Soluble
49 G H -1.6294 Soluble
50 L H 0.0000 Buried
51 E H -1.6092 Soluble
52 W H 0.0000 Buried
53 I H 0.0000 Buried
54 G H 0.0000 Buried
55 Y H 0.1018 Aggregation-prone
56 I H 0.0000 Buried
57 S H -1.5105 Soluble
58 D H -2.3281 Soluble
59 R H -3.1806 Soluble
63 E H -3.0711 Soluble
64 S H -1.7193 Soluble
65 A H -0.5960 Soluble
66 T H 0.1145 Aggregation-prone
67 Y H 0.0708 Aggregation-prone
68 N H 0.0000 Buried
69 P H -0.7423 Soluble
70 S H -0.7906 Soluble
71 L H -0.8012 Soluble
72 N H -1.4951 Soluble
74 S H -0.8183 Soluble
75 R H -0.9225 Soluble
76 V H 0.0000 Buried
77 V H 0.3791 Aggregation-prone
78 I H 0.0000 Buried
79 S H -0.6337 Soluble
80 R H -1.4679 Soluble
81 D H -1.7566 Soluble
82 T H -1.6807 Soluble
83 S H -1.6822 Soluble
84 K H -2.6183 Soluble
85 N H -2.4380 Soluble
86 Q H -1.6730 Soluble
87 L H 0.0000 Buried
88 S H -0.6446 Soluble
89 L H 0.0000 Buried
90 K H -1.0759 Soluble
91 L H 0.0000 Buried
92 N H -1.3925 Soluble
93 S H -1.0685 Soluble
94 V H -0.7945 Soluble
95 T H -0.5646 Soluble
96 P H -0.2546 Soluble
97 A H -0.0907 Soluble
98 D H 0.0000 Buried
99 T H 0.0623 Aggregation-prone
100 A H 0.0000 Buried
101 V H -0.1227 Soluble
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 T H 0.0000 Buried
107 A H 0.0000 Buried
108 R H -1.5088 Soluble
109 R H -1.7199 Soluble
110 G H -1.1373 Soluble
111 Q H -0.6447 Soluble
111A R H -0.0969 Soluble
111B I H 1.4184 Aggregation-prone
111C Y H 1.1282 Aggregation-prone
111D G H 1.3265 Aggregation-prone
111E V H 2.4613 Aggregation-prone
111F V H 2.8039 Aggregation-prone
112G S H 1.6933 Aggregation-prone
112F F H 2.3351 Aggregation-prone
112E G H 1.2142 Aggregation-prone
112D E H 1.0044 Aggregation-prone
112C F H 1.2846 Aggregation-prone
112B F H 0.1597 Aggregation-prone
112A Y H 0.1097 Aggregation-prone
112 Y H 0.0000 Buried
113 Y H 0.0000 Buried
114 S H 0.0000 Buried
115 M H 0.0000 Buried
116 D H -0.1732 Soluble
117 V H 0.3033 Aggregation-prone
118 W H 0.0000 Buried
119 G H 0.0000 Buried
120 K H -2.1260 Soluble
121 G H 0.0000 Buried
122 T H -0.6492 Soluble
123 T H 0.0684 Aggregation-prone
124 V H 0.0000 Buried
125 T H 0.2462 Aggregation-prone
11 L L 0.8819 Aggregation-prone
12 S L 0.7520 Aggregation-prone
13 V L 0.5565 Aggregation-prone
14 A L 0.4505 Aggregation-prone
15 L L 0.7229 Aggregation-prone
16 G L -0.8767 Soluble
17 E L -1.8131 Soluble
18 T L -1.2799 Soluble
19 A L 0.0000 Buried
20 R L -1.8940 Soluble
21 I L 0.0000 Buried
22 S L -1.0883 Soluble
23 C L -1.3128 Soluble
24 G L -1.3165 Soluble
25 R L -1.7455 Soluble
26 Q L -1.7760 Soluble
27 A L -0.4369 Soluble
28 L L 0.8784 Aggregation-prone
29 G L 0.2282 Aggregation-prone
36 S L 0.4671 Aggregation-prone
37 R L 0.0000 Buried
38 A L 0.0000 Buried
39 V L 0.0000 Buried
40 Q L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 H L 0.0000 Buried
45 R L -1.2751 Soluble
46 P L -0.9702 Soluble
47 G L -1.3259 Soluble
48 Q L -1.5212 Soluble
49 A L -0.9193 Soluble
50 P L 0.0000 Buried
51 I L 0.4654 Aggregation-prone
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.6888 Soluble
56 N L -1.1497 Soluble
57 N L 0.0000 Buried
65 Q L -1.8259 Soluble
66 D L -1.5203 Soluble
67 R L -1.4654 Soluble
68 P L -0.6665 Soluble
69 S L -0.7590 Soluble
70 G L -0.6934 Soluble
71 I L -0.6181 Soluble
72 P L -1.2441 Soluble
74 E L -2.1791 Soluble
75 R L -1.5238 Soluble
76 F L 0.0000 Buried
77 S L -1.0627 Soluble
78 G L -0.8959 Soluble
79 T L -0.5655 Soluble
80 P L -0.6331 Soluble
81 D L 0.0354 Aggregation-prone
81A I L 1.5708 Aggregation-prone
82 N L 0.4032 Aggregation-prone
83 F L 1.4381 Aggregation-prone
84 G L 0.0004 Aggregation-prone
85 T L -0.6620 Soluble
86 R L -2.0947 Soluble
87 A L 0.0000 Buried
88 T L -1.0730 Soluble
89 L L 0.0000 Buried
90 T L -0.8151 Soluble
91 I L 0.0000 Buried
92 S L -1.4095 Soluble
93 G L -1.0923 Soluble
94 V L 0.0000 Buried
95 E L -1.6370 Soluble
96 A L -0.6797 Soluble
97 G L -1.1382 Soluble
98 D L 0.0000 Buried
99 E L -1.2048 Soluble
100 A L 0.0000 Buried
101 D L 0.0000 Buried
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 H L 0.0000 Buried
106 M L 0.0000 Buried
107 W L 0.0000 Buried
108 D L 0.0000 Buried
109 S L -0.5525 Soluble
110 R L -1.7329 Soluble
112 S L -0.9606 Soluble
113 G L -0.6789 Soluble
114 F L 0.3485 Aggregation-prone
115 S L 0.0000 Buried
116 W L -0.0247 Soluble
117 S L -0.5097 Soluble
118 F L 0.0000 Buried
119 G L -0.9687 Soluble
120 G L -1.2967 Soluble
121 A L -1.0602 Soluble
122 T L -0.8323 Soluble
123 R L -1.7277 Soluble
124 L L 0.0000 Buried
125 T L 0.2605 Aggregation-prone
126 V L 1.4963 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
Load structure to view sequence…
Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.37 4.5431 CSV PDB
4.5 -0.4033 4.5011 CSV PDB
5.0 -0.4437 4.446 CSV PDB
5.5 -0.4837 4.3869 CSV PDB
6.0 -0.5158 4.3331 CSV PDB
6.5 -0.5343 4.2935 CSV PDB
7.0 -0.5381 4.2719 CSV PDB
7.5 -0.5316 4.263 CSV PDB
8.0 -0.519 4.2598 CSV PDB
8.5 -0.502 4.2588 CSV PDB
9.0 -0.4814 4.2585 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH