Zinlirvimab / 7ucg

A4DAB308_7ucg_Q_R | Source PDB: 7ucg | Chains: Q, R | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.549
Max Score
2.8085
Min Score
-3.411
Total Score
-126.27
Score CDR
-0.3697
Score non-CDR
-0.6152

Calculation Parameters

Chain Sequence(s) VQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTV input.pdb
Selected Chain(s) Q (Heavy), R (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.411
Maximum Score 2.8085
Average Score -0.549
Total Score -126.2681

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V Q 0.6048 Aggregation-prone
3 Q Q -1.0621 Soluble
4 L Q 0.0000 Buried
5 Q Q -1.9862 Soluble
6 E Q -1.3017 Soluble
7 S Q -0.8563 Soluble
8 G Q -0.4655 Soluble
9 P Q -0.0548 Soluble
11 G Q 0.3764 Aggregation-prone
12 L Q 0.9842 Aggregation-prone
13 V Q -0.1932 Soluble
14 K Q -1.6448 Soluble
15 P Q -1.2881 Soluble
16 S Q -1.2618 Soluble
17 E Q -1.4984 Soluble
18 T Q -1.2626 Soluble
19 L Q 0.0000 Buried
20 S Q -0.9069 Soluble
21 V Q 0.0000 Buried
22 T Q -0.6938 Soluble
23 C Q 0.0000 Buried
24 S Q -1.3473 Soluble
25 V Q -1.1589 Soluble
26 S Q -1.1337 Soluble
27 G Q -1.1528 Soluble
28 D Q -2.1790 Soluble
29 S Q -1.8759 Soluble
30 M Q -1.6639 Soluble
35 N Q -2.3826 Soluble
36 N Q -2.1409 Soluble
37 Y Q -1.1774 Soluble
38 Y Q -0.5462 Soluble
39 W Q 0.0000 Buried
40 T Q 0.0000 Buried
41 W Q 0.0000 Buried
42 I Q 0.0000 Buried
43 R Q 0.0000 Buried
44 Q Q -0.8536 Soluble
45 S Q -1.0138 Soluble
46 P Q -1.0714 Soluble
47 G Q -1.4873 Soluble
48 K Q -2.2763 Soluble
49 G Q -1.5410 Soluble
50 L Q 0.0000 Buried
51 E Q -1.0608 Soluble
52 W Q 0.0000 Buried
53 I Q 0.0000 Buried
54 G Q 0.0000 Buried
55 Y Q 0.1163 Aggregation-prone
56 I Q 0.0000 Buried
57 S Q -1.7231 Soluble
58 D Q -2.8177 Soluble
59 R Q -3.4110 Soluble
63 E Q -3.2592 Soluble
64 S Q -1.8571 Soluble
65 A Q -0.6911 Soluble
66 T Q 0.1210 Aggregation-prone
67 Y Q 0.0670 Aggregation-prone
68 N Q 0.0000 Buried
69 P Q -0.7616 Soluble
70 S Q -0.7567 Soluble
71 L Q -0.7949 Soluble
72 N Q -1.5138 Soluble
74 S Q -0.8311 Soluble
75 R Q -0.8831 Soluble
76 V Q 0.0000 Buried
77 V Q 0.3436 Aggregation-prone
78 I Q 0.0000 Buried
79 S Q -0.7381 Soluble
80 R Q -1.5922 Soluble
81 D Q -1.8160 Soluble
82 T Q -1.7245 Soluble
83 S Q -1.6320 Soluble
84 K Q -2.5241 Soluble
85 N Q -2.2036 Soluble
86 Q Q -1.5966 Soluble
87 L Q 0.0000 Buried
88 S Q -0.6827 Soluble
89 L Q 0.0000 Buried
90 K Q -1.1346 Soluble
91 L Q 0.0000 Buried
92 N Q -1.2138 Soluble
93 S Q -0.9898 Soluble
94 V Q -0.7872 Soluble
95 T Q -0.5864 Soluble
96 P Q -0.4528 Soluble
97 A Q -0.0999 Soluble
98 D Q 0.0000 Buried
99 T Q 0.0591 Aggregation-prone
100 A Q 0.0000 Buried
101 V Q -0.1293 Soluble
102 Y Q 0.0000 Buried
103 Y Q 0.0000 Buried
104 C Q 0.0000 Buried
105 A Q 0.0000 Buried
106 T Q 0.0000 Buried
107 A Q 0.0000 Buried
108 R Q -1.3740 Soluble
109 R Q -1.5866 Soluble
110 G Q -1.1253 Soluble
111 Q Q -0.7214 Soluble
111A R Q -0.2279 Soluble
111B I Q 1.3337 Aggregation-prone
111C Y Q 1.0789 Aggregation-prone
111D G Q 1.3110 Aggregation-prone
111E V Q 2.4855 Aggregation-prone
111F V Q 2.8085 Aggregation-prone
112G S Q 1.7044 Aggregation-prone
112F F Q 2.3540 Aggregation-prone
112E G Q 1.2184 Aggregation-prone
112D E Q 1.0291 Aggregation-prone
112C F Q 1.2675 Aggregation-prone
112B F Q 0.2967 Aggregation-prone
112A Y Q 0.1305 Aggregation-prone
112 Y Q 0.0000 Buried
113 Y Q 0.0000 Buried
114 S Q 0.0000 Buried
115 M Q 0.0000 Buried
116 D Q -0.5324 Soluble
117 V Q 0.1249 Aggregation-prone
118 W Q 0.0000 Buried
119 G Q 0.0000 Buried
120 K Q -2.4262 Soluble
121 G Q 0.0000 Buried
122 T Q -0.6932 Soluble
123 T Q 0.0527 Aggregation-prone
124 V Q 0.0000 Buried
125 T Q 0.2080 Aggregation-prone
11 L R 0.8519 Aggregation-prone
12 S R 0.5005 Aggregation-prone
13 V R 0.4470 Aggregation-prone
14 A R 0.3445 Aggregation-prone
15 L R 0.6822 Aggregation-prone
16 G R -0.9088 Soluble
17 E R -1.8992 Soluble
18 T R -1.3433 Soluble
19 A R 0.0000 Buried
20 R R -1.9291 Soluble
21 I R 0.0000 Buried
22 S R -1.2271 Soluble
23 C R -1.3126 Soluble
24 G R -1.3631 Soluble
25 R R -1.6509 Soluble
26 Q R -1.8372 Soluble
27 A R -0.6702 Soluble
28 L R 0.2401 Aggregation-prone
29 G R -0.0770 Soluble
36 S R 0.2402 Aggregation-prone
37 R R 0.0000 Buried
38 A R 0.0000 Buried
39 V R 0.0000 Buried
40 Q R 0.0000 Buried
41 W R 0.0000 Buried
42 Y R 0.0000 Buried
43 Q R -0.6181 Soluble
44 H R 0.0000 Buried
45 R R -2.6524 Soluble
46 P R -1.8381 Soluble
47 G R -1.9159 Soluble
48 Q R -2.4640 Soluble
49 A R -1.4134 Soluble
50 P R 0.0000 Buried
51 I R 0.1162 Aggregation-prone
52 L R 0.0000 Buried
53 L R 0.0000 Buried
54 I R 0.0000 Buried
55 Y R -0.9187 Soluble
56 N R -1.4857 Soluble
57 N R 0.0000 Buried
65 Q R -1.9870 Soluble
66 D R -1.7405 Soluble
67 R R -1.5877 Soluble
68 P R -0.7897 Soluble
69 S R -0.7929 Soluble
70 G R -0.6967 Soluble
71 I R -0.6450 Soluble
72 P R -1.2693 Soluble
74 E R -2.1891 Soluble
75 R R -1.5215 Soluble
76 F R 0.0000 Buried
77 S R -1.0733 Soluble
78 G R -0.9122 Soluble
79 T R -0.5018 Soluble
80 P R -0.6466 Soluble
81 D R -0.0325 Soluble
81A I R 1.5305 Aggregation-prone
82 N R 0.3775 Aggregation-prone
83 F R 1.3605 Aggregation-prone
84 G R -0.0093 Soluble
85 T R -0.4867 Soluble
86 R R -1.6591 Soluble
87 A R 0.0000 Buried
88 T R -1.0020 Soluble
89 L R 0.0000 Buried
90 T R -0.9900 Soluble
91 I R 0.0000 Buried
92 S R -1.4130 Soluble
93 G R -1.0764 Soluble
94 V R 0.0000 Buried
95 E R -1.6145 Soluble
96 A R -0.7247 Soluble
97 G R -1.3712 Soluble
98 D R 0.0000 Buried
99 E R -1.6288 Soluble
100 A R 0.0000 Buried
101 D R 0.0000 Buried
102 Y R 0.0000 Buried
103 Y R 0.0000 Buried
104 C R 0.0000 Buried
105 H R 0.0000 Buried
106 M R 0.0000 Buried
107 W R 0.0000 Buried
108 D R 0.0000 Buried
109 S R -0.6500 Soluble
110 R R -1.8119 Soluble
112 S R -0.9572 Soluble
113 G R -0.6208 Soluble
114 F R 0.4123 Aggregation-prone
115 S R 0.1686 Aggregation-prone
116 W R 0.0240 Aggregation-prone
117 S R -0.4420 Soluble
118 F R 0.0000 Buried
119 G R -1.0994 Soluble
120 G R -1.3991 Soluble
121 A R -1.1132 Soluble
122 T R -0.8860 Soluble
123 R R -1.6881 Soluble
124 L R 0.0000 Buried
125 T R 0.1173 Aggregation-prone
126 V R 1.2264 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
Load structure to view sequence…
Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.415 4.5616 CSV PDB
4.5 -0.4498 4.5238 CSV PDB
5.0 -0.4929 4.4724 CSV PDB
5.5 -0.5371 4.416 CSV PDB
6.0 -0.5743 4.3633 CSV PDB
6.5 -0.5983 4.3232 CSV PDB
7.0 -0.6072 4.3003 CSV PDB
7.5 -0.6048 4.2905 CSV PDB
8.0 -0.5958 4.287 CSV PDB
8.5 -0.5821 4.2859 CSV PDB
9.0 -0.5639 4.2855 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH