Nirsevimab / 5udd

A4DAB181_5udd_M_S | Source PDB: 5udd | Chains: M, S | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6571
Max Score
2.5549
Min Score
-3.5743
Total Score
-283.86
Score CDR
-0.0838
Score non-CDR
-0.7372

Calculation Parameters

Chain Sequence(s) QVQLVQSGAEVKKPGSSVMVSCQASGGLLEDYIINWVRQAPGQGPEWMGGIIPVLGTVHYGPKFQGRVTITADESTDTAYMELSSLRSEDTAMYYCATETALVVSETYLPHYFDNWGQGTLVTVSSASTKGPSVFPLAPSSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPDIQMTQSPSSLSAAVGDRVTITCQASQDIVNYLNWYQQKPGKAPKLLIYVASNLETGVPSRFSGSGSGTDFSLTISSLQPEDVATYYCQQYDNLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR input.pdb
Selected Chain(s) M (Heavy), S (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.5743
Maximum Score 2.5549
Average Score -0.6571
Total Score -283.8567

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q M -1.6749 Soluble
2 V M 0.0000 Buried
3 Q M -1.5804 Soluble
4 L M 0.0000 Buried
5 V M 0.5400 Aggregation-prone
6 Q M 0.0000 Buried
7 S M -0.1648 Soluble
8 G M -1.2722 Soluble
9 A M -1.2335 Soluble
11 E M -1.6015 Soluble
12 V M -1.1034 Soluble
13 K M -1.7490 Soluble
14 K M -2.4024 Soluble
15 P M -1.8938 Soluble
16 G M -1.4943 Soluble
17 S M -1.2467 Soluble
18 S M -0.8973 Soluble
19 V M 0.0000 Buried
20 M M 0.2498 Aggregation-prone
21 V M 0.0000 Buried
22 S M 0.3632 Aggregation-prone
23 C M 0.0000 Buried
24 Q M -0.0581 Soluble
25 A M 0.0000 Buried
26 S M -0.6485 Soluble
27 G M -0.8648 Soluble
28 G M -0.3894 Soluble
29 L M 0.1158 Aggregation-prone
30 L M 0.0000 Buried
35 E M -1.4943 Soluble
36 D M -0.1561 Soluble
37 Y M 0.1558 Aggregation-prone
38 I M 0.0000 Buried
39 I M 0.0000 Buried
40 N M 0.0000 Buried
41 W M 0.0000 Buried
42 V M 0.0000 Buried
43 R M 0.0000 Buried
44 Q M -0.7769 Soluble
45 A M -1.1101 Soluble
46 P M -1.1156 Soluble
47 G M -1.2205 Soluble
48 Q M -1.7942 Soluble
49 G M -1.1681 Soluble
50 P M -0.8716 Soluble
51 E M -1.1711 Soluble
52 W M 0.0000 Buried
53 M M 0.0000 Buried
54 G M 0.0000 Buried
55 G M 0.0000 Buried
56 I M 0.0000 Buried
57 I M 0.0000 Buried
58 P M -0.4846 Soluble
59 V M 0.2333 Aggregation-prone
62 L M 0.2605 Aggregation-prone
63 G M -0.0210 Soluble
64 T M 0.4142 Aggregation-prone
65 V M 0.6691 Aggregation-prone
66 H M 0.2330 Aggregation-prone
67 Y M -0.3277 Soluble
68 G M 0.0000 Buried
69 P M -1.6346 Soluble
70 K M -2.2938 Soluble
71 F M 0.0000 Buried
72 Q M -2.0265 Soluble
74 G M -1.4774 Soluble
75 R M -1.3916 Soluble
76 V M 0.0000 Buried
77 T M -0.4096 Soluble
78 I M 0.0000 Buried
79 T M -0.3282 Soluble
80 A M -1.2129 Soluble
81 D M -2.2076 Soluble
82 E M -2.5958 Soluble
83 S M -1.3527 Soluble
84 T M -1.0401 Soluble
85 D M -1.3480 Soluble
86 T M 0.0000 Buried
87 A M 0.0000 Buried
88 Y M 0.3315 Aggregation-prone
89 M M 0.0000 Buried
90 E M -0.4146 Soluble
91 L M 0.0000 Buried
92 S M -0.8101 Soluble
93 S M -1.1485 Soluble
94 L M 0.0000 Buried
95 R M -2.9563 Soluble
96 S M -2.1956 Soluble
97 E M -2.5000 Soluble
98 D M 0.0000 Buried
99 T M -0.9608 Soluble
100 A M 0.0000 Buried
101 M M -0.0326 Soluble
102 Y M 0.0000 Buried
103 Y M 0.0000 Buried
104 C M 0.0000 Buried
105 A M 0.0000 Buried
106 T M 0.0000 Buried
107 E M 0.0000 Buried
108 T M 0.2449 Aggregation-prone
109 A M 0.0000 Buried
110 L M 2.1143 Aggregation-prone
111 V M 2.5549 Aggregation-prone
111A V M 1.3424 Aggregation-prone
111B S M -0.0925 Soluble
111C E M -1.5481 Soluble
112C T M -0.6650 Soluble
112B Y M -0.0709 Soluble
112A L M 0.2188 Aggregation-prone
112 P M 0.0000 Buried
113 H M 0.1480 Aggregation-prone
114 Y M 0.2486 Aggregation-prone
115 F M 0.0000 Buried
116 D M -0.8969 Soluble
117 N M -1.1933 Soluble
118 W M 0.0000 Buried
119 G M 0.0000 Buried
120 Q M -1.5336 Soluble
121 G M -0.7939 Soluble
122 T M 0.0000 Buried
123 L M -0.3510 Soluble
124 V M 0.0000 Buried
125 T M -0.8236 Soluble
126 V M -1.4907 Soluble
127 S M -1.1163 Soluble
128 S M -0.9153 Soluble
129 A M -0.5855 Soluble
130 S M -0.7094 Soluble
131 T M -0.9703 Soluble
132 K M -1.1555 Soluble
133 G M -1.3078 Soluble
134 P M 0.0000 Buried
135 S M -0.4807 Soluble
136 V M 0.0000 Buried
137 F M 0.0000 Buried
138 P M -1.3295 Soluble
139 L M 0.0000 Buried
140 A M -0.6440 Soluble
141 P M 0.0000 Buried
142 S M -0.4702 Soluble
143 S M -0.3541 Soluble
144 G M -0.5941 Soluble
145 T M -0.4486 Soluble
146 A M -0.2481 Soluble
147 A M 0.0000 Buried
148 L M 0.0000 Buried
149 G M 0.0000 Buried
150 C M 0.0000 Buried
151 L M 0.0000 Buried
152 V M 0.0000 Buried
153 K M 0.0000 Buried
154 D M -0.2715 Soluble
155 Y M 0.0000 Buried
156 F M 0.0000 Buried
157 P M 0.0000 Buried
158 E M -0.7468 Soluble
159 P M -0.8999 Soluble
160 V M 0.0000 Buried
161 T M -0.6501 Soluble
162 V M -0.4606 Soluble
163 S M -0.2741 Soluble
164 W M 0.0000 Buried
165 N M -0.6065 Soluble
166 S M -0.6963 Soluble
167 G M -0.4888 Soluble
168 A M -0.2030 Soluble
169 L M -0.0007 Soluble
170 T M -0.1580 Soluble
171 S M -0.1990 Soluble
172 G M -0.2085 Soluble
173 V M 0.1958 Aggregation-prone
174 H M -0.2586 Soluble
175 T M -0.0874 Soluble
176 F M 0.0000 Buried
177 P M -0.2498 Soluble
178 A M 0.2149 Aggregation-prone
179 V M 0.4754 Aggregation-prone
180 L M 1.2563 Aggregation-prone
181 Q M 0.3224 Aggregation-prone
182 S M -0.1622 Soluble
183 S M -0.2160 Soluble
184 G M 0.0225 Aggregation-prone
185 L M 0.1727 Aggregation-prone
186 Y M 0.4452 Aggregation-prone
187 S M 0.0000 Buried
188 L M 0.0000 Buried
189 S M 0.0000 Buried
190 S M 0.0000 Buried
191 V M 0.0000 Buried
192 V M 0.0000 Buried
193 T M -0.1460 Soluble
194 V M 0.0000 Buried
195 P M -0.4316 Soluble
196 S M -0.4709 Soluble
197 S M -0.5305 Soluble
198 S M -0.5331 Soluble
199 L M -0.6582 Soluble
200 G M -0.9356 Soluble
201 T M -0.6899 Soluble
202 Q M -1.2300 Soluble
203 T M -1.1665 Soluble
204 Y M 0.0000 Buried
205 I M -1.3540 Soluble
206 C M 0.0000 Buried
207 N M -1.7191 Soluble
208 V M 0.0000 Buried
209 N M -2.0609 Soluble
210 H M 0.0000 Buried
211 K M -3.0667 Soluble
212 P M -2.0464 Soluble
213 S M -1.9807 Soluble
214 N M -2.6034 Soluble
215 T M -2.2794 Soluble
216 K M -2.8127 Soluble
217 V M -1.9469 Soluble
218 D M -2.8667 Soluble
219 K M -2.4257 Soluble
220 R M -2.9002 Soluble
221 V M 0.0000 Buried
222 E M -2.4430 Soluble
223 P M -1.2060 Soluble
1 D S -2.2649 Soluble
2 I S 0.0000 Buried
3 Q S -2.0619 Soluble
4 M S 0.0000 Buried
5 T S -1.0499 Soluble
6 Q S 0.0000 Buried
7 S S -0.5646 Soluble
8 P S -0.6541 Soluble
9 S S -0.9172 Soluble
10 S S -1.0321 Soluble
11 L S -0.7024 Soluble
12 S S -0.7903 Soluble
13 A S -0.8561 Soluble
14 A S -0.6790 Soluble
15 V S 0.2637 Aggregation-prone
16 G S -0.6591 Soluble
17 D S -1.6016 Soluble
18 R S -2.2596 Soluble
19 V S 0.0000 Buried
20 T S -0.6419 Soluble
21 I S 0.0000 Buried
22 T S -0.7064 Soluble
23 C S 0.0000 Buried
24 Q S -2.1216 Soluble
25 A S -1.9278 Soluble
26 S S -2.0416 Soluble
27 Q S -2.4503 Soluble
28 D S -2.2024 Soluble
29 I S 0.0000 Buried
36 V S 0.8015 Aggregation-prone
37 N S 0.4022 Aggregation-prone
38 Y S 0.8253 Aggregation-prone
39 L S 0.0000 Buried
40 N S 0.0000 Buried
41 W S 0.0000 Buried
42 Y S 0.0000 Buried
43 Q S 0.0000 Buried
44 Q S 0.0000 Buried
45 K S -1.5332 Soluble
46 P S -1.3109 Soluble
47 G S -1.7383 Soluble
48 K S -2.4854 Soluble
49 A S -1.6645 Soluble
50 P S 0.0000 Buried
51 K S -1.5969 Soluble
52 L S 0.0000 Buried
53 L S 0.0000 Buried
54 I S 0.0000 Buried
55 Y S 0.2558 Aggregation-prone
56 V S 0.7561 Aggregation-prone
57 A S 0.0000 Buried
65 S S -0.6406 Soluble
66 N S -0.8472 Soluble
67 L S -0.2863 Soluble
68 E S -0.7445 Soluble
69 T S -0.4928 Soluble
70 G S -0.5160 Soluble
71 V S -0.3876 Soluble
72 P S -0.3740 Soluble
74 S S -0.4374 Soluble
75 R S -0.6410 Soluble
76 F S 0.0000 Buried
77 S S -0.5075 Soluble
78 G S -0.4138 Soluble
79 S S -0.8167 Soluble
80 G S -0.7788 Soluble
83 S S -0.5673 Soluble
84 G S -0.8808 Soluble
85 T S -1.7552 Soluble
86 D S -2.1970 Soluble
87 F S 0.0000 Buried
88 S S -0.7500 Soluble
89 L S 0.0000 Buried
90 T S -0.6227 Soluble
91 I S 0.0000 Buried
92 S S -1.2256 Soluble
93 S S -1.0052 Soluble
94 L S 0.0000 Buried
95 Q S -0.8376 Soluble
96 P S -1.5471 Soluble
97 E S -2.1796 Soluble
98 D S 0.0000 Buried
99 V S -1.2265 Soluble
100 A S 0.0000 Buried
101 T S -0.9322 Soluble
102 Y S 0.0000 Buried
103 Y S 0.0000 Buried
104 C S 0.0000 Buried
105 Q S 0.0000 Buried
106 Q S 0.0000 Buried
107 Y S 0.0000 Buried
108 D S -0.4554 Soluble
109 N S -0.6630 Soluble
114 L S -0.2326 Soluble
115 P S -0.6633 Soluble
116 L S 0.0000 Buried
117 T S -0.7620 Soluble
118 F S -0.3459 Soluble
119 G S 0.0000 Buried
120 G S -1.0779 Soluble
121 G S -0.9890 Soluble
122 T S 0.0000 Buried
123 K S -1.9242 Soluble
124 V S 0.0000 Buried
125 E S -0.9750 Soluble
126 I S 0.0000 Buried
127 K S -1.3261 Soluble
128 R S -0.8393 Soluble
129 T S -0.0348 Soluble
130 V S 0.6767 Aggregation-prone
131 A S 0.2509 Aggregation-prone
132 A S -0.0451 Soluble
133 P S -0.0549 Soluble
134 S S -0.0178 Soluble
135 V S 0.0000 Buried
136 F S 0.1485 Aggregation-prone
137 I S 0.0520 Aggregation-prone
138 F S 0.0000 Buried
139 P S -0.7334 Soluble
140 P S -0.9259 Soluble
141 S S -1.6538 Soluble
142 D S -2.9668 Soluble
143 E S -3.0855 Soluble
144 Q S 0.0000 Buried
145 L S -2.2412 Soluble
146 K S -2.8112 Soluble
147 S S -1.7974 Soluble
148 G S -1.5165 Soluble
149 T S -1.1360 Soluble
150 A S 0.0000 Buried
151 S S 0.0000 Buried
152 V S 0.0000 Buried
153 V S 0.0000 Buried
154 C S 0.0000 Buried
155 L S 0.0000 Buried
156 L S 0.0000 Buried
157 N S -0.2678 Soluble
158 N S -0.5732 Soluble
159 F S 0.0000 Buried
160 Y S 0.0000 Buried
161 P S -1.5460 Soluble
162 R S -2.6033 Soluble
163 E S -3.1016 Soluble
164 A S -2.2581 Soluble
165 K S -2.6135 Soluble
166 V S -1.4570 Soluble
167 Q S -1.0665 Soluble
168 W S 0.0000 Buried
169 K S -0.7347 Soluble
170 V S 0.0000 Buried
171 D S -1.8996 Soluble
172 N S -1.4100 Soluble
173 A S -0.2833 Soluble
174 L S 0.5728 Aggregation-prone
175 Q S -0.2110 Soluble
176 S S -0.4938 Soluble
177 G S -1.0359 Soluble
178 N S -0.9450 Soluble
179 S S -1.2607 Soluble
180 Q S -1.4690 Soluble
181 E S -2.1073 Soluble
182 S S -0.8540 Soluble
183 V S -0.3921 Soluble
184 T S 0.0000 Buried
185 E S -1.4663 Soluble
186 Q S 0.0000 Buried
187 D S -1.7411 Soluble
188 S S -2.1278 Soluble
189 K S -2.6116 Soluble
190 D S -1.9720 Soluble
191 S S 0.0000 Buried
192 T S 0.0000 Buried
193 Y S 0.0000 Buried
194 S S 0.0000 Buried
195 L S 0.0000 Buried
196 S S 0.0000 Buried
197 S S 0.0000 Buried
198 T S -0.6566 Soluble
199 L S 0.0000 Buried
200 T S -0.4711 Soluble
201 L S -0.5979 Soluble
202 S S -1.2358 Soluble
203 K S -2.3546 Soluble
204 A S -2.0589 Soluble
205 D S -3.0140 Soluble
206 Y S 0.0000 Buried
207 E S -3.5743 Soluble
208 K S -3.5681 Soluble
209 H S -3.2842 Soluble
210 K S -3.4515 Soluble
211 V S -1.9936 Soluble
212 Y S 0.0000 Buried
213 A S 0.0000 Buried
214 C S 0.0000 Buried
215 E S -1.2169 Soluble
216 V S 0.0000 Buried
217 T S -1.1827 Soluble
218 H S -1.3977 Soluble
219 Q S -1.4004 Soluble
220 G S -0.4792 Soluble
221 L S -0.2053 Soluble
222 S S -0.4402 Soluble
223 S S -0.3022 Soluble
224 P S -0.2446 Soluble
225 V S 0.2371 Aggregation-prone
226 T S -0.5231 Soluble
227 K S -0.8302 Soluble
228 S S -0.9010 Soluble
229 F S -1.1972 Soluble
230 N S -2.5794 Soluble
231 R S -3.1258 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6429 2.6574 CSV PDB
4.5 -0.6936 2.5837 CSV PDB
5.0 -0.7538 2.4819 CSV PDB
5.5 -0.8126 2.367 CSV PDB
6.0 -0.8585 2.318 CSV PDB
6.5 -0.882 2.2896 CSV PDB
7.0 -0.8816 2.2612 CSV PDB
7.5 -0.8648 2.2328 CSV PDB
8.0 -0.8392 2.2049 CSV PDB
8.5 -0.8071 2.1782 CSV PDB
9.0 -0.7682 2.1548 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH