Zinlirvimab / 6orn

A4DAB308_6orn_F_I | Source PDB: 6orn | Chains: F, I | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6479
Max Score
2.6803
Min Score
-3.7083
Total Score
-153.55
Score CDR
-0.596
Score non-CDR
-0.6663

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSALSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) F (Heavy), I (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.7083
Maximum Score 2.6803
Average Score -0.6479
Total Score -153.5526

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q F -2.0827 Soluble
2 V F 0.0000 Buried
3 Q F -2.1889 Soluble
4 L F -1.2913 Soluble
5 Q F -1.6572 Soluble
6 E F -1.1263 Soluble
7 S F -0.8096 Soluble
8 G F -0.5613 Soluble
9 P F -0.1255 Soluble
11 G F 0.4038 Aggregation-prone
12 L F 1.0336 Aggregation-prone
13 V F -0.2226 Soluble
14 K F -1.6548 Soluble
15 P F -1.2430 Soluble
16 S F -1.3857 Soluble
17 E F -1.7690 Soluble
18 T F -1.4269 Soluble
19 L F 0.0000 Buried
20 S F -0.7908 Soluble
21 V F 0.0000 Buried
22 T F -0.7328 Soluble
23 C F 0.0000 Buried
24 S F -1.2100 Soluble
25 V F 0.0000 Buried
26 S F -1.9078 Soluble
27 G F -2.1578 Soluble
28 D F -2.9126 Soluble
29 S F -1.9847 Soluble
30 M F -1.8508 Soluble
35 N F -2.2436 Soluble
36 N F -2.1277 Soluble
37 Y F -1.4784 Soluble
38 Y F -1.1914 Soluble
39 W F 0.0000 Buried
40 T F 0.0000 Buried
41 W F 0.0000 Buried
42 I F 0.0000 Buried
43 R F -0.5243 Soluble
44 Q F -0.9162 Soluble
45 S F -0.9805 Soluble
46 P F -1.0925 Soluble
47 G F -1.5047 Soluble
48 K F -2.2523 Soluble
49 G F -1.5080 Soluble
50 L F -0.8968 Soluble
51 E F -0.9129 Soluble
52 W F 0.0000 Buried
53 I F 0.0000 Buried
54 G F 0.0000 Buried
55 Y F 0.0264 Aggregation-prone
56 I F 0.0000 Buried
57 S F -2.5298 Soluble
58 D F -3.7083 Soluble
59 R F -3.6070 Soluble
63 E F -3.3866 Soluble
64 S F -1.6964 Soluble
65 A F -0.4506 Soluble
66 T F -0.0170 Soluble
67 Y F 0.0606 Aggregation-prone
68 N F -0.3604 Soluble
69 P F -0.6692 Soluble
70 S F -0.6297 Soluble
71 L F -0.8488 Soluble
72 N F -1.6187 Soluble
74 S F -1.0939 Soluble
75 R F -1.4201 Soluble
76 V F 0.0000 Buried
77 V F 0.3995 Aggregation-prone
78 I F 0.1446 Aggregation-prone
79 S F -0.6902 Soluble
80 R F -1.8386 Soluble
81 D F -2.2024 Soluble
82 T F -1.9682 Soluble
83 S F -1.7755 Soluble
84 K F -2.7576 Soluble
85 N F -2.7864 Soluble
86 Q F -1.9368 Soluble
87 L F 0.0000 Buried
88 S F -0.5598 Soluble
89 L F 0.0000 Buried
90 K F -0.8928 Soluble
91 L F -1.1013 Soluble
92 N F -1.8910 Soluble
93 S F -1.2914 Soluble
94 V F 0.0000 Buried
95 T F -0.7483 Soluble
96 P F -0.6547 Soluble
97 A F -0.1881 Soluble
98 D F -0.3316 Soluble
99 T F -0.0786 Soluble
100 A F 0.0000 Buried
101 V F -0.2342 Soluble
102 Y F 0.0000 Buried
103 Y F 0.0000 Buried
104 C F 0.0000 Buried
105 A F 0.0000 Buried
106 T F 0.0000 Buried
107 A F 0.0000 Buried
108 R F -2.0317 Soluble
109 R F -2.1751 Soluble
110 G F -1.8055 Soluble
111 Q F -1.5331 Soluble
111A R F -1.1917 Soluble
111B I F 0.6987 Aggregation-prone
111C Y F 1.2223 Aggregation-prone
111D G F 1.0722 Aggregation-prone
111E V F 2.1464 Aggregation-prone
111F V F 2.6803 Aggregation-prone
112G S F 1.6187 Aggregation-prone
112F F F 2.2236 Aggregation-prone
112E G F 1.1010 Aggregation-prone
112D E F 1.0010 Aggregation-prone
112C F F 1.0887 Aggregation-prone
112B F F 0.1294 Aggregation-prone
112A Y F -0.1010 Soluble
112 Y F 0.0000 Buried
113 Y F -0.8880 Soluble
114 S F -0.8453 Soluble
115 M F 0.0000 Buried
116 D F -0.6485 Soluble
117 V F -0.1628 Soluble
118 W F -0.2793 Soluble
119 G F 0.0000 Buried
120 K F -2.3243 Soluble
121 G F -1.3308 Soluble
122 T F -0.7336 Soluble
123 T F 0.0200 Aggregation-prone
124 V F 0.0000 Buried
125 T F 0.1695 Aggregation-prone
126 V F 0.0000 Buried
127 S F -0.4447 Soluble
128 S F -0.6818 Soluble
129 A F -0.3728 Soluble
11 L I 0.7660 Aggregation-prone
12 S I 0.6887 Aggregation-prone
13 V I 0.0000 Buried
14 A I 0.5948 Aggregation-prone
15 L I 0.7648 Aggregation-prone
16 G I -0.8105 Soluble
17 E I -1.4196 Soluble
18 T I -1.2573 Soluble
19 A I 0.0000 Buried
20 R I -1.7979 Soluble
21 I I 0.0000 Buried
22 S I -1.1203 Soluble
23 C I -1.2161 Soluble
24 G I -1.9154 Soluble
25 R I -2.7528 Soluble
26 Q I -2.1390 Soluble
27 A I -1.0427 Soluble
28 L I -0.1031 Soluble
29 G I -0.0705 Soluble
36 S I 0.0069 Aggregation-prone
37 R I 0.0000 Buried
38 A I 0.0000 Buried
39 V I 0.0000 Buried
40 Q I 0.0000 Buried
41 W I 0.0000 Buried
42 Y I 0.0000 Buried
43 Q I -0.2754 Soluble
44 H I 0.0000 Buried
45 R I -1.6007 Soluble
46 P I -1.3795 Soluble
47 G I -1.6157 Soluble
48 Q I -2.0596 Soluble
49 A I -1.1264 Soluble
50 P I 0.0000 Buried
51 I I 0.6228 Aggregation-prone
52 L I 0.0000 Buried
53 L I 0.0000 Buried
54 I I 0.0000 Buried
55 Y I -0.8227 Soluble
56 N I -1.4690 Soluble
57 N I 0.0000 Buried
65 Q I -2.3110 Soluble
66 D I -2.1585 Soluble
67 R I -1.6719 Soluble
68 P I -0.8148 Soluble
69 S I -0.6394 Soluble
70 G I -0.7234 Soluble
71 I I -0.6795 Soluble
72 P I -1.3437 Soluble
74 E I -2.3712 Soluble
75 R I -1.8311 Soluble
76 F I 0.0000 Buried
77 S I -1.2921 Soluble
78 G I -1.1712 Soluble
79 T I -0.8012 Soluble
80 P I -1.0937 Soluble
81 D I -0.8474 Soluble
81A I I 1.1135 Aggregation-prone
82 N I 0.1728 Aggregation-prone
83 F I 1.3239 Aggregation-prone
84 G I 0.1785 Aggregation-prone
85 T I -0.2415 Soluble
86 R I -1.2969 Soluble
87 A I 0.0000 Buried
88 T I -0.8751 Soluble
89 L I 0.0000 Buried
90 T I -1.0638 Soluble
91 I I 0.0000 Buried
92 S I -1.6385 Soluble
93 G I -1.0882 Soluble
94 V I 0.0000 Buried
95 E I -1.1425 Soluble
96 A I -0.3815 Soluble
97 G I -0.8880 Soluble
98 D I -1.1573 Soluble
99 E I -1.6498 Soluble
100 A I 0.0000 Buried
101 D I 0.0000 Buried
102 Y I 0.0000 Buried
103 Y I 0.0000 Buried
104 C I 0.0000 Buried
105 H I 0.0000 Buried
106 M I -0.4261 Soluble
107 W I 0.0000 Buried
108 D I -0.5156 Soluble
109 S I -0.7303 Soluble
110 R I -1.8605 Soluble
112 S I -1.0239 Soluble
113 G I -0.5094 Soluble
114 F I 0.6711 Aggregation-prone
115 S I 0.3435 Aggregation-prone
116 W I 0.1024 Aggregation-prone
117 S I -0.2906 Soluble
118 F I 0.0000 Buried
119 G I -1.0653 Soluble
120 G I -1.4225 Soluble
121 A I -1.0793 Soluble
122 T I -0.8192 Soluble
123 R I -1.6961 Soluble
124 L I 0.0000 Buried
125 T I -0.0010 Soluble
126 V I 0.6211 Aggregation-prone
127 L I 1.4963 Aggregation-prone
128 G I 0.5826 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5108 4.5244 CSV PDB
4.5 -0.5534 4.4956 CSV PDB
5.0 -0.6044 4.4517 CSV PDB
5.5 -0.6554 4.3999 CSV PDB
6.0 -0.6981 4.3483 CSV PDB
6.5 -0.7267 4.3052 CSV PDB
7.0 -0.7404 4.2774 CSV PDB
7.5 -0.7438 4.2641 CSV PDB
8.0 -0.7407 4.2591 CSV PDB
8.5 -0.7322 4.2575 CSV PDB
9.0 -0.7181 4.2569 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH