Sonavibart / 5jw4

A4DAB244_5jw4_W_X | Source PDB: 5jw4 | Chains: W, X | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6622
Max Score
2.2092
Min Score
-3.7278
Total Score
-284.09
Score CDR
-0.0278
Score non-CDR
-0.7478

Calculation Parameters

Chain Sequence(s) QVQLQQSGPGLVKPSQTLSLTCAISGDSVSSYNAVWNWIRQSPSRGLEWLGRTYYRSGWYNDYAESVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARSGHITVFGVNVDAFDMWGQGTMVTVSSASTKGPSVFPLAPSSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPMTQSPSSLSASVGDRVTITCRTSQSLSSYTHWYQQKPGKAPKLLIYAASSRGSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) W (Heavy), X (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.7278
Maximum Score 2.2092
Average Score -0.6622
Total Score -284.0904

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q W -1.5727 Soluble
2 V W -1.3027 Soluble
3 Q W -1.9888 Soluble
4 L W 0.0000 Buried
5 Q W -1.7635 Soluble
6 Q W 0.0000 Buried
7 S W -0.6678 Soluble
8 G W -0.2378 Soluble
9 P W -0.4168 Soluble
11 G W 0.0000 Buried
12 L W -0.1818 Soluble
13 V W 0.0000 Buried
14 K W -2.1586 Soluble
15 P W -1.5368 Soluble
16 S W -1.4999 Soluble
17 Q W -2.0931 Soluble
18 T W -1.4801 Soluble
19 L W 0.0000 Buried
20 S W -0.7245 Soluble
21 L W 0.0000 Buried
22 T W -0.6727 Soluble
23 C W 0.0000 Buried
24 A W -1.2036 Soluble
25 I W 0.0000 Buried
26 S W -1.3357 Soluble
27 G W -1.2974 Soluble
28 D W -1.1913 Soluble
29 S W -0.5103 Soluble
30 V W 0.0000 Buried
31 S W -0.0459 Soluble
34 S W 0.0433 Aggregation-prone
35 Y W 0.5586 Aggregation-prone
36 N W -0.8206 Soluble
37 A W 0.0000 Buried
38 V W 0.0000 Buried
39 W W 0.0000 Buried
40 N W 0.0000 Buried
41 W W 0.0000 Buried
42 I W 0.0000 Buried
43 R W 0.0000 Buried
44 Q W -0.5333 Soluble
45 S W -1.0305 Soluble
46 P W -0.9031 Soluble
47 S W -1.6290 Soluble
48 R W -2.5149 Soluble
49 G W -1.4862 Soluble
50 L W 0.0000 Buried
51 E W 0.0000 Buried
52 W W 0.0000 Buried
53 L W 0.0000 Buried
54 G W 0.0000 Buried
55 R W -0.5881 Soluble
56 T W 0.0000 Buried
57 Y W 0.2043 Aggregation-prone
58 Y W 0.5858 Aggregation-prone
59 R W 0.1091 Aggregation-prone
60 S W 0.0066 Aggregation-prone
62 G W 0.1552 Aggregation-prone
63 W W 0.5014 Aggregation-prone
64 Y W 0.3705 Aggregation-prone
65 N W -0.6612 Soluble
66 D W -1.2382 Soluble
67 Y W -1.3899 Soluble
68 A W 0.0000 Buried
69 E W -2.5458 Soluble
70 S W -1.5773 Soluble
71 V W 0.0000 Buried
72 K W -2.6205 Soluble
74 S W -1.6153 Soluble
75 R W -1.3577 Soluble
76 I W 0.0000 Buried
77 T W -1.1914 Soluble
78 I W 0.0000 Buried
79 N W -1.5198 Soluble
80 P W -1.1798 Soluble
81 D W -1.5969 Soluble
82 T W -1.2715 Soluble
83 S W -1.3626 Soluble
84 K W -2.1999 Soluble
85 N W -1.6171 Soluble
86 Q W -1.5173 Soluble
87 F W 0.0000 Buried
88 S W -0.8548 Soluble
89 L W 0.0000 Buried
90 Q W -1.0398 Soluble
91 L W 0.0000 Buried
92 N W -1.4321 Soluble
93 S W -1.3577 Soluble
94 V W 0.0000 Buried
95 T W -1.3828 Soluble
96 P W -1.3965 Soluble
97 E W -2.2189 Soluble
98 D W 0.0000 Buried
99 T W -0.5560 Soluble
100 A W 0.0000 Buried
101 V W 0.3054 Aggregation-prone
102 Y W 0.0000 Buried
103 Y W 0.0000 Buried
104 C W 0.0000 Buried
105 A W 0.0000 Buried
106 R W 0.0000 Buried
107 S W 0.0000 Buried
108 G W 0.0000 Buried
109 H W -0.7038 Soluble
110 I W 0.1397 Aggregation-prone
111 T W 0.7055 Aggregation-prone
111A V W 1.5399 Aggregation-prone
111B F W 2.2092 Aggregation-prone
112C G W 0.8909 Aggregation-prone
112B V W 1.3469 Aggregation-prone
112A N W 0.2894 Aggregation-prone
112 V W 0.0000 Buried
113 D W 0.0000 Buried
114 A W 0.0000 Buried
115 F W 0.0000 Buried
116 D W -0.4548 Soluble
117 M W -0.6935 Soluble
118 W W 0.0000 Buried
119 G W 0.0000 Buried
120 Q W -1.9201 Soluble
121 G W -0.9329 Soluble
122 T W 0.0000 Buried
123 M W 0.4342 Aggregation-prone
124 V W 0.0000 Buried
125 T W -0.3597 Soluble
126 V W 0.0000 Buried
127 S W -0.7595 Soluble
128 S W -0.8152 Soluble
129 A W -0.5455 Soluble
130 S W -0.6814 Soluble
131 T W -0.8631 Soluble
132 K W -1.4523 Soluble
133 G W -1.5266 Soluble
134 P W -0.7095 Soluble
135 S W -0.3352 Soluble
136 V W 0.0000 Buried
137 F W 0.0000 Buried
138 P W -1.0708 Soluble
139 L W 0.0000 Buried
140 A W -0.8614 Soluble
141 P W 0.0000 Buried
142 S W -0.5989 Soluble
143 S W -0.3630 Soluble
144 G W -0.6453 Soluble
145 T W -0.4791 Soluble
146 A W 0.0000 Buried
147 A W 0.0000 Buried
148 L W 0.0000 Buried
149 G W 0.0000 Buried
150 C W 0.0000 Buried
151 L W 0.0000 Buried
152 V W 0.0000 Buried
153 K W 0.0000 Buried
154 D W -0.4549 Soluble
155 Y W 0.0000 Buried
156 F W 0.0000 Buried
157 P W 0.0000 Buried
158 E W -0.2368 Soluble
159 P W -0.5608 Soluble
160 V W 0.0000 Buried
161 T W -0.6714 Soluble
162 V W -0.4656 Soluble
163 S W -0.4376 Soluble
164 W W 0.0000 Buried
165 N W -0.7531 Soluble
166 S W -0.6741 Soluble
167 G W -0.5719 Soluble
168 A W -0.2372 Soluble
169 L W 0.0120 Aggregation-prone
170 T W -0.1706 Soluble
171 S W -0.1801 Soluble
172 G W -0.2639 Soluble
173 V W 0.1529 Aggregation-prone
174 H W -0.2985 Soluble
175 T W -0.0051 Soluble
176 F W 0.0000 Buried
177 P W -0.2154 Soluble
178 A W 0.3545 Aggregation-prone
179 V W 0.8373 Aggregation-prone
180 L W 1.5079 Aggregation-prone
181 Q W 0.4652 Aggregation-prone
182 S W -0.0208 Soluble
183 S W -0.2004 Soluble
184 G W 0.0682 Aggregation-prone
185 L W 0.2096 Aggregation-prone
186 Y W 0.5590 Aggregation-prone
187 S W 0.0000 Buried
188 L W 0.0000 Buried
189 S W 0.0000 Buried
190 S W 0.0000 Buried
191 V W 0.0000 Buried
192 V W 0.0000 Buried
193 T W -0.1318 Soluble
194 V W 0.0000 Buried
195 P W -0.4924 Soluble
196 S W -0.5499 Soluble
197 S W -0.6122 Soluble
198 S W -0.6282 Soluble
199 L W -0.7956 Soluble
200 G W -0.9288 Soluble
201 T W -0.6874 Soluble
202 Q W -1.1203 Soluble
203 T W -1.0601 Soluble
204 Y W 0.0000 Buried
205 I W -1.2807 Soluble
206 C W 0.0000 Buried
207 N W -1.5660 Soluble
208 V W 0.0000 Buried
209 N W -2.1056 Soluble
210 H W 0.0000 Buried
211 K W -2.8185 Soluble
212 P W -1.6586 Soluble
213 S W -1.9294 Soluble
214 N W -2.6146 Soluble
215 T W -2.2030 Soluble
216 K W -2.7611 Soluble
217 V W -1.6715 Soluble
218 D W -2.5836 Soluble
219 K W -2.0613 Soluble
220 K W -2.5785 Soluble
221 V W 0.0000 Buried
222 E W -2.4688 Soluble
223 P W -1.2226 Soluble
4 M X -0.8483 Soluble
5 T X -1.0153 Soluble
6 Q X 0.0000 Buried
7 S X -0.7484 Soluble
8 P X -0.5676 Soluble
9 S X -0.9769 Soluble
10 S X -1.0475 Soluble
11 L X -0.7055 Soluble
12 S X -0.9499 Soluble
13 A X -1.0957 Soluble
14 S X -1.0706 Soluble
15 V X -0.3320 Soluble
16 G X -1.0220 Soluble
17 D X -2.0150 Soluble
18 R X -2.3924 Soluble
19 V X 0.0000 Buried
20 T X -0.6285 Soluble
21 I X 0.0000 Buried
22 T X -0.7530 Soluble
23 C X 0.0000 Buried
24 R X -2.3843 Soluble
25 T X 0.0000 Buried
26 S X -1.2349 Soluble
27 Q X -1.6169 Soluble
28 S X -1.1559 Soluble
29 L X -0.2138 Soluble
36 S X -0.3516 Soluble
37 S X 0.3124 Aggregation-prone
38 Y X 0.2644 Aggregation-prone
39 T X 0.0000 Buried
40 H X 0.0000 Buried
41 W X 0.0000 Buried
42 Y X 0.0000 Buried
43 Q X -1.1180 Soluble
44 Q X -1.5317 Soluble
45 K X -1.8169 Soluble
46 P X -1.4436 Soluble
47 G X -1.6675 Soluble
48 K X -2.6440 Soluble
49 A X -1.7398 Soluble
50 P X 0.0000 Buried
51 K X -1.8311 Soluble
52 L X 0.0000 Buried
53 L X 0.0000 Buried
54 I X 0.0000 Buried
55 Y X -0.0705 Soluble
56 A X -0.0263 Soluble
57 A X 0.0000 Buried
65 S X -0.7059 Soluble
66 S X -0.8150 Soluble
67 R X -1.5506 Soluble
68 G X 0.0000 Buried
69 S X -0.8969 Soluble
70 G X -0.8934 Soluble
71 V X -0.8249 Soluble
72 P X -0.6256 Soluble
74 S X -0.7275 Soluble
75 R X -0.8156 Soluble
76 F X 0.0000 Buried
77 S X -0.7326 Soluble
78 G X -0.5719 Soluble
79 S X -0.6005 Soluble
80 G X -0.9919 Soluble
83 S X -0.9975 Soluble
84 G X -1.2227 Soluble
85 T X -1.5354 Soluble
86 D X -1.7088 Soluble
87 F X 0.0000 Buried
88 T X -0.6516 Soluble
89 L X 0.0000 Buried
90 T X -0.6093 Soluble
91 I X 0.0000 Buried
92 S X -1.3749 Soluble
93 S X -1.3047 Soluble
94 L X 0.0000 Buried
95 Q X -0.9777 Soluble
96 P X -1.4355 Soluble
97 E X -1.4765 Soluble
98 D X 0.0000 Buried
99 F X -1.3211 Soluble
100 A X 0.0000 Buried
101 T X -1.1941 Soluble
102 Y X 0.0000 Buried
103 Y X 0.0000 Buried
104 C X 0.0000 Buried
105 Q X 0.0000 Buried
106 Q X 0.0000 Buried
107 S X -0.2549 Soluble
116 R X -0.5752 Soluble
117 T X -0.3707 Soluble
118 F X -0.2607 Soluble
119 G X 0.0000 Buried
120 Q X -1.7041 Soluble
121 G X 0.0000 Buried
122 T X 0.0000 Buried
123 K X -2.0749 Soluble
124 V X 0.0000 Buried
125 E X -1.5495 Soluble
126 I X 0.0000 Buried
127 K X -1.2000 Soluble
128 R X -0.7269 Soluble
129 T X 0.2308 Aggregation-prone
130 V X 1.0730 Aggregation-prone
131 A X 0.4835 Aggregation-prone
132 A X 0.0557 Aggregation-prone
133 P X 0.0000 Buried
134 S X -0.1594 Soluble
135 V X 0.0000 Buried
136 F X -0.0594 Soluble
137 I X 0.0000 Buried
138 F X 0.0000 Buried
139 P X -0.7506 Soluble
140 P X -0.7753 Soluble
141 S X -1.4471 Soluble
142 D X -2.6534 Soluble
143 E X -2.4325 Soluble
144 Q X 0.0000 Buried
145 L X -2.0637 Soluble
146 K X -2.6186 Soluble
147 S X -1.6250 Soluble
148 G X -1.2127 Soluble
149 T X -0.9907 Soluble
150 A X 0.0000 Buried
151 S X 0.0000 Buried
152 V X 0.0000 Buried
153 V X 0.0000 Buried
154 C X 0.0000 Buried
155 L X 0.0000 Buried
156 L X 0.0000 Buried
157 N X 0.0000 Buried
158 N X -0.8656 Soluble
159 F X 0.0000 Buried
160 Y X 0.0000 Buried
161 P X -1.5204 Soluble
162 R X -3.0296 Soluble
163 E X -3.2838 Soluble
164 A X -2.3887 Soluble
165 K X -2.5543 Soluble
166 V X -1.2408 Soluble
167 Q X -0.9103 Soluble
168 W X 0.0000 Buried
169 K X -0.6785 Soluble
170 V X 0.0000 Buried
171 D X -2.0216 Soluble
172 N X -1.6501 Soluble
173 A X -0.3566 Soluble
174 L X 0.5586 Aggregation-prone
175 Q X -0.2394 Soluble
176 S X -0.4871 Soluble
177 G X -0.8774 Soluble
178 N X -0.7863 Soluble
179 S X -0.9769 Soluble
180 Q X -0.8977 Soluble
181 E X -1.4415 Soluble
182 S X -0.6097 Soluble
183 V X -0.7180 Soluble
184 T X -0.9905 Soluble
185 E X -1.8804 Soluble
186 Q X 0.0000 Buried
187 D X -1.7846 Soluble
188 S X -1.9516 Soluble
189 K X -2.3759 Soluble
190 D X -1.6549 Soluble
191 S X 0.0000 Buried
192 T X 0.0000 Buried
193 Y X 0.0000 Buried
194 S X 0.0000 Buried
195 L X 0.0000 Buried
196 S X 0.0000 Buried
197 S X 0.0000 Buried
198 T X -0.5119 Soluble
199 L X 0.0000 Buried
200 T X -0.4095 Soluble
201 L X -0.7530 Soluble
202 S X -1.3012 Soluble
203 K X -2.1443 Soluble
204 A X -2.0556 Soluble
205 D X -2.8103 Soluble
206 Y X 0.0000 Buried
207 E X -3.5589 Soluble
208 K X -3.7278 Soluble
209 H X -3.1618 Soluble
210 K X -3.0783 Soluble
211 V X -1.3641 Soluble
212 Y X 0.0000 Buried
213 A X 0.0000 Buried
214 C X 0.0000 Buried
215 E X -1.0406 Soluble
216 V X 0.0000 Buried
217 T X -1.3011 Soluble
218 H X 0.0000 Buried
219 Q X -1.6511 Soluble
220 G X -0.2277 Soluble
221 L X -0.1067 Soluble
222 S X -0.4248 Soluble
223 S X -0.4407 Soluble
224 P X -0.5630 Soluble
225 V X -0.0036 Soluble
226 T X -0.5856 Soluble
227 K X -0.8462 Soluble
228 S X -0.6385 Soluble
229 F X -0.9341 Soluble
230 N X -1.7872 Soluble
231 R X -2.5166 Soluble
232 G X -2.1467 Soluble
233 E X -2.4768 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7896 4.675 CSV PDB
4.5 -0.823 4.675 CSV PDB
5.0 -0.8614 4.675 CSV PDB
5.5 -0.896 4.675 CSV PDB
6.0 -0.9165 4.675 CSV PDB
6.5 -0.9154 4.675 CSV PDB
7.0 -0.8931 4.675 CSV PDB
7.5 -0.8572 4.675 CSV PDB
8.0 -0.8142 4.675 CSV PDB
8.5 -0.7667 4.675 CSV PDB
9.0 -0.715 4.675 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH