Zinlirvimab / 7ugn

A4DAB308_7ugn_N_Q | Source PDB: 7ugn | Chains: N, Q | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.5782
Max Score
2.9105
Min Score
-3.6652
Total Score
-137.03
Score CDR
-0.3271
Score non-CDR
-0.6671

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSALSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) N (Heavy), Q (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6652
Maximum Score 2.9105
Average Score -0.5782
Total Score -137.0336

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q N -1.4652 Soluble
2 V N -1.0364 Soluble
3 Q N -1.6312 Soluble
4 L N -1.2673 Soluble
5 Q N -1.9386 Soluble
6 E N -1.4425 Soluble
7 S N -0.8809 Soluble
8 G N -0.4439 Soluble
9 P N 0.0048 Aggregation-prone
11 G N 0.4633 Aggregation-prone
12 L N 1.0601 Aggregation-prone
13 V N -0.3911 Soluble
14 K N -1.8980 Soluble
15 P N -1.6021 Soluble
16 S N -1.7673 Soluble
17 E N -2.5163 Soluble
18 T N -1.7638 Soluble
19 L N 0.0000 Buried
20 S N -0.7156 Soluble
21 V N 0.0000 Buried
22 T N -0.7122 Soluble
23 C N 0.0000 Buried
24 S N -1.2179 Soluble
25 V N 0.0000 Buried
26 S N -1.2403 Soluble
27 G N -1.3042 Soluble
28 D N -1.5680 Soluble
29 S N -1.1811 Soluble
30 M N -1.4610 Soluble
35 N N -2.1115 Soluble
36 N N -2.0870 Soluble
37 Y N -1.1219 Soluble
38 Y N -0.5945 Soluble
39 W N 0.0000 Buried
40 T N 0.0000 Buried
41 W N 0.0000 Buried
42 I N 0.0000 Buried
43 R N 0.0000 Buried
44 Q N -1.0289 Soluble
45 S N -1.1241 Soluble
46 P N -1.1244 Soluble
47 G N -1.5395 Soluble
48 K N -2.4521 Soluble
49 G N -1.8134 Soluble
50 L N -1.2034 Soluble
51 E N -1.4339 Soluble
52 W N 0.0000 Buried
53 I N 0.0000 Buried
54 G N 0.0000 Buried
55 Y N 0.3118 Aggregation-prone
56 I N 0.0000 Buried
57 S N -1.9663 Soluble
58 D N -3.5339 Soluble
59 R N -3.6652 Soluble
63 E N -3.3831 Soluble
64 S N -1.9274 Soluble
65 A N -0.5504 Soluble
66 T N -0.0867 Soluble
67 Y N 0.0304 Aggregation-prone
68 N N 0.0000 Buried
69 P N -0.6096 Soluble
70 S N -0.5996 Soluble
71 L N -0.8119 Soluble
72 N N -1.5861 Soluble
74 S N -1.0277 Soluble
75 R N -1.2480 Soluble
76 V N 0.0000 Buried
77 V N 0.6657 Aggregation-prone
78 I N 0.2510 Aggregation-prone
79 S N -0.5432 Soluble
80 R N -1.6226 Soluble
81 D N -1.7588 Soluble
82 T N -1.4268 Soluble
83 S N -1.5528 Soluble
84 K N -2.3772 Soluble
85 N N -1.8559 Soluble
86 Q N -1.6124 Soluble
87 L N 0.0000 Buried
88 S N -0.4150 Soluble
89 L N 0.0000 Buried
90 K N -0.7892 Soluble
91 L N 0.0000 Buried
92 N N -1.8415 Soluble
93 S N -1.4809 Soluble
94 V N 0.0000 Buried
95 T N -0.9136 Soluble
96 P N -0.6793 Soluble
97 A N -0.2129 Soluble
98 D N -0.3313 Soluble
99 T N -0.2587 Soluble
100 A N 0.0000 Buried
101 V N -0.1718 Soluble
102 Y N 0.0000 Buried
103 Y N 0.0000 Buried
104 C N 0.0000 Buried
105 A N 0.0000 Buried
106 T N 0.0000 Buried
107 A N 0.0000 Buried
108 R N -1.6714 Soluble
109 R N -1.7789 Soluble
110 G N -1.2589 Soluble
111 Q N -0.7688 Soluble
111A R N 0.0505 Aggregation-prone
111B I N 1.5428 Aggregation-prone
111C Y N 1.3754 Aggregation-prone
111D G N 1.5133 Aggregation-prone
111E V N 2.6259 Aggregation-prone
111F V N 2.9105 Aggregation-prone
112G S N 1.7247 Aggregation-prone
112F F N 2.3962 Aggregation-prone
112E G N 1.3261 Aggregation-prone
112D E N 1.0957 Aggregation-prone
112C F N 1.3811 Aggregation-prone
112B F N 0.5099 Aggregation-prone
112A Y N 0.1585 Aggregation-prone
112 Y N 0.0000 Buried
113 Y N -0.7093 Soluble
114 S N 0.0000 Buried
115 M N 0.0000 Buried
116 D N -0.6826 Soluble
117 V N -0.0612 Soluble
118 W N -0.4306 Soluble
119 G N -1.3070 Soluble
120 K N -2.2608 Soluble
121 G N 0.0000 Buried
122 T N -0.7222 Soluble
123 T N -0.1471 Soluble
124 V N 0.0000 Buried
125 T N 0.1245 Aggregation-prone
126 V N 0.0000 Buried
127 S N -0.5525 Soluble
128 S N -0.6525 Soluble
129 A N -0.1984 Soluble
11 L Q 0.7875 Aggregation-prone
12 S Q 0.6797 Aggregation-prone
13 V Q 0.0000 Buried
14 A Q 0.2377 Aggregation-prone
15 L Q 0.1493 Aggregation-prone
16 G Q -1.2011 Soluble
17 E Q -1.9746 Soluble
18 T Q -1.3758 Soluble
19 A Q 0.0000 Buried
20 R Q -1.9270 Soluble
21 I Q 0.0000 Buried
22 S Q -1.0918 Soluble
23 C Q -0.9050 Soluble
24 G Q -1.3548 Soluble
25 R Q -1.5661 Soluble
26 Q Q -1.7241 Soluble
27 A Q -0.5436 Soluble
28 L Q 0.7654 Aggregation-prone
29 G Q 0.3100 Aggregation-prone
36 S Q 0.0000 Buried
37 R Q 0.0000 Buried
38 A Q 0.0000 Buried
39 V Q 0.0000 Buried
40 Q Q 0.0000 Buried
41 W Q 0.0000 Buried
42 Y Q 0.0000 Buried
43 Q Q 0.0000 Buried
44 H Q 0.0000 Buried
45 R Q -1.6883 Soluble
46 P Q -1.4446 Soluble
47 G Q -1.5756 Soluble
48 Q Q -1.9773 Soluble
49 A Q -1.0206 Soluble
50 P Q 0.0000 Buried
51 I Q 0.6161 Aggregation-prone
52 L Q 0.4651 Aggregation-prone
53 L Q 0.0000 Buried
54 I Q 0.0000 Buried
55 Y Q -0.2887 Soluble
56 N Q -0.9432 Soluble
57 N Q 0.0000 Buried
65 Q Q -1.9687 Soluble
66 D Q -1.9233 Soluble
67 R Q -2.6821 Soluble
68 P Q 0.0000 Buried
69 S Q -1.2145 Soluble
70 G Q -1.0446 Soluble
71 I Q 0.0000 Buried
72 P Q -1.6206 Soluble
74 E Q -2.5357 Soluble
75 R Q -1.6571 Soluble
76 F Q 0.0000 Buried
77 S Q -1.5114 Soluble
78 G Q -1.0964 Soluble
79 T Q -0.6141 Soluble
80 P Q -0.4089 Soluble
81 D Q 0.2836 Aggregation-prone
81A I Q 1.7491 Aggregation-prone
82 N Q 0.4548 Aggregation-prone
83 F Q 1.5097 Aggregation-prone
84 G Q 0.0302 Aggregation-prone
85 T Q -0.7543 Soluble
86 R Q -2.1251 Soluble
87 A Q -1.3726 Soluble
88 T Q -1.0231 Soluble
89 L Q 0.0000 Buried
90 T Q -1.0193 Soluble
91 I Q 0.0000 Buried
92 S Q -1.6111 Soluble
93 G Q -1.2645 Soluble
94 V Q 0.0000 Buried
95 E Q -2.2937 Soluble
96 A Q -1.1446 Soluble
97 G Q -1.5974 Soluble
98 D Q 0.0000 Buried
99 E Q -2.6607 Soluble
100 A Q 0.0000 Buried
101 D Q -1.4505 Soluble
102 Y Q 0.0000 Buried
103 Y Q 0.0000 Buried
104 C Q 0.0000 Buried
105 H Q 0.0000 Buried
106 M Q 0.0000 Buried
107 W Q 0.0000 Buried
108 D Q 0.0000 Buried
109 S Q -0.4578 Soluble
110 R Q -1.6477 Soluble
112 S Q -0.9136 Soluble
113 G Q -0.5152 Soluble
114 F Q 0.5334 Aggregation-prone
115 S Q 0.2846 Aggregation-prone
116 W Q 0.0034 Aggregation-prone
117 S Q -0.4142 Soluble
118 F Q 0.0000 Buried
119 G Q -0.7380 Soluble
120 G Q -0.9602 Soluble
121 A Q -0.9928 Soluble
122 T Q -0.8357 Soluble
123 R Q -1.8407 Soluble
124 L Q 0.0000 Buried
125 T Q -0.2006 Soluble
126 V Q 0.5417 Aggregation-prone
127 L Q 1.5236 Aggregation-prone
128 G Q 0.3538 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.4539 4.588 CSV PDB
4.5 -0.4917 4.5512 CSV PDB
5.0 -0.5385 4.5012 CSV PDB
5.5 -0.5863 4.4463 CSV PDB
6.0 -0.6263 4.4239 CSV PDB
6.5 -0.6518 4.4123 CSV PDB
7.0 -0.6616 4.401 CSV PDB
7.5 -0.6594 4.3902 CSV PDB
8.0 -0.65 4.3809 CSV PDB
8.5 -0.6355 4.3743 CSV PDB
9.0 -0.6162 4.3709 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH