Motavizumab / 4zyp

A4DAB172_4zyp_K_M | Source PDB: 4zyp | Chains: K, M | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6773
Max Score
2.7931
Min Score
-3.5603
Total Score
-287.16
Score CDR
-0.2607
Score non-CDR
-0.7279

Calculation Parameters

Chain Sequence(s) QVTLRESGPALVKPTQTLTLTCTFSGFSLSTAGMSVGWIRQPPGKALEWLADIWWDDKKHYNPSLKDRLTISKDTSKNQVVLKVTNMDPADTATYYCARDMIFNFYFDVWGQGTTVTVSSASTKGPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPDIQMTQSPSTLSASVGDRVTITCSASSRVGYMHWYQQKPGKAPKLLIYDTSKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCFQGSGYPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG input.pdb
Selected Chain(s) K (Heavy), M (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.5603
Maximum Score 2.7931
Average Score -0.6773
Total Score -287.1557

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q K -1.2411 Soluble
2 V K -0.6166 Soluble
3 T K -0.8726 Soluble
4 L K 0.0000 Buried
5 R K -1.9828 Soluble
6 E K 0.0000 Buried
7 S K -0.5875 Soluble
8 G K -0.2208 Soluble
9 P K -0.1291 Soluble
11 A K 0.1690 Aggregation-prone
12 L K 0.1587 Aggregation-prone
13 V K 0.0000 Buried
14 K K -2.1376 Soluble
15 P K -1.9629 Soluble
16 T K -2.0610 Soluble
17 Q K -2.2167 Soluble
18 T K -1.6750 Soluble
19 L K 0.0000 Buried
20 T K -0.6232 Soluble
21 L K 0.0000 Buried
22 T K -0.4561 Soluble
23 C K 0.0000 Buried
24 T K -1.0811 Soluble
25 F K 0.0000 Buried
26 S K -1.0514 Soluble
27 G K -0.8326 Soluble
28 F K -0.3508 Soluble
29 S K -0.4929 Soluble
30 L K 0.0000 Buried
31 S K -0.5439 Soluble
34 T K -0.0961 Soluble
35 A K 0.1975 Aggregation-prone
36 G K 0.0000 Buried
37 M K 0.7660 Aggregation-prone
38 S K 0.0000 Buried
39 V K 0.0000 Buried
40 G K 0.0000 Buried
41 W K 0.0000 Buried
42 I K 0.0000 Buried
43 R K 0.0000 Buried
44 Q K -0.9201 Soluble
45 P K 0.0000 Buried
46 P K -1.0953 Soluble
47 G K -1.4702 Soluble
48 K K -2.1802 Soluble
49 A K -1.2474 Soluble
50 L K 0.0000 Buried
51 E K -0.7532 Soluble
52 W K 0.0000 Buried
53 L K 0.0000 Buried
54 A K 0.0000 Buried
55 D K 0.0000 Buried
56 I K 0.0000 Buried
57 W K 0.0000 Buried
58 W K -1.0195 Soluble
59 D K -1.8727 Soluble
63 D K -2.7407 Soluble
64 K K -2.9329 Soluble
65 K K -2.0411 Soluble
66 H K -0.9154 Soluble
67 Y K -0.4051 Soluble
68 N K 0.0000 Buried
69 P K -1.0386 Soluble
70 S K -0.7427 Soluble
71 L K -0.8392 Soluble
72 K K -1.8602 Soluble
74 D K -2.4647 Soluble
75 R K -1.9253 Soluble
76 L K 0.0000 Buried
77 T K -0.8919 Soluble
78 I K 0.0000 Buried
79 S K -1.0113 Soluble
80 K K -1.2505 Soluble
81 D K -1.5742 Soluble
82 T K -1.3610 Soluble
83 S K -1.5468 Soluble
84 K K -2.3843 Soluble
85 N K -1.8342 Soluble
86 Q K -1.5415 Soluble
87 V K 0.0000 Buried
88 V K -0.1456 Soluble
89 L K 0.0000 Buried
90 K K -1.1210 Soluble
91 V K 0.0000 Buried
92 T K -1.8818 Soluble
93 N K -2.5129 Soluble
94 M K 0.0000 Buried
95 D K -2.5171 Soluble
96 P K -1.2712 Soluble
97 A K -0.6664 Soluble
98 D K 0.0000 Buried
99 T K -0.3834 Soluble
100 A K 0.0000 Buried
101 T K -0.3320 Soluble
102 Y K 0.0000 Buried
103 Y K 0.0000 Buried
104 C K 0.0000 Buried
105 A K 0.0000 Buried
106 R K 0.0000 Buried
107 D K 0.0000 Buried
108 M K 1.6577 Aggregation-prone
109 I K 2.7132 Aggregation-prone
110 F K 2.7931 Aggregation-prone
112 N K 1.4731 Aggregation-prone
113 F K 1.1972 Aggregation-prone
114 Y K 0.0000 Buried
115 F K 0.0000 Buried
116 D K -0.4584 Soluble
117 V K -0.4148 Soluble
118 W K -0.8385 Soluble
119 G K 0.0000 Buried
120 Q K -1.9981 Soluble
121 G K -1.3642 Soluble
122 T K -0.6396 Soluble
123 T K -0.1000 Soluble
124 V K 0.0000 Buried
125 T K -0.4289 Soluble
126 V K 0.0000 Buried
127 S K -0.8689 Soluble
128 S K -0.7057 Soluble
129 A K -0.5919 Soluble
130 S K -0.6698 Soluble
131 T K -0.9882 Soluble
132 K K -1.6213 Soluble
133 G K -1.2853 Soluble
134 P K -0.7486 Soluble
135 S K -0.4042 Soluble
136 V K 0.0000 Buried
137 F K 0.0000 Buried
138 P K -1.1160 Soluble
139 L K 0.0000 Buried
140 A K -1.0172 Soluble
141 P K 0.0000 Buried
142 S K -0.4229 Soluble
143 T K -0.2868 Soluble
144 A K -0.1771 Soluble
145 A K 0.0000 Buried
146 L K 0.0000 Buried
147 G K 0.0000 Buried
148 C K 0.0000 Buried
149 L K 0.0000 Buried
150 V K 0.0000 Buried
151 K K 0.0000 Buried
152 D K -0.5753 Soluble
153 Y K 0.0000 Buried
154 F K 0.0000 Buried
155 P K -1.0720 Soluble
156 E K -1.4884 Soluble
157 P K -1.2174 Soluble
158 V K -0.9421 Soluble
159 T K -0.6643 Soluble
160 V K -0.4655 Soluble
161 S K -0.4769 Soluble
162 W K 0.0000 Buried
163 N K -0.8653 Soluble
164 S K -0.7460 Soluble
165 G K -0.5830 Soluble
166 A K -0.2721 Soluble
167 L K -0.0403 Soluble
168 T K -0.2055 Soluble
169 S K -0.1564 Soluble
170 G K -0.1406 Soluble
171 V K 0.1453 Aggregation-prone
172 H K -0.3816 Soluble
173 T K -0.1589 Soluble
174 F K 0.0000 Buried
175 P K -0.3039 Soluble
176 A K 0.2264 Aggregation-prone
177 V K 0.7874 Aggregation-prone
178 L K 1.2340 Aggregation-prone
179 Q K 0.2673 Aggregation-prone
180 S K -0.1360 Soluble
181 S K -0.2647 Soluble
182 G K -0.0914 Soluble
183 L K 0.1244 Aggregation-prone
184 Y K 0.3895 Aggregation-prone
185 S K 0.0000 Buried
186 L K 0.0000 Buried
187 S K 0.0000 Buried
188 S K 0.0000 Buried
189 V K 0.0000 Buried
190 V K 0.0000 Buried
191 T K -0.1144 Soluble
192 V K 0.0000 Buried
193 P K -0.5113 Soluble
194 S K -0.4759 Soluble
195 S K -0.5465 Soluble
196 S K -0.6249 Soluble
197 L K -0.8406 Soluble
198 G K -1.1002 Soluble
199 T K -0.7603 Soluble
200 Q K -1.3408 Soluble
201 T K -1.1812 Soluble
202 Y K 0.0000 Buried
203 I K -1.1409 Soluble
204 C K 0.0000 Buried
205 N K -1.5551 Soluble
206 V K 0.0000 Buried
207 N K -1.9087 Soluble
208 H K 0.0000 Buried
209 K K -2.8367 Soluble
210 P K -1.8553 Soluble
211 S K -1.9511 Soluble
212 N K -2.6493 Soluble
213 T K -2.2916 Soluble
214 K K -2.7275 Soluble
215 V K -1.5235 Soluble
216 D K -2.5642 Soluble
217 K K -2.0969 Soluble
218 K K -2.5029 Soluble
219 V K 0.0000 Buried
220 E K -2.4523 Soluble
221 P K -1.1965 Soluble
1 D M -1.9554 Soluble
2 I M -1.5444 Soluble
3 Q M -1.6982 Soluble
4 M M 0.0000 Buried
5 T M -0.8459 Soluble
6 Q M -0.6265 Soluble
7 S M -0.5916 Soluble
8 P M -0.5343 Soluble
9 S M -0.6977 Soluble
10 T M -0.5618 Soluble
11 L M -0.2025 Soluble
12 S M -0.4949 Soluble
13 A M -0.5852 Soluble
14 S M -0.5126 Soluble
15 V M 0.1682 Aggregation-prone
16 G M -0.5727 Soluble
17 D M -1.4512 Soluble
18 R M -2.1656 Soluble
19 V M 0.0000 Buried
20 T M -0.5940 Soluble
21 I M 0.0000 Buried
22 T M -0.5485 Soluble
23 C M 0.0000 Buried
24 S M -1.3075 Soluble
25 A M 0.0000 Buried
26 S M -1.4419 Soluble
27 S M -1.7213 Soluble
28 R M -2.1654 Soluble
29 V M -0.9769 Soluble
37 G M -0.3986 Soluble
38 Y M 0.4657 Aggregation-prone
39 M M 0.0000 Buried
40 H M 0.0000 Buried
41 W M 0.0000 Buried
42 Y M 0.0000 Buried
43 Q M 0.0000 Buried
44 Q M 0.0000 Buried
45 K M -1.3647 Soluble
46 P M -1.0438 Soluble
47 G M -1.6113 Soluble
48 K M -2.4164 Soluble
49 A M -1.6403 Soluble
50 P M 0.0000 Buried
51 K M -1.6186 Soluble
52 L M -0.5548 Soluble
53 L M 0.0000 Buried
54 I M 0.0000 Buried
55 Y M -0.5711 Soluble
56 D M -0.9990 Soluble
57 T M -0.6420 Soluble
65 S M -1.0971 Soluble
66 K M -1.8537 Soluble
67 L M -0.6510 Soluble
68 A M -0.6186 Soluble
69 S M -0.4378 Soluble
70 G M -0.4195 Soluble
71 V M -0.2363 Soluble
72 P M -0.3442 Soluble
74 S M -0.4234 Soluble
75 R M -0.7705 Soluble
76 F M 0.0000 Buried
77 S M -0.6495 Soluble
78 G M -0.7889 Soluble
79 S M -0.8131 Soluble
80 G M -0.7679 Soluble
83 S M -1.0548 Soluble
84 G M -1.3763 Soluble
85 T M -1.8063 Soluble
86 E M -2.1426 Soluble
87 F M 0.0000 Buried
88 T M -0.6195 Soluble
89 L M 0.0000 Buried
90 T M -0.6336 Soluble
91 I M 0.0000 Buried
92 S M -1.2835 Soluble
93 S M -1.0877 Soluble
94 L M 0.0000 Buried
95 Q M -0.7640 Soluble
96 P M -0.8257 Soluble
97 D M -1.6737 Soluble
98 D M 0.0000 Buried
99 F M -0.2163 Soluble
100 A M 0.0000 Buried
101 T M 0.0000 Buried
102 Y M 0.0000 Buried
103 Y M 0.0000 Buried
104 C M 0.0000 Buried
105 F M 0.0000 Buried
106 Q M 0.0000 Buried
107 G M 0.1224 Aggregation-prone
108 S M -0.0919 Soluble
109 G M -0.3024 Soluble
114 Y M -0.0768 Soluble
115 P M -0.4757 Soluble
116 F M 0.0000 Buried
117 T M -0.6335 Soluble
118 F M 0.0000 Buried
119 G M 0.0000 Buried
120 G M -1.2153 Soluble
121 G M -0.9791 Soluble
122 T M 0.0000 Buried
123 K M -1.2481 Soluble
124 V M 0.0000 Buried
125 E M 0.0000 Buried
126 I M -0.1326 Soluble
127 K M -0.7392 Soluble
128 R M -1.6070 Soluble
129 T M -0.4577 Soluble
130 V M 0.5670 Aggregation-prone
131 A M 0.0672 Aggregation-prone
132 A M -0.0481 Soluble
133 P M 0.0000 Buried
134 S M -0.0283 Soluble
135 V M 0.1456 Aggregation-prone
136 F M 0.1617 Aggregation-prone
137 I M 0.1373 Aggregation-prone
138 F M 0.0000 Buried
139 P M -0.5736 Soluble
140 P M 0.0000 Buried
141 S M -1.5665 Soluble
142 D M -2.8906 Soluble
143 E M -2.9102 Soluble
144 Q M 0.0000 Buried
145 L M -2.1018 Soluble
146 K M -2.7581 Soluble
147 S M -1.7374 Soluble
148 G M -1.1875 Soluble
149 T M -0.9534 Soluble
150 A M 0.0000 Buried
151 S M 0.0000 Buried
152 V M 0.0000 Buried
153 V M 0.0000 Buried
154 C M 0.0000 Buried
155 L M 0.0000 Buried
156 L M 0.0000 Buried
157 N M 0.0000 Buried
158 N M -0.8540 Soluble
159 F M 0.0000 Buried
160 Y M 0.0000 Buried
161 P M -1.1351 Soluble
162 R M -1.8680 Soluble
163 E M -2.7017 Soluble
164 A M -2.0571 Soluble
165 K M -2.4648 Soluble
166 V M -1.4215 Soluble
167 Q M -1.0526 Soluble
168 W M 0.0000 Buried
169 K M -0.7517 Soluble
170 V M 0.0000 Buried
171 D M -1.8841 Soluble
172 N M -1.5946 Soluble
173 A M -0.3272 Soluble
174 L M 0.6583 Aggregation-prone
175 Q M -0.2732 Soluble
176 S M -0.4931 Soluble
177 G M -0.9003 Soluble
178 N M -0.8164 Soluble
179 S M -1.0990 Soluble
180 Q M -1.1967 Soluble
181 E M -1.7294 Soluble
182 S M -0.7142 Soluble
183 V M -0.2418 Soluble
184 T M -0.9213 Soluble
185 E M -2.1213 Soluble
186 Q M -1.9701 Soluble
187 D M -2.1814 Soluble
188 S M -1.8108 Soluble
189 K M -2.3263 Soluble
190 D M -1.9729 Soluble
191 S M -1.7080 Soluble
192 T M 0.0000 Buried
193 Y M 0.0000 Buried
194 S M 0.0000 Buried
195 L M 0.0000 Buried
196 S M 0.0000 Buried
197 S M 0.0000 Buried
198 T M -0.6449 Soluble
199 L M 0.0000 Buried
200 T M -0.3929 Soluble
201 L M -0.6812 Soluble
202 S M -0.9487 Soluble
203 K M -1.7118 Soluble
204 A M -1.6730 Soluble
205 D M -2.5025 Soluble
206 Y M 0.0000 Buried
207 E M -3.3819 Soluble
208 K M -3.5603 Soluble
209 H M -2.9818 Soluble
210 K M -3.1810 Soluble
211 V M -1.5883 Soluble
212 Y M 0.0000 Buried
213 A M -0.9446 Soluble
214 C M 0.0000 Buried
215 E M -0.9517 Soluble
216 V M 0.0000 Buried
217 T M -1.2679 Soluble
218 H M 0.0000 Buried
219 Q M -1.6340 Soluble
220 G M -0.3740 Soluble
221 L M -0.1782 Soluble
222 S M -0.4153 Soluble
223 S M -0.3549 Soluble
224 P M -0.4217 Soluble
225 V M 0.4089 Aggregation-prone
226 T M -0.2709 Soluble
227 K M -0.5918 Soluble
228 S M -0.5487 Soluble
229 F M -0.9115 Soluble
230 N M -1.9906 Soluble
231 R M -2.3641 Soluble
232 G M -1.5081 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6526 5.5584 CSV PDB
4.5 -0.6972 5.5584 CSV PDB
5.0 -0.748 5.5584 CSV PDB
5.5 -0.7955 5.5584 CSV PDB
6.0 -0.8285 5.5584 CSV PDB
6.5 -0.8387 5.5584 CSV PDB
7.0 -0.8263 5.5584 CSV PDB
7.5 -0.7989 5.5584 CSV PDB
8.0 -0.7629 5.5584 CSV PDB
8.5 -0.7195 5.5584 CSV PDB
9.0 -0.6679 5.5584 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH