Beludavimab / 9au1

A4DAB038_9au1_M_N | Source PDB: 9au1 | Chains: M, N | Done
99.57
Yes
10 Å
Yes
Avg A4D Score
-0.708
Max Score
2.1642
Min Score
-3.5192
Total Score
-312.95
Score CDR
-0.1842
Score non-CDR
-0.7809

Calculation Parameters

Chain Sequence(s) QVQLVQSGAEVKKPGASVKVSCKASGYPFTSYGISWVRQAPGQGLEWMGWISTYNGNTNYAQKFQGRVTMTTDTSTTTGYMELRRLRSDDTAVYYCARDYTRGAWFGESLIGGFDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCEIVLTQSPGTLSLSPGERATLSCRASQTVSSTSLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQHDTSLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTQGTTSVTKSFNRGEC input.pdb
Selected Chain(s) M (Heavy), N (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.5192
Maximum Score 2.1642
Average Score -0.708
Total Score -312.9489

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q M -1.5257 Soluble
2 V M -1.2408 Soluble
3 Q M -1.4497 Soluble
4 L M 0.0000 Buried
5 V M 0.4751 Aggregation-prone
6 Q M 0.0000 Buried
7 S M -0.3758 Soluble
8 G M -0.3712 Soluble
9 A M 0.1882 Aggregation-prone
11 E M -0.0767 Soluble
12 V M 0.4880 Aggregation-prone
13 K M -1.0935 Soluble
14 K M -2.3128 Soluble
15 P M -2.3300 Soluble
16 G M -2.0382 Soluble
17 A M -1.6580 Soluble
18 S M -1.8993 Soluble
19 V M 0.0000 Buried
20 K M -2.0039 Soluble
21 V M 0.0000 Buried
22 S M -0.4178 Soluble
23 C M 0.0000 Buried
24 K M -0.5481 Soluble
25 A M 0.0000 Buried
26 S M -0.8482 Soluble
27 G M -1.1207 Soluble
28 Y M -0.5797 Soluble
29 P M -0.2950 Soluble
30 F M 0.0000 Buried
35 T M 0.1175 Aggregation-prone
36 S M 0.3038 Aggregation-prone
37 Y M 0.4082 Aggregation-prone
38 G M 0.0000 Buried
39 I M 0.0000 Buried
40 S M 0.0000 Buried
41 W M 0.0000 Buried
42 V M 0.0000 Buried
43 R M 0.0000 Buried
44 Q M -0.5279 Soluble
45 A M -0.8850 Soluble
46 P M -0.7446 Soluble
47 G M -1.2524 Soluble
48 Q M -1.7406 Soluble
49 G M -1.0920 Soluble
50 L M 0.0000 Buried
51 E M -0.5532 Soluble
52 W M -0.2006 Soluble
53 M M 0.0000 Buried
54 G M 0.0000 Buried
55 W M 0.0000 Buried
56 I M 0.0000 Buried
57 S M 0.0000 Buried
58 T M 0.0000 Buried
59 Y M 0.5123 Aggregation-prone
62 N M -0.6192 Soluble
63 G M -1.2345 Soluble
64 N M -1.4318 Soluble
65 T M -1.1162 Soluble
66 N M -1.1398 Soluble
67 Y M -0.9778 Soluble
68 A M -1.4436 Soluble
69 Q M -2.5075 Soluble
70 K M -2.6764 Soluble
71 F M 0.0000 Buried
72 Q M -2.4358 Soluble
74 G M -1.8581 Soluble
75 R M -1.8641 Soluble
76 V M 0.0000 Buried
77 T M -0.7314 Soluble
78 M M 0.0000 Buried
79 T M -0.4676 Soluble
80 T M -0.7370 Soluble
81 D M -1.0291 Soluble
82 T M -0.6137 Soluble
83 S M -0.5389 Soluble
84 T M -0.5806 Soluble
85 T M -0.6421 Soluble
86 T M 0.0000 Buried
87 G M 0.0000 Buried
88 Y M -0.4554 Soluble
89 M M 0.0000 Buried
90 E M -1.3422 Soluble
91 L M 0.0000 Buried
92 R M -2.3350 Soluble
93 R M -2.9840 Soluble
94 L M 0.0000 Buried
95 R M -3.4142 Soluble
96 S M -2.3390 Soluble
97 D M -2.4851 Soluble
98 D M 0.0000 Buried
99 T M -0.6888 Soluble
100 A M 0.0000 Buried
101 V M 0.4648 Aggregation-prone
102 Y M 0.0000 Buried
103 Y M 0.0000 Buried
104 C M 0.0000 Buried
105 A M 0.0000 Buried
106 R M -0.3190 Soluble
107 D M 0.0000 Buried
108 Y M 0.8475 Aggregation-prone
109 T M 0.0000 Buried
110 R M -0.2716 Soluble
111 G M 0.0000 Buried
111A A M 0.0000 Buried
111B W M 1.6092 Aggregation-prone
111C F M 1.6424 Aggregation-prone
112D G M -0.3124 Soluble
112C E M -1.3396 Soluble
112B S M -0.5823 Soluble
112A L M 0.5798 Aggregation-prone
112 I M 2.1642 Aggregation-prone
113 G M 0.0000 Buried
114 G M 0.0000 Buried
115 F M 0.0000 Buried
116 D M -0.7531 Soluble
117 N M -1.1503 Soluble
118 W M -0.8074 Soluble
119 G M 0.0000 Buried
120 Q M -1.2399 Soluble
121 G M -0.3282 Soluble
122 T M 0.0000 Buried
123 L M 0.9843 Aggregation-prone
124 V M 0.0000 Buried
125 T M -0.2884 Soluble
126 V M 0.0000 Buried
127 S M -1.1710 Soluble
128 S M -0.8432 Soluble
129 A M -0.6182 Soluble
130 S M -0.7133 Soluble
131 T M -0.8619 Soluble
132 K M -1.7427 Soluble
133 G M -1.6209 Soluble
134 P M 0.0000 Buried
135 S M -0.3197 Soluble
136 V M 0.0000 Buried
137 F M 0.0000 Buried
138 P M -1.0865 Soluble
139 L M 0.0000 Buried
140 A M -1.2467 Soluble
141 P M 0.0000 Buried
142 S M -1.6397 Soluble
143 S M -1.8915 Soluble
144 K M -2.0854 Soluble
145 S M -1.4400 Soluble
146 T M -0.8650 Soluble
147 S M -0.7240 Soluble
148 G M -0.8517 Soluble
149 G M -0.9235 Soluble
150 T M -0.6388 Soluble
151 A M -0.5907 Soluble
152 A M 0.0000 Buried
153 L M 0.0000 Buried
154 G M 0.0000 Buried
155 C M 0.0000 Buried
156 L M 0.0000 Buried
157 V M 0.0000 Buried
158 K M 0.0000 Buried
159 D M -0.4777 Soluble
160 Y M 0.0000 Buried
161 F M 0.0000 Buried
162 P M 0.0000 Buried
163 E M -0.6583 Soluble
164 P M -0.9956 Soluble
165 V M -0.7552 Soluble
166 T M -0.5551 Soluble
167 V M -0.2683 Soluble
168 S M -0.3389 Soluble
169 W M 0.0000 Buried
170 N M -0.7217 Soluble
171 S M -0.6422 Soluble
172 G M -0.5912 Soluble
173 A M -0.2531 Soluble
174 L M 0.0178 Aggregation-prone
175 T M -0.1801 Soluble
176 S M -0.1793 Soluble
177 G M -0.2150 Soluble
178 V M 0.1919 Aggregation-prone
179 H M -0.2965 Soluble
180 T M 0.0004 Aggregation-prone
181 F M 0.0000 Buried
182 P M -0.4222 Soluble
183 A M 0.1972 Aggregation-prone
184 V M 0.5951 Aggregation-prone
185 L M 1.2713 Aggregation-prone
186 Q M 0.3225 Aggregation-prone
187 S M 0.0076 Aggregation-prone
188 S M -0.1578 Soluble
189 G M 0.0730 Aggregation-prone
190 L M 0.0192 Aggregation-prone
191 Y M 0.3212 Aggregation-prone
192 S M 0.0000 Buried
193 L M 0.0000 Buried
194 S M 0.0000 Buried
195 S M 0.0000 Buried
196 V M 0.0000 Buried
197 V M 0.0000 Buried
198 T M -0.1113 Soluble
199 V M 0.0000 Buried
200 P M -0.6679 Soluble
201 S M -0.9012 Soluble
202 S M -0.6787 Soluble
203 S M -0.7246 Soluble
204 L M -0.9418 Soluble
205 G M -1.0195 Soluble
206 T M -0.8441 Soluble
207 Q M -1.4473 Soluble
208 T M -1.1748 Soluble
209 Y M 0.0000 Buried
210 I M -1.0270 Soluble
211 C M 0.0000 Buried
212 N M -1.3085 Soluble
213 V M 0.0000 Buried
214 N M -1.7570 Soluble
215 H M 0.0000 Buried
216 K M -2.7690 Soluble
217 P M -1.8117 Soluble
218 S M -1.9860 Soluble
219 N M -2.6299 Soluble
220 T M -2.0880 Soluble
221 K M -2.5619 Soluble
222 V M -1.3865 Soluble
223 D M -2.1045 Soluble
224 K M -1.8803 Soluble
225 K M -2.1384 Soluble
226 V M 0.0000 Buried
227 E M -2.8441 Soluble
228 P M -2.2675 Soluble
229 K M -2.3409 Soluble
230 S M -1.2490 Soluble
231 C M -0.2481 Soluble
1 E N -1.5838 Soluble
2 I N 0.0000 Buried
3 V N 0.5502 Aggregation-prone
4 L N 0.0000 Buried
5 T N -0.6686 Soluble
6 Q N 0.0000 Buried
7 S N -0.8582 Soluble
8 P N -0.5569 Soluble
9 G N -0.7776 Soluble
10 T N -0.4460 Soluble
11 L N -0.2334 Soluble
12 S N -0.4051 Soluble
13 L N -0.9772 Soluble
14 S N -1.6554 Soluble
15 P N -2.2046 Soluble
16 G N -2.6812 Soluble
17 E N -3.2822 Soluble
18 R N -3.3043 Soluble
19 A N 0.0000 Buried
20 T N -0.6965 Soluble
21 L N 0.0000 Buried
22 S N -0.9974 Soluble
23 C N 0.0000 Buried
24 R N -2.4236 Soluble
25 A N -1.4601 Soluble
26 S N -1.0950 Soluble
27 Q N -1.8042 Soluble
28 T N -1.3419 Soluble
29 V N 0.0000 Buried
30 S N -0.6348 Soluble
36 S N -0.2234 Soluble
37 T N 0.3972 Aggregation-prone
38 S N 0.0000 Buried
39 L N 0.0000 Buried
40 A N 0.0000 Buried
41 W N 0.0000 Buried
42 Y N 0.0000 Buried
43 Q N 0.0000 Buried
44 Q N 0.0000 Buried
45 K N -1.8511 Soluble
46 P N -1.5290 Soluble
47 G N -1.5074 Soluble
48 Q N -2.1917 Soluble
49 A N -1.5765 Soluble
50 P N 0.0000 Buried
51 R N -1.8262 Soluble
52 L N 0.0000 Buried
53 L N 0.0000 Buried
54 I N 0.0000 Buried
55 Y N 0.4347 Aggregation-prone
56 G N 0.4213 Aggregation-prone
57 A N 0.0000 Buried
65 S N -0.6143 Soluble
66 S N -0.3445 Soluble
67 R N -1.3072 Soluble
68 A N -0.9595 Soluble
69 T N -0.7636 Soluble
70 G N -0.8826 Soluble
71 I N 0.0000 Buried
72 P N -1.2878 Soluble
74 D N -2.1810 Soluble
75 R N -1.9315 Soluble
76 F N 0.0000 Buried
77 S N -0.8927 Soluble
78 G N -0.4849 Soluble
79 S N -0.7501 Soluble
80 G N -1.2233 Soluble
83 S N -1.1602 Soluble
84 G N -1.2380 Soluble
85 T N -1.8311 Soluble
86 D N -2.3895 Soluble
87 F N 0.0000 Buried
88 T N -0.8474 Soluble
89 L N 0.0000 Buried
90 T N -0.8209 Soluble
91 I N 0.0000 Buried
92 S N -2.4791 Soluble
93 R N -3.5192 Soluble
94 L N 0.0000 Buried
95 E N -2.6744 Soluble
96 P N -1.9528 Soluble
97 E N -2.4486 Soluble
98 D N 0.0000 Buried
99 F N 0.0000 Buried
100 A N 0.0000 Buried
101 V N -0.2870 Soluble
102 Y N 0.0000 Buried
103 Y N 0.0000 Buried
104 C N 0.0000 Buried
105 Q N 0.0000 Buried
106 Q N 0.0000 Buried
107 H N 0.0000 Buried
108 D N -1.0975 Soluble
114 T N -1.0817 Soluble
115 S N -0.9332 Soluble
116 L N 0.0000 Buried
117 T N -0.0929 Soluble
118 F N 0.2699 Aggregation-prone
119 G N 0.0000 Buried
120 G N -0.6724 Soluble
121 G N -0.6712 Soluble
122 T N 0.0000 Buried
123 K N -0.7004 Soluble
124 V N 0.0000 Buried
125 E N 0.0000 Buried
126 I N -0.5577 Soluble
127 K N -0.9308 Soluble
128 R N -0.5986 Soluble
129 T N 0.2780 Aggregation-prone
130 V N 1.3397 Aggregation-prone
131 A N 0.5612 Aggregation-prone
132 A N 0.3357 Aggregation-prone
133 P N 0.0380 Aggregation-prone
134 S N -0.1946 Soluble
135 V N 0.0000 Buried
136 F N 0.0879 Aggregation-prone
137 I N 0.1471 Aggregation-prone
138 F N 0.0000 Buried
139 P N -0.4822 Soluble
140 P N 0.0000 Buried
141 S N -1.8990 Soluble
142 D N -3.0334 Soluble
143 E N -3.1132 Soluble
144 Q N 0.0000 Buried
145 L N -2.3726 Soluble
146 K N -2.8914 Soluble
147 S N -1.8391 Soluble
148 G N -1.4158 Soluble
149 T N -0.9311 Soluble
150 A N 0.0000 Buried
151 S N 0.0000 Buried
152 V N 0.0000 Buried
153 V N 0.0000 Buried
154 C N 0.0000 Buried
155 L N 0.0000 Buried
156 L N 0.0000 Buried
157 N N 0.0000 Buried
158 N N -0.8394 Soluble
159 F N 0.0000 Buried
160 Y N 0.0000 Buried
161 P N -1.0574 Soluble
162 R N -2.3339 Soluble
163 E N -2.8583 Soluble
164 A N -2.1968 Soluble
165 K N -2.4003 Soluble
166 V N -1.2695 Soluble
167 Q N -0.8027 Soluble
168 W N 0.0000 Buried
169 K N -0.7537 Soluble
170 V N 0.0000 Buried
171 D N -1.8220 Soluble
172 N N -1.6107 Soluble
173 A N -0.4858 Soluble
174 L N 0.1985 Aggregation-prone
175 Q N -0.5455 Soluble
176 S N -0.7993 Soluble
177 G N -1.3465 Soluble
178 N N -1.6923 Soluble
179 S N -1.5533 Soluble
180 Q N -1.5495 Soluble
181 E N -1.4586 Soluble
182 S N -0.8037 Soluble
183 V N -0.6859 Soluble
184 T N -1.1455 Soluble
185 E N -2.1954 Soluble
186 Q N -1.7586 Soluble
187 D N -1.8494 Soluble
188 S N -1.6613 Soluble
189 K N -2.1772 Soluble
190 D N -1.5834 Soluble
191 S N -1.5510 Soluble
192 T N 0.0000 Buried
193 Y N 0.0000 Buried
194 S N 0.0000 Buried
195 L N 0.0000 Buried
196 S N 0.0000 Buried
197 S N 0.0000 Buried
198 T N -0.7285 Soluble
199 L N 0.0000 Buried
200 T N -0.6928 Soluble
201 L N -0.7984 Soluble
202 S N -1.2158 Soluble
203 K N -2.1067 Soluble
204 A N -1.7639 Soluble
205 D N -2.3054 Soluble
206 Y N 0.0000 Buried
207 E N -3.0246 Soluble
208 K N -3.3119 Soluble
209 H N -2.6775 Soluble
210 K N -2.5122 Soluble
211 V N -1.1887 Soluble
212 Y N 0.0000 Buried
213 A N 0.0000 Buried
214 C N 0.0000 Buried
215 E N -0.7673 Soluble
216 V N 0.0000 Buried
217 T N -1.1848 Soluble
218 Q N -1.4275 Soluble
219 G N -1.0877 Soluble
220 T N -0.4354 Soluble
221 T N -0.3105 Soluble
222 S N -0.5383 Soluble
223 V N -0.0040 Soluble
224 T N -0.4317 Soluble
225 K N -0.6246 Soluble
226 S N -0.3706 Soluble
227 F N -0.5824 Soluble
228 N N -1.4488 Soluble
229 R N -2.0159 Soluble
230 G N -1.6239 Soluble
231 E N -1.8720 Soluble
232 C N -0.6442 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7105 5.3073 CSV PDB
4.5 -0.752 5.2434 CSV PDB
5.0 -0.8007 5.138 CSV PDB
5.5 -0.8465 5.0259 CSV PDB
6.0 -0.878 4.9616 CSV PDB
6.5 -0.8866 4.9051 CSV PDB
7.0 -0.8719 4.8657 CSV PDB
7.5 -0.841 4.8455 CSV PDB
8.0 -0.8011 4.8375 CSV PDB
8.5 -0.7545 4.8346 CSV PDB
9.0 -0.7019 4.8334 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH