Diridavumab / 5c0s

A4DAB087_5c0s_H_L | Source PDB: 5c0s | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6569
Max Score
2.9998
Min Score
-3.3604
Total Score
-284.42
Score CDR
-0.2265
Score non-CDR
-0.7169

Calculation Parameters

Chain Sequence(s) EVQLVESGAEVKKPGSSVKVSCKASGGPFRSYAISWVRQAPGQGPEWMGGIIPIFGTTKYAPKFQGRVTITADDFAGTVYMELSSLRSEDTAMYYCAKHMGYQVRETMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPVLTQPPSVSAAPGQKVTISCSGSSSNIGNDYVSWYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTSATLGITGLQTGDEANYYCATWDRRPTAYVVFGGGTKLTVLQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTE input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.3604
Maximum Score 2.9998
Average Score -0.6569
Total Score -284.4173

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E H -2.0379 Soluble
2 V H -1.3592 Soluble
3 Q H -1.5594 Soluble
4 L H 0.0000 Buried
5 V H 0.5274 Aggregation-prone
6 E H -0.2565 Soluble
7 S H -0.4635 Soluble
8 G H -0.4578 Soluble
9 A H -0.2956 Soluble
11 E H -0.4530 Soluble
12 V H 0.0958 Aggregation-prone
13 K H -1.2017 Soluble
14 K H -1.9916 Soluble
15 P H -2.0233 Soluble
16 G H -1.4817 Soluble
17 S H -1.2018 Soluble
18 S H -1.4376 Soluble
19 V H 0.0000 Buried
20 K H -2.1906 Soluble
21 V H 0.0000 Buried
22 S H -0.6937 Soluble
23 C H 0.0000 Buried
24 K H -1.2606 Soluble
25 A H 0.0000 Buried
26 S H -0.9346 Soluble
27 G H -1.0300 Soluble
28 G H -0.1221 Soluble
29 P H 0.2761 Aggregation-prone
30 F H 1.7287 Aggregation-prone
35 R H 0.7805 Aggregation-prone
36 S H 0.5519 Aggregation-prone
37 Y H 0.6690 Aggregation-prone
38 A H 0.0000 Buried
39 I H 0.0000 Buried
40 S H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H 0.0000 Buried
45 A H -0.9688 Soluble
46 P H -1.1261 Soluble
47 G H -1.2397 Soluble
48 Q H -1.7014 Soluble
49 G H -1.0980 Soluble
50 P H 0.0000 Buried
51 E H -0.6027 Soluble
52 W H 0.0000 Buried
53 M H 0.0000 Buried
54 G H 0.0000 Buried
55 G H 0.0000 Buried
56 I H 0.0000 Buried
57 I H 0.0000 Buried
58 P H 0.0000 Buried
59 I H 2.9998 Aggregation-prone
62 F H 2.8440 Aggregation-prone
63 G H 1.0329 Aggregation-prone
64 T H 0.4639 Aggregation-prone
65 T H -0.1649 Soluble
66 K H -0.7502 Soluble
67 Y H -0.8440 Soluble
68 A H 0.0000 Buried
69 P H -1.4510 Soluble
70 K H -2.1740 Soluble
71 F H 0.0000 Buried
72 Q H -1.8651 Soluble
74 G H -1.4074 Soluble
75 R H -1.3116 Soluble
76 V H 0.0000 Buried
77 T H -0.9325 Soluble
78 I H 0.0000 Buried
79 T H -0.4353 Soluble
80 A H -0.0762 Soluble
81 D H -0.3747 Soluble
82 D H 0.1020 Aggregation-prone
83 F H 1.5495 Aggregation-prone
84 A H 0.3546 Aggregation-prone
85 G H -0.1193 Soluble
86 T H 0.0000 Buried
87 V H 0.0000 Buried
88 Y H -0.7088 Soluble
89 M H 0.0000 Buried
90 E H -1.7890 Soluble
91 L H 0.0000 Buried
92 S H -1.2163 Soluble
93 S H -1.1328 Soluble
94 L H 0.0000 Buried
95 R H -2.7395 Soluble
96 S H -2.2363 Soluble
97 E H -2.4628 Soluble
98 D H 0.0000 Buried
99 T H -0.9729 Soluble
100 A H 0.0000 Buried
101 M H 0.0186 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 K H 0.0000 Buried
107 H H 0.0000 Buried
108 M H 0.4045 Aggregation-prone
109 G H 0.0217 Aggregation-prone
110 Y H 0.6914 Aggregation-prone
111 Q H -0.8917 Soluble
112A V H 0.0000 Buried
112 R H -0.5613 Soluble
113 E H 0.0000 Buried
114 T H 0.0000 Buried
115 M H 0.0000 Buried
116 D H -0.2881 Soluble
117 V H -0.6635 Soluble
118 W H -0.4406 Soluble
119 G H 0.0000 Buried
120 K H -1.4919 Soluble
121 G H 0.0000 Buried
122 T H 0.0000 Buried
123 T H 0.0297 Aggregation-prone
124 V H 0.0000 Buried
125 T H 0.0000 Buried
126 V H 0.0000 Buried
127 S H -1.1656 Soluble
128 S H -1.0951 Soluble
129 A H -0.6564 Soluble
130 S H -0.7351 Soluble
131 T H -0.8165 Soluble
132 K H -1.6370 Soluble
133 G H -1.5632 Soluble
134 P H -0.7673 Soluble
135 S H -0.3308 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -0.9090 Soluble
139 L H 0.0000 Buried
140 A H -0.8926 Soluble
141 P H 0.0000 Buried
142 S H -1.1173 Soluble
143 S H -1.2899 Soluble
144 K H -2.0485 Soluble
145 S H -1.2234 Soluble
146 T H -1.0672 Soluble
147 S H -0.9310 Soluble
148 G H -0.8905 Soluble
149 G H -0.8619 Soluble
150 T H -0.6044 Soluble
151 A H 0.0000 Buried
152 A H -0.2756 Soluble
153 L H 0.0000 Buried
154 G H 0.0000 Buried
155 C H 0.0000 Buried
156 L H 0.0000 Buried
157 V H 0.0000 Buried
158 K H 0.0000 Buried
159 D H -0.7327 Soluble
160 Y H 0.0000 Buried
161 F H 0.0000 Buried
162 P H -0.9082 Soluble
163 E H -1.0255 Soluble
164 P H -0.9972 Soluble
165 V H -0.7550 Soluble
166 T H -0.6512 Soluble
167 V H -0.1781 Soluble
168 S H -0.4022 Soluble
169 W H 0.0000 Buried
170 N H -0.8489 Soluble
171 S H -0.7209 Soluble
172 G H -0.5402 Soluble
173 A H -0.2231 Soluble
174 L H 0.0491 Aggregation-prone
175 T H -0.1550 Soluble
176 S H -0.2651 Soluble
177 G H -0.3156 Soluble
178 V H 0.1533 Aggregation-prone
179 H H -0.1460 Soluble
180 T H -0.0068 Soluble
181 F H 0.0000 Buried
182 P H -0.2137 Soluble
183 A H 0.0489 Aggregation-prone
184 V H 0.0000 Buried
185 L H 0.6661 Aggregation-prone
186 Q H -0.1372 Soluble
187 S H -0.3300 Soluble
188 S H -0.3511 Soluble
189 G H -0.2256 Soluble
190 L H 0.0000 Buried
191 Y H -0.0920 Soluble
192 S H 0.0000 Buried
193 L H 0.0000 Buried
194 S H 0.0000 Buried
195 S H 0.0000 Buried
196 V H 0.1835 Aggregation-prone
197 V H 0.0000 Buried
198 T H -0.1509 Soluble
199 V H 0.0000 Buried
200 P H -0.5981 Soluble
201 S H -0.6245 Soluble
202 S H -0.6298 Soluble
203 S H -0.6236 Soluble
204 L H -0.8561 Soluble
205 G H -1.1290 Soluble
206 T H -0.7607 Soluble
207 Q H -1.3434 Soluble
208 T H -1.1761 Soluble
209 Y H 0.0000 Buried
210 I H -1.3478 Soluble
211 C H 0.0000 Buried
212 N H -1.5563 Soluble
213 V H 0.0000 Buried
214 N H -1.8675 Soluble
215 H H 0.0000 Buried
216 K H -2.8312 Soluble
217 P H -1.8048 Soluble
218 S H -1.9338 Soluble
219 N H -2.6494 Soluble
220 T H -2.0767 Soluble
221 K H -2.6375 Soluble
222 V H -1.4283 Soluble
223 D H -2.5686 Soluble
224 K H -2.1125 Soluble
225 R H -2.7404 Soluble
226 V H 0.0000 Buried
227 E H -2.5692 Soluble
228 P H -1.2744 Soluble
3 V L 1.5668 Aggregation-prone
4 L L 0.0000 Buried
5 T L 0.0265 Aggregation-prone
6 Q L 0.0000 Buried
7 P L -0.5555 Soluble
8 P L -0.8078 Soluble
9 S L -0.8183 Soluble
11 V L -0.1355 Soluble
12 S L -0.1963 Soluble
13 A L 0.0000 Buried
14 A L -0.5697 Soluble
15 P L -1.2739 Soluble
16 G L -1.8131 Soluble
17 Q L -2.2507 Soluble
18 K L -2.5293 Soluble
19 V L -0.9434 Soluble
20 T L -0.4135 Soluble
21 I L 0.0000 Buried
22 S L -0.3412 Soluble
23 C L 0.0000 Buried
24 S L -0.3097 Soluble
25 G L -0.1340 Soluble
26 S L -0.5817 Soluble
27 S L -1.1876 Soluble
28 S L -1.6102 Soluble
29 N L 0.0000 Buried
30 I L 0.0000 Buried
35 G L -1.0435 Soluble
36 N L -1.4908 Soluble
37 D L 0.0000 Buried
38 Y L 0.2365 Aggregation-prone
39 V L 0.0000 Buried
40 S L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L -0.6128 Soluble
45 L L -0.3226 Soluble
46 P L -0.6104 Soluble
47 G L -0.7644 Soluble
48 T L -0.7751 Soluble
49 A L -0.8057 Soluble
50 P L 0.0000 Buried
51 K L -0.8811 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.9374 Soluble
56 D L -0.9716 Soluble
57 N L -1.3727 Soluble
65 N L -2.3890 Soluble
66 K L -2.5527 Soluble
67 R L -2.4938 Soluble
68 P L -1.0938 Soluble
69 S L -0.8333 Soluble
70 G L -0.8726 Soluble
71 I L -1.0700 Soluble
72 P L -1.4185 Soluble
74 D L -2.2793 Soluble
75 R L -1.6193 Soluble
76 F L 0.0000 Buried
77 S L -1.5762 Soluble
78 G L -1.3511 Soluble
79 S L -1.1862 Soluble
80 K L -1.0250 Soluble
83 S L -0.8073 Soluble
84 G L -1.0605 Soluble
85 T L -0.8805 Soluble
86 S L -0.7030 Soluble
87 A L 0.0000 Buried
88 T L -0.6060 Soluble
89 L L 0.0000 Buried
90 G L -0.5710 Soluble
91 I L 0.0000 Buried
92 T L -1.8010 Soluble
93 G L -1.7047 Soluble
94 L L 0.0000 Buried
95 Q L -1.6106 Soluble
96 T L -0.9739 Soluble
97 G L -0.8581 Soluble
98 D L 0.0000 Buried
99 E L -0.7766 Soluble
100 A L 0.0000 Buried
101 N L -1.0296 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 A L 0.0000 Buried
106 T L 0.0000 Buried
107 W L -0.6489 Soluble
108 D L 0.0000 Buried
109 R L -2.7525 Soluble
110 R L -2.7761 Soluble
112 P L -1.5731 Soluble
113 T L -1.1722 Soluble
114 A L -1.3154 Soluble
115 Y L -0.6783 Soluble
116 V L 0.0000 Buried
117 V L 0.0000 Buried
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 G L -0.5542 Soluble
121 G L -1.0296 Soluble
122 T L 0.0000 Buried
123 K L -1.6107 Soluble
124 L L 0.0000 Buried
125 T L -0.1353 Soluble
126 V L 0.0000 Buried
127 L L 0.7940 Aggregation-prone
128 Q L -0.8216 Soluble
129 P L -1.1478 Soluble
130 K L -2.1152 Soluble
131 A L -1.4609 Soluble
132 A L -0.8809 Soluble
133 P L -0.7288 Soluble
134 S L -0.3292 Soluble
135 V L 0.0000 Buried
136 T L -0.6813 Soluble
137 L L 0.0000 Buried
138 F L 0.0000 Buried
139 P L -0.1504 Soluble
140 P L -0.4539 Soluble
141 S L -0.7080 Soluble
142 S L -1.1898 Soluble
143 E L -1.7134 Soluble
144 E L 0.0000 Buried
145 L L -1.8154 Soluble
146 Q L -2.1251 Soluble
147 A L -1.7468 Soluble
148 N L -2.5790 Soluble
149 K L -2.4945 Soluble
150 A L 0.0000 Buried
151 T L 0.0000 Buried
152 L L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 I L 0.0000 Buried
157 S L -0.7162 Soluble
158 D L -1.5698 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -0.9377 Soluble
162 G L -0.9462 Soluble
163 A L -0.2232 Soluble
164 V L -0.1282 Soluble
165 T L -0.0916 Soluble
166 V L -0.0448 Soluble
167 A L -0.4854 Soluble
168 W L 0.0000 Buried
169 K L -0.8459 Soluble
170 A L -1.1647 Soluble
171 D L -1.3574 Soluble
172 S L -0.8763 Soluble
173 S L -0.5916 Soluble
174 P L -0.8473 Soluble
175 V L -0.8366 Soluble
176 K L -1.6716 Soluble
177 A L -0.8871 Soluble
178 G L -0.7829 Soluble
179 V L -0.5410 Soluble
180 E L -0.6397 Soluble
181 T L -0.1417 Soluble
182 T L -0.0755 Soluble
183 T L -0.2728 Soluble
184 P L -0.3902 Soluble
185 S L -0.8892 Soluble
186 K L -1.9002 Soluble
187 Q L -1.8065 Soluble
188 S L -1.6895 Soluble
189 N L -2.4361 Soluble
190 N L -2.6190 Soluble
191 K L -2.4220 Soluble
192 Y L -1.3914 Soluble
193 A L 0.0000 Buried
194 A L 0.0000 Buried
195 S L 0.0000 Buried
196 S L 0.0000 Buried
197 Y L 0.0000 Buried
198 L L 0.0000 Buried
199 S L -0.6955 Soluble
200 L L 0.0000 Buried
201 T L -1.9114 Soluble
202 P L -2.4978 Soluble
203 E L -3.2452 Soluble
204 Q L -2.4565 Soluble
205 W L 0.0000 Buried
206 K L -3.3604 Soluble
207 S L -2.4861 Soluble
208 H L -2.4307 Soluble
209 R L -2.8214 Soluble
210 S L 0.0000 Buried
211 Y L 0.0000 Buried
212 S L 0.0000 Buried
213 C L 0.0000 Buried
214 Q L -1.1003 Soluble
215 V L 0.0000 Buried
216 T L -0.7757 Soluble
217 H L 0.0000 Buried
218 E L -2.3133 Soluble
219 G L -1.4209 Soluble
220 S L -0.9196 Soluble
221 T L -0.8721 Soluble
222 V L -0.9274 Soluble
223 E L -2.1571 Soluble
224 K L -1.9069 Soluble
225 T L -1.2210 Soluble
226 V L 0.0000 Buried
227 A L -1.6193 Soluble
228 P L -1.7112 Soluble
229 T L -1.2206 Soluble
230 E L -2.3221 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6199 5.7475 CSV PDB
4.5 -0.6509 5.7475 CSV PDB
5.0 -0.6871 5.7475 CSV PDB
5.5 -0.7196 5.7475 CSV PDB
6.0 -0.7375 5.7475 CSV PDB
6.5 -0.7319 5.7475 CSV PDB
7.0 -0.703 5.7475 CSV PDB
7.5 -0.6595 5.7475 CSV PDB
8.0 -0.6089 5.7475 CSV PDB
8.5 -0.5541 5.7474 CSV PDB
9.0 -0.4957 5.7471 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH