Abazistobart / 7vux

A4DAB001_7vux_H_L | Source PDB: 7vux | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6954
Max Score
1.5057
Min Score
-3.7416
Total Score
-294.87
Score CDR
-0.2941
Score non-CDR
-0.7419

Calculation Parameters

Chain Sequence(s) EVKLVESGGGLVQPGGLRLSCAASGFAFSSYDMSWVRQAPGKRLEWVATISGGGRYTYYPDTVKGRFTISRDNAKNSHYLQMNSLRAEDTAVYFCASPYGGYFDVWGQGTLVTVSSASTKGPSVFPLAPSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVEEIVLTQSPATLSLSPGERATLSCRASQSISNFLHWYQQKPGQAPRLLIKYASQSISGIPARFSGGSGTDFTLTISSLEPEDFAVYFCQQSNSWPHTFGQGTKVEIKRTVAAPVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQEVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.7416
Maximum Score 1.5057
Average Score -0.6954
Total Score -294.8681

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E H -1.9773 Soluble
2 V H -0.8568 Soluble
3 K H -1.6875 Soluble
4 L H 0.0000 Buried
5 V H -0.1853 Soluble
6 E H -0.3337 Soluble
7 S H -0.5466 Soluble
8 G H -0.7052 Soluble
9 G H 0.0523 Aggregation-prone
11 G H 0.5652 Aggregation-prone
12 L H 0.8352 Aggregation-prone
13 V H 0.0000 Buried
14 Q H -1.5346 Soluble
15 P H -1.8494 Soluble
16 G H -1.6211 Soluble
17 G H -1.2160 Soluble
19 L H -0.7995 Soluble
20 R H -1.6731 Soluble
21 L H 0.0000 Buried
22 S H -0.4914 Soluble
23 C H 0.0000 Buried
24 A H -0.6152 Soluble
25 A H 0.0000 Buried
26 S H -0.9470 Soluble
27 G H -1.0314 Soluble
28 F H -0.2567 Soluble
29 A H 0.0251 Aggregation-prone
30 F H 0.0000 Buried
35 S H -0.7198 Soluble
36 S H -0.3028 Soluble
37 Y H 0.1700 Aggregation-prone
38 D H -0.2581 Soluble
39 M H 0.0000 Buried
40 S H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.5288 Soluble
45 A H -0.9616 Soluble
46 P H -0.9864 Soluble
47 G H -1.4952 Soluble
48 K H -2.1969 Soluble
49 R H -1.7545 Soluble
50 L H 0.0000 Buried
51 E H -0.6656 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 A H 0.0000 Buried
55 T H 0.0000 Buried
56 I H 0.0000 Buried
57 S H -0.4753 Soluble
58 G H -0.7556 Soluble
59 G H -1.2136 Soluble
62 G H -1.2774 Soluble
63 R H -1.4898 Soluble
64 Y H 0.3147 Aggregation-prone
65 T H 0.4040 Aggregation-prone
66 Y H 0.7099 Aggregation-prone
67 Y H -0.3795 Soluble
68 P H 0.0000 Buried
69 D H -2.4251 Soluble
70 T H -1.4736 Soluble
71 V H 0.0000 Buried
72 K H -2.5503 Soluble
74 G H -1.8308 Soluble
75 R H -1.6768 Soluble
76 F H 0.0000 Buried
77 T H -0.7699 Soluble
78 I H 0.0000 Buried
79 S H -0.4822 Soluble
80 R H -1.3057 Soluble
81 D H -1.7249 Soluble
82 N H -1.7704 Soluble
83 A H -1.4049 Soluble
84 K H -2.3309 Soluble
85 N H -1.7486 Soluble
86 S H -1.1597 Soluble
87 H H 0.0000 Buried
88 Y H -0.4373 Soluble
89 L H 0.0000 Buried
90 Q H -1.0796 Soluble
91 M H 0.0000 Buried
92 N H -1.7867 Soluble
93 S H -1.4776 Soluble
94 L H 0.0000 Buried
95 R H -2.7153 Soluble
96 A H -1.8706 Soluble
97 E H -2.3361 Soluble
98 D H 0.0000 Buried
99 T H -0.4732 Soluble
100 A H 0.0000 Buried
101 V H 0.7222 Aggregation-prone
102 Y H 0.0000 Buried
103 F H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 S H 0.0000 Buried
107 P H 0.0000 Buried
108 Y H 0.8288 Aggregation-prone
109 G H 0.0856 Aggregation-prone
113 G H 0.0291 Aggregation-prone
114 Y H 0.0000 Buried
115 F H 0.0000 Buried
116 D H -0.9463 Soluble
117 V H -0.3143 Soluble
118 W H -0.7180 Soluble
119 G H 0.0000 Buried
120 Q H -1.4539 Soluble
121 G H -0.4795 Soluble
122 T H 0.3576 Aggregation-prone
123 L H 1.5057 Aggregation-prone
124 V H 0.0000 Buried
125 T H 0.0175 Aggregation-prone
126 V H 0.0000 Buried
127 S H -0.7117 Soluble
128 S H -0.6695 Soluble
129 A H -0.4117 Soluble
130 S H -0.4754 Soluble
131 T H -0.6968 Soluble
132 K H -1.1714 Soluble
133 G H -1.4149 Soluble
134 P H 0.0000 Buried
135 S H -0.4755 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.2478 Soluble
139 L H 0.0000 Buried
140 A H -0.8691 Soluble
141 P H -0.8698 Soluble
143 S H -1.4097 Soluble
144 R H -2.3975 Soluble
145 S H -1.5184 Soluble
146 T H -1.4559 Soluble
147 S H -1.1959 Soluble
148 E H -2.1274 Soluble
149 S H -1.2550 Soluble
150 T H -0.8187 Soluble
151 A H 0.0000 Buried
152 A H 0.0000 Buried
153 L H 0.0000 Buried
154 G H 0.0000 Buried
155 C H 0.0000 Buried
156 L H 0.0000 Buried
157 V H 0.0000 Buried
158 K H 0.0000 Buried
159 D H -0.5401 Soluble
160 Y H 0.0000 Buried
161 F H 0.0000 Buried
162 P H -0.6564 Soluble
163 E H -1.0574 Soluble
164 P H -1.0659 Soluble
165 V H -0.7961 Soluble
166 T H -0.6066 Soluble
167 V H -0.1674 Soluble
168 S H -0.4567 Soluble
169 W H 0.0000 Buried
170 N H -1.0266 Soluble
171 S H -0.7704 Soluble
172 G H -0.5912 Soluble
173 A H -0.2761 Soluble
174 L H -0.0980 Soluble
175 T H -0.1948 Soluble
176 S H -0.1947 Soluble
177 G H -0.2423 Soluble
178 V H 0.1421 Aggregation-prone
179 H H -0.2489 Soluble
180 T H 0.1111 Aggregation-prone
181 F H 0.0000 Buried
182 P H -0.2273 Soluble
183 A H 0.2221 Aggregation-prone
184 V H 0.5925 Aggregation-prone
185 L H 1.2709 Aggregation-prone
186 Q H 0.3380 Aggregation-prone
187 S H -0.0049 Soluble
188 S H -0.1820 Soluble
189 G H 0.0709 Aggregation-prone
190 L H 0.0465 Aggregation-prone
191 Y H 0.4092 Aggregation-prone
192 S H 0.1507 Aggregation-prone
193 L H 0.0000 Buried
194 S H 0.0000 Buried
195 S H 0.0000 Buried
196 V H 0.0000 Buried
197 V H 0.0000 Buried
198 T H -0.1281 Soluble
199 V H 0.0000 Buried
200 P H -0.6392 Soluble
201 S H -1.0099 Soluble
202 S H -0.7427 Soluble
203 S H 0.0000 Buried
204 L H -1.0848 Soluble
205 G H -1.1905 Soluble
206 T H -0.8795 Soluble
207 K H -1.4478 Soluble
208 T H -1.4684 Soluble
209 Y H 0.0000 Buried
210 T H 0.0000 Buried
211 C H 0.0000 Buried
212 N H -1.5890 Soluble
213 V H 0.0000 Buried
214 D H -1.9464 Soluble
215 H H 0.0000 Buried
216 K H -2.7855 Soluble
217 P H -1.6953 Soluble
218 S H -1.8435 Soluble
219 N H -2.5565 Soluble
220 T H -2.0666 Soluble
221 K H -2.6694 Soluble
222 V H -1.7097 Soluble
223 D H -2.6551 Soluble
224 K H -2.2104 Soluble
225 R H -2.8510 Soluble
226 V H 0.0000 Buried
227 E H -2.6078 Soluble
1 E L -1.5299 Soluble
2 I L 0.0000 Buried
3 V L -0.0627 Soluble
4 L L 0.0000 Buried
5 T L -0.7965 Soluble
6 Q L 0.0000 Buried
7 S L -0.6222 Soluble
8 P L -0.2289 Soluble
9 A L -0.1931 Soluble
10 T L -0.0781 Soluble
11 L L 0.0259 Aggregation-prone
12 S L -0.4035 Soluble
13 L L -0.7866 Soluble
14 S L -1.2118 Soluble
15 P L -1.5961 Soluble
16 G L -1.6580 Soluble
17 E L -2.0560 Soluble
18 R L -2.4031 Soluble
19 A L 0.0000 Buried
20 T L -0.6555 Soluble
21 L L 0.0000 Buried
22 S L -0.9709 Soluble
23 C L 0.0000 Buried
24 R L -2.5904 Soluble
25 A L 0.0000 Buried
26 S L -1.3083 Soluble
27 Q L -1.9335 Soluble
28 S L -1.4023 Soluble
29 I L 0.0000 Buried
36 S L -0.7071 Soluble
37 N L -0.4947 Soluble
38 F L 0.3521 Aggregation-prone
39 L L 0.0000 Buried
40 H L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L -0.8769 Soluble
44 Q L -1.1926 Soluble
45 K L -1.6595 Soluble
46 P L -1.3737 Soluble
47 G L -1.5040 Soluble
48 Q L -2.2400 Soluble
49 A L -1.5005 Soluble
50 P L 0.0000 Buried
51 R L -1.8430 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 K L -0.7818 Soluble
56 Y L -0.2221 Soluble
57 A L 0.0000 Buried
65 S L -0.8886 Soluble
66 Q L -1.4214 Soluble
67 S L -0.8591 Soluble
68 I L -0.5643 Soluble
69 S L -0.4570 Soluble
70 G L -0.4455 Soluble
71 I L -0.1360 Soluble
72 P L -0.2131 Soluble
74 A L -0.2055 Soluble
75 R L -0.7018 Soluble
76 F L 0.0000 Buried
77 S L -0.5368 Soluble
78 G L -0.6626 Soluble
80 G L -1.3469 Soluble
83 S L -0.9314 Soluble
84 G L -1.2991 Soluble
85 T L -2.0048 Soluble
86 D L -2.5736 Soluble
87 F L 0.0000 Buried
88 T L -0.8835 Soluble
89 L L 0.0000 Buried
90 T L -0.6049 Soluble
91 I L 0.0000 Buried
92 S L -1.3192 Soluble
93 S L -1.6576 Soluble
94 L L 0.0000 Buried
95 E L -2.1926 Soluble
96 P L -1.6678 Soluble
97 E L -2.3510 Soluble
98 D L 0.0000 Buried
99 F L -0.5960 Soluble
100 A L 0.0000 Buried
101 V L -0.0942 Soluble
102 Y L 0.0000 Buried
103 F L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 S L 0.0259 Aggregation-prone
108 N L -0.4009 Soluble
109 S L -0.0802 Soluble
114 W L 0.5479 Aggregation-prone
115 P L -0.1887 Soluble
116 H L -0.0907 Soluble
117 T L -0.2716 Soluble
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 Q L -1.1029 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 K L -0.3647 Soluble
124 V L 0.0000 Buried
125 E L 0.0000 Buried
126 I L -0.3924 Soluble
127 K L -1.1174 Soluble
128 R L -0.9003 Soluble
129 T L -0.0930 Soluble
130 V L 0.5429 Aggregation-prone
131 A L 0.1899 Aggregation-prone
132 A L -0.0314 Soluble
133 P L -0.0254 Soluble
135 V L 0.2518 Aggregation-prone
136 F L 0.3343 Aggregation-prone
137 I L 0.2268 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.4486 Soluble
140 P L -0.8505 Soluble
141 S L -1.6194 Soluble
142 D L -2.9284 Soluble
143 E L -2.9685 Soluble
144 Q L 0.0000 Buried
145 L L -2.2791 Soluble
146 K L -2.8542 Soluble
147 S L -1.7758 Soluble
148 G L -1.2791 Soluble
149 T L -1.1389 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L -0.2721 Soluble
158 N L -0.6696 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.0052 Soluble
162 R L -1.3108 Soluble
163 E L -2.5215 Soluble
164 A L -1.9059 Soluble
165 K L -1.9740 Soluble
166 V L -0.9771 Soluble
167 Q L -0.4347 Soluble
168 W L 0.0000 Buried
169 K L -0.5851 Soluble
170 V L 0.0000 Buried
171 D L -1.8773 Soluble
172 N L -1.3752 Soluble
173 A L -0.2807 Soluble
174 L L 0.7236 Aggregation-prone
175 Q L -0.3184 Soluble
176 S L -0.6502 Soluble
177 G L -1.2981 Soluble
178 N L -1.6460 Soluble
179 S L -1.5507 Soluble
180 Q L -1.6098 Soluble
181 E L -1.7996 Soluble
183 V L 0.2468 Aggregation-prone
184 T L -0.5982 Soluble
185 E L -1.8897 Soluble
186 Q L -1.5485 Soluble
187 D L -1.9225 Soluble
188 S L -1.6697 Soluble
189 K L -2.2208 Soluble
190 D L -1.6126 Soluble
191 S L -1.5711 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L -0.3715 Soluble
197 S L 0.0000 Buried
198 T L -0.8352 Soluble
199 L L 0.0000 Buried
200 T L -0.7571 Soluble
201 L L -1.0728 Soluble
202 S L -1.3390 Soluble
203 K L -2.3865 Soluble
204 A L -2.1842 Soluble
205 D L -3.1094 Soluble
206 Y L 0.0000 Buried
207 E L -3.7040 Soluble
208 K L -3.7416 Soluble
209 H L -2.9918 Soluble
210 K L -3.1546 Soluble
211 V L -1.6103 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.6394 Soluble
216 V L 0.0000 Buried
217 T L -1.1063 Soluble
218 H L 0.0000 Buried
219 Q L -1.3707 Soluble
220 G L -0.3183 Soluble
221 L L -0.0679 Soluble
222 S L -0.3765 Soluble
223 S L -0.3749 Soluble
224 P L -0.4896 Soluble
225 V L 0.1711 Aggregation-prone
226 T L -0.2534 Soluble
227 K L -0.3385 Soluble
228 S L -0.3493 Soluble
229 F L -1.0008 Soluble
230 N L -2.1843 Soluble
231 R L -2.6894 Soluble
232 G L -2.3336 Soluble
233 E L -2.6344 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
Load structure to view sequence…
Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6578 2.7881 CSV PDB
4.5 -0.7023 2.7249 CSV PDB
5.0 -0.7568 2.6415 CSV PDB
5.5 -0.8112 2.5538 CSV PDB
6.0 -0.8539 2.475 CSV PDB
6.5 -0.8749 2.4159 CSV PDB
7.0 -0.872 2.3824 CSV PDB
7.5 -0.8519 2.3681 CSV PDB
8.0 -0.8219 2.363 CSV PDB
8.5 -0.7851 2.3612 CSV PDB
9.0 -0.7421 2.3604 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH