Sonavibart / 5jw4

A4DAB244_5jw4_Q_R | Source PDB: 5jw4 | Chains: Q, R | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.4865
Max Score
3.1856
Min Score
-3.1222
Total Score
-158.11
Score CDR
-0.0174
Score non-CDR
-0.5738

Calculation Parameters

Chain Sequence(s) QVQLQQSGPGLVKPSQTLSLTCAISGDSVSSYNAVWNWIRQSPSRGLEWLGRTYYRSGWYNDYAESVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARSGHITVFGVNVDAFDMWGQGTMVTVSSASTKGPSVFCLVKDYFPEPVTVTFPAVLQSSGLYSLSSVVNHKPSNTKVMTQSPSSLSASVGDRVTITCRTSQSLSSYTHWYQQKPGKAPKLLIYAASSRGSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSRTFGQGTKVEIKRTVAAPSVFICLLNNFYPREAKVESVTEQDSKDSTYSLSCEVTHQGVT input.pdb
Selected Chain(s) Q (Heavy), R (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.1222
Maximum Score 3.1856
Average Score -0.4865
Total Score -158.1145

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q Q -1.4561 Soluble
2 V Q -1.0576 Soluble
3 Q Q -1.4746 Soluble
4 L Q 0.0000 Buried
5 Q Q -1.6341 Soluble
6 Q Q 0.0000 Buried
7 S Q -0.8318 Soluble
8 G Q -0.3890 Soluble
9 P Q -0.2254 Soluble
11 G Q 0.2066 Aggregation-prone
12 L Q 0.1285 Aggregation-prone
13 V Q 0.0000 Buried
14 K Q -2.1137 Soluble
15 P Q -1.5524 Soluble
16 S Q -1.5367 Soluble
17 Q Q -2.0956 Soluble
18 T Q -1.4469 Soluble
19 L Q 0.0000 Buried
20 S Q -0.7444 Soluble
21 L Q 0.0000 Buried
22 T Q -0.7263 Soluble
23 C Q 0.0000 Buried
24 A Q -1.1102 Soluble
25 I Q 0.0000 Buried
26 S Q -1.1132 Soluble
27 G Q -1.1892 Soluble
28 D Q -1.2012 Soluble
29 S Q -0.5501 Soluble
30 V Q 0.0000 Buried
31 S Q -0.0602 Soluble
34 S Q 0.0069 Aggregation-prone
35 Y Q 0.5496 Aggregation-prone
36 N Q -0.8605 Soluble
37 A Q 0.0000 Buried
38 V Q 0.0000 Buried
39 W Q 0.0000 Buried
40 N Q 0.0000 Buried
41 W Q 0.0000 Buried
42 I Q 0.0000 Buried
43 R Q 0.0000 Buried
44 Q Q -0.5049 Soluble
45 S Q -0.9997 Soluble
46 P Q -0.9072 Soluble
47 S Q -1.5153 Soluble
48 R Q -2.5255 Soluble
49 G Q -1.5219 Soluble
50 L Q 0.0000 Buried
51 E Q 0.0000 Buried
52 W Q 0.0000 Buried
53 L Q 0.0000 Buried
54 G Q 0.0000 Buried
55 R Q -0.5932 Soluble
56 T Q 0.0000 Buried
57 Y Q 0.2668 Aggregation-prone
58 Y Q 0.6318 Aggregation-prone
59 R Q 0.1293 Aggregation-prone
60 S Q 0.0172 Aggregation-prone
62 G Q 0.1721 Aggregation-prone
63 W Q 0.5595 Aggregation-prone
64 Y Q 0.4321 Aggregation-prone
65 N Q -0.6005 Soluble
66 D Q -1.3602 Soluble
67 Y Q -1.4512 Soluble
68 A Q 0.0000 Buried
69 E Q -2.5689 Soluble
70 S Q -1.5741 Soluble
71 V Q 0.0000 Buried
72 K Q -2.6465 Soluble
74 S Q -1.6002 Soluble
75 R Q -1.3150 Soluble
76 I Q 0.0000 Buried
77 T Q -1.1398 Soluble
78 I Q 0.0000 Buried
79 N Q -1.4907 Soluble
80 P Q -1.1843 Soluble
81 D Q -1.6302 Soluble
82 T Q -1.2884 Soluble
83 S Q -1.3732 Soluble
84 K Q -2.2077 Soluble
85 N Q -1.6263 Soluble
86 Q Q -1.5157 Soluble
87 F Q 0.0000 Buried
88 S Q -0.8652 Soluble
89 L Q 0.0000 Buried
90 Q Q -0.9413 Soluble
91 L Q 0.0000 Buried
92 N Q -1.3373 Soluble
93 S Q -1.3362 Soluble
94 V Q 0.0000 Buried
95 T Q -1.3986 Soluble
96 P Q -1.4117 Soluble
97 E Q -2.2182 Soluble
98 D Q 0.0000 Buried
99 T Q -0.4596 Soluble
100 A Q 0.0000 Buried
101 V Q 0.4473 Aggregation-prone
102 Y Q 0.0000 Buried
103 Y Q 0.0000 Buried
104 C Q 0.0000 Buried
105 A Q 0.0000 Buried
106 R Q 0.0000 Buried
107 S Q 0.0000 Buried
108 G Q 0.0000 Buried
109 H Q -0.7545 Soluble
110 I Q 0.1057 Aggregation-prone
111 T Q 0.7327 Aggregation-prone
111A V Q 1.5904 Aggregation-prone
111B F Q 2.2936 Aggregation-prone
112C G Q 0.9676 Aggregation-prone
112B V Q 1.5046 Aggregation-prone
112A N Q 0.3156 Aggregation-prone
112 V Q 0.0000 Buried
113 D Q 0.0000 Buried
114 A Q 0.0000 Buried
115 F Q 0.0000 Buried
116 D Q -0.3723 Soluble
117 M Q -0.5146 Soluble
118 W Q 0.0000 Buried
119 G Q 0.0000 Buried
120 Q Q -1.8772 Soluble
121 G Q -0.9048 Soluble
122 T Q -0.0678 Soluble
123 M Q 0.7839 Aggregation-prone
124 V Q 0.0000 Buried
125 T Q 0.0000 Buried
126 V Q 0.0000 Buried
127 S Q -0.7081 Soluble
128 S Q -0.8381 Soluble
129 A Q -0.5632 Soluble
130 S Q -0.4764 Soluble
131 T Q -0.9648 Soluble
132 K Q -1.3115 Soluble
133 G Q -1.2960 Soluble
134 P Q -0.1584 Soluble
135 S Q 0.5940 Aggregation-prone
136 V Q 1.9500 Aggregation-prone
137 F Q 2.5182 Aggregation-prone
138 C Q 2.3047 Aggregation-prone
139 L Q 1.9071 Aggregation-prone
140 V Q 0.0000 Buried
141 K Q 0.1530 Aggregation-prone
142 D Q -0.7003 Soluble
143 Y Q 0.0000 Buried
144 F Q 0.0000 Buried
145 P Q -1.1896 Soluble
146 E Q -1.8257 Soluble
147 P Q -1.5094 Soluble
148 V Q -0.6309 Soluble
149 T Q 0.2019 Aggregation-prone
150 V Q 2.0552 Aggregation-prone
151 T Q 0.8084 Aggregation-prone
152 F Q 0.0000 Buried
153 P Q -0.2362 Soluble
154 A Q 0.1973 Aggregation-prone
155 V Q 1.2030 Aggregation-prone
156 L Q 1.0527 Aggregation-prone
157 Q Q 0.2199 Aggregation-prone
158 S Q -0.1165 Soluble
159 S Q -0.3245 Soluble
160 G Q -0.0347 Soluble
161 L Q -0.2153 Soluble
162 Y Q 0.0000 Buried
163 S Q 0.0000 Buried
164 L Q 0.0000 Buried
165 S Q 1.3718 Aggregation-prone
166 S Q 1.5384 Aggregation-prone
167 V Q 2.1408 Aggregation-prone
168 V Q 0.9412 Aggregation-prone
169 N Q -0.7254 Soluble
170 H Q 0.0000 Buried
171 K Q -2.8683 Soluble
172 P Q -1.8800 Soluble
173 S Q -1.8647 Soluble
174 N Q -2.5642 Soluble
175 T Q -1.7264 Soluble
176 K Q -1.2868 Soluble
177 V Q 1.2035 Aggregation-prone
4 M R -0.8556 Soluble
5 T R -1.0347 Soluble
6 Q R 0.0000 Buried
7 S R -0.9539 Soluble
8 P R -0.6012 Soluble
9 S R -1.0049 Soluble
10 S R -0.9633 Soluble
11 L R -0.6873 Soluble
12 S R -1.0384 Soluble
13 A R 0.0000 Buried
14 S R -0.8621 Soluble
15 V R -0.1239 Soluble
16 G R -0.8890 Soluble
17 D R -1.7519 Soluble
18 R R -2.3523 Soluble
19 V R 0.0000 Buried
20 T R -0.6324 Soluble
21 I R 0.0000 Buried
22 T R -0.7633 Soluble
23 C R 0.0000 Buried
24 R R -2.4027 Soluble
25 T R 0.0000 Buried
26 S R -1.1914 Soluble
27 Q R -1.6101 Soluble
28 S R -1.0206 Soluble
29 L R 0.1451 Aggregation-prone
36 S R -0.1711 Soluble
37 S R 0.4156 Aggregation-prone
38 Y R 0.3715 Aggregation-prone
39 T R 0.0000 Buried
40 H R 0.0000 Buried
41 W R 0.0000 Buried
42 Y R 0.0000 Buried
43 Q R -1.0184 Soluble
44 Q R 0.0000 Buried
45 K R -1.9833 Soluble
46 P R -1.4540 Soluble
47 G R -1.6900 Soluble
48 K R -2.6902 Soluble
49 A R -1.7235 Soluble
50 P R 0.0000 Buried
51 K R -1.6365 Soluble
52 L R 0.0000 Buried
53 L R 0.0000 Buried
54 I R 0.0000 Buried
55 Y R -0.0592 Soluble
56 A R 0.0505 Aggregation-prone
57 A R 0.0000 Buried
65 S R -0.6954 Soluble
66 S R -0.7956 Soluble
67 R R -1.5466 Soluble
68 G R 0.0000 Buried
69 S R -0.7932 Soluble
70 G R -0.8267 Soluble
71 V R 0.0000 Buried
72 P R -0.7114 Soluble
74 S R -0.7582 Soluble
75 R R -0.9491 Soluble
76 F R 0.0000 Buried
77 S R -0.7096 Soluble
78 G R -0.5679 Soluble
79 S R -0.6060 Soluble
80 G R -0.9561 Soluble
83 S R -0.9612 Soluble
84 G R -1.1722 Soluble
85 T R -1.4978 Soluble
86 D R -1.6975 Soluble
87 F R 0.0000 Buried
88 T R -0.6629 Soluble
89 L R 0.0000 Buried
90 T R -0.6018 Soluble
91 I R 0.0000 Buried
92 S R -1.3040 Soluble
93 S R -1.2077 Soluble
94 L R 0.0000 Buried
95 Q R -0.8561 Soluble
96 P R -0.8936 Soluble
97 E R -1.8041 Soluble
98 D R 0.0000 Buried
99 F R -0.6609 Soluble
100 A R 0.0000 Buried
101 T R -1.0861 Soluble
102 Y R 0.0000 Buried
103 Y R 0.0000 Buried
104 C R 0.0000 Buried
105 Q R 0.0000 Buried
106 Q R 0.0000 Buried
107 S R -0.5446 Soluble
116 R R -1.2821 Soluble
117 T R -0.7168 Soluble
118 F R -0.4346 Soluble
119 G R 0.0000 Buried
120 Q R -1.6660 Soluble
121 G R 0.0000 Buried
122 T R 0.0000 Buried
123 K R -1.9364 Soluble
124 V R 0.0000 Buried
125 E R -0.9956 Soluble
126 I R -0.9168 Soluble
127 K R -1.6917 Soluble
128 R R -1.3761 Soluble
129 T R -0.1011 Soluble
130 V R 0.7125 Aggregation-prone
131 A R 0.1419 Aggregation-prone
132 A R -0.2240 Soluble
133 P R 0.0381 Aggregation-prone
134 S R 0.3951 Aggregation-prone
135 V R 1.6782 Aggregation-prone
136 F R 3.0224 Aggregation-prone
137 I R 3.1856 Aggregation-prone
138 C R 1.5839 Aggregation-prone
139 L R 1.6150 Aggregation-prone
140 L R 0.0000 Buried
141 N R -0.0683 Soluble
142 N R -1.2114 Soluble
143 F R 0.0000 Buried
144 Y R 0.0000 Buried
145 P R -1.6950 Soluble
146 R R -2.7737 Soluble
147 E R -3.1222 Soluble
148 A R -2.2685 Soluble
149 K R -2.3740 Soluble
150 V R -0.6428 Soluble
151 E R -1.4705 Soluble
152 S R -0.8176 Soluble
153 V R -0.9162 Soluble
154 T R -1.2961 Soluble
155 E R -2.2963 Soluble
156 Q R -1.9884 Soluble
157 D R -2.1790 Soluble
158 S R -1.8508 Soluble
159 K R -2.3786 Soluble
160 D R -2.0674 Soluble
161 S R -2.0735 Soluble
162 T R 0.0000 Buried
163 Y R 0.0000 Buried
164 S R -0.7527 Soluble
165 L R 0.0000 Buried
166 S R 0.2301 Aggregation-prone
167 C R 0.6510 Aggregation-prone
168 E R -1.1118 Soluble
169 V R 0.0000 Buried
170 T R -1.1276 Soluble
171 H R -1.3768 Soluble
172 Q R -1.7977 Soluble
173 G R -0.6261 Soluble
174 V R 1.3088 Aggregation-prone
175 T R 0.7775 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5593 5.5629 CSV PDB
4.5 -0.5879 5.5629 CSV PDB
5.0 -0.622 5.5629 CSV PDB
5.5 -0.6525 5.5629 CSV PDB
6.0 -0.6699 5.5629 CSV PDB
6.5 -0.6671 5.5629 CSV PDB
7.0 -0.6441 5.5629 CSV PDB
7.5 -0.607 5.5629 CSV PDB
8.0 -0.5626 5.5629 CSV PDB
8.5 -0.514 5.5629 CSV PDB
9.0 -0.4626 5.5629 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH