Zinlirvimab / 8ttw

A4DAB308_8ttw_O_P | Source PDB: 8ttw | Chains: O, P | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.511
Max Score
2.799
Min Score
-3.6695
Total Score
-118.54
Score CDR
-0.2398
Score non-CDR
-0.6099

Calculation Parameters

Chain Sequence(s) VQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTV input.pdb
Selected Chain(s) O (Heavy), P (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6695
Maximum Score 2.799
Average Score -0.511
Total Score -118.5429

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V O -0.1010 Soluble
3 Q O -1.3685 Soluble
4 L O 0.0000 Buried
5 Q O -1.8041 Soluble
6 E O 0.0000 Buried
7 S O -0.7126 Soluble
8 G O -0.3205 Soluble
9 P O 0.0859 Aggregation-prone
11 G O 0.5175 Aggregation-prone
12 L O 1.0392 Aggregation-prone
13 V O -0.4440 Soluble
14 K O -1.9295 Soluble
15 P O -1.6164 Soluble
16 S O -1.7937 Soluble
17 E O -2.5511 Soluble
18 T O -1.7613 Soluble
19 L O 0.0000 Buried
20 S O -0.6971 Soluble
21 V O 0.0000 Buried
22 T O -0.6570 Soluble
23 C O 0.0000 Buried
24 S O -1.2317 Soluble
25 V O 0.0000 Buried
26 S O -1.1533 Soluble
27 G O -1.2133 Soluble
28 D O -2.1774 Soluble
29 S O -1.5647 Soluble
30 M O 0.0000 Buried
35 N O -2.2175 Soluble
36 N O -1.9637 Soluble
37 Y O -0.7894 Soluble
38 Y O -0.6610 Soluble
39 W O 0.0000 Buried
40 T O 0.0000 Buried
41 W O 0.0000 Buried
42 I O 0.0000 Buried
43 R O -0.8615 Soluble
44 Q O -1.2945 Soluble
45 S O -1.2276 Soluble
46 P O -1.0785 Soluble
47 G O -1.4926 Soluble
48 K O -2.4277 Soluble
49 G O -1.8185 Soluble
50 L O 0.0000 Buried
51 E O -2.1625 Soluble
52 W O 0.0000 Buried
53 I O 0.0000 Buried
54 G O 0.0000 Buried
55 Y O -0.0359 Soluble
56 I O 0.0000 Buried
57 S O -2.2682 Soluble
58 D O -3.6400 Soluble
59 R O -3.6695 Soluble
63 E O -3.4583 Soluble
64 S O -2.0137 Soluble
65 A O -0.9469 Soluble
66 T O -0.0813 Soluble
67 Y O -0.1687 Soluble
68 N O 0.0000 Buried
69 P O -0.6121 Soluble
70 S O -0.7887 Soluble
71 L O -1.1755 Soluble
72 N O -1.9541 Soluble
74 S O -1.4877 Soluble
75 R O -2.4993 Soluble
76 V O 0.0000 Buried
77 V O -0.0759 Soluble
78 I O 0.0000 Buried
79 S O -0.8153 Soluble
80 R O -1.3519 Soluble
81 D O -1.7205 Soluble
82 T O -1.6365 Soluble
83 S O -1.5443 Soluble
84 K O -2.4334 Soluble
85 N O -2.2366 Soluble
86 Q O -1.7674 Soluble
87 L O 0.0000 Buried
88 S O -0.6009 Soluble
89 L O 0.0000 Buried
90 K O -1.2768 Soluble
91 L O 0.0000 Buried
92 N O -2.2350 Soluble
93 S O -1.6236 Soluble
94 V O 0.0000 Buried
95 T O -0.8950 Soluble
96 P O -0.8897 Soluble
97 A O -0.2464 Soluble
98 D O -0.3472 Soluble
99 T O -0.1021 Soluble
100 A O 0.0000 Buried
101 V O -0.1755 Soluble
102 Y O 0.0000 Buried
103 Y O 0.0000 Buried
104 C O 0.0000 Buried
105 A O 0.0000 Buried
106 T O 0.0000 Buried
107 A O 0.0000 Buried
108 R O -1.7432 Soluble
109 R O -1.4229 Soluble
110 G O -1.0433 Soluble
111 Q O -0.3941 Soluble
111A R O 0.6619 Aggregation-prone
111B I O 2.3548 Aggregation-prone
111C Y O 2.0704 Aggregation-prone
111D G O 1.8989 Aggregation-prone
111E V O 2.7536 Aggregation-prone
111F V O 2.7990 Aggregation-prone
112G S O 1.6251 Aggregation-prone
112F F O 2.3593 Aggregation-prone
112E G O 1.4211 Aggregation-prone
112D E O 1.4443 Aggregation-prone
112C F O 1.8630 Aggregation-prone
112B F O 0.8241 Aggregation-prone
112A Y O 0.5496 Aggregation-prone
112 Y O 0.0000 Buried
113 Y O 0.0000 Buried
114 S O 0.0000 Buried
115 M O 0.0000 Buried
116 D O -1.3132 Soluble
117 V O -0.3427 Soluble
118 W O 0.0000 Buried
119 G O 0.0000 Buried
120 K O -2.4842 Soluble
121 G O 0.0000 Buried
122 T O -0.6455 Soluble
123 T O -0.1238 Soluble
124 V O 0.0000 Buried
125 T O 0.0706 Aggregation-prone
126 V O 0.0000 Buried
127 S O -0.4890 Soluble
11 L P 1.1027 Aggregation-prone
12 S P 0.6754 Aggregation-prone
13 V P 0.9049 Aggregation-prone
14 A P 0.5955 Aggregation-prone
15 L P 0.4058 Aggregation-prone
16 G P -1.0206 Soluble
17 E P -1.9285 Soluble
18 T P -1.3363 Soluble
19 A P -1.1527 Soluble
20 R P -1.8937 Soluble
21 I P 0.0000 Buried
22 S P -0.8647 Soluble
23 C P 0.0000 Buried
24 G P -1.1636 Soluble
25 R P -1.2521 Soluble
26 Q P -1.3740 Soluble
27 A P -0.3118 Soluble
28 L P 0.5640 Aggregation-prone
29 G P 0.2838 Aggregation-prone
36 S P 0.7999 Aggregation-prone
37 R P 0.0000 Buried
38 A P 0.0000 Buried
39 V P 0.0000 Buried
40 Q P 0.0000 Buried
41 W P 0.0000 Buried
42 Y P 0.0000 Buried
43 Q P -0.2942 Soluble
44 H P 0.0000 Buried
45 R P -1.3271 Soluble
46 P P -1.1755 Soluble
47 G P -1.5792 Soluble
48 Q P -2.0291 Soluble
49 A P -1.2785 Soluble
50 P P 0.0000 Buried
51 I P 0.1040 Aggregation-prone
52 L P 0.0000 Buried
53 L P 0.0000 Buried
54 I P 0.0000 Buried
55 Y P -0.8652 Soluble
56 N P -1.0945 Soluble
57 N P 0.0000 Buried
65 Q P -1.5246 Soluble
66 D P -1.8006 Soluble
67 R P -1.6546 Soluble
68 P P -1.1423 Soluble
69 S P -0.8929 Soluble
70 G P -0.7948 Soluble
71 I P -0.6940 Soluble
72 P P -1.3073 Soluble
74 E P -2.2281 Soluble
75 R P -1.4554 Soluble
76 F P 0.0000 Buried
77 S P -1.2058 Soluble
78 G P 0.0000 Buried
79 T P -0.2569 Soluble
80 P P -0.4364 Soluble
81 D P 0.3366 Aggregation-prone
81A I P 1.6395 Aggregation-prone
82 N P 0.4043 Aggregation-prone
83 F P 1.6990 Aggregation-prone
84 G P 0.3039 Aggregation-prone
85 T P -0.0861 Soluble
86 R P -0.6892 Soluble
87 A P 0.0000 Buried
88 T P -0.7321 Soluble
89 L P 0.0000 Buried
90 T P -0.9467 Soluble
91 I P 0.0000 Buried
92 S P -1.2647 Soluble
93 G P -1.2529 Soluble
94 V P 0.0000 Buried
95 E P -1.8432 Soluble
96 A P -0.6051 Soluble
97 G P -0.8807 Soluble
98 D P 0.0000 Buried
99 E P -1.2157 Soluble
100 A P 0.0000 Buried
101 D P -1.2403 Soluble
102 Y P 0.0000 Buried
103 Y P 0.0000 Buried
104 C P 0.0000 Buried
105 H P 0.0000 Buried
106 M P 0.0000 Buried
107 W P 0.0000 Buried
108 D P 0.0000 Buried
109 S P -0.2878 Soluble
110 R P -1.6079 Soluble
112 S P -0.8039 Soluble
113 G P -0.4864 Soluble
114 F P 0.5098 Aggregation-prone
115 S P 0.0000 Buried
116 W P -0.0989 Soluble
117 S P -0.5922 Soluble
118 F P 0.0000 Buried
119 G P -0.8375 Soluble
120 G P -1.1710 Soluble
121 A P -1.0567 Soluble
122 T P -0.7727 Soluble
123 R P -1.4354 Soluble
124 L P 0.0000 Buried
125 T P 0.4956 Aggregation-prone
126 V P 1.4042 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.3443 4.7577 CSV PDB
4.5 -0.3853 4.7374 CSV PDB
5.0 -0.4374 4.7154 CSV PDB
5.5 -0.4917 4.693 CSV PDB
6.0 -0.5389 4.6703 CSV PDB
6.5 -0.5716 4.6476 CSV PDB
7.0 -0.5875 4.6251 CSV PDB
7.5 -0.5915 4.6032 CSV PDB
8.0 -0.5887 4.5829 CSV PDB
8.5 -0.5816 4.5664 CSV PDB
9.0 -0.5702 4.5559 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH