Zinlirvimab / 7ugn

A4DAB308_7ugn_O_R | Source PDB: 7ugn | Chains: O, R | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.5953
Max Score
2.9807
Min Score
-3.6632
Total Score
-141.09
Score CDR
-0.3684
Score non-CDR
-0.6757

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSALSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) O (Heavy), R (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6632
Maximum Score 2.9807
Average Score -0.5953
Total Score -141.0912

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q O -1.7474 Soluble
2 V O 0.0000 Buried
3 Q O -1.9627 Soluble
4 L O -1.3652 Soluble
5 Q O -1.9669 Soluble
6 E O -1.4293 Soluble
7 S O -0.8667 Soluble
8 G O -0.4085 Soluble
9 P O 0.0130 Aggregation-prone
11 G O 0.4768 Aggregation-prone
12 L O 1.0628 Aggregation-prone
13 V O -0.3550 Soluble
14 K O -1.8344 Soluble
15 P O -1.5205 Soluble
16 S O -1.6171 Soluble
17 E O -2.2553 Soluble
18 T O -1.6283 Soluble
19 L O 0.0000 Buried
20 S O -0.6834 Soluble
21 V O 0.0000 Buried
22 T O -0.6982 Soluble
23 C O 0.0000 Buried
24 S O -1.3056 Soluble
25 V O 0.0000 Buried
26 S O -1.5961 Soluble
27 G O -1.7377 Soluble
28 D O -2.1744 Soluble
29 S O -1.4091 Soluble
30 M O -1.4519 Soluble
35 N O -2.1237 Soluble
36 N O -2.1476 Soluble
37 Y O -1.1012 Soluble
38 Y O -0.6523 Soluble
39 W O 0.0000 Buried
40 T O 0.0000 Buried
41 W O 0.0000 Buried
42 I O 0.0000 Buried
43 R O -0.5344 Soluble
44 Q O -1.0548 Soluble
45 S O -1.1479 Soluble
46 P O -1.1469 Soluble
47 G O -1.5568 Soluble
48 K O -2.3972 Soluble
49 G O -1.7671 Soluble
50 L O -1.0178 Soluble
51 E O -1.0899 Soluble
52 W O 0.0000 Buried
53 I O 0.0000 Buried
54 G O 0.0000 Buried
55 Y O 0.3143 Aggregation-prone
56 I O 0.0000 Buried
57 S O -1.9236 Soluble
58 D O -3.4967 Soluble
59 R O -3.6632 Soluble
63 E O -3.3960 Soluble
64 S O -1.9277 Soluble
65 A O -0.5868 Soluble
66 T O -0.1005 Soluble
67 Y O 0.0293 Aggregation-prone
68 N O 0.0000 Buried
69 P O -0.6114 Soluble
70 S O -0.6041 Soluble
71 L O -0.7464 Soluble
72 N O -1.5430 Soluble
74 S O -0.9792 Soluble
75 R O -1.1566 Soluble
76 V O 0.0000 Buried
77 V O 0.6204 Aggregation-prone
78 I O 0.1850 Aggregation-prone
79 S O -0.5806 Soluble
80 R O -1.5772 Soluble
81 D O -1.6196 Soluble
82 T O -1.3160 Soluble
83 S O -1.4727 Soluble
84 K O -2.2856 Soluble
85 N O -1.7833 Soluble
86 Q O -1.4467 Soluble
87 L O 0.0000 Buried
88 S O -0.4035 Soluble
89 L O 0.0000 Buried
90 K O -0.8007 Soluble
91 L O 0.0000 Buried
92 N O -1.7318 Soluble
93 S O -1.3749 Soluble
94 V O 0.0000 Buried
95 T O -0.9033 Soluble
96 P O -0.6894 Soluble
97 A O -0.2606 Soluble
98 D O -0.4875 Soluble
99 T O -0.3468 Soluble
100 A O 0.0000 Buried
101 V O -0.2235 Soluble
102 Y O 0.0000 Buried
103 Y O 0.0000 Buried
104 C O 0.0000 Buried
105 A O 0.0000 Buried
106 T O 0.0000 Buried
107 A O 0.0000 Buried
108 R O -2.4423 Soluble
109 R O -2.0207 Soluble
110 G O -1.4039 Soluble
111 Q O -0.7230 Soluble
111A R O 0.0453 Aggregation-prone
111B I O 1.6609 Aggregation-prone
111C Y O 1.5910 Aggregation-prone
111D G O 1.6497 Aggregation-prone
111E V O 2.7301 Aggregation-prone
111F V O 2.9807 Aggregation-prone
112G S O 1.7468 Aggregation-prone
112F F O 2.4229 Aggregation-prone
112E G O 1.3783 Aggregation-prone
112D E O 1.1983 Aggregation-prone
112C F O 1.4763 Aggregation-prone
112B F O 0.5362 Aggregation-prone
112A Y O 0.2185 Aggregation-prone
112 Y O 0.0000 Buried
113 Y O -0.9325 Soluble
114 S O 0.0000 Buried
115 M O 0.0000 Buried
116 D O -0.5949 Soluble
117 V O -0.1576 Soluble
118 W O -0.2704 Soluble
119 G O -1.3036 Soluble
120 K O -2.2145 Soluble
121 G O 0.0000 Buried
122 T O -0.7427 Soluble
123 T O -0.1717 Soluble
124 V O 0.0000 Buried
125 T O 0.0682 Aggregation-prone
126 V O 0.0000 Buried
127 S O -0.4990 Soluble
128 S O -0.6283 Soluble
129 A O -0.1982 Soluble
11 L R 0.7730 Aggregation-prone
12 S R 0.6520 Aggregation-prone
13 V R 0.0000 Buried
14 A R 0.2456 Aggregation-prone
15 L R 0.1575 Aggregation-prone
16 G R -1.1929 Soluble
17 E R -1.9558 Soluble
18 T R -1.3660 Soluble
19 A R 0.0000 Buried
20 R R -1.9384 Soluble
21 I R 0.0000 Buried
22 S R -1.2298 Soluble
23 C R -0.9663 Soluble
24 G R -1.3922 Soluble
25 R R -1.5979 Soluble
26 Q R -1.7641 Soluble
27 A R -0.5969 Soluble
28 L R 0.7207 Aggregation-prone
29 G R 0.2940 Aggregation-prone
36 S R 0.0000 Buried
37 R R 0.0000 Buried
38 A R 0.0000 Buried
39 V R 0.0000 Buried
40 Q R 0.0000 Buried
41 W R 0.0000 Buried
42 Y R 0.0000 Buried
43 Q R 0.0000 Buried
44 H R 0.0000 Buried
45 R R -1.6695 Soluble
46 P R -1.4298 Soluble
47 G R -1.5659 Soluble
48 Q R -1.9411 Soluble
49 A R -0.9897 Soluble
50 P R 0.0000 Buried
51 I R 0.7017 Aggregation-prone
52 L R 0.6340 Aggregation-prone
53 L R 0.0000 Buried
54 I R 0.0000 Buried
55 Y R -0.3694 Soluble
56 N R -1.1104 Soluble
57 N R 0.0000 Buried
65 Q R -2.0517 Soluble
66 D R -2.0332 Soluble
67 R R -2.8154 Soluble
68 P R -1.7571 Soluble
69 S R -1.2200 Soluble
70 G R -0.9284 Soluble
71 I R -0.8094 Soluble
72 P R -1.4600 Soluble
74 E R -2.4468 Soluble
75 R R -1.5424 Soluble
76 F R -1.1558 Soluble
77 S R -1.4613 Soluble
78 G R -1.1279 Soluble
79 T R -0.6024 Soluble
80 P R -0.3625 Soluble
81 D R 0.3004 Aggregation-prone
81A I R 1.7659 Aggregation-prone
82 N R 0.4603 Aggregation-prone
83 F R 1.5183 Aggregation-prone
84 G R 0.0320 Aggregation-prone
85 T R -0.7469 Soluble
86 R R -2.1379 Soluble
87 A R -1.4124 Soluble
88 T R -1.1201 Soluble
89 L R 0.0000 Buried
90 T R -0.9983 Soluble
91 I R 0.0000 Buried
92 S R -1.5670 Soluble
93 G R -1.2353 Soluble
94 V R 0.0000 Buried
95 E R -2.2352 Soluble
96 A R -1.1281 Soluble
97 G R -1.5962 Soluble
98 D R 0.0000 Buried
99 E R -2.6015 Soluble
100 A R 0.0000 Buried
101 D R -1.4907 Soluble
102 Y R 0.0000 Buried
103 Y R 0.0000 Buried
104 C R 0.0000 Buried
105 H R 0.0000 Buried
106 M R 0.0000 Buried
107 W R 0.0000 Buried
108 D R -0.5629 Soluble
109 S R -0.6428 Soluble
110 R R -1.6973 Soluble
112 S R -0.9402 Soluble
113 G R -0.5038 Soluble
114 F R 0.6247 Aggregation-prone
115 S R 0.2943 Aggregation-prone
116 W R 0.0930 Aggregation-prone
117 S R -0.3270 Soluble
118 F R 0.0000 Buried
119 G R -0.7162 Soluble
120 G R -0.9887 Soluble
121 A R -0.9900 Soluble
122 T R -0.8394 Soluble
123 R R -1.8253 Soluble
124 L R 0.0000 Buried
125 T R -0.1681 Soluble
126 V R 0.5696 Aggregation-prone
127 L R 1.5422 Aggregation-prone
128 G R 0.5400 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.514 4.6175 CSV PDB
4.5 -0.5498 4.5839 CSV PDB
5.0 -0.5959 4.5364 CSV PDB
5.5 -0.6441 4.483 CSV PDB
6.0 -0.6856 4.432 CSV PDB
6.5 -0.7135 4.3917 CSV PDB
7.0 -0.7253 4.3678 CSV PDB
7.5 -0.7244 4.3572 CSV PDB
8.0 -0.716 4.3533 CSV PDB
8.5 -0.7025 4.352 CSV PDB
9.0 -0.6845 4.3516 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH