Zinlirvimab / 6udj

A4DAB308_6udj_Q_B | Source PDB: 6udj | Chains: Q, B | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.4953
Max Score
2.8848
Min Score
-3.7687
Total Score
-117.39
Score CDR
-0.2815
Score non-CDR
-0.5711

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSALSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) Q (Heavy), B (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.7687
Maximum Score 2.8848
Average Score -0.4953
Total Score -117.3866

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q Q -1.7466 Soluble
2 V Q -1.4193 Soluble
3 Q Q -1.9345 Soluble
4 L Q -1.2373 Soluble
5 Q Q -1.8365 Soluble
6 E Q 0.0000 Buried
7 S Q -0.6922 Soluble
8 G Q -0.4245 Soluble
9 P Q -0.0283 Soluble
11 G Q 0.4638 Aggregation-prone
12 L Q 1.0462 Aggregation-prone
13 V Q -0.2346 Soluble
14 K Q -1.6987 Soluble
15 P Q -1.4346 Soluble
16 S Q -1.2031 Soluble
17 E Q -1.4680 Soluble
18 T Q -1.0835 Soluble
19 L Q 0.0000 Buried
20 S Q -0.4690 Soluble
21 V Q 0.0000 Buried
22 T Q -0.5837 Soluble
23 C Q 0.0000 Buried
24 S Q -1.1263 Soluble
25 V Q -1.4108 Soluble
26 S Q -1.7284 Soluble
27 G Q -1.9794 Soluble
28 D Q -2.6804 Soluble
29 S Q -1.7088 Soluble
30 M Q -1.8318 Soluble
35 N Q -2.3309 Soluble
36 N Q -2.2180 Soluble
37 Y Q -1.2937 Soluble
38 Y Q -1.0574 Soluble
39 W Q 0.0000 Buried
40 T Q 0.0000 Buried
41 W Q 0.0000 Buried
42 I Q 0.0000 Buried
43 R Q -0.4442 Soluble
44 Q Q -0.9481 Soluble
45 S Q -1.0176 Soluble
46 P Q -1.1149 Soluble
47 G Q -1.5057 Soluble
48 K Q -2.2940 Soluble
49 G Q -1.5458 Soluble
50 L Q 0.0000 Buried
51 E Q -0.8868 Soluble
52 W Q 0.0000 Buried
53 I Q 0.0000 Buried
54 G Q 0.0000 Buried
55 Y Q 0.1225 Aggregation-prone
56 I Q 0.0000 Buried
57 S Q 0.0000 Buried
58 D Q -3.7687 Soluble
59 R Q -3.6265 Soluble
63 E Q -3.5788 Soluble
64 S Q -1.9388 Soluble
65 A Q -0.5293 Soluble
66 T Q -0.0221 Soluble
67 Y Q 0.1607 Aggregation-prone
68 N Q 0.0000 Buried
69 P Q -0.6052 Soluble
70 S Q -0.7029 Soluble
71 L Q 0.0000 Buried
72 N Q -1.6640 Soluble
74 S Q -0.9800 Soluble
75 R Q -1.0442 Soluble
76 V Q 0.0000 Buried
77 V Q 0.6201 Aggregation-prone
78 I Q 0.0000 Buried
79 S Q -0.6746 Soluble
80 R Q 0.0000 Buried
81 D Q -2.9948 Soluble
82 T Q -2.0742 Soluble
83 S Q -1.8145 Soluble
84 K Q -2.6306 Soluble
85 N Q -2.2727 Soluble
86 Q Q -1.9124 Soluble
87 L Q 0.0000 Buried
88 S Q -0.4040 Soluble
89 L Q 0.0000 Buried
90 K Q -0.4413 Soluble
91 L Q 0.0000 Buried
92 N Q -1.2183 Soluble
93 S Q -1.1876 Soluble
94 V Q 0.0000 Buried
95 T Q -0.7610 Soluble
96 P Q -0.6374 Soluble
97 A Q -0.2322 Soluble
98 D Q -0.4271 Soluble
99 T Q -0.1030 Soluble
100 A Q 0.0000 Buried
101 V Q -0.2623 Soluble
102 Y Q 0.0000 Buried
103 Y Q 0.0000 Buried
104 C Q 0.0000 Buried
105 A Q 0.0000 Buried
106 T Q 0.0000 Buried
107 A Q 0.0000 Buried
108 R Q -1.7092 Soluble
109 R Q -1.9052 Soluble
110 G Q -0.9699 Soluble
111 Q Q -0.1513 Soluble
111A R Q 0.3091 Aggregation-prone
111B I Q 1.9280 Aggregation-prone
111C Y Q 1.4483 Aggregation-prone
111D G Q 1.4931 Aggregation-prone
111E V Q 2.5507 Aggregation-prone
111F V Q 2.8848 Aggregation-prone
112G S Q 1.7040 Aggregation-prone
112F F Q 2.4086 Aggregation-prone
112E G Q 1.4696 Aggregation-prone
112D E Q 1.3387 Aggregation-prone
112C F Q 1.6492 Aggregation-prone
112B F Q 0.7146 Aggregation-prone
112A Y Q 0.4514 Aggregation-prone
112 Y Q 0.0000 Buried
113 Y Q 0.0000 Buried
114 S Q 0.0000 Buried
115 M Q 0.0000 Buried
116 D Q -0.0713 Soluble
117 V Q 0.1442 Aggregation-prone
118 W Q 0.0000 Buried
119 G Q 0.0000 Buried
120 K Q -2.1966 Soluble
121 G Q 0.0000 Buried
122 T Q -0.6378 Soluble
123 T Q -0.1284 Soluble
124 V Q 0.0000 Buried
125 T Q 0.1264 Aggregation-prone
126 V Q 0.0000 Buried
127 S Q -0.5661 Soluble
128 S Q -0.7136 Soluble
129 A Q -0.1704 Soluble
11 L B 0.7691 Aggregation-prone
12 S B 0.6374 Aggregation-prone
13 V B 0.5573 Aggregation-prone
14 A B 0.4195 Aggregation-prone
15 L B 0.2755 Aggregation-prone
16 G B -1.0566 Soluble
17 E B -1.5414 Soluble
18 T B -1.3920 Soluble
19 A B 0.0000 Buried
20 R B -1.7054 Soluble
21 I B 0.0000 Buried
22 S B -1.2673 Soluble
23 C B 0.0000 Buried
24 G B -1.3731 Soluble
25 R B -1.4686 Soluble
26 Q B -1.7017 Soluble
27 A B -0.5042 Soluble
28 L B 0.7853 Aggregation-prone
29 G B 0.3374 Aggregation-prone
36 S B 0.7127 Aggregation-prone
37 R B 0.0000 Buried
38 A B 0.0000 Buried
39 V B 0.0000 Buried
40 Q B 0.0000 Buried
41 W B 0.0000 Buried
42 Y B 0.0000 Buried
43 Q B 0.0000 Buried
44 H B 0.0000 Buried
45 R B -1.4015 Soluble
46 P B -1.1046 Soluble
47 G B -1.4299 Soluble
48 Q B -1.7674 Soluble
49 A B -1.1326 Soluble
50 P B 0.0000 Buried
51 I B 0.4214 Aggregation-prone
52 L B 0.0000 Buried
53 L B 0.0000 Buried
54 I B 0.0000 Buried
55 Y B -0.6823 Soluble
56 N B -1.0835 Soluble
57 N B 0.0000 Buried
65 Q B -1.6539 Soluble
66 D B -1.5357 Soluble
67 R B -1.6090 Soluble
68 P B -0.7606 Soluble
69 S B -0.6096 Soluble
70 G B -0.7193 Soluble
71 I B -0.6657 Soluble
72 P B -1.2750 Soluble
74 E B -2.1822 Soluble
75 R B -1.4192 Soluble
76 F B 0.0000 Buried
77 S B -1.2732 Soluble
78 G B 0.0000 Buried
79 T B -0.6325 Soluble
80 P B -0.3185 Soluble
81 D B 0.2105 Aggregation-prone
81A I B 1.6771 Aggregation-prone
82 N B 0.4334 Aggregation-prone
83 F B 1.5009 Aggregation-prone
84 G B 0.0352 Aggregation-prone
85 T B -0.7097 Soluble
86 R B -2.1774 Soluble
87 A B 0.0000 Buried
88 T B -1.2085 Soluble
89 L B 0.0000 Buried
90 T B -0.9085 Soluble
91 I B 0.0000 Buried
92 S B -1.4567 Soluble
93 G B -1.2314 Soluble
94 V B 0.0000 Buried
95 E B -1.9019 Soluble
96 A B -0.9130 Soluble
97 G B -1.3680 Soluble
98 D B 0.0000 Buried
99 E B -1.7970 Soluble
100 A B 0.0000 Buried
101 D B 0.0000 Buried
102 Y B 0.0000 Buried
103 Y B 0.0000 Buried
104 C B 0.0000 Buried
105 H B 0.0000 Buried
106 M B 0.0000 Buried
107 W B 0.0000 Buried
108 D B 0.0000 Buried
109 S B -0.3633 Soluble
110 R B -1.5688 Soluble
112 S B -0.8787 Soluble
113 G B -0.5941 Soluble
114 F B 0.3896 Aggregation-prone
115 S B 0.0000 Buried
116 W B 0.0934 Aggregation-prone
117 S B -0.2685 Soluble
118 F B 0.0000 Buried
119 G B -0.6917 Soluble
120 G B -1.1880 Soluble
121 A B -1.0320 Soluble
122 T B -0.7542 Soluble
123 R B -1.7038 Soluble
124 L B 0.0000 Buried
125 T B 0.1460 Aggregation-prone
126 V B 0.3596 Aggregation-prone
127 L B 1.5348 Aggregation-prone
128 G B 0.6107 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.3788 4.5432 CSV PDB
4.5 -0.4138 4.5164 CSV PDB
5.0 -0.4566 4.4767 CSV PDB
5.5 -0.4999 4.4304 CSV PDB
6.0 -0.5361 4.385 CSV PDB
6.5 -0.56 4.3477 CSV PDB
7.0 -0.5708 4.3242 CSV PDB
7.5 -0.5721 4.3132 CSV PDB
8.0 -0.5676 4.3091 CSV PDB
8.5 -0.5585 4.3078 CSV PDB
9.0 -0.5448 4.3073 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH