Zinlirvimab / 8dok

A4DAB308_8dok_M_N | Source PDB: 8dok | Chains: M, N | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.5792
Max Score
2.3778
Min Score
-3.3615
Total Score
-136.12
Score CDR
-0.349
Score non-CDR
-0.6617

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) M (Heavy), N (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.3615
Maximum Score 2.3778
Average Score -0.5792
Total Score -136.116

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q M -1.4880 Soluble
2 V M -0.9860 Soluble
3 Q M -1.8071 Soluble
4 L M -1.2748 Soluble
5 Q M -1.8135 Soluble
6 E M 0.0000 Buried
7 S M -0.7871 Soluble
8 G M -0.6158 Soluble
9 P M -0.0672 Soluble
11 G M 0.3514 Aggregation-prone
12 L M 0.9663 Aggregation-prone
13 V M 0.0000 Buried
14 K M -1.9718 Soluble
15 P M -1.5239 Soluble
16 S M -1.7690 Soluble
17 E M -2.7666 Soluble
18 T M -1.9177 Soluble
19 L M 0.0000 Buried
20 S M -0.9358 Soluble
21 V M 0.0000 Buried
22 T M 0.0000 Buried
23 C M 0.0000 Buried
24 S M -1.1223 Soluble
25 V M 0.0000 Buried
26 S M -1.3207 Soluble
27 G M -1.2374 Soluble
28 D M -1.5762 Soluble
29 S M -1.2531 Soluble
30 M M -1.3706 Soluble
35 N M -2.4459 Soluble
36 N M -1.9893 Soluble
37 Y M -1.2734 Soluble
38 Y M -1.1885 Soluble
39 W M 0.0000 Buried
40 T M 0.0000 Buried
41 W M 0.0000 Buried
42 I M 0.0000 Buried
43 R M 0.0000 Buried
44 Q M -1.0036 Soluble
45 S M -1.0643 Soluble
46 P M -1.1142 Soluble
47 G M -1.5229 Soluble
48 K M -2.3690 Soluble
49 G M -1.6749 Soluble
50 L M 0.0000 Buried
51 E M -1.0775 Soluble
52 W M 0.0000 Buried
53 I M 0.0000 Buried
54 G M 0.0000 Buried
55 Y M 0.1649 Aggregation-prone
56 I M 0.0000 Buried
57 S M -1.5383 Soluble
58 D M -2.3592 Soluble
59 R M -3.1143 Soluble
63 E M -3.1225 Soluble
64 S M -1.6906 Soluble
65 A M -0.6484 Soluble
66 T M -0.0925 Soluble
67 Y M 0.0446 Aggregation-prone
68 N M -0.4121 Soluble
69 P M -0.7906 Soluble
70 S M -0.8395 Soluble
71 L M 0.0000 Buried
72 N M -1.6816 Soluble
74 S M -1.0416 Soluble
75 R M -1.3566 Soluble
76 V M 0.0000 Buried
77 V M 0.1164 Aggregation-prone
78 I M 0.0000 Buried
79 S M -0.9402 Soluble
80 R M -1.5492 Soluble
81 D M -1.5071 Soluble
82 T M -1.2672 Soluble
83 S M -1.3941 Soluble
84 K M -2.2619 Soluble
85 N M -1.6644 Soluble
86 Q M -1.4515 Soluble
87 L M 0.0000 Buried
88 S M -0.7880 Soluble
89 L M 0.0000 Buried
90 K M -1.3479 Soluble
91 L M 0.0000 Buried
92 N M -1.7492 Soluble
93 S M -1.5055 Soluble
94 V M 0.0000 Buried
95 T M -0.7234 Soluble
96 P M -0.4191 Soluble
97 A M -0.0784 Soluble
98 D M 0.0000 Buried
99 T M 0.0000 Buried
100 A M 0.0000 Buried
101 V M -0.1958 Soluble
102 Y M 0.0000 Buried
103 Y M 0.0000 Buried
104 C M 0.0000 Buried
105 A M 0.0000 Buried
106 T M 0.0000 Buried
107 A M 0.0000 Buried
108 R M -1.5795 Soluble
109 R M -1.4746 Soluble
110 G M -1.0752 Soluble
111 Q M -0.8397 Soluble
111A R M -0.2665 Soluble
111B I M 1.2808 Aggregation-prone
111C Y M 1.3512 Aggregation-prone
111D G M 1.3339 Aggregation-prone
111E V M 2.2923 Aggregation-prone
111F V M 2.3778 Aggregation-prone
112G S M 1.5120 Aggregation-prone
112F F M 2.2987 Aggregation-prone
112E G M 1.4236 Aggregation-prone
112D E M 1.0570 Aggregation-prone
112C F M 1.4220 Aggregation-prone
112B F M 0.2634 Aggregation-prone
112A Y M 0.0569 Aggregation-prone
112 Y M 0.0000 Buried
113 Y M 0.0000 Buried
114 S M 0.0000 Buried
115 M M 0.0000 Buried
116 D M -0.4820 Soluble
117 V M 0.1869 Aggregation-prone
118 W M 0.0000 Buried
119 G M 0.0000 Buried
120 K M -2.2914 Soluble
121 G M -1.3600 Soluble
122 T M -0.7303 Soluble
123 T M 0.0006 Aggregation-prone
124 V M 0.0000 Buried
125 T M 0.2388 Aggregation-prone
126 V M 0.0394 Aggregation-prone
127 S M -0.2038 Soluble
11 L N 0.9994 Aggregation-prone
12 S N 0.5463 Aggregation-prone
13 V N 0.0000 Buried
14 A N 0.3355 Aggregation-prone
15 L N 0.8426 Aggregation-prone
16 G N -0.7400 Soluble
17 E N -1.5562 Soluble
18 T N -1.2608 Soluble
19 A N -1.0511 Soluble
20 R N -1.8019 Soluble
21 I N -0.7320 Soluble
22 S N -1.3069 Soluble
23 C N 0.0000 Buried
24 G N -1.8463 Soluble
25 R N -2.6281 Soluble
26 Q N -2.2617 Soluble
27 A N -1.1389 Soluble
28 L N -0.2227 Soluble
29 G N -0.0682 Soluble
36 S N 0.2990 Aggregation-prone
37 R N 0.0000 Buried
38 A N 0.0000 Buried
39 V N 0.0000 Buried
40 Q N 0.0000 Buried
41 W N 0.0000 Buried
42 Y N 0.0000 Buried
43 Q N 0.0000 Buried
44 H N 0.0000 Buried
45 R N -1.1993 Soluble
46 P N -1.2115 Soluble
47 G N -1.5766 Soluble
48 Q N -1.9766 Soluble
49 A N -0.9653 Soluble
50 P N 0.0000 Buried
51 I N 0.9416 Aggregation-prone
52 L N 0.0000 Buried
53 L N 0.0000 Buried
54 I N 0.0000 Buried
55 Y N -1.0881 Soluble
56 N N -1.5142 Soluble
57 N N 0.0000 Buried
65 Q N -2.5917 Soluble
66 D N -3.3615 Soluble
67 R N -3.1631 Soluble
68 P N 0.0000 Buried
69 S N -1.0573 Soluble
70 G N -0.8278 Soluble
71 I N -1.0855 Soluble
72 P N -1.6100 Soluble
74 E N -2.7831 Soluble
75 R N -1.6591 Soluble
76 F N 0.0000 Buried
77 S N -1.8332 Soluble
78 G N -1.4901 Soluble
79 T N -0.6417 Soluble
80 P N -0.7956 Soluble
81 D N -0.2264 Soluble
81A I N 1.4201 Aggregation-prone
82 N N 0.3461 Aggregation-prone
83 F N 1.1970 Aggregation-prone
84 G N -0.0771 Soluble
85 T N -0.7630 Soluble
86 R N -2.2681 Soluble
87 A N 0.0000 Buried
88 T N -1.0405 Soluble
89 L N 0.0000 Buried
90 T N 0.0000 Buried
91 I N 0.0000 Buried
92 S N -1.2717 Soluble
93 G N -0.8723 Soluble
94 V N -0.8476 Soluble
95 E N -2.0354 Soluble
96 A N -1.4707 Soluble
97 G N -1.2452 Soluble
98 D N 0.0000 Buried
99 E N -2.6477 Soluble
100 A N 0.0000 Buried
101 D N 0.0000 Buried
102 Y N 0.0000 Buried
103 Y N 0.0000 Buried
104 C N -0.3792 Soluble
105 H N 0.0000 Buried
106 M N 0.0000 Buried
107 W N 0.0000 Buried
108 D N 0.0000 Buried
109 S N -0.5687 Soluble
110 R N -1.7521 Soluble
112 S N -0.8923 Soluble
113 G N -0.3379 Soluble
114 F N 0.3984 Aggregation-prone
115 S N 0.3100 Aggregation-prone
116 W N 0.3841 Aggregation-prone
117 S N -0.2727 Soluble
118 F N 0.0000 Buried
119 G N -1.0281 Soluble
120 G N -1.2176 Soluble
121 A N -0.8606 Soluble
122 T N -0.8743 Soluble
123 R N -1.7955 Soluble
124 L N 0.0000 Buried
125 T N -0.1382 Soluble
126 V N 0.7980 Aggregation-prone
127 L N 1.7809 Aggregation-prone
128 G N 0.5969 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.4767 4.4889 CSV PDB
4.5 -0.5078 4.4721 CSV PDB
5.0 -0.5498 4.4475 CSV PDB
5.5 -0.5946 4.4193 CSV PDB
6.0 -0.6331 4.3918 CSV PDB
6.5 -0.6583 4.3695 CSV PDB
7.0 -0.6677 4.3557 CSV PDB
7.5 -0.6646 4.3494 CSV PDB
8.0 -0.6544 4.347 CSV PDB
8.5 -0.6404 4.3463 CSV PDB
9.0 -0.6237 4.346 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH