Nirsevimab / 5udd

A4DAB181_5udd_J_P | Source PDB: 5udd | Chains: J, P | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6474
Max Score
2.6091
Min Score
-3.8461
Total Score
-282.27
Score CDR
-0.103
Score non-CDR
-0.7227

Calculation Parameters

Chain Sequence(s) QVQLVQSGAEVKKPGSSVMVSCQASGGLLEDYIINWVRQAPGQGPEWMGGIIPVLGTVHYGPKFQGRVTITADESTDTAYMELSSLRSEDTAMYYCATETALVVSETYLPHYFDNWGQGTLVTVSSASTKGPSVFPLAPSSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSDIQMTQSPSSLSAAVGDRVTITCQASQDIVNYLNWYQQKPGKAPKLLIYVASNLETGVPSRFSGSGSGTDFSLTISSLQPEDVATYYCQQYDNLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG input.pdb
Selected Chain(s) J (Heavy), P (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.8461
Maximum Score 2.6091
Average Score -0.6474
Total Score -282.2692

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q J -1.5655 Soluble
2 V J -1.0880 Soluble
3 Q J -1.4616 Soluble
4 L J 0.0000 Buried
5 V J 0.5651 Aggregation-prone
6 Q J 0.0000 Buried
7 S J -0.1787 Soluble
8 G J -1.0484 Soluble
9 A J -1.1580 Soluble
11 E J -1.6069 Soluble
12 V J -1.1481 Soluble
13 K J -2.0421 Soluble
14 K J -2.5987 Soluble
15 P J -2.1252 Soluble
16 G J -1.6947 Soluble
17 S J -1.3658 Soluble
18 S J -0.9311 Soluble
19 V J 0.0000 Buried
20 M J 0.5061 Aggregation-prone
21 V J 0.0000 Buried
22 S J 0.1911 Aggregation-prone
23 C J 0.0000 Buried
24 Q J -0.3011 Soluble
25 A J 0.0000 Buried
26 S J -0.6275 Soluble
27 G J -0.8279 Soluble
28 G J -0.5352 Soluble
29 L J -0.3217 Soluble
30 L J 0.0000 Buried
35 E J -1.0422 Soluble
36 D J -0.1095 Soluble
37 Y J 0.2345 Aggregation-prone
38 I J 0.0000 Buried
39 I J 0.0000 Buried
40 N J 0.0000 Buried
41 W J 0.0000 Buried
42 V J 0.0000 Buried
43 R J -0.5313 Soluble
44 Q J -0.7431 Soluble
45 A J -1.0409 Soluble
46 P J -0.8735 Soluble
47 G J -1.2564 Soluble
48 Q J -1.7780 Soluble
49 G J -1.1256 Soluble
50 P J 0.0000 Buried
51 E J -0.8187 Soluble
52 W J 0.0000 Buried
53 M J 0.0000 Buried
54 G J 0.0000 Buried
55 G J 0.0000 Buried
56 I J 0.6744 Aggregation-prone
57 I J 0.0000 Buried
58 P J -0.2397 Soluble
59 V J 0.4920 Aggregation-prone
62 L J 0.2965 Aggregation-prone
63 G J 0.1319 Aggregation-prone
64 T J 0.4359 Aggregation-prone
65 V J 1.1093 Aggregation-prone
66 H J 0.4224 Aggregation-prone
67 Y J -0.3759 Soluble
68 G J 0.0000 Buried
69 P J -1.6291 Soluble
70 K J -2.2428 Soluble
71 F J 0.0000 Buried
72 Q J -2.0674 Soluble
74 G J -1.5233 Soluble
75 R J -1.4319 Soluble
76 V J 0.0000 Buried
77 T J -0.4121 Soluble
78 I J 0.0000 Buried
79 T J -0.2381 Soluble
80 A J -0.9456 Soluble
81 D J -1.9116 Soluble
82 E J -2.3688 Soluble
83 S J -1.3132 Soluble
84 T J -1.0656 Soluble
85 D J -1.3740 Soluble
86 T J 0.0000 Buried
87 A J 0.0000 Buried
88 Y J 0.0545 Aggregation-prone
89 M J 0.0000 Buried
90 E J -0.4858 Soluble
91 L J 0.0000 Buried
92 S J -0.8234 Soluble
93 S J -1.2168 Soluble
94 L J 0.0000 Buried
95 R J -3.0955 Soluble
96 S J -2.2698 Soluble
97 E J -2.4905 Soluble
98 D J 0.0000 Buried
99 T J -1.0155 Soluble
100 A J 0.0000 Buried
101 M J -0.0344 Soluble
102 Y J 0.0000 Buried
103 Y J 0.0000 Buried
104 C J 0.0000 Buried
105 A J 0.0000 Buried
106 T J 0.0000 Buried
107 E J 0.0000 Buried
108 T J 0.2470 Aggregation-prone
109 A J 0.0000 Buried
110 L J 2.1464 Aggregation-prone
111 V J 2.6091 Aggregation-prone
111A V J 1.2458 Aggregation-prone
111B S J -0.1645 Soluble
111C E J -1.5599 Soluble
112C T J -0.6566 Soluble
112B Y J 0.0547 Aggregation-prone
112A L J 0.2007 Aggregation-prone
112 P J 0.0000 Buried
113 H J 0.0218 Aggregation-prone
114 Y J 0.1454 Aggregation-prone
115 F J 0.0000 Buried
116 D J -1.1122 Soluble
117 N J -1.2541 Soluble
118 W J -0.6928 Soluble
119 G J 0.0000 Buried
120 Q J -1.4145 Soluble
121 G J -0.7202 Soluble
122 T J 0.0000 Buried
123 L J -0.3161 Soluble
124 V J 0.0000 Buried
125 T J 0.0000 Buried
126 V J 0.0000 Buried
127 S J -1.1789 Soluble
128 S J -0.8782 Soluble
129 A J -0.6280 Soluble
130 S J -0.8010 Soluble
131 T J -1.0763 Soluble
132 K J -1.5221 Soluble
133 G J -1.6021 Soluble
134 P J 0.0000 Buried
135 S J -0.4065 Soluble
136 V J 0.0000 Buried
137 F J 0.0000 Buried
138 P J 0.0000 Buried
139 L J 0.0000 Buried
140 A J -0.9084 Soluble
141 P J 0.0000 Buried
142 S J -0.6537 Soluble
143 S J -0.4192 Soluble
144 G J -0.7926 Soluble
145 G J -0.8756 Soluble
146 T J -0.5974 Soluble
147 A J -0.3429 Soluble
148 A J 0.0000 Buried
149 L J 0.0000 Buried
150 G J 0.0000 Buried
151 C J 0.0000 Buried
152 L J 0.0000 Buried
153 V J 0.0000 Buried
154 K J -0.3833 Soluble
155 D J -0.6314 Soluble
156 Y J 0.0000 Buried
157 F J 0.0000 Buried
158 P J 0.0000 Buried
159 E J -0.6324 Soluble
160 P J -0.8185 Soluble
161 V J 0.0000 Buried
162 T J -0.6026 Soluble
163 V J -0.3644 Soluble
164 S J -0.4057 Soluble
165 W J 0.0000 Buried
166 N J -0.7779 Soluble
167 S J -0.6803 Soluble
168 G J -0.4683 Soluble
169 A J -0.1816 Soluble
170 L J 0.0489 Aggregation-prone
171 T J -0.1137 Soluble
172 S J -0.3329 Soluble
173 G J -0.1881 Soluble
174 V J 0.2322 Aggregation-prone
175 H J 0.0000 Buried
176 T J -0.1386 Soluble
177 F J 0.0000 Buried
178 P J -0.4034 Soluble
179 A J 0.1753 Aggregation-prone
180 V J 0.4940 Aggregation-prone
181 L J 1.2918 Aggregation-prone
182 Q J 0.2806 Aggregation-prone
183 S J -0.1606 Soluble
184 S J -0.1816 Soluble
185 G J 0.1665 Aggregation-prone
186 L J 0.1617 Aggregation-prone
187 Y J 0.4002 Aggregation-prone
188 S J 0.0000 Buried
189 L J 0.0000 Buried
190 S J 0.0000 Buried
191 S J 0.0000 Buried
192 V J 0.0000 Buried
193 V J 0.0000 Buried
194 T J -0.0727 Soluble
195 V J 0.0000 Buried
196 P J -0.5228 Soluble
197 S J -0.6072 Soluble
198 S J -0.6059 Soluble
199 S J -0.6592 Soluble
200 L J -0.8540 Soluble
201 G J -1.1109 Soluble
202 T J -0.8401 Soluble
203 Q J -1.5150 Soluble
204 T J -1.3476 Soluble
205 Y J 0.0000 Buried
206 I J -1.4304 Soluble
207 C J 0.0000 Buried
208 N J -1.4665 Soluble
209 V J 0.0000 Buried
210 N J -1.7098 Soluble
211 H J 0.0000 Buried
212 K J -2.9111 Soluble
213 P J -1.9717 Soluble
214 S J -2.0234 Soluble
215 N J -2.4815 Soluble
216 T J -2.0627 Soluble
217 K J -2.6011 Soluble
218 V J -1.6471 Soluble
219 D J -2.5270 Soluble
220 K J -1.9939 Soluble
221 R J -2.6880 Soluble
222 V J 0.0000 Buried
223 E J -2.8757 Soluble
224 P J -1.9526 Soluble
225 K J -2.5886 Soluble
226 S J -1.1449 Soluble
1 D P -2.3171 Soluble
2 I P 0.0000 Buried
3 Q P -1.9692 Soluble
4 M P 0.0000 Buried
5 T P -1.0122 Soluble
6 Q P -0.8768 Soluble
7 S P -0.5561 Soluble
8 P P -0.6582 Soluble
9 S P -0.8995 Soluble
10 S P -1.0471 Soluble
11 L P -0.7825 Soluble
12 S P -0.9801 Soluble
13 A P -0.9969 Soluble
14 A P -0.7923 Soluble
15 V P -0.1314 Soluble
16 G P -0.7587 Soluble
17 D P -1.6546 Soluble
18 R P -2.2176 Soluble
19 V P 0.0000 Buried
20 T P -0.6187 Soluble
21 I P 0.0000 Buried
22 T P -0.6623 Soluble
23 C P 0.0000 Buried
24 Q P -1.9106 Soluble
25 A P -1.6241 Soluble
26 S P -1.9208 Soluble
27 Q P -2.2838 Soluble
28 D P -2.1999 Soluble
29 I P 0.0000 Buried
36 V P 0.4020 Aggregation-prone
37 N P 0.0143 Aggregation-prone
38 Y P 0.4787 Aggregation-prone
39 L P 0.0000 Buried
40 N P 0.0000 Buried
41 W P 0.0000 Buried
42 Y P 0.0000 Buried
43 Q P 0.0000 Buried
44 Q P 0.0000 Buried
45 K P -1.5311 Soluble
46 P P -1.3863 Soluble
47 G P -1.7358 Soluble
48 K P -2.3853 Soluble
49 A P -1.5229 Soluble
50 P P 0.0000 Buried
51 K P -1.4290 Soluble
52 L P 0.0000 Buried
53 L P 0.0000 Buried
54 I P 0.0000 Buried
55 Y P 0.5208 Aggregation-prone
56 V P 0.6855 Aggregation-prone
57 A P 0.0000 Buried
65 S P -0.3347 Soluble
66 N P -0.2194 Soluble
67 L P 0.2996 Aggregation-prone
68 E P -0.4461 Soluble
69 T P -0.3518 Soluble
70 G P -0.4524 Soluble
71 V P -0.2609 Soluble
72 P P -0.3043 Soluble
74 S P -0.4003 Soluble
75 R P -0.7766 Soluble
76 F P 0.0000 Buried
77 S P -0.4114 Soluble
78 G P -0.2934 Soluble
79 S P -0.8309 Soluble
80 G P -0.9259 Soluble
83 S P -0.7715 Soluble
84 G P -0.9587 Soluble
85 T P -1.6323 Soluble
86 D P -2.0810 Soluble
87 F P 0.0000 Buried
88 S P -0.7297 Soluble
89 L P 0.0000 Buried
90 T P -0.6272 Soluble
91 I P 0.0000 Buried
92 S P -1.2957 Soluble
93 S P -1.1197 Soluble
94 L P 0.0000 Buried
95 Q P -0.8636 Soluble
96 P P -1.4027 Soluble
97 E P -1.3574 Soluble
98 D P 0.0000 Buried
99 V P 0.0000 Buried
100 A P 0.0000 Buried
101 T P -1.0369 Soluble
102 Y P 0.0000 Buried
103 Y P 0.0000 Buried
104 C P 0.0000 Buried
105 Q P 0.0000 Buried
106 Q P 0.0000 Buried
107 Y P 0.0000 Buried
108 D P -0.9408 Soluble
109 N P -1.3861 Soluble
114 L P -0.5168 Soluble
115 P P -0.7982 Soluble
116 L P 0.0000 Buried
117 T P -0.8032 Soluble
118 F P -0.3194 Soluble
119 G P 0.0000 Buried
120 G P -1.1974 Soluble
121 G P -1.0172 Soluble
122 T P 0.0000 Buried
123 K P -2.0597 Soluble
124 V P 0.0000 Buried
125 E P -1.6759 Soluble
126 I P 0.0000 Buried
127 K P -1.3049 Soluble
128 R P -0.6798 Soluble
129 T P 0.2658 Aggregation-prone
130 V P 1.1959 Aggregation-prone
131 A P 0.4966 Aggregation-prone
132 A P 0.0550 Aggregation-prone
133 P P 0.0000 Buried
134 S P -0.0730 Soluble
135 V P 0.0000 Buried
136 F P 0.1921 Aggregation-prone
137 I P 0.0690 Aggregation-prone
138 F P 0.0000 Buried
139 P P -0.4716 Soluble
140 P P 0.0000 Buried
141 S P -1.8300 Soluble
142 D P -3.1340 Soluble
143 E P -3.0103 Soluble
144 Q P 0.0000 Buried
145 L P -2.3152 Soluble
146 K P -2.8082 Soluble
147 S P -1.7717 Soluble
148 G P -1.3297 Soluble
149 T P -0.9476 Soluble
150 A P 0.0000 Buried
151 S P 0.0000 Buried
152 V P 0.0000 Buried
153 V P 0.0000 Buried
154 C P 0.0000 Buried
155 L P 0.0000 Buried
156 L P 0.0000 Buried
157 N P 0.0000 Buried
158 N P -0.6060 Soluble
159 F P 0.0000 Buried
160 Y P 0.0000 Buried
161 P P -1.4309 Soluble
162 R P -2.6038 Soluble
163 E P -3.0796 Soluble
164 A P -2.2285 Soluble
165 K P -2.3139 Soluble
166 V P -1.2292 Soluble
167 Q P -0.7895 Soluble
168 W P 0.0000 Buried
169 K P -0.7835 Soluble
170 V P 0.0000 Buried
171 D P -1.6430 Soluble
172 N P -1.4801 Soluble
173 A P -0.5974 Soluble
174 L P -0.0205 Soluble
175 Q P -0.6124 Soluble
176 S P -0.6790 Soluble
177 G P -1.1091 Soluble
178 N P -1.0976 Soluble
179 S P -1.3445 Soluble
180 Q P -1.7121 Soluble
181 E P -2.2750 Soluble
182 S P -1.1006 Soluble
183 V P -0.7714 Soluble
184 T P -1.0896 Soluble
185 E P -2.3018 Soluble
186 Q P 0.0000 Buried
187 D P -2.0280 Soluble
188 S P -1.9873 Soluble
189 K P -2.4966 Soluble
190 D P -1.8566 Soluble
191 S P 0.0000 Buried
192 T P 0.0000 Buried
193 Y P 0.0000 Buried
194 S P 0.0000 Buried
195 L P 0.0000 Buried
196 S P 0.0000 Buried
197 S P 0.0000 Buried
198 T P -0.8072 Soluble
199 L P 0.0000 Buried
200 T P -0.3203 Soluble
201 L P -0.5107 Soluble
202 S P -1.1865 Soluble
203 K P -2.3165 Soluble
204 A P -2.1525 Soluble
205 D P -3.0641 Soluble
206 Y P 0.0000 Buried
207 E P -3.8461 Soluble
208 K P -3.8051 Soluble
209 H P -2.9517 Soluble
210 K P -2.8606 Soluble
211 V P -1.2553 Soluble
212 Y P 0.0000 Buried
213 A P 0.0000 Buried
214 C P 0.0000 Buried
215 E P -0.7735 Soluble
216 V P 0.0000 Buried
217 T P -1.0528 Soluble
218 H P 0.0000 Buried
219 Q P -1.2020 Soluble
220 G P -0.2935 Soluble
221 L P -0.1680 Soluble
222 S P -0.4410 Soluble
223 S P -0.3427 Soluble
224 P P -0.2224 Soluble
225 V P 0.2516 Aggregation-prone
226 T P -0.3346 Soluble
227 K P -0.6387 Soluble
228 S P -0.7051 Soluble
229 F P -0.8970 Soluble
230 N P -1.7705 Soluble
231 R P -1.8602 Soluble
232 G P -1.2830 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6308 2.7036 CSV PDB
4.5 -0.6796 2.6479 CSV PDB
5.0 -0.7373 2.5655 CSV PDB
5.5 -0.7936 2.4684 CSV PDB
6.0 -0.8374 2.3858 CSV PDB
6.5 -0.8594 2.3559 CSV PDB
7.0 -0.858 2.3258 CSV PDB
7.5 -0.8404 2.2957 CSV PDB
8.0 -0.8137 2.2659 CSV PDB
8.5 -0.7802 2.2369 CSV PDB
9.0 -0.7396 2.2102 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH