Alomfilimab / 7joo

A4DAB010_7joo_H_L | Source PDB: 7joo | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7145
Max Score
1.6123
Min Score
-3.6261
Total Score
-307.97
Score CDR
-0.3826
Score non-CDR
-0.7601

Calculation Parameters

Chain Sequence(s) VQLVESGGGVVRPGGSLRLSCVASGVTFDDYGMSWVRQAPGKGLEWVSGINWNGGDTDYSDSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCARDFYGSGSYYHVPFDYWGQGILVTVSSASTKGPSVFPLAPSSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKEIVLTQSPGTLSLSPGERATLSCRASQSVSRSYLAWYQQKRGQAPRLLIYGASSRATGIPDRFSGDGSGTDFTLSISRLEPEDFAVYYCHQYDMSPFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6261
Maximum Score 1.6123
Average Score -0.7145
Total Score -307.9701

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V H 1.1147 Aggregation-prone
3 Q H 0.1720 Aggregation-prone
4 L H 0.7884 Aggregation-prone
5 V H 1.4821 Aggregation-prone
6 E H 0.4620 Aggregation-prone
7 S H 0.0172 Aggregation-prone
8 G H -0.7822 Soluble
9 G H 0.1658 Aggregation-prone
11 G H 1.0418 Aggregation-prone
12 V H 1.4721 Aggregation-prone
13 V H -0.1829 Soluble
14 R H -1.9093 Soluble
15 P H -2.0002 Soluble
16 G H -1.5855 Soluble
17 G H -1.1448 Soluble
18 S H -1.2929 Soluble
19 L H -0.8885 Soluble
20 R H -2.0196 Soluble
21 L H 0.0000 Buried
22 S H -0.2142 Soluble
23 C H 0.0000 Buried
24 V H 0.3505 Aggregation-prone
25 A H 0.0000 Buried
26 S H 0.0106 Aggregation-prone
27 G H 0.1247 Aggregation-prone
28 V H -0.0060 Soluble
29 T H -0.7783 Soluble
30 F H 0.0000 Buried
35 D H -2.2438 Soluble
36 D H -1.7169 Soluble
37 Y H -0.6044 Soluble
38 G H 0.0000 Buried
39 M H 0.0000 Buried
40 S H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.7609 Soluble
45 A H -1.1115 Soluble
46 P H -0.7980 Soluble
47 G H -1.4860 Soluble
48 K H -2.2804 Soluble
49 G H -1.3846 Soluble
50 L H 0.0000 Buried
51 E H -1.3152 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 S H 0.0000 Buried
55 G H 0.0000 Buried
56 I H 0.0000 Buried
57 N H -0.9277 Soluble
58 W H -1.0104 Soluble
59 N H -2.0153 Soluble
62 G H -1.6287 Soluble
63 G H -1.4266 Soluble
64 D H -1.6044 Soluble
65 T H -0.8585 Soluble
66 D H -0.8502 Soluble
67 Y H -1.1447 Soluble
68 S H 0.0000 Buried
69 D H -2.6086 Soluble
70 S H -1.8785 Soluble
71 V H 0.0000 Buried
72 K H -2.7233 Soluble
74 G H -1.9047 Soluble
75 R H -1.7592 Soluble
76 F H 0.0000 Buried
77 T H -0.9199 Soluble
78 I H 0.0000 Buried
79 S H -0.8661 Soluble
80 R H -1.3558 Soluble
81 D H -2.2885 Soluble
82 N H -2.0821 Soluble
83 A H -1.5378 Soluble
84 K H -2.1925 Soluble
85 N H -1.5666 Soluble
86 S H 0.0000 Buried
87 L H 0.0000 Buried
88 Y H -0.6465 Soluble
89 L H 0.0000 Buried
90 Q H -1.3049 Soluble
91 M H 0.0000 Buried
92 N H -1.6450 Soluble
93 S H -1.4441 Soluble
94 L H 0.0000 Buried
95 R H -2.3758 Soluble
96 A H -1.8038 Soluble
97 E H -2.2104 Soluble
98 D H 0.0000 Buried
99 T H -0.3161 Soluble
100 A H 0.0000 Buried
101 L H 0.6809 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H -0.0487 Soluble
107 D H 0.0000 Buried
108 F H 0.8762 Aggregation-prone
109 Y H 1.1839 Aggregation-prone
110 G H 0.0320 Aggregation-prone
111 S H -0.0882 Soluble
111A G H 0.0000 Buried
111B S H 0.0774 Aggregation-prone
112B Y H 0.3734 Aggregation-prone
112A Y H 0.6979 Aggregation-prone
112 H H 0.3225 Aggregation-prone
113 V H 0.6762 Aggregation-prone
114 P H 0.5412 Aggregation-prone
115 F H 0.3912 Aggregation-prone
116 D H -0.0973 Soluble
117 Y H -0.3065 Soluble
118 W H -0.4230 Soluble
119 G H -0.8318 Soluble
120 Q H -1.3460 Soluble
121 G H -0.5336 Soluble
122 I H 0.0000 Buried
123 L H 1.6123 Aggregation-prone
124 V H 0.0000 Buried
125 T H 0.2377 Aggregation-prone
126 V H 0.0000 Buried
127 S H -0.8912 Soluble
128 S H -0.9145 Soluble
129 A H -0.6674 Soluble
130 S H -0.7364 Soluble
131 T H -0.7225 Soluble
132 K H -1.1479 Soluble
133 G H -1.3715 Soluble
134 P H 0.0000 Buried
135 S H -0.2517 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.2136 Soluble
139 L H 0.0000 Buried
140 A H -1.2227 Soluble
141 P H 0.0000 Buried
142 S H -0.7896 Soluble
143 S H -0.3862 Soluble
144 T H -0.2899 Soluble
145 A H 0.0000 Buried
146 A H 0.0000 Buried
147 L H 0.0000 Buried
148 G H 0.0000 Buried
149 C H 0.0000 Buried
150 L H 0.0000 Buried
151 V H 0.0000 Buried
152 K H 0.0000 Buried
153 D H -0.4869 Soluble
154 Y H 0.0000 Buried
155 F H 0.0000 Buried
156 P H -0.7227 Soluble
157 E H -0.9953 Soluble
158 P H -1.0944 Soluble
159 V H -0.8209 Soluble
160 T H -0.6414 Soluble
161 V H -0.3944 Soluble
162 S H -0.3581 Soluble
163 W H 0.0000 Buried
164 N H -0.8285 Soluble
165 S H -0.6777 Soluble
166 G H -0.5814 Soluble
167 A H -0.2166 Soluble
168 L H 0.0128 Aggregation-prone
169 T H -0.1495 Soluble
170 S H -0.1425 Soluble
171 G H -0.1328 Soluble
172 V H 0.1914 Aggregation-prone
173 H H -0.3322 Soluble
174 T H -0.0067 Soluble
175 F H 0.0000 Buried
176 P H -0.5154 Soluble
177 A H 0.0514 Aggregation-prone
178 V H 0.4526 Aggregation-prone
179 L H 0.9890 Aggregation-prone
180 Q H 0.1940 Aggregation-prone
181 S H -0.2105 Soluble
182 S H -0.2613 Soluble
183 G H -0.0117 Soluble
184 L H -0.0631 Soluble
185 Y H 0.1816 Aggregation-prone
186 S H 0.0000 Buried
187 L H 0.0000 Buried
188 S H 0.0000 Buried
189 S H 0.0000 Buried
190 V H 0.0000 Buried
191 V H 0.0000 Buried
192 T H -0.0971 Soluble
193 V H 0.0000 Buried
194 P H -0.4126 Soluble
195 S H -0.5074 Soluble
196 S H -0.5632 Soluble
197 S H -0.5854 Soluble
198 L H -0.7877 Soluble
199 G H -0.8929 Soluble
200 T H -0.9804 Soluble
201 Q H -1.4404 Soluble
202 T H -1.3428 Soluble
203 Y H 0.0000 Buried
204 I H -1.3260 Soluble
205 C H 0.0000 Buried
206 N H -1.5119 Soluble
207 V H 0.0000 Buried
208 N H -1.9528 Soluble
209 H H 0.0000 Buried
210 K H -2.8740 Soluble
211 P H -1.7780 Soluble
212 S H -1.8824 Soluble
213 N H -2.6502 Soluble
214 T H -2.1036 Soluble
215 K H -2.6700 Soluble
216 V H -1.6165 Soluble
217 D H -2.4582 Soluble
218 K H -2.3021 Soluble
219 K H -2.6257 Soluble
220 V H 0.0000 Buried
221 E H -3.0688 Soluble
222 P H -2.0222 Soluble
223 K H -2.4063 Soluble
1 E L -1.4979 Soluble
2 I L 0.0000 Buried
3 V L 0.7716 Aggregation-prone
4 L L 0.0000 Buried
5 T L -0.4140 Soluble
6 Q L 0.0000 Buried
7 S L -0.6825 Soluble
8 P L -0.4824 Soluble
9 G L -0.6539 Soluble
10 T L -0.6415 Soluble
11 L L -0.1402 Soluble
12 S L -0.5569 Soluble
13 L L -0.9514 Soluble
14 S L -1.5731 Soluble
15 P L -1.9228 Soluble
16 G L -2.5470 Soluble
17 E L -3.1397 Soluble
18 R L -3.3758 Soluble
19 A L 0.0000 Buried
20 T L -0.5445 Soluble
21 L L 0.0000 Buried
22 S L -0.7887 Soluble
23 C L 0.0000 Buried
24 R L -1.9626 Soluble
25 A L 0.0000 Buried
26 S L -0.9570 Soluble
27 Q L -1.6958 Soluble
28 S L -1.4765 Soluble
29 V L 0.0000 Buried
30 S L -0.8783 Soluble
36 R L -1.6357 Soluble
37 S L -0.6815 Soluble
38 Y L -0.1148 Soluble
39 L L 0.0000 Buried
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 K L -2.2677 Soluble
46 R L -2.8641 Soluble
47 G L -2.3419 Soluble
48 Q L -2.6893 Soluble
49 A L -1.6577 Soluble
50 P L 0.0000 Buried
51 R L -0.9035 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.2618 Soluble
56 G L -0.6608 Soluble
57 A L 0.0000 Buried
65 S L -1.1464 Soluble
66 S L -0.7442 Soluble
67 R L -1.1742 Soluble
68 A L 0.0000 Buried
69 T L -0.2399 Soluble
70 G L -0.7435 Soluble
71 I L -0.7607 Soluble
72 P L -1.0934 Soluble
74 D L -1.9924 Soluble
75 R L 0.0000 Buried
76 F L 0.0000 Buried
77 S L -1.0712 Soluble
78 G L -1.0602 Soluble
79 D L -1.9972 Soluble
80 G L -1.7267 Soluble
83 S L -1.5641 Soluble
84 G L -1.3820 Soluble
85 T L -1.7318 Soluble
86 D L -2.2578 Soluble
87 F L 0.0000 Buried
88 T L -1.0800 Soluble
89 L L 0.0000 Buried
90 S L -0.9802 Soluble
91 I L 0.0000 Buried
92 S L -2.3911 Soluble
93 R L -3.5012 Soluble
94 L L 0.0000 Buried
95 E L -2.3922 Soluble
96 P L -1.4951 Soluble
97 E L -1.7459 Soluble
98 D L 0.0000 Buried
99 F L -0.4931 Soluble
100 A L 0.0000 Buried
101 V L -0.2281 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 H L 0.0000 Buried
106 Q L 0.0000 Buried
107 Y L 0.0000 Buried
108 D L -0.1333 Soluble
109 M L 0.0018 Aggregation-prone
114 S L -0.4286 Soluble
115 P L -0.8754 Soluble
116 F L 0.0000 Buried
117 T L -0.1067 Soluble
118 F L 0.1534 Aggregation-prone
119 G L 0.0000 Buried
120 P L -0.4960 Soluble
121 G L -0.5360 Soluble
122 T L 0.0000 Buried
123 K L -0.4113 Soluble
124 V L 0.0000 Buried
125 D L 0.0000 Buried
126 I L -0.5789 Soluble
127 K L -1.5713 Soluble
128 R L -1.1536 Soluble
129 T L -0.0788 Soluble
130 V L 0.7283 Aggregation-prone
131 A L 0.2437 Aggregation-prone
132 A L 0.0227 Aggregation-prone
133 P L 0.0000 Buried
134 S L -0.0528 Soluble
135 V L 0.0000 Buried
136 F L 0.0582 Aggregation-prone
137 I L 0.0707 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.5972 Soluble
140 P L -0.8130 Soluble
141 S L -1.9444 Soluble
142 D L -3.1520 Soluble
143 E L -3.2276 Soluble
144 Q L 0.0000 Buried
145 L L -2.4370 Soluble
146 K L -2.9355 Soluble
147 S L -1.8581 Soluble
148 G L -1.6278 Soluble
149 T L -1.3189 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.7284 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.3129 Soluble
162 R L -2.0841 Soluble
163 E L -2.8847 Soluble
164 A L -2.1480 Soluble
165 K L -2.3627 Soluble
166 V L -1.1196 Soluble
167 Q L -0.6509 Soluble
168 W L 0.0000 Buried
169 K L -0.5428 Soluble
170 V L 0.0000 Buried
171 D L -1.9192 Soluble
172 N L -1.4868 Soluble
173 A L -0.2851 Soluble
174 L L 0.7426 Aggregation-prone
175 Q L -0.2676 Soluble
176 S L -0.6902 Soluble
177 G L -1.1949 Soluble
178 N L -1.4640 Soluble
179 S L -1.4477 Soluble
180 Q L -1.5250 Soluble
181 E L -1.9369 Soluble
182 S L -0.8533 Soluble
183 V L -0.7601 Soluble
184 T L -1.0036 Soluble
185 E L -2.3244 Soluble
186 Q L -1.9021 Soluble
187 D L -2.1393 Soluble
188 S L -1.7690 Soluble
189 K L -2.3130 Soluble
190 D L -1.7956 Soluble
191 S L -1.8285 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.7489 Soluble
199 L L 0.0000 Buried
200 T L -0.5780 Soluble
201 L L -0.9174 Soluble
202 S L -1.2287 Soluble
203 K L -2.1875 Soluble
204 A L -1.9850 Soluble
205 D L -2.8995 Soluble
206 Y L 0.0000 Buried
207 E L -3.4215 Soluble
208 K L -3.6261 Soluble
209 H L -3.2421 Soluble
210 K L -3.3876 Soluble
211 V L -1.9339 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.7321 Soluble
216 V L 0.0000 Buried
217 T L -1.1498 Soluble
218 H L 0.0000 Buried
219 Q L -1.6796 Soluble
220 G L -0.3851 Soluble
221 L L -0.1798 Soluble
222 S L -0.4267 Soluble
223 S L -0.3622 Soluble
224 P L -0.5388 Soluble
225 V L 0.1301 Aggregation-prone
226 T L -0.4506 Soluble
227 K L -0.7392 Soluble
228 S L -0.7294 Soluble
229 F L -1.0523 Soluble
230 N L -2.2514 Soluble
231 R L -2.4097 Soluble
232 G L -1.4137 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6862 2.2457 CSV PDB
4.5 -0.7369 2.2457 CSV PDB
5.0 -0.7967 2.2457 CSV PDB
5.5 -0.8556 2.2457 CSV PDB
6.0 -0.9021 2.2457 CSV PDB
6.5 -0.9269 2.2457 CSV PDB
7.0 -0.9293 2.2457 CSV PDB
7.5 -0.9165 2.2457 CSV PDB
8.0 -0.895 2.2457 CSV PDB
8.5 -0.8663 2.2457 CSV PDB
9.0 -0.829 2.2457 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH