Ociperlimab / 8jep

A4DAB185_8jep_C_D | Source PDB: 8jep | Chains: C, D | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6772
Max Score
1.072
Min Score
-3.491
Total Score
-290.5
Score CDR
-0.3966
Score non-CDR
-0.7108

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVQPGGSLRLSCAASGFTFSDYYMYWVRQAPGKGLEWVAYITKGGGSTYYPDSVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCARQTNYDFTMDYWGQGTLVTVSSASTKGPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCEIVMTQSPATLSVSPGERATLSCKASQDVGTSVAWYQQKPGQAPRLLIYWASARHTGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYSSYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC input.pdb
Selected Chain(s) C (Heavy), D (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.491
Maximum Score 1.072
Average Score -0.6772
Total Score -290.4998

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E C -2.1643 Soluble
2 V C -1.3009 Soluble
3 Q C -1.3127 Soluble
4 L C 0.0000 Buried
5 V C 0.8139 Aggregation-prone
6 E C 0.0000 Buried
7 S C -0.4190 Soluble
8 G C -0.9199 Soluble
9 G C -0.5212 Soluble
11 G C -0.4322 Soluble
12 L C -0.0479 Soluble
13 V C -0.6017 Soluble
14 Q C -1.5635 Soluble
15 P C -1.6789 Soluble
16 G C -1.4682 Soluble
17 G C -1.1257 Soluble
18 S C -1.2764 Soluble
19 L C -1.1489 Soluble
20 R C -2.0191 Soluble
21 L C 0.0000 Buried
22 S C -0.3043 Soluble
23 C C 0.0000 Buried
24 A C -0.1233 Soluble
25 A C 0.0000 Buried
26 S C -1.0906 Soluble
27 G C -1.2992 Soluble
28 F C -0.7937 Soluble
29 T C -0.7233 Soluble
30 F C 0.0000 Buried
35 S C -1.8021 Soluble
36 D C -2.2616 Soluble
37 Y C -1.0251 Soluble
38 Y C -0.3885 Soluble
39 M C 0.0000 Buried
40 Y C 0.0000 Buried
41 W C 0.0000 Buried
42 V C 0.0000 Buried
43 R C 0.0000 Buried
44 Q C -0.7661 Soluble
45 A C -1.1780 Soluble
46 P C -0.9511 Soluble
47 G C -1.4683 Soluble
48 K C -2.2626 Soluble
49 G C -1.3634 Soluble
50 L C 0.0000 Buried
51 E C -0.9258 Soluble
52 W C 0.0000 Buried
53 V C 0.0000 Buried
54 A C 0.0000 Buried
55 Y C 0.0000 Buried
56 I C 0.0000 Buried
57 T C -0.9045 Soluble
58 K C -1.9362 Soluble
59 G C -1.6621 Soluble
62 G C -1.1783 Soluble
63 G C -0.9866 Soluble
64 S C -0.4776 Soluble
65 T C 0.1859 Aggregation-prone
66 Y C 0.4030 Aggregation-prone
67 Y C -0.5190 Soluble
68 P C -1.2983 Soluble
69 D C -2.4186 Soluble
70 S C -1.7461 Soluble
71 V C 0.0000 Buried
72 K C -2.4985 Soluble
74 G C -1.7634 Soluble
75 R C -1.4736 Soluble
76 F C 0.0000 Buried
77 T C -0.6359 Soluble
78 I C 0.0000 Buried
79 S C -0.3954 Soluble
80 R C -1.0989 Soluble
81 D C -1.4270 Soluble
82 N C -1.9177 Soluble
83 A C -1.2973 Soluble
84 K C -2.2356 Soluble
85 N C -1.6458 Soluble
86 T C -0.8451 Soluble
87 L C 0.0000 Buried
88 Y C -0.2268 Soluble
89 L C 0.0000 Buried
90 Q C -1.0648 Soluble
91 M C 0.0000 Buried
92 N C -1.5063 Soluble
93 S C -1.3236 Soluble
94 L C 0.0000 Buried
95 R C -2.2857 Soluble
96 A C -1.6838 Soluble
97 E C -2.2231 Soluble
98 D C 0.0000 Buried
99 T C -0.6970 Soluble
100 A C 0.0000 Buried
101 V C 0.2748 Aggregation-prone
102 Y C 0.0000 Buried
103 Y C 0.0000 Buried
104 C C 0.0000 Buried
105 A C 0.0000 Buried
106 R C 0.0000 Buried
107 Q C 0.0000 Buried
108 T C 0.0943 Aggregation-prone
109 N C -0.4840 Soluble
110 Y C 0.8728 Aggregation-prone
112 D C 0.4861 Aggregation-prone
113 F C 0.9045 Aggregation-prone
114 T C 0.0000 Buried
115 M C 0.0000 Buried
116 D C -0.1848 Soluble
117 Y C 0.1290 Aggregation-prone
118 W C -0.2362 Soluble
119 G C 0.0000 Buried
120 Q C -1.2436 Soluble
121 G C 0.0000 Buried
122 T C -0.0085 Soluble
123 L C 0.0907 Aggregation-prone
124 V C 0.0000 Buried
125 T C -0.4042 Soluble
126 V C 0.0000 Buried
127 S C -0.7239 Soluble
128 S C -0.6909 Soluble
129 A C -0.4217 Soluble
130 S C -0.5577 Soluble
131 T C -0.7502 Soluble
132 K C -1.2075 Soluble
133 G C -1.4375 Soluble
134 P C -0.6522 Soluble
135 S C -0.3980 Soluble
136 V C 0.0000 Buried
137 F C 0.0000 Buried
138 P C -1.1008 Soluble
139 L C 0.0000 Buried
140 A C -1.1596 Soluble
141 P C 0.0000 Buried
142 S C -0.4506 Soluble
143 T C -0.2705 Soluble
144 A C -0.1637 Soluble
145 A C 0.0000 Buried
146 L C 0.0000 Buried
147 G C 0.0000 Buried
148 C C 0.0000 Buried
149 L C 0.0000 Buried
150 V C 0.0000 Buried
151 K C -0.2882 Soluble
152 D C -0.4782 Soluble
153 Y C 0.0000 Buried
154 F C 0.0000 Buried
155 P C 0.0000 Buried
156 E C -0.5956 Soluble
157 P C -0.6965 Soluble
158 V C -0.6725 Soluble
159 T C -0.5705 Soluble
160 V C -0.1912 Soluble
161 S C -0.4161 Soluble
162 W C 0.0000 Buried
163 N C -0.7754 Soluble
164 S C -0.6972 Soluble
165 G C -0.5971 Soluble
166 A C -0.2611 Soluble
167 L C -0.0030 Soluble
168 T C -0.1847 Soluble
169 S C -0.1881 Soluble
170 G C -0.2409 Soluble
171 V C 0.1543 Aggregation-prone
172 H C -0.2864 Soluble
173 T C 0.0117 Aggregation-prone
174 F C 0.0000 Buried
175 P C -0.2014 Soluble
176 A C 0.2687 Aggregation-prone
177 V C 0.6114 Aggregation-prone
178 L C 1.0720 Aggregation-prone
179 Q C 0.2218 Aggregation-prone
180 S C -0.1795 Soluble
181 S C -0.2260 Soluble
182 G C 0.0391 Aggregation-prone
183 L C 0.1074 Aggregation-prone
184 Y C 0.4115 Aggregation-prone
185 S C 0.0000 Buried
186 L C 0.0000 Buried
187 S C 0.0000 Buried
188 S C 0.0000 Buried
189 V C 0.0000 Buried
190 V C 0.0000 Buried
191 T C -0.1660 Soluble
192 V C 0.0000 Buried
193 P C -0.5021 Soluble
194 S C -0.5661 Soluble
195 S C -0.5670 Soluble
196 S C 0.0000 Buried
197 L C -0.8645 Soluble
198 G C -1.0067 Soluble
199 T C -0.7438 Soluble
200 Q C -1.2644 Soluble
201 T C -1.0769 Soluble
202 Y C 0.0000 Buried
203 I C -1.1340 Soluble
204 C C 0.0000 Buried
205 N C -1.4818 Soluble
206 V C 0.0000 Buried
207 N C -2.0329 Soluble
208 H C 0.0000 Buried
209 K C -2.7883 Soluble
210 P C -1.6093 Soluble
211 S C -1.8552 Soluble
212 N C -2.5603 Soluble
213 T C -2.0969 Soluble
214 K C -2.7286 Soluble
215 V C -1.7167 Soluble
216 D C -2.4868 Soluble
217 K C -1.9224 Soluble
218 K C -2.3380 Soluble
219 V C 0.0000 Buried
220 E C -2.7468 Soluble
221 P C -1.6917 Soluble
222 K C -1.8468 Soluble
223 S C -1.0434 Soluble
224 C C 0.1237 Aggregation-prone
1 E D -1.4039 Soluble
2 I D 0.0000 Buried
3 V D 0.6827 Aggregation-prone
4 M D 0.0000 Buried
5 T D -0.4944 Soluble
6 Q D 0.0000 Buried
7 S D -0.5598 Soluble
8 P D -0.3435 Soluble
9 A D -0.2817 Soluble
10 T D -0.2527 Soluble
11 L D -0.1886 Soluble
12 S D -0.5908 Soluble
13 V D -1.3241 Soluble
14 S D -1.8156 Soluble
15 P D -1.9395 Soluble
16 G D -2.0853 Soluble
17 E D -3.2284 Soluble
18 R D -3.0200 Soluble
19 A D 0.0000 Buried
20 T D -0.7094 Soluble
21 L D 0.0000 Buried
22 S D -0.8888 Soluble
23 C D 0.0000 Buried
24 K D -2.3020 Soluble
25 A D 0.0000 Buried
26 S D -1.3747 Soluble
27 Q D -2.5281 Soluble
28 D D -3.0203 Soluble
29 V D 0.0000 Buried
36 G D -1.2366 Soluble
37 T D -0.3605 Soluble
38 S D 0.1750 Aggregation-prone
39 V D 0.0000 Buried
40 A D 0.0000 Buried
41 W D 0.0000 Buried
42 Y D 0.0000 Buried
43 Q D 0.0000 Buried
44 Q D 0.0000 Buried
45 K D -1.3827 Soluble
46 P D -1.2517 Soluble
47 G D -1.5408 Soluble
48 Q D -2.0015 Soluble
49 A D -1.2287 Soluble
50 P D 0.0000 Buried
51 R D -1.1009 Soluble
52 L D 0.0000 Buried
53 L D 0.0000 Buried
54 I D 0.0000 Buried
55 Y D 0.7358 Aggregation-prone
56 W D 1.0138 Aggregation-prone
57 A D 0.0000 Buried
65 S D -0.1175 Soluble
66 A D -0.1579 Soluble
67 R D -0.9795 Soluble
68 H D -0.7117 Soluble
69 T D -0.5953 Soluble
70 G D -0.6230 Soluble
71 I D -0.5642 Soluble
72 P D -0.4216 Soluble
74 A D -0.4373 Soluble
75 R D -0.7820 Soluble
76 F D 0.0000 Buried
77 S D -0.5147 Soluble
78 G D 0.0000 Buried
79 S D -0.5414 Soluble
80 G D -1.0333 Soluble
83 S D -1.1665 Soluble
84 G D -2.0195 Soluble
85 T D -2.5511 Soluble
86 E D -2.9741 Soluble
87 F D 0.0000 Buried
88 T D -0.8258 Soluble
89 L D 0.0000 Buried
90 T D -0.6640 Soluble
91 I D 0.0000 Buried
92 S D -1.7821 Soluble
93 S D -1.8906 Soluble
94 L D 0.0000 Buried
95 Q D -1.9382 Soluble
96 S D -1.8373 Soluble
97 E D -1.5210 Soluble
98 D D 0.0000 Buried
99 F D 0.0000 Buried
100 A D 0.0000 Buried
101 V D -0.2309 Soluble
102 Y D 0.0000 Buried
103 Y D 0.0000 Buried
104 C D 0.0000 Buried
105 Q D 0.0000 Buried
106 Q D 0.0000 Buried
107 Y D 0.5735 Aggregation-prone
108 S D -0.0300 Soluble
109 S D 0.0844 Aggregation-prone
114 Y D 0.4972 Aggregation-prone
115 P D 0.1394 Aggregation-prone
116 L D 0.0000 Buried
117 T D 0.0000 Buried
118 F D 0.2467 Aggregation-prone
119 G D 0.0000 Buried
120 G D -0.7032 Soluble
121 G D 0.0000 Buried
122 T D 0.0000 Buried
123 K D -0.6460 Soluble
124 V D 0.0000 Buried
125 E D -0.8795 Soluble
126 I D 0.0000 Buried
127 K D -1.5322 Soluble
128 R D -1.0304 Soluble
129 T D -0.0169 Soluble
130 V D 0.4359 Aggregation-prone
131 A D -0.0074 Soluble
132 A D -0.1182 Soluble
133 P D 0.0000 Buried
134 S D -0.1860 Soluble
135 V D 0.0000 Buried
136 F D 0.1192 Aggregation-prone
137 I D 0.1278 Aggregation-prone
138 F D 0.0000 Buried
139 P D -0.5587 Soluble
140 P D -0.6364 Soluble
141 S D -1.5271 Soluble
142 D D -2.7286 Soluble
143 E D -2.2125 Soluble
144 Q D 0.0000 Buried
145 L D -2.0140 Soluble
146 K D -2.5680 Soluble
147 S D -1.5626 Soluble
148 G D -1.1751 Soluble
149 T D -1.0535 Soluble
150 A D 0.0000 Buried
151 S D 0.0000 Buried
152 V D 0.0000 Buried
153 V D 0.0000 Buried
154 C D 0.0000 Buried
155 L D 0.0000 Buried
156 L D 0.0000 Buried
157 N D -0.4092 Soluble
158 N D -1.0147 Soluble
159 F D 0.0000 Buried
160 Y D 0.0000 Buried
161 P D -1.7761 Soluble
162 R D -3.0825 Soluble
163 E D -3.2842 Soluble
164 A D -2.4298 Soluble
165 K D -2.5206 Soluble
166 V D -1.1488 Soluble
167 Q D -0.8610 Soluble
168 W D 0.0000 Buried
169 K D -0.8334 Soluble
170 V D 0.0000 Buried
171 D D -1.8622 Soluble
172 N D -1.4722 Soluble
173 A D -0.4984 Soluble
174 L D 0.1767 Aggregation-prone
175 Q D -0.4303 Soluble
176 S D -0.5186 Soluble
177 G D -0.8765 Soluble
178 N D -0.7976 Soluble
179 S D -0.9909 Soluble
180 Q D -1.1436 Soluble
181 E D -1.3534 Soluble
182 S D -0.6655 Soluble
183 V D -0.5650 Soluble
184 T D -0.9781 Soluble
185 E D -1.8923 Soluble
186 Q D 0.0000 Buried
187 D D -1.8927 Soluble
188 S D -1.9895 Soluble
189 K D -2.5403 Soluble
190 D D -2.0630 Soluble
191 S D 0.0000 Buried
192 T D 0.0000 Buried
193 Y D 0.0000 Buried
194 S D 0.0000 Buried
195 L D 0.0000 Buried
196 S D 0.0000 Buried
197 S D 0.0000 Buried
198 T D -0.5247 Soluble
199 L D 0.0000 Buried
200 T D -0.3989 Soluble
201 L D -0.6193 Soluble
202 S D -0.9762 Soluble
203 K D -1.9640 Soluble
204 A D -1.8168 Soluble
205 D D -2.4630 Soluble
206 Y D 0.0000 Buried
207 E D -3.3882 Soluble
208 K D -3.4910 Soluble
209 H D -2.7066 Soluble
210 K D -2.3413 Soluble
211 V D -0.9180 Soluble
212 Y D 0.0000 Buried
213 A D 0.0000 Buried
214 C D 0.0000 Buried
215 E D -0.8916 Soluble
216 V D 0.0000 Buried
217 T D -1.2859 Soluble
218 H D 0.0000 Buried
219 Q D -1.7377 Soluble
220 G D -0.3941 Soluble
221 L D -0.1968 Soluble
222 S D -0.4353 Soluble
223 S D -0.4353 Soluble
224 P D -0.6036 Soluble
225 V D -0.0840 Soluble
226 T D -0.4931 Soluble
227 K D -0.5878 Soluble
228 S D -0.3818 Soluble
229 F D -0.5578 Soluble
230 N D -1.4412 Soluble
231 R D -1.9559 Soluble
232 G D -1.6752 Soluble
233 E D -1.9216 Soluble
234 C D -0.4524 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6125 2.8095 CSV PDB
4.5 -0.6571 2.797 CSV PDB
5.0 -0.7103 2.784 CSV PDB
5.5 -0.762 2.7718 CSV PDB
6.0 -0.8004 2.7616 CSV PDB
6.5 -0.8157 2.7527 CSV PDB
7.0 -0.8071 2.7429 CSV PDB
7.5 -0.7822 2.7313 CSV PDB
8.0 -0.7481 2.7191 CSV PDB
8.5 -0.7074 2.7083 CSV PDB
9.0 -0.6603 2.7003 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH