Sonavibart / 5jw5

A4DAB244_5jw5_H_L | Source PDB: 5jw5 | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7024
Max Score
2.2494
Min Score
-3.495
Total Score
-299.9
Score CDR
-0.0613
Score non-CDR
-0.7893

Calculation Parameters

Chain Sequence(s) QQLQQSGPGLVKPSQTSLTCAIGDSVSSYNAVWNWIRQSPSRGLEWLGRTYYRSGWYNDYAESVKSRITINPDTSKNQFSLQLNSVTPDTAVYYCARSGHITVFGVNVDAFDMWGQGTMVTVSSASTKGPSVFPLAPSSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVHKPSNTKVDKKVEPKDIQMTQSPSSLSASVGDRVTITCRTSQSLSSYTHWYQQKPGKAPKLLIYAASSRGSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNAQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.495
Maximum Score 2.2494
Average Score -0.7024
Total Score -299.9049

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.6403 Soluble
3 Q H -1.9001 Soluble
4 L H 0.0000 Buried
5 Q H -1.5649 Soluble
6 Q H 0.0000 Buried
7 S H -0.7458 Soluble
8 G H -0.3608 Soluble
9 P H -0.5108 Soluble
11 G H 0.0000 Buried
12 L H -0.1796 Soluble
13 V H 0.0000 Buried
14 K H -1.8517 Soluble
15 P H -1.4145 Soluble
16 S H -1.4500 Soluble
17 Q H -2.0066 Soluble
18 T H -1.4395 Soluble
20 S H -0.7635 Soluble
21 L H 0.0000 Buried
22 T H -0.6946 Soluble
23 C H 0.0000 Buried
24 A H -1.0448 Soluble
25 I H -0.9328 Soluble
27 G H -1.2474 Soluble
28 D H -1.1062 Soluble
29 S H -0.5922 Soluble
30 V H 0.0000 Buried
31 S H 0.0504 Aggregation-prone
34 S H 0.2179 Aggregation-prone
35 Y H 0.7911 Aggregation-prone
36 N H -0.6117 Soluble
37 A H 0.0000 Buried
38 V H 0.0000 Buried
39 W H 0.0000 Buried
40 N H 0.0000 Buried
41 W H 0.0000 Buried
42 I H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.6515 Soluble
45 S H -0.8923 Soluble
46 P H -0.9215 Soluble
47 S H -1.4186 Soluble
48 R H -2.3408 Soluble
49 G H -1.5492 Soluble
50 L H 0.0000 Buried
51 E H -0.9956 Soluble
52 W H 0.0000 Buried
53 L H 0.0000 Buried
54 G H 0.0000 Buried
55 R H -0.8014 Soluble
56 T H 0.0000 Buried
57 Y H 0.3233 Aggregation-prone
58 Y H 0.8270 Aggregation-prone
59 R H 0.3424 Aggregation-prone
60 S H 0.1117 Aggregation-prone
62 G H 0.2478 Aggregation-prone
63 W H 0.5267 Aggregation-prone
64 Y H 0.2526 Aggregation-prone
65 N H -1.0537 Soluble
66 D H -1.6201 Soluble
67 Y H -1.7753 Soluble
68 A H 0.0000 Buried
69 E H -2.5408 Soluble
70 S H -1.5936 Soluble
71 V H 0.0000 Buried
72 K H -2.5025 Soluble
74 S H -1.5458 Soluble
75 R H -1.3101 Soluble
76 I H 0.0000 Buried
77 T H -1.2519 Soluble
78 I H 0.0000 Buried
79 N H -1.5986 Soluble
80 P H -1.3353 Soluble
81 D H -1.7462 Soluble
82 T H -1.3531 Soluble
83 S H -1.4196 Soluble
84 K H -2.2193 Soluble
85 N H -1.6053 Soluble
86 Q H -1.4776 Soluble
87 F H 0.0000 Buried
88 S H -0.8672 Soluble
89 L H 0.0000 Buried
90 Q H -1.0264 Soluble
91 L H 0.0000 Buried
92 N H -1.4483 Soluble
93 S H -1.3571 Soluble
94 V H 0.0000 Buried
95 T H -0.8618 Soluble
96 P H -0.5845 Soluble
98 D H -0.4054 Soluble
99 T H -0.1094 Soluble
100 A H 0.0000 Buried
101 V H 0.2036 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H 0.0000 Buried
107 S H 0.0000 Buried
108 G H -0.4934 Soluble
109 H H -0.5684 Soluble
110 I H -0.1260 Soluble
111 T H 0.6297 Aggregation-prone
111A V H 1.5296 Aggregation-prone
111B F H 2.2494 Aggregation-prone
112C G H 1.2858 Aggregation-prone
112B V H 1.8064 Aggregation-prone
112A N H 0.0301 Aggregation-prone
112 V H 0.0000 Buried
113 D H -0.8367 Soluble
114 A H 0.0000 Buried
115 F H 0.0000 Buried
116 D H -0.5551 Soluble
117 M H -0.7598 Soluble
118 W H -0.9210 Soluble
119 G H 0.0000 Buried
120 Q H -1.9098 Soluble
121 G H -0.9323 Soluble
122 T H 0.0000 Buried
123 M H 0.3269 Aggregation-prone
124 V H 0.0000 Buried
125 T H 0.0000 Buried
126 V H 0.0000 Buried
127 S H -0.6615 Soluble
128 S H -0.7336 Soluble
129 A H -0.4768 Soluble
130 S H -0.6089 Soluble
131 T H -0.7383 Soluble
132 K H -1.2025 Soluble
133 G H -1.2680 Soluble
134 P H -0.5408 Soluble
135 S H -0.2696 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.1847 Soluble
139 L H 0.0000 Buried
140 A H -1.2880 Soluble
141 P H 0.0000 Buried
142 S H -1.0207 Soluble
143 S H -0.6405 Soluble
144 G H -0.6392 Soluble
145 T H -0.4795 Soluble
146 A H -0.2757 Soluble
147 A H 0.0000 Buried
148 L H 0.0000 Buried
149 G H 0.0000 Buried
150 C H 0.0000 Buried
151 L H 0.0000 Buried
152 V H 0.0000 Buried
153 K H 0.0000 Buried
154 D H -0.3940 Soluble
155 Y H 0.0000 Buried
156 F H 0.0000 Buried
157 P H 0.0000 Buried
158 E H -0.2029 Soluble
159 P H -0.4161 Soluble
160 V H -0.4834 Soluble
161 T H -0.4221 Soluble
162 V H -0.3127 Soluble
163 S H -0.3537 Soluble
164 W H 0.0000 Buried
165 N H -0.6993 Soluble
166 S H -0.6533 Soluble
167 G H -0.5712 Soluble
168 A H -0.2332 Soluble
169 L H 0.0361 Aggregation-prone
170 T H -0.1607 Soluble
171 S H -0.1700 Soluble
172 G H -0.1839 Soluble
173 V H 0.1838 Aggregation-prone
174 H H -0.2986 Soluble
175 T H 0.0118 Aggregation-prone
176 F H 0.0000 Buried
177 P H -0.3328 Soluble
178 A H 0.3110 Aggregation-prone
179 V H 0.7220 Aggregation-prone
180 L H 1.4869 Aggregation-prone
181 Q H 0.4691 Aggregation-prone
182 S H -0.0035 Soluble
183 S H -0.1682 Soluble
184 G H 0.1198 Aggregation-prone
185 L H 0.2538 Aggregation-prone
186 Y H 0.5639 Aggregation-prone
187 S H 0.0000 Buried
188 L H 0.0000 Buried
189 S H 0.0000 Buried
190 S H 0.0000 Buried
191 V H 0.0000 Buried
192 V H 0.0000 Buried
193 T H -0.1239 Soluble
194 V H 0.0000 Buried
195 P H -0.5645 Soluble
196 S H -0.5526 Soluble
197 S H -0.6010 Soluble
198 S H -0.5648 Soluble
199 L H -0.7861 Soluble
200 G H -0.9347 Soluble
201 T H -0.6603 Soluble
202 Q H -1.0787 Soluble
203 T H -1.0296 Soluble
204 Y H 0.0000 Buried
205 I H -1.1685 Soluble
206 C H 0.0000 Buried
207 N H -1.4243 Soluble
208 V H 0.0000 Buried
210 H H 0.0000 Buried
211 K H -2.6311 Soluble
212 P H -1.5376 Soluble
213 S H -1.7831 Soluble
214 N H -2.4871 Soluble
215 T H -1.9478 Soluble
216 K H -2.4866 Soluble
217 V H -1.4387 Soluble
218 D H -2.4779 Soluble
219 K H -2.0805 Soluble
220 K H -2.5900 Soluble
221 V H 0.0000 Buried
222 E H -2.8369 Soluble
223 P H -2.0182 Soluble
224 K H -2.5045 Soluble
1 D L -2.5186 Soluble
2 I L -1.7801 Soluble
3 Q L -2.3430 Soluble
4 M L 0.0000 Buried
5 T L -1.3878 Soluble
6 Q L 0.0000 Buried
7 S L -0.7655 Soluble
8 P L -0.5833 Soluble
9 S L -0.9819 Soluble
10 S L -1.0584 Soluble
11 L L -0.7713 Soluble
12 S L -1.0595 Soluble
13 A L -1.1349 Soluble
14 S L -1.0756 Soluble
15 V L -0.3830 Soluble
16 G L -0.9194 Soluble
17 D L -1.9991 Soluble
18 R L -2.3905 Soluble
19 V L 0.0000 Buried
20 T L -0.6440 Soluble
21 I L 0.0000 Buried
22 T L -0.7671 Soluble
23 C L 0.0000 Buried
24 R L -2.4506 Soluble
25 T L 0.0000 Buried
26 S L -1.6410 Soluble
27 Q L -1.6410 Soluble
28 S L -0.4293 Soluble
29 L L 1.1351 Aggregation-prone
36 S L 0.4222 Aggregation-prone
37 S L -0.0111 Soluble
38 Y L 0.2893 Aggregation-prone
39 T L 0.0000 Buried
40 H L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L -1.3284 Soluble
45 K L -1.8387 Soluble
46 P L -1.5169 Soluble
47 G L -1.8153 Soluble
48 K L -2.5436 Soluble
49 A L -1.6461 Soluble
50 P L 0.0000 Buried
51 K L -1.5140 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.2328 Soluble
56 A L -0.1431 Soluble
57 A L -0.3651 Soluble
65 S L -0.6380 Soluble
66 S L -0.8209 Soluble
67 R L -1.6381 Soluble
68 G L 0.0000 Buried
69 S L -0.9476 Soluble
70 G L -0.8386 Soluble
71 V L 0.0000 Buried
72 P L -0.7150 Soluble
74 S L -0.7645 Soluble
75 R L -0.9515 Soluble
76 F L 0.0000 Buried
77 S L -0.7270 Soluble
78 G L -0.5926 Soluble
79 S L -0.5985 Soluble
80 G L -1.0133 Soluble
83 S L -1.0283 Soluble
84 G L -0.8626 Soluble
85 T L -1.1964 Soluble
86 D L -1.6367 Soluble
87 F L 0.0000 Buried
88 T L -0.6732 Soluble
89 L L 0.0000 Buried
90 T L -0.6137 Soluble
91 I L 0.0000 Buried
92 S L -1.3416 Soluble
93 S L -1.2484 Soluble
94 L L 0.0000 Buried
95 Q L -0.9461 Soluble
96 P L -1.5903 Soluble
97 E L -1.7912 Soluble
98 D L 0.0000 Buried
99 F L -1.4522 Soluble
100 A L 0.0000 Buried
101 T L -1.1261 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 S L -1.2993 Soluble
116 R L -2.2387 Soluble
117 T L -1.4785 Soluble
118 F L -0.7789 Soluble
119 G L 0.0000 Buried
120 Q L -1.7255 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 K L -2.1234 Soluble
124 V L 0.0000 Buried
125 E L -1.6819 Soluble
126 I L 0.0000 Buried
127 K L -1.4467 Soluble
128 R L -0.9425 Soluble
129 T L -0.0801 Soluble
130 V L 0.3924 Aggregation-prone
131 A L 0.1801 Aggregation-prone
132 A L -0.0779 Soluble
133 P L 0.0000 Buried
134 S L -0.1464 Soluble
135 V L 0.0000 Buried
136 F L 0.1257 Aggregation-prone
137 I L 0.1126 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.5241 Soluble
140 P L -0.8971 Soluble
141 S L -1.9119 Soluble
142 D L -3.0867 Soluble
143 E L -3.2697 Soluble
144 Q L 0.0000 Buried
145 L L -2.3740 Soluble
146 K L -2.9219 Soluble
147 S L -1.8123 Soluble
148 G L -1.4215 Soluble
149 T L -1.0578 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.7908 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.6509 Soluble
162 R L -3.0171 Soluble
163 E L -3.2212 Soluble
164 A L -2.3381 Soluble
165 K L -2.6375 Soluble
166 V L -1.4689 Soluble
167 Q L -1.8069 Soluble
168 W L 0.0000 Buried
169 K L -1.7737 Soluble
170 V L 0.0000 Buried
171 D L -2.3049 Soluble
172 N L -2.1300 Soluble
173 A L -1.1990 Soluble
175 Q L -1.4307 Soluble
176 S L -1.0607 Soluble
177 G L -0.9180 Soluble
178 N L -0.7992 Soluble
179 S L -1.0636 Soluble
180 Q L -0.9931 Soluble
181 E L -1.5755 Soluble
182 S L -0.7031 Soluble
183 V L -0.8353 Soluble
184 T L -1.1725 Soluble
185 E L -2.3052 Soluble
186 Q L 0.0000 Buried
187 D L -2.0053 Soluble
188 S L -2.1865 Soluble
189 K L -2.5611 Soluble
190 D L -1.8941 Soluble
191 S L 0.0000 Buried
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.5190 Soluble
199 L L 0.0000 Buried
200 T L -0.3726 Soluble
201 L L -0.6343 Soluble
202 S L -1.0051 Soluble
203 K L -2.0052 Soluble
204 A L -1.8085 Soluble
205 D L -2.4452 Soluble
206 Y L 0.0000 Buried
207 E L -3.2273 Soluble
208 K L -3.4950 Soluble
209 H L -3.0607 Soluble
210 K L -3.2518 Soluble
211 V L -1.5143 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -1.2657 Soluble
216 V L 0.0000 Buried
217 T L -1.3987 Soluble
218 H L 0.0000 Buried
219 Q L -1.7325 Soluble
220 G L -0.3918 Soluble
221 L L -0.2094 Soluble
222 S L -0.4477 Soluble
223 S L -0.4804 Soluble
224 P L -0.6557 Soluble
225 V L -0.1513 Soluble
226 T L -0.6233 Soluble
227 K L -0.5995 Soluble
228 S L -0.4847 Soluble
229 F L -0.9468 Soluble
230 N L -1.9587 Soluble
231 R L -2.6019 Soluble
232 G L -2.1508 Soluble
233 E L -2.7259 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.8165 4.7054 CSV PDB
4.5 -0.8551 4.7054 CSV PDB
5.0 -0.8991 4.7054 CSV PDB
5.5 -0.9393 4.7054 CSV PDB
6.0 -0.9651 4.7054 CSV PDB
6.5 -0.9686 4.7054 CSV PDB
7.0 -0.9502 4.7054 CSV PDB
7.5 -0.9175 4.7054 CSV PDB
8.0 -0.8772 4.7054 CSV PDB
8.5 -0.8314 4.7054 CSV PDB
9.0 -0.7798 4.7054 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH