Diridavumab / 3gbm

A4DAB087_3gbm_H_L | Source PDB: 3gbm | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6623
Max Score
3.075
Min Score
-3.2392
Total Score
-279.49
Score CDR
-0.3956
Score non-CDR
-0.7325

Calculation Parameters

Chain Sequence(s) EVQLVESGAEVKKPGSSVKVSCKASGGPFRSYAISWVRQAPGQGPEWMGGIIPIFGTTKYAPKFQGRVTITADDFAGTVYMELSSLRSEDTAMYYCAKHMGYQVRETMDVWGKGTTVTVSSASTKGPSVFPLAPGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPVLTQPPSVSAAPGQKVTISCSGSSSNIGNDYVSWYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTSATLGITGLQTGDEANYYCATWDRTAYVVFGGGTKLTQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTE input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.2392
Maximum Score 3.075
Average Score -0.6623
Total Score -279.4853

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E H -2.0048 Soluble
2 V H -1.2329 Soluble
3 Q H -1.7694 Soluble
4 L H 0.0000 Buried
5 V H -0.4772 Soluble
6 E H -0.7487 Soluble
7 S H -0.7244 Soluble
8 G H -0.6125 Soluble
9 A H -0.3520 Soluble
11 E H -0.7180 Soluble
12 V H -0.0481 Soluble
13 K H -1.0864 Soluble
14 K H -1.7861 Soluble
15 P H -1.8174 Soluble
16 G H -1.4050 Soluble
17 S H -1.0601 Soluble
18 S H -1.2220 Soluble
19 V H 0.0000 Buried
20 K H -1.9858 Soluble
21 V H 0.0000 Buried
22 S H -0.7233 Soluble
23 C H 0.0000 Buried
24 K H -1.7711 Soluble
25 A H 0.0000 Buried
26 S H -1.1031 Soluble
27 G H -1.0300 Soluble
28 G H 0.1183 Aggregation-prone
29 P H 0.3700 Aggregation-prone
30 F H 1.8193 Aggregation-prone
35 R H 0.8860 Aggregation-prone
36 S H 0.6488 Aggregation-prone
37 Y H 0.7508 Aggregation-prone
38 A H 0.0000 Buried
39 I H 0.0000 Buried
40 S H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.6294 Soluble
45 A H -1.0538 Soluble
46 P H -1.0354 Soluble
47 G H -1.2095 Soluble
48 Q H -1.7397 Soluble
49 G H -1.1814 Soluble
50 P H 0.0000 Buried
51 E H -0.9472 Soluble
52 W H 0.0000 Buried
53 M H 0.0000 Buried
54 G H 0.0000 Buried
55 G H 0.0000 Buried
56 I H 0.0000 Buried
57 I H 0.0000 Buried
58 P H 0.0000 Buried
59 I H 3.0750 Aggregation-prone
62 F H 2.8303 Aggregation-prone
63 G H 1.1076 Aggregation-prone
64 T H 0.4478 Aggregation-prone
65 T H -0.3221 Soluble
66 K H -1.0297 Soluble
67 Y H -0.9849 Soluble
68 A H 0.0000 Buried
69 P H -1.4907 Soluble
70 K H -2.1939 Soluble
71 F H 0.0000 Buried
72 Q H -2.0788 Soluble
74 G H -1.4400 Soluble
75 R H -1.1670 Soluble
76 V H 0.0000 Buried
77 T H -0.7940 Soluble
78 I H 0.0000 Buried
79 T H -0.4402 Soluble
80 A H -0.5637 Soluble
81 D H -0.9441 Soluble
82 D H 0.1634 Aggregation-prone
83 F H 1.5614 Aggregation-prone
84 A H 0.2561 Aggregation-prone
85 G H 0.0000 Buried
86 T H -0.5842 Soluble
87 V H 0.0000 Buried
88 Y H -0.6251 Soluble
89 M H 0.0000 Buried
90 E H -1.3129 Soluble
91 L H 0.0000 Buried
92 S H -1.0348 Soluble
93 S H -1.0614 Soluble
94 L H 0.0000 Buried
95 R H -2.4740 Soluble
96 S H -2.0361 Soluble
97 E H -2.3746 Soluble
98 D H 0.0000 Buried
99 T H -0.9539 Soluble
100 A H 0.0000 Buried
101 M H 0.0222 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 K H 0.0000 Buried
107 H H 0.0000 Buried
108 M H 0.3257 Aggregation-prone
109 G H 0.1233 Aggregation-prone
110 Y H 0.9942 Aggregation-prone
111 Q H -0.4740 Soluble
112A V H 0.0000 Buried
112 R H -0.6851 Soluble
113 E H 0.0000 Buried
114 T H 0.0000 Buried
115 M H 0.0000 Buried
116 D H -0.3096 Soluble
117 V H -0.4261 Soluble
118 W H -0.4208 Soluble
119 G H 0.0000 Buried
120 K H -1.6483 Soluble
121 G H 0.0000 Buried
122 T H 0.0000 Buried
123 T H -0.0437 Soluble
124 V H 0.0000 Buried
125 T H -0.6850 Soluble
126 V H 0.0000 Buried
127 S H -1.0082 Soluble
128 S H -0.9762 Soluble
129 A H 0.0000 Buried
130 S H -0.6478 Soluble
131 T H -0.6513 Soluble
132 K H -1.1285 Soluble
133 G H -1.3512 Soluble
134 P H -0.5683 Soluble
135 S H -0.1914 Soluble
136 V H -0.3424 Soluble
137 F H 0.0000 Buried
138 P H 0.0000 Buried
139 L H 0.0000 Buried
140 A H -0.8125 Soluble
141 P H -0.5253 Soluble
142 G H -0.6020 Soluble
143 T H -0.4799 Soluble
144 A H -0.2642 Soluble
145 A H -0.1126 Soluble
146 L H 0.0000 Buried
147 G H 0.0000 Buried
148 C H 0.0000 Buried
149 L H 0.0000 Buried
150 V H 0.0000 Buried
151 K H -0.2789 Soluble
152 D H -0.3770 Soluble
153 Y H 0.0000 Buried
154 F H 0.0000 Buried
155 P H 0.0000 Buried
156 E H -1.2603 Soluble
157 P H -1.1151 Soluble
158 V H -0.7203 Soluble
159 T H -0.7424 Soluble
160 V H -0.3236 Soluble
161 S H -0.4311 Soluble
162 W H 0.0000 Buried
163 N H -0.6899 Soluble
164 S H -0.6445 Soluble
165 G H -0.5201 Soluble
166 A H -0.1462 Soluble
167 L H 0.1543 Aggregation-prone
168 T H -0.0762 Soluble
169 S H -0.2308 Soluble
170 G H -0.3491 Soluble
171 V H 0.1277 Aggregation-prone
172 H H -0.2127 Soluble
173 T H -0.0415 Soluble
174 F H 0.0000 Buried
175 P H -0.0115 Soluble
176 A H 0.1569 Aggregation-prone
177 V H 0.0000 Buried
178 L H 1.1604 Aggregation-prone
179 Q H 0.2486 Aggregation-prone
180 S H -0.1235 Soluble
181 S H -0.1520 Soluble
182 G H 0.0829 Aggregation-prone
183 L H 0.0122 Aggregation-prone
184 Y H 0.2522 Aggregation-prone
185 S H 0.0000 Buried
186 L H 0.0000 Buried
187 S H 0.0000 Buried
188 S H 0.0000 Buried
189 V H 0.0000 Buried
190 V H 0.0000 Buried
191 T H -0.2540 Soluble
192 V H 0.0000 Buried
193 P H -0.4578 Soluble
194 S H -0.4853 Soluble
195 S H -0.5663 Soluble
196 S H 0.0000 Buried
197 L H -0.8140 Soluble
198 G H -1.1241 Soluble
199 T H -1.0215 Soluble
200 Q H -1.5393 Soluble
201 T H -1.3095 Soluble
202 Y H 0.0000 Buried
203 I H -1.3831 Soluble
204 C H 0.0000 Buried
205 N H -1.6033 Soluble
206 V H 0.0000 Buried
207 N H -2.1532 Soluble
208 H H 0.0000 Buried
209 K H -2.8286 Soluble
210 P H -1.7255 Soluble
211 S H -1.8160 Soluble
212 N H -2.5266 Soluble
213 T H -2.0146 Soluble
214 K H -2.6998 Soluble
215 V H -1.4664 Soluble
216 D H -2.5636 Soluble
217 K H -2.1290 Soluble
218 R H -2.8128 Soluble
219 V H 0.0000 Buried
220 E H -2.6161 Soluble
221 P H -1.2185 Soluble
3 V L 1.5895 Aggregation-prone
4 L L 0.0000 Buried
5 T L 0.0317 Aggregation-prone
6 Q L -0.3068 Soluble
7 P L -0.5650 Soluble
8 P L -0.8337 Soluble
9 S L -0.8138 Soluble
11 V L -0.2669 Soluble
12 S L -0.6174 Soluble
13 A L -0.7190 Soluble
14 A L -0.9865 Soluble
15 P L -1.4215 Soluble
16 G L -1.8418 Soluble
17 Q L -2.5050 Soluble
18 K L -2.5487 Soluble
19 V L 0.0000 Buried
20 T L -0.5176 Soluble
21 I L 0.0000 Buried
22 S L -0.3014 Soluble
23 C L 0.0000 Buried
24 S L -0.2198 Soluble
25 G L -0.0890 Soluble
26 S L -0.4975 Soluble
27 S L -1.2205 Soluble
28 S L -1.3900 Soluble
29 N L 0.0000 Buried
30 I L 0.0000 Buried
35 G L -1.3087 Soluble
36 N L -1.6600 Soluble
37 D L 0.0000 Buried
38 Y L -0.1056 Soluble
39 V L 0.0000 Buried
40 S L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L -0.8225 Soluble
45 L L -0.5026 Soluble
46 P L -0.5639 Soluble
47 G L -0.7382 Soluble
48 T L -0.7602 Soluble
49 A L -0.7211 Soluble
50 P L 0.0000 Buried
51 K L -0.9289 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -1.3115 Soluble
56 D L -1.4295 Soluble
57 N L -1.5119 Soluble
65 N L -2.5502 Soluble
66 K L -2.8505 Soluble
67 R L -2.3403 Soluble
68 P L -1.2944 Soluble
69 S L -0.9275 Soluble
70 G L -0.8156 Soluble
71 I L -0.9418 Soluble
72 P L -1.3235 Soluble
74 D L -2.2498 Soluble
75 R L -1.6256 Soluble
76 F L 0.0000 Buried
77 S L -1.5247 Soluble
78 G L -1.2585 Soluble
79 S L -1.1808 Soluble
80 K L -0.9137 Soluble
83 S L -0.7278 Soluble
84 G L -0.8447 Soluble
85 T L -0.9271 Soluble
86 S L -0.6404 Soluble
87 A L 0.0000 Buried
88 T L -0.5118 Soluble
89 L L 0.0000 Buried
90 G L -0.7228 Soluble
91 I L 0.0000 Buried
92 T L -1.9713 Soluble
93 G L -1.6105 Soluble
94 L L 0.0000 Buried
95 Q L -2.0607 Soluble
96 T L -1.4826 Soluble
97 G L -1.4335 Soluble
98 D L 0.0000 Buried
99 E L -2.4942 Soluble
100 A L 0.0000 Buried
101 N L -1.3215 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 A L 0.0000 Buried
106 T L 0.0000 Buried
107 W L 0.0000 Buried
108 D L -1.2398 Soluble
109 R L -2.1697 Soluble
113 T L -0.6775 Soluble
114 A L -0.8877 Soluble
115 Y L -0.7316 Soluble
116 V L 0.0000 Buried
117 V L 0.0000 Buried
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 G L -0.6592 Soluble
121 G L -1.0377 Soluble
122 T L 0.0000 Buried
123 K L -1.9099 Soluble
124 L L 0.0000 Buried
125 T L -1.0310 Soluble
126 Q L -1.9076 Soluble
127 P L -1.6505 Soluble
128 K L -2.3226 Soluble
129 A L -1.4254 Soluble
130 A L -0.7347 Soluble
131 P L -0.4248 Soluble
132 S L -0.2806 Soluble
133 V L 0.0000 Buried
134 T L -0.4356 Soluble
135 L L 0.0000 Buried
136 F L 0.0000 Buried
137 P L -0.0782 Soluble
138 P L 0.0000 Buried
139 S L -0.6578 Soluble
140 S L -1.1194 Soluble
141 E L -1.5253 Soluble
142 E L 0.0000 Buried
143 L L -1.6294 Soluble
144 Q L -2.0889 Soluble
145 A L -1.8052 Soluble
146 N L -2.6809 Soluble
147 K L -2.7798 Soluble
148 A L 0.0000 Buried
149 T L 0.0000 Buried
150 L L 0.0000 Buried
151 V L 0.0000 Buried
152 C L 0.0000 Buried
153 L L 0.0000 Buried
154 I L 0.0000 Buried
155 S L -0.7314 Soluble
156 D L -1.5344 Soluble
157 F L 0.0000 Buried
158 Y L -1.4352 Soluble
159 P L -1.0093 Soluble
160 G L -0.9596 Soluble
161 A L -0.1844 Soluble
162 V L -0.1248 Soluble
163 T L -0.1194 Soluble
164 V L 0.1280 Aggregation-prone
165 A L -0.4230 Soluble
166 W L 0.0000 Buried
167 K L -0.9463 Soluble
168 A L 0.0000 Buried
169 D L -1.2116 Soluble
170 S L -0.8054 Soluble
171 S L -0.5338 Soluble
172 P L -0.7961 Soluble
173 V L -0.7728 Soluble
174 K L -1.6656 Soluble
175 A L -0.8528 Soluble
176 G L -0.7599 Soluble
177 V L -0.5766 Soluble
178 E L -0.5402 Soluble
179 T L -0.0517 Soluble
180 T L -0.0107 Soluble
181 T L -0.1735 Soluble
182 P L -0.5736 Soluble
183 S L -1.2942 Soluble
184 K L -2.5846 Soluble
185 Q L -2.1990 Soluble
186 S L -1.7173 Soluble
187 N L -2.5055 Soluble
188 N L -2.8459 Soluble
189 K L -2.6619 Soluble
190 Y L -1.5376 Soluble
191 A L 0.0000 Buried
192 A L 0.0000 Buried
193 S L 0.0000 Buried
194 S L 0.0000 Buried
195 Y L 0.0000 Buried
196 L L 0.0000 Buried
197 S L -0.6355 Soluble
198 L L -1.1683 Soluble
199 T L -1.8437 Soluble
200 P L -2.5100 Soluble
201 E L -3.1952 Soluble
202 Q L -2.2726 Soluble
203 W L 0.0000 Buried
204 K L -3.2392 Soluble
205 S L -2.3847 Soluble
206 H L -2.3261 Soluble
207 R L -2.6982 Soluble
208 S L -1.6623 Soluble
209 Y L 0.0000 Buried
210 S L 0.0000 Buried
211 C L 0.0000 Buried
212 Q L -0.9434 Soluble
213 V L 0.0000 Buried
214 T L -0.6495 Soluble
215 H L 0.0000 Buried
216 E L -2.3013 Soluble
217 G L -1.3937 Soluble
218 S L -1.0184 Soluble
219 T L -0.6645 Soluble
220 V L -0.5607 Soluble
221 E L -1.8706 Soluble
222 K L -1.5647 Soluble
223 T L -1.0539 Soluble
224 V L -0.6019 Soluble
225 A L -1.3847 Soluble
226 P L -1.6162 Soluble
227 T L -1.1842 Soluble
228 E L -2.2744 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5515 5.9337 CSV PDB
4.5 -0.5834 5.8073 CSV PDB
5.0 -0.6221 5.7658 CSV PDB
5.5 -0.6579 5.7658 CSV PDB
6.0 -0.6795 5.7658 CSV PDB
6.5 -0.6779 5.7658 CSV PDB
7.0 -0.6527 5.7658 CSV PDB
7.5 -0.6115 5.7658 CSV PDB
8.0 -0.5624 5.7658 CSV PDB
8.5 -0.509 5.7657 CSV PDB
9.0 -0.4519 5.7654 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH