Ociperlimab / 8jel

A4DAB185_8jel_F_G | Source PDB: 8jel | Chains: F, G | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6983
Max Score
1.3737
Min Score
-3.1686
Total Score
-293.99
Score CDR
-0.5043
Score non-CDR
-0.7221

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVQPGGSLRLSCAASGFTFSDYYMYWVRQAPGKGLEWVAYITKGGGSTYYPDSVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCARQTNYDFTMDYWGQGTLVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPEIVMTQSPATLSVSPGERATLSCKASQDVGTSVAWYQQKPGQAPRLLIYWASARHTGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYSSYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKS input.pdb
Selected Chain(s) F (Heavy), G (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.1686
Maximum Score 1.3737
Average Score -0.6983
Total Score -293.9886

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E F -1.9496 Soluble
2 V F -0.7602 Soluble
3 Q F -0.6969 Soluble
4 L F 0.0000 Buried
5 V F 1.2269 Aggregation-prone
6 E F 0.2021 Aggregation-prone
7 S F -0.4172 Soluble
8 G F -0.8591 Soluble
9 G F -0.4995 Soluble
11 G F -0.1228 Soluble
12 L F -0.1367 Soluble
13 V F -0.6904 Soluble
14 Q F -1.6912 Soluble
15 P F -1.9015 Soluble
16 G F -1.5769 Soluble
17 G F -1.2146 Soluble
18 S F -1.3729 Soluble
19 L F -1.0611 Soluble
20 R F -2.0550 Soluble
21 L F 0.0000 Buried
22 S F -0.3822 Soluble
23 C F 0.0000 Buried
24 A F -0.0974 Soluble
25 A F 0.0000 Buried
26 S F -0.6354 Soluble
27 G F -1.0820 Soluble
28 F F -0.6473 Soluble
29 T F -0.7128 Soluble
30 F F 0.0000 Buried
35 S F -1.7526 Soluble
36 D F -2.1989 Soluble
37 Y F -1.1839 Soluble
38 Y F -0.5127 Soluble
39 M F 0.0000 Buried
40 Y F 0.0000 Buried
41 W F 0.0000 Buried
42 V F 0.0000 Buried
43 R F 0.0000 Buried
44 Q F -0.7826 Soluble
45 A F -1.1763 Soluble
46 P F -0.9485 Soluble
47 G F -1.4616 Soluble
48 K F -2.2820 Soluble
49 G F -1.4056 Soluble
50 L F 0.0000 Buried
51 E F -1.1277 Soluble
52 W F 0.0000 Buried
53 V F 0.0000 Buried
54 A F 0.0000 Buried
55 Y F 0.0000 Buried
56 I F 0.0000 Buried
57 T F -0.8546 Soluble
58 K F -1.6406 Soluble
59 G F -1.5872 Soluble
62 G F -1.1709 Soluble
63 G F -0.9835 Soluble
64 S F -0.5856 Soluble
65 T F -0.0198 Soluble
66 Y F 0.1017 Aggregation-prone
67 Y F 0.0000 Buried
68 P F 0.0000 Buried
69 D F -2.5049 Soluble
70 S F -1.6737 Soluble
71 V F 0.0000 Buried
72 K F -2.5935 Soluble
74 G F -1.8100 Soluble
75 R F -1.4762 Soluble
76 F F 0.0000 Buried
77 T F -0.7733 Soluble
78 I F 0.0000 Buried
79 S F -0.5727 Soluble
80 R F -1.3043 Soluble
81 D F -1.8925 Soluble
82 N F -2.0330 Soluble
83 A F -1.4459 Soluble
84 K F -2.3636 Soluble
85 N F -1.7649 Soluble
86 T F 0.0000 Buried
87 L F 0.0000 Buried
88 Y F -0.5779 Soluble
89 L F 0.0000 Buried
90 Q F -1.1779 Soluble
91 M F 0.0000 Buried
92 N F -1.6397 Soluble
93 S F -1.4739 Soluble
94 L F 0.0000 Buried
95 R F -2.6403 Soluble
96 A F -1.9220 Soluble
97 E F -2.2734 Soluble
98 D F 0.0000 Buried
99 T F -0.7099 Soluble
100 A F 0.0000 Buried
101 V F 0.2949 Aggregation-prone
102 Y F 0.0000 Buried
103 Y F 0.0000 Buried
104 C F 0.0000 Buried
105 A F 0.0000 Buried
106 R F 0.0000 Buried
107 Q F 0.0000 Buried
108 T F 0.0000 Buried
109 N F -1.0412 Soluble
110 Y F 0.2864 Aggregation-prone
112 D F 0.1989 Aggregation-prone
113 F F 0.5508 Aggregation-prone
114 T F 0.0000 Buried
115 M F 0.0000 Buried
116 D F -0.4172 Soluble
117 Y F -0.3030 Soluble
118 W F 0.0000 Buried
119 G F 0.0000 Buried
120 Q F -1.2197 Soluble
121 G F 0.0000 Buried
122 T F 0.0123 Aggregation-prone
123 L F 0.2435 Aggregation-prone
124 V F 0.0000 Buried
125 T F 0.0000 Buried
126 V F 0.0000 Buried
127 S F -1.1185 Soluble
128 S F -0.6580 Soluble
129 A F -0.4740 Soluble
130 S F -0.5325 Soluble
131 T F -0.6450 Soluble
132 K F -1.1833 Soluble
133 G F -1.3220 Soluble
134 P F 0.0000 Buried
135 S F -0.2389 Soluble
136 V F 0.0000 Buried
137 F F -0.7095 Soluble
138 P F -1.0040 Soluble
139 L F 0.0000 Buried
140 A F -0.8252 Soluble
141 P F -0.5096 Soluble
142 S F -0.2497 Soluble
143 G F -0.4981 Soluble
144 T F -0.1889 Soluble
145 A F -0.0055 Soluble
146 A F 0.0000 Buried
147 L F 0.0000 Buried
148 G F 0.0000 Buried
149 C F 0.0000 Buried
150 L F 0.0000 Buried
151 V F 0.0000 Buried
152 K F 0.0000 Buried
153 D F -0.3223 Soluble
154 Y F 0.0000 Buried
155 F F 0.0000 Buried
156 P F 0.0000 Buried
157 E F -0.6018 Soluble
158 P F -0.8557 Soluble
159 V F -0.7343 Soluble
160 T F -0.5915 Soluble
161 V F -0.3881 Soluble
162 S F -0.4052 Soluble
163 W F 0.0000 Buried
164 N F -0.7732 Soluble
165 S F -0.6657 Soluble
166 G F -0.5796 Soluble
167 A F -0.2543 Soluble
168 L F 0.0926 Aggregation-prone
169 T F -0.0248 Soluble
170 S F 0.1314 Aggregation-prone
171 G F 0.1826 Aggregation-prone
172 V F 0.4317 Aggregation-prone
173 H F -0.2984 Soluble
174 T F 0.0098 Aggregation-prone
175 F F 0.0000 Buried
176 P F -0.3708 Soluble
177 A F 0.1775 Aggregation-prone
178 V F 0.5898 Aggregation-prone
179 L F 1.3737 Aggregation-prone
180 Q F 0.4214 Aggregation-prone
181 S F -0.1077 Soluble
182 S F -0.1393 Soluble
183 G F 0.1786 Aggregation-prone
184 L F 0.1573 Aggregation-prone
185 Y F 0.4177 Aggregation-prone
186 S F 0.0000 Buried
187 L F 0.0000 Buried
188 S F 0.0000 Buried
189 S F 0.0000 Buried
190 V F 0.0000 Buried
191 V F 0.0000 Buried
192 T F 0.4048 Aggregation-prone
193 V F 0.9052 Aggregation-prone
194 P F 0.0000 Buried
195 S F -0.1266 Soluble
196 S F -0.4098 Soluble
197 S F -0.7000 Soluble
198 L F -0.8234 Soluble
199 G F -0.9744 Soluble
200 T F -0.7932 Soluble
201 Q F -1.3491 Soluble
202 T F -1.0388 Soluble
203 Y F 0.0000 Buried
204 I F -1.0730 Soluble
205 C F 0.0000 Buried
206 N F -1.5698 Soluble
207 V F 0.0000 Buried
208 N F -1.9659 Soluble
209 H F 0.0000 Buried
210 K F -2.8067 Soluble
211 P F -1.6915 Soluble
212 S F -1.8931 Soluble
213 N F -2.5898 Soluble
214 T F -2.2356 Soluble
215 K F -2.8149 Soluble
216 V F -1.8656 Soluble
217 D F -2.5989 Soluble
218 K F -1.9973 Soluble
219 K F -1.9001 Soluble
220 V F 0.0000 Buried
221 E F -2.1334 Soluble
222 P F -1.0917 Soluble
1 E G -1.3596 Soluble
2 I G -0.4930 Soluble
3 V G 0.9453 Aggregation-prone
4 M G 0.0000 Buried
5 T G -0.0748 Soluble
6 Q G -0.4195 Soluble
7 S G -0.5011 Soluble
8 P G -0.5339 Soluble
9 A G -0.5647 Soluble
10 T G -0.8089 Soluble
11 L G -0.6883 Soluble
12 S G -1.1647 Soluble
13 V G 0.0000 Buried
14 S G -2.0616 Soluble
15 P G -2.1330 Soluble
16 G G -2.1133 Soluble
17 E G -3.1523 Soluble
18 R G -3.0517 Soluble
19 A G 0.0000 Buried
20 T G -0.5462 Soluble
21 L G 0.0000 Buried
22 S G -0.7651 Soluble
23 C G 0.0000 Buried
24 K G -1.8174 Soluble
25 A G 0.0000 Buried
26 S G -1.1466 Soluble
27 Q G -2.3935 Soluble
28 D G -2.8879 Soluble
29 V G 0.0000 Buried
36 G G -1.1494 Soluble
37 T G -0.4560 Soluble
38 S G -0.0136 Soluble
39 V G 0.0000 Buried
40 A G 0.0000 Buried
41 W G 0.0000 Buried
42 Y G 0.0000 Buried
43 Q G 0.0000 Buried
44 Q G 0.0000 Buried
45 K G -1.9836 Soluble
46 P G -1.4907 Soluble
47 G G -1.5441 Soluble
48 Q G -2.2863 Soluble
49 A G -1.6086 Soluble
50 P G 0.0000 Buried
51 R G -1.9240 Soluble
52 L G 0.0000 Buried
53 L G 0.0000 Buried
54 I G 0.0000 Buried
55 Y G 0.3429 Aggregation-prone
56 W G 0.7701 Aggregation-prone
57 A G 0.0000 Buried
65 S G -0.3927 Soluble
66 A G -0.4913 Soluble
67 R G -1.3816 Soluble
68 H G -1.0815 Soluble
69 T G -0.7227 Soluble
70 G G -0.7547 Soluble
71 I G 0.0000 Buried
72 P G -0.5249 Soluble
74 A G -0.4607 Soluble
75 R G -0.7163 Soluble
76 F G 0.0000 Buried
77 S G -0.6788 Soluble
78 G G -0.4570 Soluble
79 S G -0.6460 Soluble
80 G G -1.0668 Soluble
83 S G -1.2851 Soluble
84 G G -1.9031 Soluble
85 T G -2.3529 Soluble
86 E G -2.7536 Soluble
87 F G 0.0000 Buried
88 T G -0.8127 Soluble
89 L G 0.0000 Buried
90 T G -0.6137 Soluble
91 I G 0.0000 Buried
92 S G -1.5325 Soluble
93 S G -1.9508 Soluble
94 L G 0.0000 Buried
95 Q G -1.8952 Soluble
96 S G -1.7426 Soluble
97 E G -2.2302 Soluble
98 D G 0.0000 Buried
99 F G 0.0000 Buried
100 A G 0.0000 Buried
101 V G -0.9085 Soluble
102 Y G 0.0000 Buried
103 Y G 0.0000 Buried
104 C G 0.0000 Buried
105 Q G 0.0000 Buried
106 Q G 0.0000 Buried
107 Y G 0.0000 Buried
108 S G -0.4256 Soluble
109 S G -0.2388 Soluble
114 Y G 0.1053 Aggregation-prone
115 P G -0.4852 Soluble
116 L G 0.0000 Buried
117 T G 0.0288 Aggregation-prone
118 F G 0.1648 Aggregation-prone
119 G G 0.0000 Buried
120 G G -0.9027 Soluble
121 G G -0.9582 Soluble
122 T G 0.0000 Buried
123 K G -1.9013 Soluble
124 V G 0.0000 Buried
125 E G -1.6919 Soluble
126 I G -1.3282 Soluble
127 K G -1.9094 Soluble
128 R G -1.1877 Soluble
129 T G 0.1306 Aggregation-prone
130 V G 1.2070 Aggregation-prone
131 A G 0.4936 Aggregation-prone
132 A G 0.1296 Aggregation-prone
133 P G -0.1592 Soluble
134 S G -0.1646 Soluble
135 V G -0.0716 Soluble
136 F G 0.0682 Aggregation-prone
137 I G 0.0000 Buried
138 F G 0.0000 Buried
139 P G -0.6960 Soluble
140 P G -0.5665 Soluble
141 S G -1.4122 Soluble
142 D G -2.6764 Soluble
143 E G -2.8564 Soluble
144 Q G 0.0000 Buried
145 L G -1.1912 Soluble
146 K G -2.3184 Soluble
147 S G -1.4257 Soluble
148 G G -0.9670 Soluble
149 T G -0.5449 Soluble
150 A G 0.0000 Buried
151 S G 0.0000 Buried
152 V G 0.1774 Aggregation-prone
153 V G 0.0000 Buried
154 C G 0.0000 Buried
155 L G 0.0000 Buried
156 L G 0.0000 Buried
157 N G 0.0000 Buried
158 N G -0.7232 Soluble
159 F G 0.0000 Buried
160 Y G -0.7655 Soluble
161 P G -1.4479 Soluble
162 R G -2.9902 Soluble
163 E G -3.1686 Soluble
164 A G -2.2779 Soluble
165 K G -2.3279 Soluble
166 V G -1.2343 Soluble
167 Q G -1.0901 Soluble
168 W G 0.0000 Buried
169 K G -0.8786 Soluble
170 V G -1.2601 Soluble
171 D G -2.6082 Soluble
172 N G -1.8793 Soluble
173 A G -0.5927 Soluble
174 L G 0.2537 Aggregation-prone
175 Q G -1.0046 Soluble
176 S G -0.7520 Soluble
177 G G -1.0015 Soluble
178 N G -1.0060 Soluble
179 S G -1.0236 Soluble
180 Q G -1.0783 Soluble
181 E G -1.7730 Soluble
182 S G -0.8054 Soluble
183 V G -0.9388 Soluble
184 T G -1.2840 Soluble
185 E G -2.4078 Soluble
186 Q G -2.1249 Soluble
187 D G -2.2213 Soluble
188 S G -2.0996 Soluble
189 K G -2.3870 Soluble
190 D G -1.9401 Soluble
191 S G -2.0714 Soluble
192 T G 0.0000 Buried
193 Y G 0.0000 Buried
194 S G 0.0000 Buried
195 L G 0.0000 Buried
196 S G 0.0000 Buried
197 S G 0.0000 Buried
198 T G 0.0000 Buried
199 L G 0.0000 Buried
200 T G -0.2580 Soluble
201 L G -0.3968 Soluble
202 S G -1.2156 Soluble
203 K G -1.9884 Soluble
204 A G -1.3531 Soluble
205 D G -2.2239 Soluble
206 Y G -1.2202 Soluble
207 E G -2.5462 Soluble
208 K G -2.1563 Soluble
209 H G -1.9858 Soluble
210 K G -2.4228 Soluble
211 V G -1.0535 Soluble
212 Y G -1.1338 Soluble
213 A G -0.9325 Soluble
214 C G 0.0000 Buried
215 E G -1.4456 Soluble
216 V G 0.0000 Buried
217 T G -1.2078 Soluble
218 H G 0.0000 Buried
219 Q G -1.4601 Soluble
220 G G -0.1741 Soluble
221 L G -0.0804 Soluble
222 S G -0.4465 Soluble
223 S G -0.3353 Soluble
224 P G -0.3305 Soluble
225 V G 0.1193 Aggregation-prone
226 T G -0.5094 Soluble
227 K G -0.7762 Soluble
228 S G -0.5719 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6202 2.1098 CSV PDB
4.5 -0.6718 2.0955 CSV PDB
5.0 -0.7341 2.0805 CSV PDB
5.5 -0.7956 2.0655 CSV PDB
6.0 -0.8438 2.0513 CSV PDB
6.5 -0.8673 2.0387 CSV PDB
7.0 -0.8643 2.0279 CSV PDB
7.5 -0.8436 2.0175 CSV PDB
8.0 -0.814 2.007 CSV PDB
8.5 -0.7782 1.9978 CSV PDB
9.0 -0.7355 1.9915 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH