Beludavimab / 8vye

A4DAB038_8vye_I_J | Source PDB: 8vye | Chains: I, J | Done
99.57
Yes
10 Å
Yes
Avg A4D Score
-0.6878
Max Score
1.7153
Min Score
-3.5815
Total Score
-159.57
Score CDR
-0.2363
Score non-CDR
-0.8248

Calculation Parameters

Chain Sequence(s) QVQLVQSGAEVKKPGASVKVSCKASGYPFTSYGISWVRQAPGQGLEWMGWISTYNGNTNYAQKFQGRVTMTTDTSTTTGYMELRRLRSDDTAVYYCARDYTRGAWFGESLIGGFDNWGQGTLVTVSEIVLTQSPGTLSLSPGERATLSCRASQTVSSTSLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQHDTSLTFGGGTKVEI input.pdb
Selected Chain(s) I (Heavy), J (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.5815
Maximum Score 1.7153
Average Score -0.6878
Total Score -159.5729

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q I -1.5194 Soluble
2 V I -1.2068 Soluble
3 Q I -1.5778 Soluble
4 L I 0.0000 Buried
5 V I 0.3325 Aggregation-prone
6 Q I -0.0839 Soluble
7 S I -0.6008 Soluble
8 G I -0.5795 Soluble
9 A I 0.0279 Aggregation-prone
11 E I -0.3805 Soluble
12 V I 0.7844 Aggregation-prone
13 K I -1.0083 Soluble
14 K I -2.2291 Soluble
15 P I -2.5070 Soluble
16 G I -2.0166 Soluble
17 A I -1.7402 Soluble
18 S I -2.0238 Soluble
19 V I 0.0000 Buried
20 K I -2.0420 Soluble
21 V I 0.0000 Buried
22 S I 0.0000 Buried
23 C I 0.0000 Buried
24 K I -0.8782 Soluble
25 A I 0.0000 Buried
26 S I -0.9140 Soluble
27 G I -1.0860 Soluble
28 Y I -0.5453 Soluble
29 P I -0.2690 Soluble
30 F I 0.0000 Buried
35 T I 0.2339 Aggregation-prone
36 S I 0.3440 Aggregation-prone
37 Y I 0.5739 Aggregation-prone
38 G I 0.0000 Buried
39 I I 0.0000 Buried
40 S I 0.0000 Buried
41 W I 0.0000 Buried
42 V I 0.0000 Buried
43 R I 0.0000 Buried
44 Q I 0.0000 Buried
45 A I -0.9246 Soluble
46 P I -0.8038 Soluble
47 G I -1.2192 Soluble
48 Q I -1.7481 Soluble
49 G I -1.1259 Soluble
50 L I 0.0000 Buried
51 E I -1.1853 Soluble
52 W I 0.0000 Buried
53 M I 0.0000 Buried
54 G I 0.0000 Buried
55 W I 0.0000 Buried
56 I I 0.0000 Buried
57 S I 0.0000 Buried
58 T I 0.0000 Buried
59 Y I 0.3248 Aggregation-prone
62 N I -0.6215 Soluble
63 G I -1.1566 Soluble
64 N I -1.7485 Soluble
65 T I -1.3721 Soluble
66 N I -1.5378 Soluble
67 Y I -1.0950 Soluble
68 A I -1.5127 Soluble
69 Q I -2.3172 Soluble
70 K I -2.6145 Soluble
71 F I 0.0000 Buried
72 Q I -2.5482 Soluble
74 G I -2.1819 Soluble
75 R I -2.7344 Soluble
76 V I 0.0000 Buried
77 T I -1.0010 Soluble
78 M I 0.0000 Buried
79 T I -0.4463 Soluble
80 T I -0.7333 Soluble
81 D I -1.0320 Soluble
82 T I -0.5282 Soluble
83 S I -0.5135 Soluble
84 T I -0.6340 Soluble
85 T I -0.7145 Soluble
86 T I 0.0000 Buried
87 G I 0.0000 Buried
88 Y I -0.4719 Soluble
89 M I 0.0000 Buried
90 E I -1.4247 Soluble
91 L I 0.0000 Buried
92 R I -2.6501 Soluble
93 R I -3.2105 Soluble
94 L I 0.0000 Buried
95 R I -3.5647 Soluble
96 S I -2.4396 Soluble
97 D I -2.6425 Soluble
98 D I -1.9778 Soluble
99 T I -0.7358 Soluble
100 A I 0.0000 Buried
101 V I 0.5347 Aggregation-prone
102 Y I 0.0000 Buried
103 Y I 0.0000 Buried
104 C I 0.0000 Buried
105 A I 0.0000 Buried
106 R I -0.3351 Soluble
107 D I 0.0000 Buried
108 Y I 0.9422 Aggregation-prone
109 T I 0.0000 Buried
110 R I -0.1905 Soluble
111 G I 0.3058 Aggregation-prone
111A A I 0.4884 Aggregation-prone
111B W I 1.4867 Aggregation-prone
111C F I 1.5464 Aggregation-prone
112D G I -0.4896 Soluble
112C E I -1.3902 Soluble
112B S I -0.7816 Soluble
112A L I 0.3795 Aggregation-prone
112 I I 1.7153 Aggregation-prone
113 G I 0.0000 Buried
114 G I 0.0000 Buried
115 F I 0.0000 Buried
116 D I -0.8304 Soluble
117 N I -1.0744 Soluble
118 W I -0.6991 Soluble
119 G I 0.0000 Buried
120 Q I -1.2656 Soluble
121 G I -0.4653 Soluble
122 T I 0.0000 Buried
123 L I 0.7727 Aggregation-prone
124 V I 0.0000 Buried
125 T I -0.2931 Soluble
126 V I 0.0000 Buried
127 S I -1.1624 Soluble
1 E J -1.8189 Soluble
2 I J 0.0000 Buried
3 V J 0.7501 Aggregation-prone
4 L J 0.0000 Buried
5 T J -0.7028 Soluble
6 Q J -1.1756 Soluble
7 S J -0.8179 Soluble
8 P J -0.5852 Soluble
9 G J -0.8399 Soluble
10 T J -0.9237 Soluble
11 L J -0.3603 Soluble
12 S J -0.2620 Soluble
13 L J 0.0000 Buried
14 S J -0.7267 Soluble
15 P J -1.7460 Soluble
16 G J -2.3622 Soluble
17 E J -3.3531 Soluble
18 R J -3.5815 Soluble
19 A J 0.0000 Buried
20 T J -0.5203 Soluble
21 L J 0.0000 Buried
22 S J -1.0397 Soluble
23 C J 0.0000 Buried
24 R J -2.5313 Soluble
25 A J -1.3472 Soluble
26 S J -1.0742 Soluble
27 Q J -1.8891 Soluble
28 T J -1.5212 Soluble
29 V J 0.0000 Buried
30 S J -0.7355 Soluble
36 S J -0.4951 Soluble
37 T J 0.2061 Aggregation-prone
38 S J 0.0000 Buried
39 L J 0.0000 Buried
40 A J 0.0000 Buried
41 W J 0.0000 Buried
42 Y J 0.0000 Buried
43 Q J 0.0000 Buried
44 Q J -1.3882 Soluble
45 K J -2.2623 Soluble
46 P J -1.4863 Soluble
47 G J -1.6327 Soluble
48 Q J -2.2946 Soluble
49 A J -1.5104 Soluble
50 P J 0.0000 Buried
51 R J -1.4340 Soluble
52 L J 0.0000 Buried
53 L J 0.0000 Buried
54 I J 0.0000 Buried
55 Y J 0.4527 Aggregation-prone
56 G J 0.0000 Buried
57 A J 0.0000 Buried
65 S J -0.3741 Soluble
66 S J -0.4174 Soluble
67 R J -1.2602 Soluble
68 A J 0.0000 Buried
69 T J -0.5326 Soluble
70 G J -0.7522 Soluble
71 I J -0.8864 Soluble
72 P J -1.2366 Soluble
74 D J -2.1615 Soluble
75 R J -1.9758 Soluble
76 F J 0.0000 Buried
77 S J -0.8764 Soluble
78 G J -0.4773 Soluble
79 S J -0.7705 Soluble
80 G J -1.3081 Soluble
83 S J -1.2637 Soluble
84 G J -1.4340 Soluble
85 T J -2.0998 Soluble
86 D J -2.9096 Soluble
87 F J 0.0000 Buried
88 T J -0.9150 Soluble
89 L J 0.0000 Buried
90 T J -0.7717 Soluble
91 I J 0.0000 Buried
92 S J -2.4136 Soluble
93 R J -3.5372 Soluble
94 L J 0.0000 Buried
95 E J -2.8887 Soluble
96 P J -1.6609 Soluble
97 E J -2.4652 Soluble
98 D J 0.0000 Buried
99 F J -1.1446 Soluble
100 A J 0.0000 Buried
101 V J -0.7581 Soluble
102 Y J 0.0000 Buried
103 Y J 0.0000 Buried
104 C J 0.0000 Buried
105 Q J 0.0000 Buried
106 Q J 0.0000 Buried
107 H J 0.0000 Buried
108 D J -1.7084 Soluble
114 T J -1.3595 Soluble
115 S J -1.0834 Soluble
116 L J 0.0000 Buried
117 T J -0.2498 Soluble
118 F J 0.1930 Aggregation-prone
119 G J 0.0000 Buried
120 G J -0.6739 Soluble
121 G J -0.7779 Soluble
122 T J 0.0000 Buried
123 K J -1.3571 Soluble
124 V J 0.0000 Buried
125 E J -0.8184 Soluble
126 I J 1.1228 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5791 5.328 CSV PDB
4.5 -0.6259 5.2271 CSV PDB
5.0 -0.6804 5.1232 CSV PDB
5.5 -0.7336 5.0555 CSV PDB
6.0 -0.7768 4.9941 CSV PDB
6.5 -0.8039 4.9495 CSV PDB
7.0 -0.8149 4.9254 CSV PDB
7.5 -0.8153 4.9155 CSV PDB
8.0 -0.8094 4.912 CSV PDB
8.5 -0.7982 4.9108 CSV PDB
9.0 -0.7808 4.9099 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH