Zinlirvimab / 6ccb

A4DAB308_6ccb_D_E | Source PDB: 6ccb | Chains: D, E | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6404
Max Score
2.9642
Min Score
-3.228
Total Score
-280.51
Score CDR
-0.2804
Score non-CDR
-0.6998

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSASTKGPSVFPLAPSSKTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTEC input.pdb
Selected Chain(s) D (Heavy), E (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.228
Maximum Score 2.9642
Average Score -0.6404
Total Score -280.5125

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q D -1.6357 Soluble
2 V D -1.0397 Soluble
3 Q D -1.7447 Soluble
4 L D 0.0000 Buried
5 Q D -1.1715 Soluble
6 E D 0.0000 Buried
7 S D -0.4804 Soluble
8 G D -0.4175 Soluble
9 P D -0.5983 Soluble
11 G D 0.0000 Buried
12 L D -0.3858 Soluble
13 V D -1.1429 Soluble
14 K D -2.3280 Soluble
15 P D -1.7356 Soluble
16 S D -1.7945 Soluble
17 E D -2.6596 Soluble
18 T D -1.7966 Soluble
19 L D 0.0000 Buried
20 S D -0.7654 Soluble
21 V D 0.0000 Buried
22 T D -0.4895 Soluble
23 C D 0.0000 Buried
24 S D -1.0187 Soluble
25 V D 0.0000 Buried
26 S D -1.5604 Soluble
27 G D -1.6631 Soluble
28 D D -2.0967 Soluble
29 S D -1.4449 Soluble
30 M D 0.0000 Buried
35 N D -2.5799 Soluble
36 N D -1.9526 Soluble
37 Y D -0.9658 Soluble
38 Y D 0.0000 Buried
39 W D 0.0000 Buried
40 T D 0.0000 Buried
41 W D 0.0000 Buried
42 I D 0.0000 Buried
43 R D -0.5274 Soluble
44 Q D -1.0099 Soluble
45 S D -1.0458 Soluble
46 P D -1.0970 Soluble
47 G D -1.5162 Soluble
48 K D -2.2943 Soluble
49 G D -1.6582 Soluble
50 L D 0.0000 Buried
51 E D -1.1232 Soluble
52 W D 0.0000 Buried
53 I D 0.0000 Buried
54 G D 0.0000 Buried
55 Y D 0.1798 Aggregation-prone
56 I D 0.0000 Buried
57 S D -1.7348 Soluble
58 D D -2.4923 Soluble
59 R D -3.1935 Soluble
63 E D -3.2280 Soluble
64 S D -1.7732 Soluble
65 A D -0.7207 Soluble
66 T D 0.0054 Aggregation-prone
67 Y D 0.1860 Aggregation-prone
68 N D 0.0000 Buried
69 P D -0.6567 Soluble
70 S D -0.7158 Soluble
71 L D 0.0000 Buried
72 N D -1.5771 Soluble
74 S D -1.0141 Soluble
75 R D -1.1111 Soluble
76 V D 0.0000 Buried
77 V D 0.1153 Aggregation-prone
78 I D 0.0000 Buried
79 S D -0.7796 Soluble
80 R D -1.4571 Soluble
81 D D -1.8120 Soluble
82 T D -1.4668 Soluble
83 S D -1.4705 Soluble
84 K D -2.3943 Soluble
85 N D -2.2041 Soluble
86 Q D -1.6363 Soluble
87 L D 0.0000 Buried
88 S D -0.6330 Soluble
89 L D 0.0000 Buried
90 K D -0.9223 Soluble
91 L D 0.0000 Buried
92 N D -1.6354 Soluble
93 S D -1.5654 Soluble
94 V D 0.0000 Buried
95 T D -0.8948 Soluble
96 P D -0.5579 Soluble
97 A D -0.1197 Soluble
98 D D 0.0000 Buried
99 T D -0.0533 Soluble
100 A D 0.0000 Buried
101 V D 0.1437 Aggregation-prone
102 Y D 0.0000 Buried
103 Y D 0.0000 Buried
104 C D 0.0000 Buried
105 A D 0.0000 Buried
106 T D 0.0000 Buried
107 A D 0.0000 Buried
108 R D -1.6090 Soluble
109 R D -1.6127 Soluble
110 G D -0.8959 Soluble
111 Q D -0.3874 Soluble
111A R D 0.2517 Aggregation-prone
111B I D 1.9068 Aggregation-prone
111C Y D 1.5408 Aggregation-prone
111D G D 1.7345 Aggregation-prone
111E V D 2.6905 Aggregation-prone
111F V D 2.9642 Aggregation-prone
112G S D 1.7694 Aggregation-prone
112F F D 2.3601 Aggregation-prone
112E G D 1.4172 Aggregation-prone
112D E D 1.3504 Aggregation-prone
112C F D 1.5091 Aggregation-prone
112B F D 0.4620 Aggregation-prone
112A Y D 0.3395 Aggregation-prone
112 Y D -0.1408 Soluble
113 Y D 0.0000 Buried
114 S D 0.0000 Buried
115 M D 0.0000 Buried
116 D D -0.5381 Soluble
117 V D 0.0685 Aggregation-prone
118 W D -0.3288 Soluble
119 G D 0.0000 Buried
120 K D -2.2583 Soluble
121 G D -1.2087 Soluble
122 T D -0.5424 Soluble
123 T D -0.0972 Soluble
124 V D 0.0000 Buried
125 T D -0.1810 Soluble
126 V D 0.0000 Buried
127 S D -0.6997 Soluble
128 S D -0.8435 Soluble
129 A D -0.5705 Soluble
130 S D -0.7719 Soluble
131 T D -0.9936 Soluble
132 K D -2.0302 Soluble
133 G D -1.9883 Soluble
134 P D -1.0414 Soluble
135 S D -0.4628 Soluble
136 V D 0.0000 Buried
137 F D -0.5387 Soluble
138 P D -1.2283 Soluble
139 L D 0.0000 Buried
140 A D -1.4846 Soluble
141 P D 0.0000 Buried
142 S D -1.1932 Soluble
143 S D -1.3768 Soluble
144 K D -1.7920 Soluble
145 T D -0.4567 Soluble
146 A D -0.5457 Soluble
147 A D -0.2878 Soluble
148 L D 0.0000 Buried
149 G D 0.0000 Buried
150 C D 0.0000 Buried
151 L D 0.0000 Buried
152 V D 0.0000 Buried
153 K D 0.0000 Buried
154 D D -0.8050 Soluble
155 Y D 0.0000 Buried
156 F D -0.7089 Soluble
157 P D 0.0000 Buried
158 E D -0.5313 Soluble
159 P D -0.6640 Soluble
160 V D -0.6799 Soluble
161 T D -0.7223 Soluble
162 V D -0.3503 Soluble
163 S D -0.3816 Soluble
164 W D 0.0000 Buried
165 N D -0.8998 Soluble
166 S D -0.6388 Soluble
167 G D -0.5302 Soluble
168 A D -0.2401 Soluble
169 L D 0.0016 Aggregation-prone
170 T D -0.0973 Soluble
171 S D -0.1633 Soluble
172 G D -0.1378 Soluble
173 V D 0.4110 Aggregation-prone
174 H D -0.0216 Soluble
175 T D 0.0183 Aggregation-prone
176 F D 0.0000 Buried
177 P D 0.0404 Aggregation-prone
178 A D 0.2160 Aggregation-prone
179 V D 0.0000 Buried
180 L D 1.2906 Aggregation-prone
181 Q D 0.2708 Aggregation-prone
182 S D -0.1328 Soluble
183 S D -0.2408 Soluble
184 G D 0.0186 Aggregation-prone
185 L D 0.0098 Aggregation-prone
186 Y D 0.4708 Aggregation-prone
187 S D 0.0000 Buried
188 L D 0.0000 Buried
189 S D 0.0000 Buried
190 S D 0.0000 Buried
191 V D 0.2823 Aggregation-prone
192 V D 0.0000 Buried
193 T D -0.1217 Soluble
194 V D 0.0000 Buried
195 P D -0.3456 Soluble
196 S D -0.6192 Soluble
197 S D -0.5138 Soluble
198 S D 0.0000 Buried
199 L D -0.6893 Soluble
200 G D -1.0203 Soluble
201 T D -0.8220 Soluble
202 Q D -1.4952 Soluble
203 T D -1.2846 Soluble
204 Y D 0.0000 Buried
205 I D -1.4890 Soluble
206 C D 0.0000 Buried
207 N D -1.5495 Soluble
208 V D 0.0000 Buried
209 N D -2.4126 Soluble
210 H D 0.0000 Buried
211 K D -2.8422 Soluble
212 P D -1.7076 Soluble
213 S D -2.1133 Soluble
214 N D -2.5644 Soluble
215 T D -2.1461 Soluble
216 K D -2.8798 Soluble
217 V D -1.5832 Soluble
218 D D -2.4473 Soluble
219 K D -2.0935 Soluble
220 R D -2.7445 Soluble
221 V D 0.0000 Buried
222 E D -2.9232 Soluble
223 P D -1.8604 Soluble
224 K D -1.9019 Soluble
225 S D -0.8248 Soluble
226 C D 0.0428 Aggregation-prone
11 L E 0.5951 Aggregation-prone
12 S E 0.4188 Aggregation-prone
13 V E 0.0000 Buried
14 A E -0.2806 Soluble
15 L E -0.5451 Soluble
16 G E -1.3570 Soluble
17 E E -1.7023 Soluble
18 T E -1.4106 Soluble
19 A E 0.0000 Buried
20 R E -1.8964 Soluble
21 I E 0.0000 Buried
22 S E -0.9486 Soluble
23 C E -1.3346 Soluble
24 G E -1.3732 Soluble
25 R E -1.9718 Soluble
26 Q E -2.0583 Soluble
27 A E -1.0439 Soluble
28 L E -0.5109 Soluble
29 G E -0.6229 Soluble
36 S E 0.1847 Aggregation-prone
37 R E 0.0000 Buried
38 A E 0.0000 Buried
39 V E 0.0000 Buried
40 Q E 0.0000 Buried
41 W E 0.0000 Buried
42 Y E 0.0000 Buried
43 Q E -0.0652 Soluble
44 H E 0.0000 Buried
45 R E -0.9914 Soluble
46 P E -1.1090 Soluble
47 G E -1.4131 Soluble
48 Q E -1.7340 Soluble
49 A E -0.9137 Soluble
50 P E 0.0000 Buried
51 I E 0.8038 Aggregation-prone
52 L E 0.0000 Buried
53 L E 0.0000 Buried
54 I E 0.0000 Buried
55 Y E -0.4582 Soluble
56 N E -0.8520 Soluble
57 N E -1.0990 Soluble
65 Q E -1.4017 Soluble
66 D E -1.7175 Soluble
67 R E -1.5346 Soluble
68 P E -0.8385 Soluble
69 S E -0.6524 Soluble
70 G E -0.7952 Soluble
71 I E -0.6507 Soluble
72 P E -1.3550 Soluble
74 E E -2.2891 Soluble
75 R E -1.6091 Soluble
76 F E 0.0000 Buried
77 S E -1.3290 Soluble
78 G E -1.1175 Soluble
79 T E -0.7171 Soluble
80 P E -0.3072 Soluble
81 D E 0.0888 Aggregation-prone
81A I E 1.6229 Aggregation-prone
82 N E 0.4041 Aggregation-prone
83 F E 1.1883 Aggregation-prone
84 G E 0.1107 Aggregation-prone
85 T E -0.5776 Soluble
86 R E -2.0535 Soluble
87 A E 0.0000 Buried
88 T E 0.0000 Buried
89 L E 0.0000 Buried
90 T E -1.0397 Soluble
91 I E 0.0000 Buried
92 S E -1.5781 Soluble
93 G E -1.3070 Soluble
94 V E 0.0000 Buried
95 E E -2.1245 Soluble
96 A E -1.3464 Soluble
97 G E -1.3842 Soluble
98 D E 0.0000 Buried
99 E E -0.9004 Soluble
100 A E 0.0000 Buried
101 D E 0.0000 Buried
102 Y E 0.0000 Buried
103 Y E 0.0000 Buried
104 C E 0.0000 Buried
105 H E 0.0000 Buried
106 M E 0.0000 Buried
107 W E 0.0000 Buried
108 D E 0.0000 Buried
109 S E -0.9516 Soluble
110 R E -1.8700 Soluble
112 S E -0.8896 Soluble
113 G E -0.3401 Soluble
114 F E 0.6020 Aggregation-prone
115 S E 0.3241 Aggregation-prone
116 W E 0.0888 Aggregation-prone
117 S E -0.3372 Soluble
118 F E 0.0000 Buried
119 G E -0.8604 Soluble
120 G E -1.0925 Soluble
121 A E -1.0501 Soluble
122 T E -0.8215 Soluble
123 R E -1.5861 Soluble
124 L E 0.0000 Buried
125 T E -0.0617 Soluble
126 V E 0.0000 Buried
127 L E 0.4188 Aggregation-prone
128 G E -0.3080 Soluble
129 Q E -0.9026 Soluble
130 P E -1.1978 Soluble
131 K E -2.2608 Soluble
132 A E -1.0648 Soluble
133 A E -0.6410 Soluble
134 P E 0.0000 Buried
135 S E -0.2765 Soluble
136 V E 0.0000 Buried
137 T E -0.4962 Soluble
138 L E 0.0000 Buried
139 F E 0.0000 Buried
140 P E -0.0802 Soluble
141 P E 0.0000 Buried
142 S E 0.0000 Buried
143 S E -1.5115 Soluble
144 E E -2.3350 Soluble
145 E E 0.0000 Buried
146 L E -2.1863 Soluble
147 Q E -2.3981 Soluble
148 A E -1.9918 Soluble
149 N E -2.7557 Soluble
150 K E -2.7571 Soluble
151 A E 0.0000 Buried
152 T E 0.0000 Buried
153 L E 0.0000 Buried
154 V E 0.0000 Buried
155 C E 0.0000 Buried
156 L E 0.0000 Buried
157 I E 0.0000 Buried
158 S E -0.6325 Soluble
159 D E -1.3343 Soluble
160 F E 0.0000 Buried
161 Y E -1.3558 Soluble
162 P E -0.9146 Soluble
163 G E -0.7853 Soluble
164 A E -0.3047 Soluble
165 V E -0.1891 Soluble
166 T E -0.1113 Soluble
167 V E 0.0228 Aggregation-prone
168 A E -0.3395 Soluble
169 W E 0.0000 Buried
170 K E -0.6934 Soluble
171 A E 0.0000 Buried
172 D E -1.1924 Soluble
173 S E -0.5906 Soluble
174 S E -0.6687 Soluble
175 P E -0.7165 Soluble
176 V E -0.5606 Soluble
177 K E -1.4776 Soluble
178 A E -0.6114 Soluble
179 G E -0.3693 Soluble
180 V E -0.1229 Soluble
181 E E -0.0973 Soluble
182 T E 0.1211 Aggregation-prone
183 T E 0.0000 Buried
184 T E -0.1959 Soluble
185 P E -0.3823 Soluble
186 S E -0.7572 Soluble
187 K E -1.5582 Soluble
188 Q E -1.4745 Soluble
189 S E -1.2751 Soluble
190 N E -1.5554 Soluble
191 N E -1.8981 Soluble
192 K E -1.7967 Soluble
193 Y E -0.9688 Soluble
194 A E 0.0000 Buried
195 A E 0.0000 Buried
196 S E 0.0000 Buried
197 S E 0.0000 Buried
198 Y E 0.0000 Buried
199 L E 0.0000 Buried
200 S E -0.2760 Soluble
201 L E -0.7404 Soluble
202 T E -1.7506 Soluble
203 P E 0.0000 Buried
204 E E -3.1477 Soluble
205 Q E -2.2389 Soluble
206 W E 0.0000 Buried
207 K E -3.0600 Soluble
208 S E -2.4225 Soluble
209 H E -2.3555 Soluble
210 R E -2.4859 Soluble
211 S E -1.6771 Soluble
212 Y E 0.0000 Buried
213 S E 0.0000 Buried
214 C E 0.0000 Buried
215 Q E -0.9530 Soluble
216 V E 0.0000 Buried
217 T E -0.6742 Soluble
218 H E 0.0000 Buried
219 E E -2.3005 Soluble
220 G E -1.4442 Soluble
221 S E -0.8769 Soluble
222 T E -0.6639 Soluble
223 V E -0.5441 Soluble
224 E E -1.8340 Soluble
225 K E -1.5606 Soluble
226 T E -0.8785 Soluble
227 V E -0.5214 Soluble
228 A E -1.2440 Soluble
229 P E -1.4498 Soluble
230 T E -1.4307 Soluble
231 E E -1.4778 Soluble
232 C E -0.6886 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6211 4.4871 CSV PDB
4.5 -0.6552 4.4572 CSV PDB
5.0 -0.6973 4.4159 CSV PDB
5.5 -0.7379 4.3701 CSV PDB
6.0 -0.7662 4.3269 CSV PDB
6.5 -0.7733 4.2935 CSV PDB
7.0 -0.7576 4.2741 CSV PDB
7.5 -0.7258 4.2657 CSV PDB
8.0 -0.6854 4.2626 CSV PDB
8.5 -0.6402 4.2616 CSV PDB
9.0 -0.5918 4.2613 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH