Zinlirvimab / 6udk

A4DAB308_6udk_A_B | Source PDB: 6udk | Chains: A, B | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6055
Max Score
2.7504
Min Score
-3.7312
Total Score
-143.5
Score CDR
-0.4084
Score non-CDR
-0.6753

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSALSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) A (Heavy), B (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.7312
Maximum Score 2.7504
Average Score -0.6055
Total Score -143.4961

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q A -1.6546 Soluble
2 V A -1.1879 Soluble
3 Q A -1.4150 Soluble
4 L A 0.0000 Buried
5 Q A -1.5178 Soluble
6 E A -1.2154 Soluble
7 S A -0.7598 Soluble
8 G A -0.4443 Soluble
9 P A -0.0299 Soluble
11 G A 0.2711 Aggregation-prone
12 L A 1.0820 Aggregation-prone
13 V A -0.2595 Soluble
14 K A -1.5805 Soluble
15 P A -1.3141 Soluble
16 S A -1.5191 Soluble
17 E A -2.1769 Soluble
18 T A -1.7393 Soluble
19 L A 0.0000 Buried
20 S A -0.8887 Soluble
21 V A 0.0000 Buried
22 T A -0.7264 Soluble
23 C A 0.0000 Buried
24 S A -1.1186 Soluble
25 V A 0.0000 Buried
26 S A -1.3560 Soluble
27 G A -1.6488 Soluble
28 D A -2.0599 Soluble
29 S A -1.3740 Soluble
30 M A -1.5570 Soluble
35 N A -2.2868 Soluble
36 N A -2.4801 Soluble
37 Y A -1.5574 Soluble
38 Y A -1.0973 Soluble
39 W A 0.0000 Buried
40 T A 0.0000 Buried
41 W A 0.0000 Buried
42 I A 0.0000 Buried
43 R A -0.7918 Soluble
44 Q A -1.1444 Soluble
45 S A -1.2377 Soluble
46 P A -1.1436 Soluble
47 G A -1.4920 Soluble
48 K A -2.3470 Soluble
49 G A -1.6601 Soluble
50 L A 0.0000 Buried
51 E A -1.6602 Soluble
52 W A 0.0000 Buried
53 I A 0.0000 Buried
54 G A 0.0000 Buried
55 Y A -0.0191 Soluble
56 I A 0.0000 Buried
57 S A -2.5795 Soluble
58 D A -3.7312 Soluble
59 R A -3.6382 Soluble
63 E A -3.4318 Soluble
64 S A -1.9228 Soluble
65 A A -0.6034 Soluble
66 T A -0.1361 Soluble
67 Y A -0.0403 Soluble
68 N A -0.5699 Soluble
69 P A -0.7593 Soluble
70 S A -0.7223 Soluble
71 L A -0.8912 Soluble
72 N A -1.6362 Soluble
74 S A -1.2023 Soluble
75 R A -1.6496 Soluble
76 V A 0.0000 Buried
77 V A -0.3258 Soluble
78 I A 0.0000 Buried
79 S A -0.8379 Soluble
80 R A -1.3025 Soluble
81 D A -1.4505 Soluble
82 T A -1.4092 Soluble
83 S A -1.4540 Soluble
84 K A -2.3742 Soluble
85 N A -2.0381 Soluble
86 Q A -1.4896 Soluble
87 L A 0.0000 Buried
88 S A -0.6897 Soluble
89 L A 0.0000 Buried
90 K A -2.0711 Soluble
91 L A 0.0000 Buried
92 N A -2.2452 Soluble
93 S A -1.2899 Soluble
94 V A -1.0791 Soluble
95 T A -0.6894 Soluble
96 P A -0.6534 Soluble
97 A A -0.3250 Soluble
98 D A -0.6676 Soluble
99 T A -0.4209 Soluble
100 A A 0.0000 Buried
101 V A -0.1243 Soluble
102 Y A 0.0000 Buried
103 Y A 0.0000 Buried
104 C A 0.0000 Buried
105 A A 0.0000 Buried
106 T A 0.0000 Buried
107 A A 0.0000 Buried
108 R A -2.1564 Soluble
109 R A -1.6602 Soluble
110 G A -1.0903 Soluble
111 Q A -0.5358 Soluble
111A R A -0.1521 Soluble
111B I A 1.4267 Aggregation-prone
111C Y A 1.2993 Aggregation-prone
111D G A 1.2245 Aggregation-prone
111E V A 2.2896 Aggregation-prone
111F V A 2.7504 Aggregation-prone
112G S A 1.6626 Aggregation-prone
112F F A 2.2429 Aggregation-prone
112E G A 1.3462 Aggregation-prone
112D E A 0.9998 Aggregation-prone
112C F A 1.4366 Aggregation-prone
112B F A 0.6942 Aggregation-prone
112A Y A 0.4397 Aggregation-prone
112 Y A 0.0000 Buried
113 Y A 0.0000 Buried
114 S A 0.0000 Buried
115 M A 0.0000 Buried
116 D A -0.0878 Soluble
117 V A 0.2281 Aggregation-prone
118 W A 0.0000 Buried
119 G A 0.0000 Buried
120 K A -2.2372 Soluble
121 G A -1.3666 Soluble
122 T A -0.7199 Soluble
123 T A -0.1938 Soluble
124 V A 0.0000 Buried
125 T A -0.0112 Soluble
126 V A 0.0000 Buried
127 S A -0.5160 Soluble
128 S A -0.7008 Soluble
129 A A -0.1828 Soluble
11 L B 0.6190 Aggregation-prone
12 S B 0.6192 Aggregation-prone
13 V B 0.4365 Aggregation-prone
14 A B 0.4072 Aggregation-prone
15 L B 0.3289 Aggregation-prone
16 G B -1.1375 Soluble
17 E B -1.8309 Soluble
18 T B -1.3671 Soluble
19 A B 0.0000 Buried
20 R B -1.7501 Soluble
21 I B 0.0000 Buried
22 S B -1.1335 Soluble
23 C B -0.9631 Soluble
24 G B -1.2294 Soluble
25 R B -1.4873 Soluble
26 Q B -1.6897 Soluble
27 A B -0.6575 Soluble
28 L B -0.0417 Soluble
29 G B -0.1879 Soluble
36 S B 0.4262 Aggregation-prone
37 R B 0.0000 Buried
38 A B 0.0000 Buried
39 V B 0.0000 Buried
40 Q B 0.0000 Buried
41 W B 0.0000 Buried
42 Y B 0.0000 Buried
43 Q B -0.3083 Soluble
44 H B 0.0000 Buried
45 R B -1.8857 Soluble
46 P B -1.5083 Soluble
47 G B -1.5930 Soluble
48 Q B -1.9338 Soluble
49 A B -1.0952 Soluble
50 P B 0.0000 Buried
51 I B 0.7056 Aggregation-prone
52 L B 0.0000 Buried
53 L B 0.0000 Buried
54 I B 0.0000 Buried
55 Y B -0.9397 Soluble
56 N B -1.3697 Soluble
57 N B 0.0000 Buried
65 Q B -2.2901 Soluble
66 D B -2.6142 Soluble
67 R B -2.9932 Soluble
68 P B -1.2501 Soluble
69 S B -1.0463 Soluble
70 G B -0.9471 Soluble
71 I B -0.8517 Soluble
72 P B -1.4585 Soluble
74 E B -2.4506 Soluble
75 R B -1.4989 Soluble
76 F B -1.2808 Soluble
77 S B -1.2810 Soluble
78 G B -1.3117 Soluble
79 T B -0.5599 Soluble
80 P B -0.1659 Soluble
81 D B 0.3875 Aggregation-prone
81A I B 1.7365 Aggregation-prone
82 N B 0.4333 Aggregation-prone
83 F B 1.4289 Aggregation-prone
84 G B 0.1106 Aggregation-prone
85 T B -0.4311 Soluble
86 R B -1.5154 Soluble
87 A B 0.0000 Buried
88 T B -1.0394 Soluble
89 L B 0.0000 Buried
90 T B -0.9027 Soluble
91 I B 0.0000 Buried
92 S B -1.5916 Soluble
93 G B -1.2853 Soluble
94 V B 0.0000 Buried
95 E B -1.4692 Soluble
96 A B -0.5634 Soluble
97 G B -1.0467 Soluble
98 D B 0.0000 Buried
99 E B -2.0344 Soluble
100 A B 0.0000 Buried
101 D B 0.0000 Buried
102 Y B 0.0000 Buried
103 Y B 0.0000 Buried
104 C B 0.0000 Buried
105 H B 0.0000 Buried
106 M B 0.0000 Buried
107 W B 0.0000 Buried
108 D B 0.0000 Buried
109 S B -0.7543 Soluble
110 R B -1.8970 Soluble
112 S B -0.9827 Soluble
113 G B -0.3818 Soluble
114 F B 0.6581 Aggregation-prone
115 S B 0.3328 Aggregation-prone
116 W B -0.0623 Soluble
117 S B -0.5038 Soluble
118 F B 0.0000 Buried
119 G B -0.8941 Soluble
120 G B -1.2851 Soluble
121 A B -1.1155 Soluble
122 T B -0.8485 Soluble
123 R B -1.8431 Soluble
124 L B 0.0000 Buried
125 T B -0.2772 Soluble
126 V B 0.0000 Buried
127 L B 1.4149 Aggregation-prone
128 G B 0.4224 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5259 4.4816 CSV PDB
4.5 -0.5622 4.4668 CSV PDB
5.0 -0.6073 4.4505 CSV PDB
5.5 -0.6532 4.4336 CSV PDB
6.0 -0.6915 4.4166 CSV PDB
6.5 -0.7152 4.3995 CSV PDB
7.0 -0.7227 4.3825 CSV PDB
7.5 -0.718 4.3658 CSV PDB
8.0 -0.7057 4.3501 CSV PDB
8.5 -0.6888 4.3368 CSV PDB
9.0 -0.6686 4.3278 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH