Tixagevimab / 7u0d

A4DAB270_7u0d_O_P | Source PDB: 7u0d | Chains: O, P | Done
95.26
Yes
10 Å
Yes
Avg A4D Score
-0.6806
Max Score
2.4697
Min Score
-3.5735
Total Score
-291.3
Score CDR
-0.3126
Score non-CDR
-0.7304

Calculation Parameters

Chain Sequence(s) MQLVQSGPEVKKPGTSVKVSCKASGFTFTSSAVQWVRQARGQRLEWIGWIVVGSGNTNYAQKFQERVTITRDMSTSTAYMELSSLRSEDTAVYYCAAPYCSGGSCFDGFDIWGQGTMVTVSSASTKGPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGFPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGNSPWTFGQGTKVEIRRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG input.pdb
Selected Chain(s) O (Heavy), P (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.5735
Maximum Score 2.4697
Average Score -0.6806
Total Score -291.3029

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 M O 0.4454 Aggregation-prone
3 Q O -0.7093 Soluble
4 L O -0.4431 Soluble
5 V O -0.2202 Soluble
6 Q O 0.0000 Buried
7 S O -0.8288 Soluble
8 G O -0.7040 Soluble
9 P O -0.6737 Soluble
11 E O -1.1123 Soluble
12 V O 0.0138 Aggregation-prone
13 K O -0.9104 Soluble
14 K O -1.8739 Soluble
15 P O -1.6542 Soluble
16 G O -1.2279 Soluble
17 T O -0.5876 Soluble
18 S O -1.0178 Soluble
19 V O -1.2010 Soluble
20 K O -1.8795 Soluble
21 V O 0.0000 Buried
22 S O -0.5266 Soluble
23 C O 0.0000 Buried
24 K O -1.1183 Soluble
25 A O 0.0000 Buried
26 S O -0.3599 Soluble
27 G O -0.1705 Soluble
28 F O 0.1089 Aggregation-prone
29 T O -0.1178 Soluble
30 F O 0.1542 Aggregation-prone
35 T O -0.2037 Soluble
36 S O -0.3827 Soluble
37 S O 0.0559 Aggregation-prone
38 A O 0.0006 Aggregation-prone
39 V O 0.0000 Buried
40 Q O 0.0000 Buried
41 W O 0.0000 Buried
42 V O 0.0000 Buried
43 R O -0.8072 Soluble
44 Q O -1.3778 Soluble
45 A O -2.0168 Soluble
46 R O -2.7012 Soluble
47 G O -2.2798 Soluble
48 Q O -2.8571 Soluble
49 R O -2.5801 Soluble
50 L O 0.0000 Buried
51 E O -0.9975 Soluble
52 W O 0.0000 Buried
53 I O 0.0000 Buried
54 G O 0.0000 Buried
55 W O -0.0767 Soluble
56 I O 0.0000 Buried
57 V O -0.5636 Soluble
58 V O 0.0000 Buried
59 G O -1.0000 Soluble
62 S O -1.2626 Soluble
63 G O -1.5912 Soluble
64 N O -1.9257 Soluble
65 T O -1.0898 Soluble
66 N O -1.4440 Soluble
67 Y O -1.4639 Soluble
68 A O 0.0000 Buried
69 Q O -2.5293 Soluble
70 K O -2.8940 Soluble
71 F O -2.5429 Soluble
72 Q O -3.1359 Soluble
74 E O -3.5735 Soluble
75 R O -3.1888 Soluble
76 V O 0.0000 Buried
77 T O -0.9420 Soluble
78 I O -0.7198 Soluble
79 T O -0.9386 Soluble
80 R O -2.0573 Soluble
81 D O -1.3644 Soluble
82 M O -0.4778 Soluble
83 S O -0.5860 Soluble
84 T O -0.3996 Soluble
85 S O -0.6622 Soluble
86 T O 0.0000 Buried
87 A O 0.0000 Buried
88 Y O -0.7687 Soluble
89 M O 0.0000 Buried
90 E O -1.3745 Soluble
91 L O -1.1875 Soluble
92 S O -1.5426 Soluble
93 S O -1.3006 Soluble
94 L O -1.4499 Soluble
95 R O -2.5456 Soluble
96 S O -2.2520 Soluble
97 E O -2.5855 Soluble
98 D O -1.5404 Soluble
99 T O -0.9786 Soluble
100 A O 0.0000 Buried
101 V O -0.0843 Soluble
102 Y O 0.0000 Buried
103 Y O -0.1787 Soluble
104 C O 0.0000 Buried
105 A O 0.0000 Buried
106 A O 0.0000 Buried
107 P O 0.0000 Buried
108 Y O 0.7428 Aggregation-prone
109 C O 0.0000 Buried
110 S O -0.2525 Soluble
111 G O -0.7317 Soluble
111A G O -0.7080 Soluble
112B S O -0.3335 Soluble
112A C O 0.2967 Aggregation-prone
112 F O 0.2156 Aggregation-prone
113 D O -0.6919 Soluble
114 G O 0.0000 Buried
115 F O 0.0000 Buried
116 D O -0.2896 Soluble
117 I O 0.0484 Aggregation-prone
118 W O 0.0000 Buried
119 G O -0.8263 Soluble
120 Q O -1.2866 Soluble
121 G O -0.6419 Soluble
122 T O 0.0000 Buried
123 M O 0.0856 Aggregation-prone
124 V O -0.0664 Soluble
125 T O 0.0000 Buried
126 V O -1.0655 Soluble
127 S O -0.6383 Soluble
128 S O -0.5090 Soluble
129 A O -0.5145 Soluble
130 S O -0.6054 Soluble
131 T O -0.8408 Soluble
132 K O -1.6994 Soluble
133 G O -1.5540 Soluble
134 P O 0.0000 Buried
135 S O -0.7288 Soluble
136 V O 0.0000 Buried
137 F O 0.0539 Aggregation-prone
138 P O -0.4236 Soluble
139 L O -0.2339 Soluble
140 A O -0.6774 Soluble
141 P O 0.0000 Buried
142 S O 0.0359 Aggregation-prone
143 T O -0.1708 Soluble
144 A O 0.1195 Aggregation-prone
145 A O 0.3591 Aggregation-prone
146 L O 0.1568 Aggregation-prone
147 G O 0.0000 Buried
148 C O 0.0000 Buried
149 L O 0.0000 Buried
150 V O 0.0000 Buried
151 K O -1.0389 Soluble
152 D O -1.9426 Soluble
153 Y O 0.0000 Buried
154 F O 0.0000 Buried
155 P O 0.2157 Aggregation-prone
156 E O 0.0000 Buried
157 P O -0.5635 Soluble
158 V O 0.0000 Buried
159 T O -0.3913 Soluble
160 V O -0.1132 Soluble
161 S O -0.3674 Soluble
162 W O 0.0000 Buried
163 N O -1.2396 Soluble
164 S O -0.7959 Soluble
165 G O -0.6954 Soluble
166 A O -0.0280 Soluble
167 L O 0.6536 Aggregation-prone
168 T O 0.3608 Aggregation-prone
169 S O 0.1408 Aggregation-prone
170 G O 0.1587 Aggregation-prone
171 V O 0.5006 Aggregation-prone
172 H O 0.0768 Aggregation-prone
173 T O 0.0791 Aggregation-prone
174 F O 0.0000 Buried
175 P O -0.0659 Soluble
176 A O 0.5824 Aggregation-prone
177 V O 1.6338 Aggregation-prone
178 L O 1.8855 Aggregation-prone
179 Q O 0.2940 Aggregation-prone
180 S O -0.2391 Soluble
181 S O -0.3316 Soluble
182 G O 0.2911 Aggregation-prone
183 L O 0.2399 Aggregation-prone
184 Y O 0.4644 Aggregation-prone
185 S O -0.0963 Soluble
186 L O 0.0000 Buried
187 S O -0.0561 Soluble
188 S O 0.0000 Buried
189 V O 0.0000 Buried
190 V O 0.4171 Aggregation-prone
191 T O 0.1104 Aggregation-prone
192 V O 0.0841 Aggregation-prone
193 P O -0.3021 Soluble
194 S O -0.3686 Soluble
195 S O -0.3704 Soluble
196 S O -0.4979 Soluble
197 L O -0.4013 Soluble
198 G O -0.8371 Soluble
199 T O -0.8133 Soluble
200 Q O -1.1876 Soluble
201 T O -1.1183 Soluble
202 Y O -0.6592 Soluble
203 I O -1.1770 Soluble
204 C O 0.0000 Buried
205 N O -1.6053 Soluble
206 V O 0.0000 Buried
207 N O -2.2884 Soluble
208 H O 0.0000 Buried
209 K O -2.8388 Soluble
210 P O -1.7303 Soluble
211 S O -1.9606 Soluble
212 N O -2.8254 Soluble
213 T O -2.2192 Soluble
214 K O -2.8090 Soluble
215 V O -1.5999 Soluble
216 D O -2.6607 Soluble
217 K O -2.1158 Soluble
218 K O -2.5356 Soluble
219 V O 0.0000 Buried
220 E O -2.0595 Soluble
221 P O -1.0073 Soluble
1 E P -0.8539 Soluble
2 I P 1.5673 Aggregation-prone
3 V P 1.8765 Aggregation-prone
4 L P 0.0000 Buried
5 T P 0.4015 Aggregation-prone
6 Q P -0.3963 Soluble
7 S P -0.4959 Soluble
8 P P -0.5865 Soluble
9 G P -0.8883 Soluble
10 T P -0.7726 Soluble
11 L P -0.2281 Soluble
12 S P -0.5257 Soluble
13 L P -0.5622 Soluble
14 S P -1.1370 Soluble
15 P P -1.5077 Soluble
16 G P -1.9406 Soluble
17 E P 0.0000 Buried
18 R P -2.3352 Soluble
19 A P 0.0000 Buried
20 T P -0.5797 Soluble
21 L P 0.0000 Buried
22 S P -0.5634 Soluble
23 C P 0.0000 Buried
24 R P -0.4927 Soluble
25 A P -0.5430 Soluble
26 S P -0.5104 Soluble
27 Q P -1.3616 Soluble
28 S P -1.0823 Soluble
29 V P -0.5513 Soluble
30 S P -0.2926 Soluble
36 S P -0.1760 Soluble
37 S P 0.0181 Aggregation-prone
38 Y P 0.5683 Aggregation-prone
39 L P 0.0000 Buried
40 A P 0.0000 Buried
41 W P 0.0000 Buried
42 Y P 0.0000 Buried
43 Q P -0.5692 Soluble
44 Q P -0.9617 Soluble
45 K P -1.4279 Soluble
46 P P -1.4731 Soluble
47 G P -1.4899 Soluble
48 Q P -1.7023 Soluble
49 A P 0.0000 Buried
50 P P 0.0000 Buried
51 R P -0.9819 Soluble
52 L P 0.0000 Buried
53 L P 0.0000 Buried
54 I P 0.0000 Buried
55 Y P -0.2328 Soluble
56 G P 0.0000 Buried
57 A P 0.0000 Buried
65 S P -0.5489 Soluble
66 S P -0.9218 Soluble
67 R P -1.6489 Soluble
68 A P -0.9220 Soluble
69 T P -0.4412 Soluble
70 G P -0.4536 Soluble
71 F P 0.1071 Aggregation-prone
72 P P -1.3454 Soluble
74 D P -2.5767 Soluble
75 R P -2.8464 Soluble
76 F P -1.5772 Soluble
77 S P -1.1548 Soluble
78 G P -0.4529 Soluble
79 S P -0.6126 Soluble
80 G P -0.7989 Soluble
83 S P -0.8974 Soluble
84 G P -1.0574 Soluble
85 T P -1.2053 Soluble
86 D P -1.4349 Soluble
87 F P 0.0000 Buried
88 T P -0.5426 Soluble
89 L P 0.0000 Buried
90 T P -0.7090 Soluble
91 I P 0.0000 Buried
92 S P -2.2118 Soluble
93 R P -3.0979 Soluble
94 L P 0.0000 Buried
95 E P -2.7300 Soluble
96 P P -2.2116 Soluble
97 E P -2.5790 Soluble
98 D P -1.8190 Soluble
99 F P -1.2586 Soluble
100 A P -1.0355 Soluble
101 V P 0.0000 Buried
102 Y P 0.0000 Buried
103 Y P -0.2854 Soluble
104 C P 0.0000 Buried
105 Q P 0.0000 Buried
106 Q P 0.0000 Buried
107 Y P 0.1440 Aggregation-prone
108 G P -0.3786 Soluble
109 N P -0.9201 Soluble
114 S P -0.8330 Soluble
115 P P -0.6368 Soluble
116 W P -0.1985 Soluble
117 T P -0.0039 Soluble
118 F P 0.0000 Buried
119 G P 0.0000 Buried
120 Q P -0.7066 Soluble
121 G P -0.9334 Soluble
122 T P 0.0000 Buried
123 K P -1.6446 Soluble
124 V P -0.5631 Soluble
125 E P -0.7328 Soluble
126 I P -0.7979 Soluble
127 R P -1.7988 Soluble
128 R P -1.4612 Soluble
129 T P -0.6820 Soluble
130 V P -0.4898 Soluble
131 A P -0.3546 Soluble
132 A P 0.0388 Aggregation-prone
133 P P 0.0000 Buried
134 S P 0.9419 Aggregation-prone
135 V P 2.4697 Aggregation-prone
136 F P 2.0520 Aggregation-prone
137 I P 0.9278 Aggregation-prone
138 F P 0.7264 Aggregation-prone
139 P P 0.0392 Aggregation-prone
140 P P -0.7491 Soluble
141 S P -1.4978 Soluble
142 D P -2.8980 Soluble
143 E P -2.9205 Soluble
144 Q P 0.0000 Buried
145 L P -1.0986 Soluble
146 K P -2.1444 Soluble
147 S P -1.6247 Soluble
148 G P -1.2934 Soluble
149 T P -0.5970 Soluble
150 A P 0.0000 Buried
151 S P -0.1479 Soluble
152 V P 0.0000 Buried
153 V P 0.1848 Aggregation-prone
154 C P 0.0000 Buried
155 L P 0.0000 Buried
156 L P 0.0000 Buried
157 N P -0.6092 Soluble
158 N P -1.6722 Soluble
159 F P 0.0000 Buried
160 Y P -1.1355 Soluble
161 P P -1.5717 Soluble
162 R P -2.4373 Soluble
163 E P -2.8576 Soluble
164 A P -1.9108 Soluble
165 K P -2.2383 Soluble
166 V P -1.1406 Soluble
167 Q P -1.5982 Soluble
168 W P -0.8996 Soluble
169 K P -1.6341 Soluble
170 V P -0.7439 Soluble
171 D P -1.3008 Soluble
172 N P -1.6195 Soluble
173 A P -0.6412 Soluble
174 L P 0.3368 Aggregation-prone
175 Q P -0.9995 Soluble
176 S P -0.9779 Soluble
177 G P -1.0600 Soluble
178 N P -1.2652 Soluble
179 S P -0.9354 Soluble
180 Q P -0.3452 Soluble
181 E P -0.4903 Soluble
182 S P 0.0511 Aggregation-prone
183 V P -0.1985 Soluble
184 T P -0.9234 Soluble
185 E P -2.4743 Soluble
186 Q P -2.7723 Soluble
187 D P -3.0233 Soluble
188 S P -2.5266 Soluble
189 K P -2.9005 Soluble
190 D P -2.9069 Soluble
191 S P -2.5665 Soluble
192 T P 0.0000 Buried
193 Y P 0.0000 Buried
194 S P 0.0000 Buried
195 L P 0.0000 Buried
196 S P -0.0739 Soluble
197 S P 0.0000 Buried
198 T P -0.2176 Soluble
199 L P 0.0000 Buried
200 T P -0.2132 Soluble
201 L P -0.3106 Soluble
202 S P -0.7284 Soluble
203 K P -0.9303 Soluble
204 A P -0.7014 Soluble
205 D P -1.3385 Soluble
206 Y P -1.4978 Soluble
207 E P -2.9722 Soluble
208 K P -2.9375 Soluble
209 H P 0.0000 Buried
210 K P -1.3606 Soluble
211 V P -0.6006 Soluble
212 Y P 0.0000 Buried
213 A P 0.0000 Buried
214 C P 0.0000 Buried
215 E P 0.0000 Buried
216 V P 0.0000 Buried
217 T P -1.0698 Soluble
218 H P -1.3654 Soluble
219 Q P -1.5263 Soluble
220 G P -1.0570 Soluble
221 L P -0.6408 Soluble
222 S P -0.7831 Soluble
223 S P -0.1662 Soluble
224 P P 0.7768 Aggregation-prone
225 V P 1.6090 Aggregation-prone
226 T P 0.5520 Aggregation-prone
227 K P -0.9551 Soluble
228 S P 0.0000 Buried
229 F P 0.8626 Aggregation-prone
230 N P -0.7083 Soluble
231 R P -1.0182 Soluble
232 G P -1.1794 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6749 2.8876 CSV PDB
4.5 -0.7211 2.8904 CSV PDB
5.0 -0.7748 2.8988 CSV PDB
5.5 -0.8258 2.9221 CSV PDB
6.0 -0.8634 2.9755 CSV PDB
6.5 -0.8786 3.0674 CSV PDB
7.0 -0.8708 3.188 CSV PDB
7.5 -0.8475 3.3222 CSV PDB
8.0 -0.8155 3.4614 CSV PDB
8.5 -0.777 3.6019 CSV PDB
9.0 -0.7323 3.7415 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH