Paridiprubart / 4r7n

A4DAB203_4r7n_S_T | Source PDB: 4r7n | Chains: S, T | Done
96
Yes
10 Å
Yes
Avg A4D Score
-0.6915
Max Score
1.7713
Min Score
-3.9809
Total Score
-296.66
Score CDR
-0.2414
Score non-CDR
-0.7443

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSDTLSLTCAVSGYPIRFGYSWHWIRQPPGKGLEWMGYIHYSGYTDFNPSLKTRITISRDTSKNQFSLKLSSVTAVDTAVYYCARKDSGNYFPYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPEIVLTQSPDFQSVTPKEKVTITCRASQSISDHLHWYQQKPDQSPKLLIKYASHAISGVPSRFSGSGSGTDFTLTINSLEAEDAATYYCQQGYDFPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR input.pdb
Selected Chain(s) S (Heavy), T (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.9809
Maximum Score 1.7713
Average Score -0.6915
Total Score -296.6575

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q S -1.4036 Soluble
2 V S -0.9571 Soluble
3 Q S -1.7900 Soluble
4 L S 0.0000 Buried
5 Q S -1.9184 Soluble
6 E S 0.0000 Buried
7 S S -0.7724 Soluble
8 G S -0.4291 Soluble
9 P S -0.4669 Soluble
11 G S -0.4294 Soluble
12 L S -0.2758 Soluble
13 V S 0.0000 Buried
14 K S -2.0474 Soluble
15 P S -1.1323 Soluble
16 S S -1.1051 Soluble
17 D S -1.3682 Soluble
18 T S -0.9894 Soluble
19 L S 0.0000 Buried
20 S S -0.6201 Soluble
21 L S 0.0000 Buried
22 T S -0.7159 Soluble
23 C S 0.0000 Buried
24 A S -1.2315 Soluble
25 V S 0.0000 Buried
26 S S -1.2381 Soluble
27 G S -0.9121 Soluble
28 Y S -0.1611 Soluble
29 P S -0.2554 Soluble
30 I S 0.0000 Buried
31 R S -0.9773 Soluble
35 F S 1.1844 Aggregation-prone
36 G S 0.6469 Aggregation-prone
37 Y S 0.5641 Aggregation-prone
38 S S 0.0000 Buried
39 W S 0.0000 Buried
40 H S 0.0000 Buried
41 W S 0.0000 Buried
42 I S 0.0000 Buried
43 R S 0.0000 Buried
44 Q S -0.7909 Soluble
45 P S -0.6267 Soluble
46 P S -1.0367 Soluble
47 G S -1.5123 Soluble
48 K S -2.3180 Soluble
49 G S -1.4953 Soluble
50 L S 0.0000 Buried
51 E S -0.7242 Soluble
52 W S 0.0000 Buried
53 M S 0.0000 Buried
54 G S 0.0000 Buried
55 Y S 0.0000 Buried
56 I S 0.0000 Buried
57 H S -0.0894 Soluble
58 Y S -0.0385 Soluble
59 S S 0.0649 Aggregation-prone
63 G S -0.0577 Soluble
64 Y S 0.7268 Aggregation-prone
65 T S -0.2729 Soluble
66 D S -1.3510 Soluble
67 F S -0.6501 Soluble
68 N S 0.0000 Buried
69 P S -0.9156 Soluble
70 S S -0.4340 Soluble
71 L S -0.0980 Soluble
72 K S -1.0572 Soluble
74 T S -0.6910 Soluble
75 R S -0.7203 Soluble
76 I S 0.0000 Buried
77 T S -0.7565 Soluble
78 I S 0.0000 Buried
79 S S -0.8762 Soluble
80 R S -1.7317 Soluble
81 D S -1.8683 Soluble
82 T S -1.7377 Soluble
83 S S -1.6748 Soluble
84 K S -2.3081 Soluble
85 N S -1.8211 Soluble
86 Q S -1.7009 Soluble
87 F S 0.0000 Buried
88 S S -0.7226 Soluble
89 L S 0.0000 Buried
90 K S -0.9402 Soluble
91 L S 0.0000 Buried
92 S S -0.7736 Soluble
93 S S -0.8328 Soluble
94 V S 0.0000 Buried
95 T S 0.0514 Aggregation-prone
96 A S 0.6201 Aggregation-prone
97 V S 1.7713 Aggregation-prone
98 D S 0.0000 Buried
99 T S 0.6439 Aggregation-prone
100 A S 0.0000 Buried
101 V S 0.1282 Aggregation-prone
102 Y S 0.0000 Buried
103 Y S 0.0000 Buried
104 C S 0.0000 Buried
105 A S 0.0000 Buried
106 R S 0.0000 Buried
107 K S -0.2521 Soluble
108 D S -0.2346 Soluble
109 S S -0.3586 Soluble
110 G S -0.3552 Soluble
113 N S -0.3536 Soluble
114 Y S -0.1069 Soluble
115 F S 0.0000 Buried
116 P S -0.0609 Soluble
117 Y S 0.0204 Aggregation-prone
118 W S -0.5881 Soluble
119 G S 0.0000 Buried
120 Q S -2.1341 Soluble
121 G S -1.2036 Soluble
122 T S -0.3661 Soluble
123 L S 0.2898 Aggregation-prone
124 V S 0.0000 Buried
125 T S 0.0000 Buried
126 V S 0.0000 Buried
127 S S -0.6890 Soluble
128 S S -0.8796 Soluble
129 A S -0.5738 Soluble
130 S S -0.7097 Soluble
131 T S -0.9158 Soluble
132 K S -1.6586 Soluble
133 G S -1.5987 Soluble
134 P S 0.0000 Buried
135 S S -0.3966 Soluble
136 V S 0.0000 Buried
137 F S -0.7294 Soluble
138 P S -1.0951 Soluble
139 L S 0.0000 Buried
140 A S -0.5464 Soluble
141 P S 0.0000 Buried
142 S S -0.7404 Soluble
143 S S -1.2230 Soluble
144 K S -2.1595 Soluble
145 S S -1.5042 Soluble
146 T S -1.0760 Soluble
147 S S -1.2462 Soluble
148 G S -1.1965 Soluble
149 G S -0.9987 Soluble
150 T S -0.7120 Soluble
151 A S 0.0000 Buried
152 A S 0.0000 Buried
153 L S 0.0000 Buried
154 G S 0.0000 Buried
155 C S 0.0000 Buried
156 L S 0.0000 Buried
157 V S 0.0000 Buried
158 K S -0.3811 Soluble
159 D S -0.7912 Soluble
160 Y S 0.0000 Buried
161 F S 0.0000 Buried
162 P S 0.0000 Buried
163 E S -0.4381 Soluble
164 P S -0.6657 Soluble
165 V S -0.7866 Soluble
166 T S -0.8141 Soluble
167 V S -0.4270 Soluble
168 S S -0.4309 Soluble
169 W S 0.0000 Buried
170 N S -0.6569 Soluble
171 S S -0.5799 Soluble
172 G S -0.6260 Soluble
173 A S -0.2662 Soluble
174 L S -0.0823 Soluble
175 T S -0.2452 Soluble
176 S S -0.3004 Soluble
177 G S -0.2959 Soluble
178 V S 0.0887 Aggregation-prone
179 H S -0.3306 Soluble
180 T S 0.0524 Aggregation-prone
181 F S 0.0000 Buried
182 P S -0.2050 Soluble
183 A S 0.4898 Aggregation-prone
184 V S 0.5364 Aggregation-prone
185 L S 1.2755 Aggregation-prone
186 Q S 0.1678 Aggregation-prone
187 S S -0.1097 Soluble
188 S S -0.3069 Soluble
189 G S -0.0619 Soluble
190 L S -0.1057 Soluble
191 Y S 0.3334 Aggregation-prone
192 S S 0.0000 Buried
193 L S 0.2643 Aggregation-prone
194 S S 0.0000 Buried
195 S S 0.0000 Buried
196 V S 0.0000 Buried
197 V S 0.0000 Buried
198 T S -0.1852 Soluble
199 V S 0.0000 Buried
200 P S -0.5693 Soluble
201 S S 0.0000 Buried
202 S S -0.9555 Soluble
203 S S -0.6610 Soluble
204 L S -0.8391 Soluble
205 G S -1.0070 Soluble
206 T S -0.7153 Soluble
207 Q S -1.0287 Soluble
208 T S -1.1721 Soluble
209 Y S 0.0000 Buried
210 I S -1.1516 Soluble
211 C S 0.0000 Buried
212 N S -1.3315 Soluble
213 V S 0.0000 Buried
214 N S -2.3012 Soluble
215 H S 0.0000 Buried
216 K S -2.7066 Soluble
217 P S -1.6748 Soluble
218 S S -1.9479 Soluble
219 N S -2.5855 Soluble
220 T S -2.2469 Soluble
221 K S -2.6464 Soluble
222 V S -1.1751 Soluble
223 D S -1.6265 Soluble
224 K S -1.7124 Soluble
225 R S -2.5800 Soluble
226 V S 0.0000 Buried
227 E S -2.4448 Soluble
228 P S -1.2136 Soluble
1 E T -1.3963 Soluble
2 I T -0.1001 Soluble
3 V T 0.8863 Aggregation-prone
4 L T 0.0000 Buried
5 T T -0.8257 Soluble
6 Q T -1.1573 Soluble
7 S T -1.0740 Soluble
8 P T -0.9958 Soluble
9 D T -1.7445 Soluble
10 F T -0.2123 Soluble
11 Q T -0.5393 Soluble
12 S T -0.5166 Soluble
13 V T -1.3469 Soluble
14 T T -1.9511 Soluble
15 P T -2.5035 Soluble
16 K T -3.5043 Soluble
17 E T -3.9343 Soluble
18 K T -3.4610 Soluble
19 V T 0.0000 Buried
20 T T -0.7052 Soluble
21 I T 0.0000 Buried
22 T T -0.8514 Soluble
23 C T 0.0000 Buried
24 R T -2.2575 Soluble
25 A T 0.0000 Buried
26 S T -0.8912 Soluble
27 Q T -1.2943 Soluble
28 S T -1.3430 Soluble
29 I T 0.0000 Buried
36 S T -1.2751 Soluble
37 D T -1.7971 Soluble
38 H T -0.9762 Soluble
39 L T 0.0000 Buried
40 H T 0.0000 Buried
41 W T 0.0000 Buried
42 Y T 0.0000 Buried
43 Q T 0.0000 Buried
44 Q T 0.0000 Buried
45 K T -1.9235 Soluble
46 P T -1.8683 Soluble
47 D T -2.7663 Soluble
48 Q T -2.4764 Soluble
49 S T -1.5628 Soluble
50 P T 0.0000 Buried
51 K T -1.5656 Soluble
52 L T 0.0000 Buried
53 L T 0.0000 Buried
54 I T 0.0000 Buried
55 K T -0.5919 Soluble
56 Y T -0.6271 Soluble
57 A T 0.0000 Buried
65 S T -0.9076 Soluble
66 H T -0.9189 Soluble
67 A T -0.3087 Soluble
68 I T 0.2112 Aggregation-prone
69 S T -0.1894 Soluble
70 G T -0.2809 Soluble
71 V T -0.2242 Soluble
72 P T -0.2810 Soluble
74 S T -0.6434 Soluble
75 R T -1.2088 Soluble
76 F T 0.0000 Buried
77 S T -0.7666 Soluble
78 G T -0.4992 Soluble
79 S T -0.7018 Soluble
80 G T -1.2007 Soluble
83 S T -1.1980 Soluble
84 G T -1.4860 Soluble
85 T T -1.5779 Soluble
86 D T -1.8986 Soluble
87 F T 0.0000 Buried
88 T T -0.7385 Soluble
89 L T 0.0000 Buried
90 T T -0.8702 Soluble
91 I T 0.0000 Buried
92 N T -2.8684 Soluble
93 S T -2.9189 Soluble
94 L T 0.0000 Buried
95 E T -2.6441 Soluble
96 A T -2.3722 Soluble
97 E T -2.2290 Soluble
98 D T 0.0000 Buried
99 A T -1.5099 Soluble
100 A T 0.0000 Buried
101 T T -0.8363 Soluble
102 Y T 0.0000 Buried
103 Y T 0.0000 Buried
104 C T 0.0000 Buried
105 Q T 0.0000 Buried
106 Q T 0.0000 Buried
107 G T 0.0000 Buried
108 Y T -0.0757 Soluble
109 D T -1.0211 Soluble
114 F T 0.1275 Aggregation-prone
115 P T -0.3476 Soluble
116 L T 0.0000 Buried
117 T T -0.0459 Soluble
118 F T 0.2712 Aggregation-prone
119 G T 0.0000 Buried
120 G T -1.1201 Soluble
121 G T -1.1686 Soluble
122 T T 0.0000 Buried
123 K T -1.5810 Soluble
124 V T 0.0000 Buried
125 E T -0.9281 Soluble
126 I T 0.0000 Buried
127 K T -1.2781 Soluble
128 R T -0.7798 Soluble
129 T T 0.2557 Aggregation-prone
130 V T 1.1940 Aggregation-prone
131 A T 0.4587 Aggregation-prone
132 A T -0.0035 Soluble
133 P T 0.0000 Buried
134 S T -0.1480 Soluble
135 V T 0.0000 Buried
136 F T 0.1347 Aggregation-prone
137 I T 0.1685 Aggregation-prone
138 F T 0.0000 Buried
139 P T -0.6325 Soluble
140 P T -0.5847 Soluble
141 S T -1.4653 Soluble
142 D T -2.7255 Soluble
143 E T -2.5862 Soluble
144 Q T 0.0000 Buried
145 L T -2.1490 Soluble
146 K T -2.6207 Soluble
147 S T -1.6293 Soluble
148 G T -1.2699 Soluble
149 T T -0.8173 Soluble
150 A T 0.0000 Buried
151 S T 0.0000 Buried
152 V T 0.0000 Buried
153 V T 0.0000 Buried
154 C T 0.0000 Buried
155 L T 0.0000 Buried
156 L T 0.0000 Buried
157 N T 0.0000 Buried
158 N T -0.7850 Soluble
159 F T 0.0000 Buried
160 Y T 0.0000 Buried
161 P T -1.2037 Soluble
162 R T -2.2515 Soluble
163 E T -2.7808 Soluble
164 A T -2.0852 Soluble
165 K T -2.1619 Soluble
166 V T -1.0695 Soluble
167 Q T -0.5526 Soluble
168 W T 0.0000 Buried
169 K T -0.4351 Soluble
170 V T 0.0000 Buried
171 D T -1.5723 Soluble
172 N T -1.3115 Soluble
173 A T -0.1015 Soluble
174 L T 0.8686 Aggregation-prone
175 Q T -0.0173 Soluble
176 S T -0.4591 Soluble
177 G T -0.9079 Soluble
178 N T -0.7996 Soluble
179 S T -1.2653 Soluble
180 Q T -1.7915 Soluble
181 E T -2.0331 Soluble
182 S T -0.7220 Soluble
183 V T -0.3267 Soluble
184 T T -0.8467 Soluble
185 E T -2.2887 Soluble
186 Q T -1.9293 Soluble
187 D T -2.0722 Soluble
188 S T -2.3140 Soluble
189 K T -2.7543 Soluble
190 D T -2.0865 Soluble
191 S T 0.0000 Buried
192 T T 0.0000 Buried
193 Y T 0.0000 Buried
194 S T 0.0000 Buried
195 L T 0.0000 Buried
196 S T 0.0000 Buried
197 S T 0.0000 Buried
198 T T -0.8444 Soluble
199 L T 0.0000 Buried
200 T T -0.3070 Soluble
201 L T -0.6467 Soluble
202 S T -1.0855 Soluble
203 K T -2.1045 Soluble
204 A T -1.8819 Soluble
205 D T -2.8741 Soluble
206 Y T 0.0000 Buried
207 E T -3.9809 Soluble
208 K T -3.7257 Soluble
209 H T -3.3721 Soluble
210 K T -3.5838 Soluble
211 V T -1.8041 Soluble
212 Y T 0.0000 Buried
213 A T 0.0000 Buried
214 C T 0.0000 Buried
215 E T -0.8181 Soluble
216 V T 0.0000 Buried
217 T T -1.1810 Soluble
218 H T 0.0000 Buried
219 Q T -1.3435 Soluble
220 G T -0.2927 Soluble
221 L T -0.2211 Soluble
222 S T -0.5153 Soluble
223 S T -0.4323 Soluble
224 P T -0.5537 Soluble
225 V T 0.0698 Aggregation-prone
226 T T -0.4023 Soluble
227 K T -0.6312 Soluble
228 S T -0.6388 Soluble
229 F T -1.1044 Soluble
230 N T -2.5630 Soluble
231 R T -3.2291 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7204 2.8981 CSV PDB
4.5 -0.7629 2.723 CSV PDB
5.0 -0.8129 2.4757 CSV PDB
5.5 -0.8589 2.4779 CSV PDB
6.0 -0.8879 2.4827 CSV PDB
6.5 -0.8918 2.487 CSV PDB
7.0 -0.8727 2.4895 CSV PDB
7.5 -0.8389 2.4905 CSV PDB
8.0 -0.7974 2.4908 CSV PDB
8.5 -0.7498 2.4907 CSV PDB
9.0 -0.6957 2.49 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH