Tixagevimab / 7l7e

A4DAB270_7l7e_T_U | Source PDB: 7l7e | Chains: T, U | Done
99.14
Yes
10 Å
Yes
Avg A4D Score
-0.743
Max Score
1.8304
Min Score
-3.6449
Total Score
-319.51
Score CDR
-0.3321
Score non-CDR
-0.7996

Calculation Parameters

Chain Sequence(s) EVQLVQSGPEVKKPGTSVKVSCKASGFTFMSSAVQWVRQARGQRLEWIGWIVIGSGNTNYAQKFQERVTITRDMSTSTAYMELSSLRSEDTAVYYCAAPYCSSISCNDGFDIWGQGTMVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQHYGSSRGWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR input.pdb
Selected Chain(s) T (Heavy), U (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6449
Maximum Score 1.8304
Average Score -0.743
Total Score -319.5094

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E T -1.7148 Soluble
2 V T -0.4041 Soluble
3 Q T -1.0416 Soluble
4 L T 0.0000 Buried
5 V T -0.2492 Soluble
6 Q T 0.0000 Buried
7 S T -0.7879 Soluble
8 G T -0.7446 Soluble
9 P T -0.5473 Soluble
11 E T -0.7696 Soluble
12 V T -0.0933 Soluble
13 K T -1.2820 Soluble
14 K T -2.2795 Soluble
15 P T -1.9207 Soluble
16 G T -1.5136 Soluble
17 T T -1.1614 Soluble
18 S T -1.3252 Soluble
19 V T 0.0000 Buried
20 K T -2.0653 Soluble
21 V T 0.0000 Buried
22 S T -0.7150 Soluble
23 C T 0.0000 Buried
24 K T -1.2819 Soluble
25 A T 0.0000 Buried
26 S T -0.8049 Soluble
27 G T -0.7317 Soluble
28 F T -0.0758 Soluble
29 T T 0.3944 Aggregation-prone
30 F T 0.0000 Buried
35 M T 0.1965 Aggregation-prone
36 S T 0.2541 Aggregation-prone
37 S T 0.0000 Buried
38 A T 0.0947 Aggregation-prone
39 V T 0.0000 Buried
40 Q T 0.0000 Buried
41 W T 0.0000 Buried
42 V T 0.0000 Buried
43 R T 0.0000 Buried
44 Q T -1.1094 Soluble
45 A T -1.7609 Soluble
46 R T -2.4974 Soluble
47 G T -2.1466 Soluble
48 Q T -2.5627 Soluble
49 R T -2.0396 Soluble
50 L T 0.0000 Buried
51 E T -0.8805 Soluble
52 W T 0.0000 Buried
53 I T 0.0000 Buried
54 G T 0.0000 Buried
55 W T -0.2319 Soluble
56 I T 0.0000 Buried
57 V T -0.0953 Soluble
58 I T 0.0000 Buried
59 G T -0.4154 Soluble
62 S T -0.7116 Soluble
63 G T -0.9117 Soluble
64 N T -1.3872 Soluble
65 T T -0.8928 Soluble
66 N T -1.1591 Soluble
67 Y T -1.4273 Soluble
68 A T -1.9833 Soluble
69 Q T -3.0975 Soluble
70 K T -2.8466 Soluble
71 F T 0.0000 Buried
72 Q T -2.6596 Soluble
74 E T -2.8399 Soluble
75 R T -1.7485 Soluble
76 V T 0.0000 Buried
77 T T -0.8974 Soluble
78 I T 0.0000 Buried
79 T T -0.4703 Soluble
80 R T -0.8387 Soluble
81 D T -0.9096 Soluble
82 M T -0.1526 Soluble
83 S T -0.2781 Soluble
84 T T -0.5810 Soluble
85 S T -0.5594 Soluble
86 T T 0.0000 Buried
87 A T 0.0000 Buried
88 Y T -0.7174 Soluble
89 M T 0.0000 Buried
90 E T -1.4527 Soluble
91 L T 0.0000 Buried
92 S T -1.2821 Soluble
93 S T -1.2676 Soluble
94 L T 0.0000 Buried
95 R T -3.0004 Soluble
96 S T -2.3559 Soluble
97 E T -2.5068 Soluble
98 D T 0.0000 Buried
99 T T -1.1522 Soluble
100 A T 0.0000 Buried
101 V T -0.0189 Soluble
102 Y T 0.0000 Buried
103 Y T 0.0000 Buried
104 C T 0.0000 Buried
105 A T 0.0000 Buried
106 A T 0.0000 Buried
107 P T -0.4954 Soluble
108 Y T -0.0927 Soluble
109 C T 0.0000 Buried
110 S T 0.5449 Aggregation-prone
111 S T 0.7719 Aggregation-prone
111A I T 1.8304 Aggregation-prone
112B S T 0.5037 Aggregation-prone
112A C T -0.1349 Soluble
112 N T -1.4436 Soluble
113 D T -1.9835 Soluble
114 G T 0.0000 Buried
115 F T 0.0000 Buried
116 D T -0.8229 Soluble
117 I T 0.0000 Buried
118 W T 0.0000 Buried
119 G T 0.0000 Buried
120 Q T -1.3539 Soluble
121 G T -0.6757 Soluble
122 T T 0.0000 Buried
123 M T -0.0361 Soluble
124 V T 0.0000 Buried
125 T T 0.0000 Buried
126 V T 0.0000 Buried
127 S T -1.1989 Soluble
128 S T -1.0501 Soluble
129 A T -0.5470 Soluble
130 S T -0.5675 Soluble
131 T T -0.5347 Soluble
132 K T -1.1871 Soluble
133 G T -1.4192 Soluble
134 P T 0.0000 Buried
135 S T -0.4978 Soluble
136 V T 0.0000 Buried
137 F T 0.0000 Buried
138 P T -1.2156 Soluble
139 L T 0.0000 Buried
140 A T -0.6520 Soluble
141 P T 0.0000 Buried
142 S T -0.4627 Soluble
143 G T -0.6422 Soluble
144 T T -0.4886 Soluble
145 A T -0.2687 Soluble
146 A T 0.0000 Buried
147 L T 0.0000 Buried
148 G T 0.0000 Buried
149 C T 0.0000 Buried
150 L T 0.0000 Buried
151 V T 0.0000 Buried
152 K T 0.0000 Buried
153 D T -0.5052 Soluble
154 Y T 0.0000 Buried
155 F T 0.0000 Buried
156 P T 0.0000 Buried
157 E T -0.4829 Soluble
158 P T -0.8095 Soluble
159 V T -0.7642 Soluble
160 T T -0.6622 Soluble
161 V T -0.2404 Soluble
162 S T -0.4884 Soluble
163 W T 0.0000 Buried
164 N T -0.9313 Soluble
165 S T -0.7328 Soluble
166 G T -0.6097 Soluble
167 A T -0.3020 Soluble
168 L T -0.0452 Soluble
169 T T -0.2003 Soluble
170 S T -0.1978 Soluble
171 G T -0.2185 Soluble
172 V T 0.1398 Aggregation-prone
173 H T -0.2837 Soluble
174 T T 0.0423 Aggregation-prone
175 F T 0.0000 Buried
176 P T -0.5697 Soluble
177 A T 0.0414 Aggregation-prone
178 V T 0.1685 Aggregation-prone
179 L T 0.7080 Aggregation-prone
180 Q T 0.0490 Aggregation-prone
181 S T -0.1706 Soluble
182 S T -0.2555 Soluble
183 G T -0.0698 Soluble
184 L T -0.0349 Soluble
185 Y T 0.0000 Buried
186 S T 0.0000 Buried
187 L T 0.0000 Buried
188 S T 0.0000 Buried
189 S T 0.0000 Buried
190 V T 0.0000 Buried
191 V T 0.0000 Buried
192 T T -0.1504 Soluble
193 V T 0.0000 Buried
194 P T -0.5868 Soluble
195 S T -0.5698 Soluble
196 S T -0.6160 Soluble
197 S T 0.0000 Buried
198 L T -0.8766 Soluble
199 G T -1.0352 Soluble
200 T T -0.7605 Soluble
201 Q T -1.3739 Soluble
202 T T -1.2196 Soluble
203 Y T 0.0000 Buried
204 I T -1.3879 Soluble
205 C T 0.0000 Buried
206 N T -1.6633 Soluble
207 V T 0.0000 Buried
208 N T -2.3469 Soluble
209 H T 0.0000 Buried
210 K T -2.8481 Soluble
211 P T -1.6341 Soluble
212 S T -1.8874 Soluble
213 N T -2.6559 Soluble
214 T T -2.2109 Soluble
215 K T -2.8917 Soluble
216 V T -1.7888 Soluble
217 D T -2.5941 Soluble
218 K T -2.2190 Soluble
219 K T -2.6672 Soluble
220 V T 0.0000 Buried
221 E T -2.5183 Soluble
222 P T -1.2064 Soluble
1 E U -1.9494 Soluble
2 I U -0.4549 Soluble
3 V U 0.3193 Aggregation-prone
4 L U 0.0000 Buried
5 T U -0.8533 Soluble
6 Q U 0.0000 Buried
7 S U -0.7888 Soluble
8 P U -0.5057 Soluble
9 G U -0.8242 Soluble
10 T U -0.3707 Soluble
11 L U -0.1997 Soluble
12 S U -0.5237 Soluble
13 L U -1.0786 Soluble
14 S U -1.5630 Soluble
15 P U -1.7834 Soluble
16 G U -2.1636 Soluble
17 E U -2.7451 Soluble
18 R U -3.1092 Soluble
19 A U 0.0000 Buried
20 T U -0.5251 Soluble
21 L U 0.0000 Buried
22 S U -0.9029 Soluble
23 C U 0.0000 Buried
24 R U -2.4245 Soluble
25 A U 0.0000 Buried
26 S U -1.1477 Soluble
27 Q U -1.7326 Soluble
28 S U -1.2946 Soluble
29 V U -0.5102 Soluble
30 S U -0.2035 Soluble
36 S U -0.3606 Soluble
37 S U -0.1601 Soluble
38 Y U 0.3115 Aggregation-prone
39 L U 0.0000 Buried
40 A U 0.0000 Buried
41 W U 0.0000 Buried
42 Y U 0.0000 Buried
43 Q U -0.7112 Soluble
44 Q U 0.0000 Buried
45 K U -1.5225 Soluble
46 P U -1.3991 Soluble
47 G U -1.3294 Soluble
48 Q U -2.0682 Soluble
49 A U -1.3772 Soluble
50 P U 0.0000 Buried
51 R U -1.4748 Soluble
52 L U 0.0000 Buried
53 L U 0.0000 Buried
54 I U 0.0000 Buried
55 Y U -0.5132 Soluble
56 G U -0.4962 Soluble
57 A U 0.0000 Buried
65 S U -0.6679 Soluble
66 S U -0.8827 Soluble
67 R U -1.4136 Soluble
68 A U -1.0669 Soluble
69 T U -0.5895 Soluble
70 G U -0.7576 Soluble
71 I U -0.7157 Soluble
72 P U -1.1902 Soluble
74 D U -2.3336 Soluble
75 R U -1.8840 Soluble
76 F U 0.0000 Buried
77 S U -0.8935 Soluble
78 G U 0.0000 Buried
79 S U -0.7135 Soluble
80 G U -1.1804 Soluble
83 S U -1.1401 Soluble
84 G U -1.2685 Soluble
85 T U -1.8673 Soluble
86 D U -2.4091 Soluble
87 F U 0.0000 Buried
88 T U -0.8240 Soluble
89 L U 0.0000 Buried
90 T U -0.7961 Soluble
91 I U 0.0000 Buried
92 S U -2.4487 Soluble
93 R U -3.3468 Soluble
94 L U 0.0000 Buried
95 E U -1.7227 Soluble
96 P U -1.4935 Soluble
97 E U -2.0635 Soluble
98 D U 0.0000 Buried
99 F U -0.5054 Soluble
100 A U 0.0000 Buried
101 V U -0.1743 Soluble
102 Y U 0.0000 Buried
103 Y U 0.0000 Buried
104 C U 0.0000 Buried
105 Q U 0.0000 Buried
106 H U 0.0000 Buried
107 Y U 0.0000 Buried
108 G U 0.0000 Buried
109 S U -0.7757 Soluble
113 S U -1.3209 Soluble
114 R U -2.4398 Soluble
115 G U -1.6505 Soluble
116 W U 0.0000 Buried
117 T U -0.3617 Soluble
118 F U 0.0000 Buried
119 G U 0.0000 Buried
120 Q U -1.5800 Soluble
121 G U -1.0233 Soluble
122 T U 0.0000 Buried
123 K U -0.5857 Soluble
124 V U 0.0000 Buried
125 E U 0.0000 Buried
126 I U -0.8878 Soluble
127 K U -1.7064 Soluble
128 R U -1.1788 Soluble
129 T U -0.2219 Soluble
130 V U 0.4405 Aggregation-prone
131 A U 0.0741 Aggregation-prone
132 A U -0.0228 Soluble
133 P U 0.0000 Buried
134 S U -0.1440 Soluble
135 V U 0.0000 Buried
136 F U 0.1496 Aggregation-prone
137 I U 0.1434 Aggregation-prone
138 F U 0.0000 Buried
139 P U -0.7149 Soluble
140 P U -0.8045 Soluble
141 S U -1.7550 Soluble
142 D U -3.0699 Soluble
143 E U -3.2741 Soluble
144 Q U 0.0000 Buried
145 L U -2.3193 Soluble
146 K U -2.8846 Soluble
147 S U -1.8017 Soluble
148 G U -1.4442 Soluble
149 T U -1.0719 Soluble
150 A U 0.0000 Buried
151 S U 0.0000 Buried
152 V U 0.0000 Buried
153 V U 0.0000 Buried
154 C U 0.0000 Buried
155 L U 0.0000 Buried
156 L U 0.0000 Buried
157 N U 0.0000 Buried
158 N U -0.6971 Soluble
159 F U 0.0000 Buried
160 Y U 0.0000 Buried
161 P U -1.2713 Soluble
162 R U -1.8482 Soluble
163 E U -2.7619 Soluble
164 A U -2.0211 Soluble
165 K U -2.4612 Soluble
166 V U -1.1884 Soluble
167 Q U -0.7927 Soluble
168 W U 0.0000 Buried
169 K U -0.3991 Soluble
170 V U 0.0000 Buried
171 D U -1.7199 Soluble
172 N U -1.4202 Soluble
173 A U -0.2563 Soluble
174 L U 0.4604 Aggregation-prone
175 Q U -0.2497 Soluble
176 S U -0.4910 Soluble
177 G U -0.8934 Soluble
178 N U -0.8000 Soluble
179 S U -1.2112 Soluble
180 Q U -1.5132 Soluble
181 E U -2.1266 Soluble
182 S U -0.9320 Soluble
183 V U -0.4736 Soluble
184 T U 0.0000 Buried
185 E U -2.0976 Soluble
186 Q U -1.7077 Soluble
187 D U -1.8436 Soluble
188 S U -1.6754 Soluble
189 K U -2.2312 Soluble
190 D U -1.6951 Soluble
191 S U -1.7664 Soluble
192 T U 0.0000 Buried
193 Y U 0.0000 Buried
194 S U 0.0000 Buried
195 L U 0.0000 Buried
196 S U 0.0000 Buried
197 S U 0.0000 Buried
198 T U -0.6540 Soluble
199 L U 0.0000 Buried
200 T U -0.3252 Soluble
201 L U -0.7897 Soluble
202 S U -1.2629 Soluble
203 K U -2.1423 Soluble
204 A U -1.9676 Soluble
205 D U -3.0525 Soluble
206 Y U 0.0000 Buried
207 E U -3.6449 Soluble
208 K U -3.6110 Soluble
209 H U -3.2849 Soluble
210 K U -3.4065 Soluble
211 V U -1.6001 Soluble
212 Y U 0.0000 Buried
213 A U 0.0000 Buried
214 C U 0.0000 Buried
215 E U -0.9663 Soluble
216 V U 0.0000 Buried
217 T U -1.2202 Soluble
218 H U 0.0000 Buried
219 Q U -1.6476 Soluble
220 G U -0.3637 Soluble
221 L U -0.1921 Soluble
222 S U -0.4247 Soluble
223 S U -0.4342 Soluble
224 P U -0.6392 Soluble
225 V U -0.2363 Soluble
226 T U -0.6546 Soluble
227 K U -0.8236 Soluble
228 S U -0.6650 Soluble
229 F U -1.1459 Soluble
230 N U -2.5327 Soluble
231 R U -3.0501 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.815 1.845 CSV PDB
4.5 -0.859 1.845 CSV PDB
5.0 -0.9119 1.845 CSV PDB
5.5 -0.9633 1.845 CSV PDB
6.0 -1.0021 1.845 CSV PDB
6.5 -1.0188 1.845 CSV PDB
7.0 -1.0114 1.845 CSV PDB
7.5 -0.9874 1.845 CSV PDB
8.0 -0.9544 1.845 CSV PDB
8.5 -0.9152 1.845 CSV PDB
9.0 -0.8705 1.845 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH