Anvatabart / 1fvc

A4DAB021_1fvc_D_C | Source PDB: 1fvc | Chains: D, C | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6803
Max Score
1.9805
Min Score
-3.0535
Total Score
-155.11
Score CDR
-0.5869
Score non-CDR
-0.7046

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSDIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKR input.pdb
Selected Chain(s) D (Heavy), C (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.0535
Maximum Score 1.9805
Average Score -0.6803
Total Score -155.1137

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E D -2.0736 Soluble
2 V D -1.3105 Soluble
3 Q D -1.1962 Soluble
4 L D 0.0000 Buried
5 V D 0.3710 Aggregation-prone
6 E D 0.0000 Buried
7 S D -0.4436 Soluble
8 G D -0.8203 Soluble
9 G D 0.0141 Aggregation-prone
11 G D 0.7307 Aggregation-prone
12 L D 1.3723 Aggregation-prone
13 V D -0.0540 Soluble
14 Q D -1.3265 Soluble
15 P D -1.5386 Soluble
16 G D -1.3303 Soluble
17 G D -1.0021 Soluble
18 S D -1.2241 Soluble
19 L D -0.7991 Soluble
20 R D -1.9250 Soluble
21 L D 0.0000 Buried
22 S D -0.4255 Soluble
23 C D 0.0000 Buried
24 A D -0.2422 Soluble
25 A D 0.0000 Buried
26 S D -1.1302 Soluble
27 G D -1.4910 Soluble
28 F D -1.3498 Soluble
29 N D -2.0798 Soluble
30 I D 0.0000 Buried
35 K D -2.0360 Soluble
36 D D -2.5595 Soluble
37 T D 0.0000 Buried
38 Y D -0.4712 Soluble
39 I D 0.0000 Buried
40 H D 0.0000 Buried
41 W D 0.0000 Buried
42 V D 0.0000 Buried
43 R D 0.0000 Buried
44 Q D -0.8151 Soluble
45 A D -1.0965 Soluble
46 P D -0.7619 Soluble
47 G D -1.4594 Soluble
48 K D -2.4497 Soluble
49 G D -1.7260 Soluble
50 L D 0.0000 Buried
51 E D -1.4639 Soluble
52 W D 0.0000 Buried
53 V D 0.0000 Buried
54 A D 0.0000 Buried
55 R D -0.6712 Soluble
56 I D 0.0000 Buried
57 Y D -0.4363 Soluble
58 P D 0.0000 Buried
59 T D -1.2448 Soluble
62 N D -0.9906 Soluble
63 G D -0.4869 Soluble
64 Y D 0.3951 Aggregation-prone
65 T D -0.5294 Soluble
66 R D -2.0337 Soluble
67 Y D -1.9401 Soluble
68 A D -1.9004 Soluble
69 D D -2.9021 Soluble
70 S D -1.6827 Soluble
71 V D 0.0000 Buried
72 K D -3.0535 Soluble
74 G D -1.9277 Soluble
75 R D -1.6524 Soluble
76 F D 0.0000 Buried
77 T D -1.0871 Soluble
78 I D 0.0000 Buried
79 S D -0.1801 Soluble
80 A D -0.8562 Soluble
81 D D -1.3839 Soluble
82 T D -1.4785 Soluble
83 S D -1.4888 Soluble
84 K D -2.2380 Soluble
85 N D -1.6595 Soluble
86 T D 0.0000 Buried
87 A D 0.0000 Buried
88 Y D -0.5151 Soluble
89 L D 0.0000 Buried
90 Q D -1.1346 Soluble
91 M D 0.0000 Buried
92 N D -1.5471 Soluble
93 S D -1.3187 Soluble
94 L D 0.0000 Buried
95 R D -2.3498 Soluble
96 A D -1.7264 Soluble
97 E D -2.2600 Soluble
98 D D 0.0000 Buried
99 T D -0.3296 Soluble
100 A D 0.0000 Buried
101 V D 0.7204 Aggregation-prone
102 Y D 0.0000 Buried
103 Y D 0.0000 Buried
104 C D 0.0000 Buried
105 S D 0.0000 Buried
106 R D -0.0823 Soluble
107 W D 0.0000 Buried
108 G D -0.7141 Soluble
109 G D -1.5242 Soluble
110 D D -2.1282 Soluble
111 G D -1.1155 Soluble
112 F D -0.3110 Soluble
113 Y D 0.1905 Aggregation-prone
114 A D 0.0000 Buried
115 M D 0.0000 Buried
116 D D -0.0466 Soluble
117 Y D -0.1151 Soluble
118 W D -0.3630 Soluble
119 G D 0.0000 Buried
120 Q D -1.3629 Soluble
121 G D -0.3799 Soluble
122 T D 0.4695 Aggregation-prone
123 L D 1.6119 Aggregation-prone
124 V D 0.0000 Buried
125 T D 0.3317 Aggregation-prone
126 V D 0.0000 Buried
127 S D -0.6752 Soluble
128 S D -0.5019 Soluble
1 D C -2.2621 Soluble
2 I C 0.0000 Buried
3 Q C -2.1298 Soluble
4 M C 0.0000 Buried
5 T C -1.1777 Soluble
6 Q C 0.0000 Buried
7 S C -0.6531 Soluble
8 P C -0.5415 Soluble
9 S C -0.7198 Soluble
10 S C -0.7143 Soluble
11 L C -0.5361 Soluble
12 S C -1.2443 Soluble
13 A C 0.0000 Buried
14 S C -1.2481 Soluble
15 V C -0.3932 Soluble
16 G C -1.0197 Soluble
17 D C -1.8690 Soluble
18 R C -2.4056 Soluble
19 V C -1.1152 Soluble
20 T C -0.5374 Soluble
21 I C 0.0000 Buried
22 T C -0.7413 Soluble
23 C C 0.0000 Buried
24 R C -2.4348 Soluble
25 A C 0.0000 Buried
26 S C -2.1470 Soluble
27 Q C -2.9156 Soluble
28 D C -2.9875 Soluble
29 V C 0.0000 Buried
36 N C -2.0195 Soluble
37 T C -1.0718 Soluble
38 A C -0.0494 Soluble
39 V C 0.0000 Buried
40 A C 0.0000 Buried
41 W C 0.0000 Buried
42 Y C 0.0000 Buried
43 Q C -0.7572 Soluble
44 Q C 0.0000 Buried
45 K C -1.6623 Soluble
46 P C -1.3113 Soluble
47 G C -1.6505 Soluble
48 K C -2.5385 Soluble
49 A C -1.4993 Soluble
50 P C 0.0000 Buried
51 K C -1.0850 Soluble
52 L C 0.0000 Buried
53 L C 0.0000 Buried
54 I C 0.0000 Buried
55 Y C 1.1130 Aggregation-prone
56 S C 0.4025 Aggregation-prone
57 A C 0.0000 Buried
65 S C 0.6219 Aggregation-prone
66 F C 1.9805 Aggregation-prone
67 L C 1.3805 Aggregation-prone
68 Y C 0.6315 Aggregation-prone
69 S C -0.0391 Soluble
70 G C -0.4672 Soluble
71 V C 0.0000 Buried
72 P C -0.3411 Soluble
74 S C -0.4214 Soluble
75 R C -0.8383 Soluble
76 F C 0.0000 Buried
77 S C 0.0362 Aggregation-prone
78 G C 0.0132 Aggregation-prone
79 S C -0.7450 Soluble
80 R C -1.7666 Soluble
83 S C -1.4520 Soluble
84 G C -1.9340 Soluble
85 T C -2.3491 Soluble
86 D C -2.2438 Soluble
87 F C 0.0000 Buried
88 T C -0.8258 Soluble
89 L C 0.0000 Buried
90 T C -0.5498 Soluble
91 I C 0.0000 Buried
92 S C -1.3798 Soluble
93 S C -1.3142 Soluble
94 L C 0.0000 Buried
95 Q C -1.2854 Soluble
96 P C -1.0965 Soluble
97 E C -1.9683 Soluble
98 D C 0.0000 Buried
99 F C -0.7757 Soluble
100 A C 0.0000 Buried
101 T C -0.7868 Soluble
102 Y C 0.0000 Buried
103 Y C 0.0000 Buried
104 C C 0.0000 Buried
105 Q C 0.0000 Buried
106 Q C 0.0000 Buried
107 H C 0.4985 Aggregation-prone
108 Y C 0.8136 Aggregation-prone
109 T C 0.2541 Aggregation-prone
114 T C -0.4154 Soluble
115 P C -0.8644 Soluble
116 P C 0.0000 Buried
117 T C -0.7264 Soluble
118 F C -0.6137 Soluble
119 G C 0.0000 Buried
120 Q C -1.8645 Soluble
121 G C -1.1263 Soluble
122 T C 0.0000 Buried
123 K C -1.0804 Soluble
124 V C 0.0000 Buried
125 E C -1.5369 Soluble
126 I C -1.1432 Soluble
127 K C -2.3547 Soluble
128 R C -2.3960 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.673 3.412 CSV PDB
4.5 -0.715 3.412 CSV PDB
5.0 -0.7634 3.412 CSV PDB
5.5 -0.8104 3.412 CSV PDB
6.0 -0.8478 3.412 CSV PDB
6.5 -0.87 3.412 CSV PDB
7.0 -0.8777 3.412 CSV PDB
7.5 -0.8758 3.412 CSV PDB
8.0 -0.8676 3.412 CSV PDB
8.5 -0.8528 3.4119 CSV PDB
9.0 -0.8307 3.4117 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH