Zinlirvimab / 8ttw

A4DAB308_8ttw_M_N | Source PDB: 8ttw | Chains: M, N | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.5027
Max Score
2.9202
Min Score
-3.6691
Total Score
-116.62
Score CDR
-0.2051
Score non-CDR
-0.6112

Calculation Parameters

Chain Sequence(s) VQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTV input.pdb
Selected Chain(s) M (Heavy), N (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6691
Maximum Score 2.9202
Average Score -0.5027
Total Score -116.6167

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V M -0.1770 Soluble
3 Q M -1.3764 Soluble
4 L M 0.0000 Buried
5 Q M -1.7968 Soluble
6 E M 0.0000 Buried
7 S M -0.7017 Soluble
8 G M -0.3245 Soluble
9 P M 0.0826 Aggregation-prone
11 G M 0.5473 Aggregation-prone
12 L M 1.0867 Aggregation-prone
13 V M -0.3290 Soluble
14 K M -1.7981 Soluble
15 P M -1.5030 Soluble
16 S M -1.6810 Soluble
17 E M -2.3023 Soluble
18 T M -1.7325 Soluble
19 L M 0.0000 Buried
20 S M -0.7453 Soluble
21 V M 0.0000 Buried
22 T M -0.6475 Soluble
23 C M 0.0000 Buried
24 S M -1.2050 Soluble
25 V M 0.0000 Buried
26 S M -1.1765 Soluble
27 G M -1.2500 Soluble
28 D M -2.2072 Soluble
29 S M -1.5812 Soluble
30 M M 0.0000 Buried
35 N M -2.2053 Soluble
36 N M -2.0060 Soluble
37 Y M -0.8649 Soluble
38 Y M -0.7604 Soluble
39 W M 0.0000 Buried
40 T M 0.0000 Buried
41 W M 0.0000 Buried
42 I M 0.0000 Buried
43 R M -0.5575 Soluble
44 Q M -1.0059 Soluble
45 S M -1.0444 Soluble
46 P M -1.0533 Soluble
47 G M -1.4753 Soluble
48 K M -2.2872 Soluble
49 G M -1.5622 Soluble
50 L M 0.0000 Buried
51 E M -1.3548 Soluble
52 W M 0.0000 Buried
53 I M 0.0000 Buried
54 G M 0.0000 Buried
55 Y M -0.0560 Soluble
56 I M 0.0000 Buried
57 S M -2.2641 Soluble
58 D M -3.6323 Soluble
59 R M -3.6691 Soluble
63 E M -3.4625 Soluble
64 S M -2.0176 Soluble
65 A M -0.9217 Soluble
66 T M -0.0625 Soluble
67 Y M -0.0115 Soluble
68 N M 0.0000 Buried
69 P M -0.6299 Soluble
70 S M -0.7282 Soluble
71 L M -0.9188 Soluble
72 N M -1.6541 Soluble
74 S M -0.9823 Soluble
75 R M -1.5569 Soluble
76 V M 0.0000 Buried
77 V M 0.2715 Aggregation-prone
78 I M 0.0000 Buried
79 S M -0.7790 Soluble
80 R M -1.3336 Soluble
81 D M -1.7331 Soluble
82 T M -1.6419 Soluble
83 S M -1.5467 Soluble
84 K M -2.4251 Soluble
85 N M -2.2257 Soluble
86 Q M -1.6750 Soluble
87 L M 0.0000 Buried
88 S M -0.5921 Soluble
89 L M 0.0000 Buried
90 K M -1.3062 Soluble
91 L M 0.0000 Buried
92 N M -2.1379 Soluble
93 S M -1.4692 Soluble
94 V M 0.0000 Buried
95 T M -0.8375 Soluble
96 P M -0.7958 Soluble
97 A M -0.1958 Soluble
98 D M -0.2735 Soluble
99 T M -0.0269 Soluble
100 A M 0.0000 Buried
101 V M -0.1461 Soluble
102 Y M 0.0000 Buried
103 Y M 0.0000 Buried
104 C M 0.0000 Buried
105 A M 0.0000 Buried
106 T M 0.0000 Buried
107 A M 0.0000 Buried
108 R M -2.0253 Soluble
109 R M -1.6382 Soluble
110 G M -1.2144 Soluble
111 Q M -0.4986 Soluble
111A R M 0.6047 Aggregation-prone
111B I M 2.3486 Aggregation-prone
111C Y M 2.2953 Aggregation-prone
111D G M 2.0817 Aggregation-prone
111E V M 2.9158 Aggregation-prone
111F V M 2.9202 Aggregation-prone
112G S M 1.6959 Aggregation-prone
112F F M 2.4396 Aggregation-prone
112E G M 1.5325 Aggregation-prone
112D E M 1.7075 Aggregation-prone
112C F M 1.9500 Aggregation-prone
112B F M 0.8296 Aggregation-prone
112A Y M 0.4705 Aggregation-prone
112 Y M 0.0000 Buried
113 Y M 0.0000 Buried
114 S M 0.0000 Buried
115 M M 0.0000 Buried
116 D M -0.5917 Soluble
117 V M 0.1861 Aggregation-prone
118 W M -0.2256 Soluble
119 G M 0.0000 Buried
120 K M -2.4449 Soluble
121 G M 0.0000 Buried
122 T M -0.6442 Soluble
123 T M -0.1154 Soluble
124 V M 0.0000 Buried
125 T M 0.1604 Aggregation-prone
126 V M -0.2942 Soluble
127 S M -0.4052 Soluble
11 L N 1.1639 Aggregation-prone
12 S N 0.7055 Aggregation-prone
13 V N 0.9238 Aggregation-prone
14 A N 0.5881 Aggregation-prone
15 L N 0.4192 Aggregation-prone
16 G N -0.9744 Soluble
17 E N -1.9010 Soluble
18 T N -1.3076 Soluble
19 A N 0.0000 Buried
20 R N -1.8801 Soluble
21 I N 0.0000 Buried
22 S N -0.8323 Soluble
23 C N -0.7319 Soluble
24 G N -1.1449 Soluble
25 R N -1.2334 Soluble
26 Q N -1.3134 Soluble
27 A N -0.1896 Soluble
28 L N 0.8158 Aggregation-prone
29 G N 0.4703 Aggregation-prone
36 S N 0.8809 Aggregation-prone
37 R N 0.0000 Buried
38 A N 0.0000 Buried
39 V N 0.0000 Buried
40 Q N 0.0000 Buried
41 W N 0.0000 Buried
42 Y N 0.0000 Buried
43 Q N 0.0000 Buried
44 H N 0.0000 Buried
45 R N -1.2254 Soluble
46 P N -1.1325 Soluble
47 G N -1.5742 Soluble
48 Q N -1.9274 Soluble
49 A N -1.1145 Soluble
50 P N 0.0000 Buried
51 I N 0.8352 Aggregation-prone
52 L N 0.0000 Buried
53 L N 0.0000 Buried
54 I N 0.0000 Buried
55 Y N -1.0249 Soluble
56 N N -1.3265 Soluble
57 N N 0.0000 Buried
65 Q N -1.6442 Soluble
66 D N -2.0522 Soluble
67 R N -2.4008 Soluble
68 P N -1.2727 Soluble
69 S N -1.0276 Soluble
70 G N -0.9417 Soluble
71 I N -0.9461 Soluble
72 P N -1.8130 Soluble
74 E N -2.9788 Soluble
75 R N -2.8183 Soluble
76 F N -1.7383 Soluble
77 S N -1.5914 Soluble
78 G N 0.0000 Buried
79 T N -0.2642 Soluble
80 P N -0.4380 Soluble
81 D N 0.2810 Aggregation-prone
81A I N 1.6285 Aggregation-prone
82 N N 0.4045 Aggregation-prone
83 F N 1.7325 Aggregation-prone
84 G N 0.3458 Aggregation-prone
85 T N -0.0673 Soluble
86 R N -0.6895 Soluble
87 A N 0.0000 Buried
88 T N -0.7170 Soluble
89 L N 0.0000 Buried
90 T N -1.0935 Soluble
91 I N 0.0000 Buried
92 S N -1.5017 Soluble
93 G N -1.3710 Soluble
94 V N 0.0000 Buried
95 E N -1.8495 Soluble
96 A N -0.6322 Soluble
97 G N -0.9475 Soluble
98 D N -1.0450 Soluble
99 E N -1.2694 Soluble
100 A N 0.0000 Buried
101 D N -1.1817 Soluble
102 Y N 0.0000 Buried
103 Y N 0.0000 Buried
104 C N 0.0000 Buried
105 H N 0.0000 Buried
106 M N 0.0000 Buried
107 W N 0.0000 Buried
108 D N 0.0000 Buried
109 S N -0.2020 Soluble
110 R N -1.5397 Soluble
112 S N -0.7541 Soluble
113 G N -0.5029 Soluble
114 F N 0.4928 Aggregation-prone
115 S N 0.0000 Buried
116 W N 0.0231 Aggregation-prone
117 S N -0.4050 Soluble
118 F N 0.0000 Buried
119 G N -0.7428 Soluble
120 G N -1.1641 Soluble
121 A N -1.0343 Soluble
122 T N -0.7702 Soluble
123 R N -1.5909 Soluble
124 L N 0.0000 Buried
125 T N 0.4711 Aggregation-prone
126 V N 1.4259 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.3788 4.7573 CSV PDB
4.5 -0.4177 4.7333 CSV PDB
5.0 -0.4666 4.7081 CSV PDB
5.5 -0.5168 4.6826 CSV PDB
6.0 -0.5596 4.6569 CSV PDB
6.5 -0.588 4.6313 CSV PDB
7.0 -0.6006 4.6061 CSV PDB
7.5 -0.6017 4.5819 CSV PDB
8.0 -0.5963 4.5606 CSV PDB
8.5 -0.5863 4.5449 CSV PDB
9.0 -0.5716 4.5362 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH