Cosfroviximab / 5kel

A4DAB073_5kel_J_N | Source PDB: 5kel | Chains: J, N | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6204
Max Score
1.3149
Min Score
-3.3596
Total Score
-141.45
Score CDR
-0.4937
Score non-CDR
-0.6551

Calculation Parameters

Chain Sequence(s) DVKLLESGGGLVQPGGSLKLSCAASGFSLSTSGVGVGWFRQPSGKGLEWLALIWWDDDKYYNPSLKSQLSISKDFSRNQVFLKISNVDIADTATYYCARRDPFGYDNAMGYWGQGTSVTVSDIVMTQSPLSLSTSVGDRVSLTCKASQNVGTAVAWYQQKPGQSPKLLIYSASNRYTGVPDRFTGSGSGTDFTLTISNMQSEDLADYFCQQYSSYPLTFGAGTKLELR input.pdb
Selected Chain(s) J (Heavy), N (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.3596
Maximum Score 1.3149
Average Score -0.6204
Total Score -141.4515

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 D J -2.1491 Soluble
2 V J -1.5735 Soluble
3 K J -2.1700 Soluble
4 L J -1.0849 Soluble
5 L J -0.4637 Soluble
6 E J -0.7135 Soluble
7 S J -0.7969 Soluble
8 G J -1.0384 Soluble
9 G J -0.8247 Soluble
11 G J -0.0724 Soluble
12 L J 1.0300 Aggregation-prone
13 V J 0.1966 Aggregation-prone
14 Q J -1.0325 Soluble
15 P J -0.7955 Soluble
16 G J -1.3369 Soluble
17 G J -1.0152 Soluble
18 S J -1.6061 Soluble
19 L J 0.0000 Buried
20 K J -2.0802 Soluble
21 L J 0.0000 Buried
22 S J -0.7453 Soluble
23 C J 0.0000 Buried
24 A J -0.6878 Soluble
25 A J 0.0000 Buried
26 S J -1.2478 Soluble
27 G J -1.3270 Soluble
28 F J -0.5455 Soluble
29 S J -0.3169 Soluble
30 L J -0.0822 Soluble
31 S J -0.2156 Soluble
34 T J -0.2667 Soluble
35 S J -0.9023 Soluble
36 G J -0.9366 Soluble
37 V J 0.0000 Buried
38 G J 0.0000 Buried
39 V J 0.1720 Aggregation-prone
40 G J 0.0000 Buried
41 W J 0.0000 Buried
42 F J 0.0000 Buried
43 R J 0.0000 Buried
44 Q J 0.0000 Buried
45 P J -0.9447 Soluble
46 S J -1.0183 Soluble
47 G J -1.4500 Soluble
48 K J -2.1183 Soluble
49 G J -1.1431 Soluble
50 L J 0.0000 Buried
51 E J -0.7211 Soluble
52 W J 0.0000 Buried
53 L J 0.0000 Buried
54 A J 0.0000 Buried
55 L J 0.0000 Buried
56 I J 0.0000 Buried
57 W J -1.6108 Soluble
58 W J -1.4500 Soluble
59 D J -2.9394 Soluble
63 D J -3.3596 Soluble
64 D J -2.8001 Soluble
65 K J -1.9829 Soluble
66 Y J -0.4232 Soluble
67 Y J -0.3724 Soluble
68 N J -0.6766 Soluble
69 P J -1.0350 Soluble
70 S J -1.0012 Soluble
71 L J -0.8974 Soluble
72 K J -1.7699 Soluble
74 S J -1.2854 Soluble
75 Q J -1.4109 Soluble
76 L J 0.0000 Buried
77 S J -1.0450 Soluble
78 I J 0.0000 Buried
79 S J -0.6165 Soluble
80 K J -1.0396 Soluble
81 D J -0.9353 Soluble
82 F J -0.4001 Soluble
83 S J -1.0270 Soluble
84 R J -2.0785 Soluble
85 N J -1.2319 Soluble
86 Q J -0.9639 Soluble
87 V J 0.0000 Buried
88 F J -0.6761 Soluble
89 L J 0.0000 Buried
90 K J -1.7749 Soluble
91 I J 0.0000 Buried
92 S J -1.6871 Soluble
93 N J -1.9074 Soluble
94 V J 0.0000 Buried
95 D J -0.5266 Soluble
96 I J 1.3149 Aggregation-prone
97 A J 0.8002 Aggregation-prone
98 D J 0.0000 Buried
99 T J 0.5909 Aggregation-prone
100 A J 0.0000 Buried
101 T J -0.5125 Soluble
102 Y J 0.0000 Buried
103 Y J 0.0000 Buried
104 C J 0.0000 Buried
105 A J 0.0000 Buried
106 R J 0.0394 Aggregation-prone
107 R J 0.0000 Buried
108 D J -0.1413 Soluble
109 P J 0.2516 Aggregation-prone
110 F J 0.5164 Aggregation-prone
111 G J 0.2395 Aggregation-prone
112A Y J 0.9431 Aggregation-prone
112 D J 0.0823 Aggregation-prone
113 N J -0.0380 Soluble
114 A J 0.0000 Buried
115 M J 0.0000 Buried
116 G J 0.0000 Buried
117 Y J -0.2362 Soluble
118 W J -0.6134 Soluble
119 G J 0.0000 Buried
120 Q J -1.6661 Soluble
121 G J -1.0496 Soluble
122 T J -0.5967 Soluble
123 S J -0.3191 Soluble
124 V J 0.0000 Buried
125 T J 0.4664 Aggregation-prone
126 V J 0.4283 Aggregation-prone
127 S J -0.0655 Soluble
1 D N -1.0651 Soluble
2 I N 0.2403 Aggregation-prone
3 V N 1.1119 Aggregation-prone
4 M N 0.3943 Aggregation-prone
5 T N 0.2738 Aggregation-prone
6 Q N 0.0000 Buried
7 S N 0.0240 Aggregation-prone
8 P N 0.3068 Aggregation-prone
9 L N 1.0054 Aggregation-prone
10 S N -0.3515 Soluble
11 L N -0.4473 Soluble
12 S N -1.3003 Soluble
13 T N 0.0000 Buried
14 S N -0.5802 Soluble
15 V N 0.2830 Aggregation-prone
16 G N -1.1130 Soluble
17 D N -1.8006 Soluble
18 R N -2.5952 Soluble
19 V N 0.0000 Buried
20 S N -0.7777 Soluble
21 L N 0.0000 Buried
22 T N -0.5897 Soluble
23 C N 0.0000 Buried
24 K N -1.6349 Soluble
25 A N 0.0000 Buried
26 S N -0.8856 Soluble
27 Q N -1.7746 Soluble
28 N N -2.4506 Soluble
29 V N 0.0000 Buried
36 G N -1.3883 Soluble
37 T N -0.9002 Soluble
38 A N -0.3541 Soluble
39 V N 0.0000 Buried
40 A N 0.0000 Buried
41 W N 0.0000 Buried
42 Y N 0.0000 Buried
43 Q N 0.0000 Buried
44 Q N -1.4210 Soluble
45 K N -1.5523 Soluble
46 P N -1.2336 Soluble
47 G N -1.4375 Soluble
48 Q N -2.0582 Soluble
49 S N -1.5307 Soluble
50 P N 0.0000 Buried
51 K N -1.6569 Soluble
52 L N 0.0000 Buried
53 L N 0.0000 Buried
54 I N 0.0000 Buried
55 Y N -0.5962 Soluble
56 S N -0.4803 Soluble
57 A N 0.0000 Buried
65 S N -1.1431 Soluble
66 N N -1.7399 Soluble
67 R N -1.8860 Soluble
68 Y N -1.0641 Soluble
69 T N -0.7721 Soluble
70 G N -0.8352 Soluble
71 V N 0.0000 Buried
72 P N -1.3601 Soluble
74 D N -2.3641 Soluble
75 R N -1.9736 Soluble
76 F N 0.0000 Buried
77 T N -1.1486 Soluble
78 G N -0.7214 Soluble
79 S N -0.8530 Soluble
80 G N -1.1136 Soluble
83 S N -1.2952 Soluble
84 G N -1.8379 Soluble
85 T N -2.1526 Soluble
86 D N -2.4584 Soluble
87 F N 0.0000 Buried
88 T N -0.7783 Soluble
89 L N 0.0000 Buried
90 T N -0.8795 Soluble
91 I N 0.0000 Buried
92 S N -2.1851 Soluble
93 N N -2.2718 Soluble
94 M N 0.0000 Buried
95 Q N -1.1315 Soluble
96 S N -1.2733 Soluble
97 E N -1.6692 Soluble
98 D N 0.0000 Buried
99 L N -1.0850 Soluble
100 A N 0.0000 Buried
101 D N -1.1205 Soluble
102 Y N 0.0000 Buried
103 F N 0.0000 Buried
104 C N 0.0000 Buried
105 Q N 0.0000 Buried
106 Q N 0.0000 Buried
107 Y N 0.1497 Aggregation-prone
108 S N -0.3760 Soluble
109 S N 0.0322 Aggregation-prone
114 Y N 0.9029 Aggregation-prone
115 P N 0.3112 Aggregation-prone
116 L N 0.3592 Aggregation-prone
117 T N 0.0000 Buried
118 F N 0.5532 Aggregation-prone
119 G N 0.0000 Buried
120 A N 0.2203 Aggregation-prone
121 G N -0.3636 Soluble
122 T N 0.0000 Buried
123 K N -1.8660 Soluble
124 L N 0.0000 Buried
125 E N -2.3619 Soluble
126 L N -1.1665 Soluble
127 R N -1.8828 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5974 3.2548 CSV PDB
4.5 -0.6451 3.1848 CSV PDB
5.0 -0.6979 3.1066 CSV PDB
5.5 -0.7481 3.0252 CSV PDB
6.0 -0.7874 2.9428 CSV PDB
6.5 -0.8094 2.8603 CSV PDB
7.0 -0.8146 2.7781 CSV PDB
7.5 -0.8087 2.6973 CSV PDB
8.0 -0.7951 2.6206 CSV PDB
8.5 -0.773 2.5545 CSV PDB
9.0 -0.7404 2.5079 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH