Zinlirvimab / 7ucf

A4DAB308_7ucf_H_L | Source PDB: 7ucf | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.606
Max Score
2.8912
Min Score
-3.1325
Total Score
-264.83
Score CDR
-0.2037
Score non-CDR
-0.6725

Calculation Parameters

Chain Sequence(s) VQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSASTKGPSVFPLAPSSKTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTEC input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.1325
Maximum Score 2.8912
Average Score -0.606
Total Score -264.8309

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V H -0.0840 Soluble
3 Q H -1.1432 Soluble
4 L H 0.0000 Buried
5 Q H -1.4230 Soluble
6 E H 0.0000 Buried
7 S H -0.7445 Soluble
8 G H -0.7965 Soluble
9 P H -0.5619 Soluble
11 G H 0.0000 Buried
12 L H -0.3080 Soluble
13 V H 0.0000 Buried
14 K H -1.6390 Soluble
15 P H -1.2721 Soluble
16 S H -1.2320 Soluble
17 E H -1.5770 Soluble
18 T H -1.4432 Soluble
19 L H 0.0000 Buried
20 S H -0.7938 Soluble
21 V H 0.0000 Buried
22 T H -0.9207 Soluble
23 C H 0.0000 Buried
24 S H -1.2574 Soluble
25 V H 0.0000 Buried
26 S H -1.1563 Soluble
27 G H -0.8322 Soluble
28 D H -1.2606 Soluble
29 S H -1.2759 Soluble
30 M H 0.0000 Buried
35 N H -2.5786 Soluble
36 N H -1.9865 Soluble
37 Y H -1.1877 Soluble
38 Y H -1.0412 Soluble
39 W H 0.0000 Buried
40 T H 0.0000 Buried
41 W H 0.0000 Buried
42 I H 0.0000 Buried
43 R H -0.7043 Soluble
44 Q H -1.0596 Soluble
45 S H -1.0868 Soluble
46 P H -1.1700 Soluble
47 G H -1.5499 Soluble
48 K H -2.3179 Soluble
49 G H -1.6666 Soluble
50 L H -1.0434 Soluble
51 E H -1.1056 Soluble
52 W H 0.0000 Buried
53 I H 0.0000 Buried
54 G H 0.0000 Buried
55 Y H 0.2114 Aggregation-prone
56 I H 0.0000 Buried
57 S H -1.7689 Soluble
58 D H -2.4909 Soluble
59 R H -3.1325 Soluble
63 E H -3.0775 Soluble
64 S H -1.7527 Soluble
65 A H -0.4977 Soluble
66 T H 0.1574 Aggregation-prone
67 Y H 0.4013 Aggregation-prone
68 N H 0.0000 Buried
69 P H -0.6654 Soluble
70 S H -0.6878 Soluble
71 L H 0.0000 Buried
72 N H -1.5438 Soluble
74 S H -0.8141 Soluble
75 R H -0.8727 Soluble
76 V H 0.0000 Buried
77 V H 1.1554 Aggregation-prone
78 I H 0.0000 Buried
79 S H -0.5832 Soluble
80 R H 0.0000 Buried
81 D H -1.6922 Soluble
82 T H -1.5445 Soluble
83 S H -1.5177 Soluble
84 K H -2.3269 Soluble
85 N H -1.9169 Soluble
86 Q H -1.6036 Soluble
87 L H 0.0000 Buried
88 S H -0.4855 Soluble
89 L H 0.0000 Buried
90 K H -0.9772 Soluble
91 L H 0.0000 Buried
92 N H -1.3911 Soluble
93 S H -1.1464 Soluble
94 V H 0.0000 Buried
95 T H -0.7201 Soluble
96 P H -0.5018 Soluble
97 A H -0.0953 Soluble
98 D H 0.0000 Buried
99 T H -0.1141 Soluble
100 A H 0.0000 Buried
101 V H -0.2175 Soluble
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 T H 0.0000 Buried
107 A H 0.0000 Buried
108 R H -1.1834 Soluble
109 R H -1.2885 Soluble
110 G H -0.7458 Soluble
111 Q H -0.2688 Soluble
111A R H 0.1688 Aggregation-prone
111B I H 1.6797 Aggregation-prone
111C Y H 1.3514 Aggregation-prone
111D G H 1.4647 Aggregation-prone
111E V H 2.4221 Aggregation-prone
111F V H 2.8912 Aggregation-prone
112G S H 1.7409 Aggregation-prone
112F F H 2.4652 Aggregation-prone
112E G H 1.6872 Aggregation-prone
112D E H 1.1948 Aggregation-prone
112C F H 1.4848 Aggregation-prone
112B F H 0.5900 Aggregation-prone
112A Y H 0.3855 Aggregation-prone
112 Y H 0.0000 Buried
113 Y H 0.0000 Buried
114 S H 0.0000 Buried
115 M H 0.0000 Buried
116 D H -0.6763 Soluble
117 V H 0.0587 Aggregation-prone
118 W H -0.2664 Soluble
119 G H 0.0000 Buried
120 K H -1.8039 Soluble
121 G H -0.9933 Soluble
122 T H -0.5310 Soluble
123 T H -0.1633 Soluble
124 V H 0.0000 Buried
125 T H -0.2412 Soluble
126 V H 0.0000 Buried
127 S H -0.6138 Soluble
128 S H -0.7382 Soluble
129 A H -0.4701 Soluble
130 S H -0.6943 Soluble
131 T H -0.9463 Soluble
132 K H -1.5878 Soluble
133 G H -1.6121 Soluble
134 P H 0.0000 Buried
135 S H -0.3613 Soluble
136 V H 0.0000 Buried
137 F H -0.5078 Soluble
138 P H -1.0245 Soluble
139 L H 0.0000 Buried
140 A H -0.9932 Soluble
141 P H 0.0000 Buried
142 S H -1.0169 Soluble
143 S H -1.0267 Soluble
144 K H -1.7639 Soluble
145 T H -0.5580 Soluble
146 A H 0.0000 Buried
147 A H -0.1304 Soluble
148 L H 0.0000 Buried
149 G H 0.0000 Buried
150 C H 0.0000 Buried
151 L H 0.0000 Buried
152 V H 0.0000 Buried
153 K H 0.0000 Buried
154 D H -0.4248 Soluble
155 Y H 0.0000 Buried
156 F H -0.2717 Soluble
157 P H 0.0000 Buried
158 E H -0.4171 Soluble
159 P H -0.5566 Soluble
160 V H -0.5428 Soluble
161 T H -0.4820 Soluble
162 V H -0.3240 Soluble
163 S H -0.3138 Soluble
164 W H 0.0000 Buried
165 N H -0.5994 Soluble
166 S H -0.6898 Soluble
167 G H -0.5830 Soluble
168 A H -0.2589 Soluble
169 L H -0.0167 Soluble
170 T H -0.1699 Soluble
171 S H -0.2344 Soluble
172 G H -0.3036 Soluble
173 V H 0.2260 Aggregation-prone
174 H H -0.1797 Soluble
175 T H -0.0609 Soluble
176 F H 0.0000 Buried
177 P H 0.0086 Aggregation-prone
178 A H 0.2402 Aggregation-prone
179 V H 0.0000 Buried
180 L H 1.0594 Aggregation-prone
181 Q H 0.2021 Aggregation-prone
182 S H -0.1684 Soluble
183 S H -0.2701 Soluble
184 G H -0.0834 Soluble
185 L H 0.0965 Aggregation-prone
186 Y H 0.5193 Aggregation-prone
187 S H 0.0000 Buried
188 L H 0.0000 Buried
189 S H 0.0000 Buried
190 S H 0.0000 Buried
191 V H 0.0000 Buried
192 V H 0.0000 Buried
193 T H -0.2122 Soluble
194 V H 0.0000 Buried
195 P H -0.3768 Soluble
196 S H -0.6626 Soluble
197 S H -0.4559 Soluble
198 S H -0.4771 Soluble
199 L H -0.7429 Soluble
200 G H -1.1130 Soluble
201 T H -0.8206 Soluble
202 Q H -1.0663 Soluble
203 T H -1.1571 Soluble
204 Y H 0.0000 Buried
205 I H -1.4098 Soluble
206 C H 0.0000 Buried
207 N H -1.4843 Soluble
208 V H 0.0000 Buried
209 N H -1.8368 Soluble
210 H H 0.0000 Buried
211 K H -2.7775 Soluble
212 P H -1.6432 Soluble
213 S H -1.8747 Soluble
214 N H -2.6836 Soluble
215 T H -2.3035 Soluble
216 K H -2.7221 Soluble
217 V H -1.8156 Soluble
218 D H -2.6157 Soluble
219 K H -2.3015 Soluble
220 R H -2.6857 Soluble
221 V H 0.0000 Buried
222 E H -2.7016 Soluble
223 P H -1.4100 Soluble
224 K H -1.2970 Soluble
225 S H -0.4925 Soluble
226 C H 0.0112 Aggregation-prone
11 L L 0.8980 Aggregation-prone
12 S L 0.4864 Aggregation-prone
13 V L 0.0000 Buried
14 A L -0.2541 Soluble
15 L L -0.4776 Soluble
16 G L -1.2604 Soluble
17 E L -1.9193 Soluble
18 T L -1.4962 Soluble
19 A L 0.0000 Buried
20 R L -2.0984 Soluble
21 I L 0.0000 Buried
22 S L -1.4501 Soluble
23 C L -1.4020 Soluble
24 G L -1.4834 Soluble
25 R L -2.0590 Soluble
26 Q L -1.9797 Soluble
27 A L -0.5805 Soluble
28 L L 0.7243 Aggregation-prone
29 G L 0.4371 Aggregation-prone
36 S L 0.6648 Aggregation-prone
37 R L 0.0000 Buried
38 A L 0.0000 Buried
39 V L 0.0000 Buried
40 Q L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 H L 0.0000 Buried
45 R L -1.1477 Soluble
46 P L -1.1091 Soluble
47 G L -1.1339 Soluble
48 Q L -1.1066 Soluble
49 A L -0.6484 Soluble
50 P L 0.0000 Buried
51 I L 0.5403 Aggregation-prone
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -1.0400 Soluble
56 N L -1.2582 Soluble
57 N L 0.0000 Buried
65 Q L -2.1842 Soluble
66 D L -2.3113 Soluble
67 R L -2.7525 Soluble
68 P L 0.0000 Buried
69 S L -0.9616 Soluble
70 G L -0.9649 Soluble
71 I L -1.0068 Soluble
72 P L -1.4707 Soluble
74 E L -2.3742 Soluble
75 R L -1.3476 Soluble
76 F L 0.0000 Buried
77 S L -1.6263 Soluble
78 G L -1.2963 Soluble
79 T L -0.7915 Soluble
80 P L -0.7067 Soluble
81 D L 0.1161 Aggregation-prone
81A I L 1.6435 Aggregation-prone
82 N L 0.4869 Aggregation-prone
83 F L 1.5840 Aggregation-prone
84 G L 0.2691 Aggregation-prone
85 T L -0.3750 Soluble
86 R L -1.9643 Soluble
87 A L 0.0000 Buried
88 T L -1.2469 Soluble
89 L L 0.0000 Buried
90 T L -1.1393 Soluble
91 I L 0.0000 Buried
92 S L -1.5147 Soluble
93 G L -1.2015 Soluble
94 V L 0.0000 Buried
95 E L -1.7218 Soluble
96 A L -0.9219 Soluble
97 G L -1.0787 Soluble
98 D L 0.0000 Buried
99 E L -0.7679 Soluble
100 A L 0.0000 Buried
101 D L 0.0000 Buried
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 H L 0.0000 Buried
106 M L 0.0000 Buried
107 W L 0.0000 Buried
108 D L 0.0000 Buried
109 S L -0.4106 Soluble
110 R L -1.5986 Soluble
112 S L -0.7967 Soluble
113 G L -0.5648 Soluble
114 F L 0.4082 Aggregation-prone
115 S L 0.2014 Aggregation-prone
116 W L 0.0756 Aggregation-prone
117 S L -0.2837 Soluble
118 F L 0.0000 Buried
119 G L -1.0640 Soluble
120 G L -1.1658 Soluble
121 A L -1.0843 Soluble
122 T L -0.7751 Soluble
123 R L -1.5926 Soluble
124 L L 0.0000 Buried
125 T L 0.0916 Aggregation-prone
126 V L 0.0000 Buried
127 L L 0.6355 Aggregation-prone
128 G L -0.3304 Soluble
129 Q L 0.0000 Buried
130 P L -1.1438 Soluble
131 K L -2.3424 Soluble
132 A L -1.4091 Soluble
133 A L -0.9157 Soluble
134 P L 0.0000 Buried
135 S L -0.3710 Soluble
136 V L 0.0000 Buried
137 T L -0.4725 Soluble
138 L L 0.0000 Buried
139 F L 0.0000 Buried
140 P L -0.2958 Soluble
141 P L -0.5472 Soluble
142 S L 0.0000 Buried
143 S L -1.1285 Soluble
144 E L -1.6469 Soluble
145 E L 0.0000 Buried
146 L L -1.5638 Soluble
147 Q L -2.0992 Soluble
148 A L -1.7908 Soluble
149 N L -2.7063 Soluble
150 K L -2.8166 Soluble
151 A L 0.0000 Buried
152 T L 0.0000 Buried
153 L L 0.0000 Buried
154 V L 0.0000 Buried
155 C L 0.0000 Buried
156 L L 0.0000 Buried
157 I L 0.0000 Buried
158 S L -0.7381 Soluble
159 D L -1.5021 Soluble
160 F L 0.0000 Buried
161 Y L 0.0000 Buried
162 P L -1.0345 Soluble
163 G L -0.6562 Soluble
164 A L -0.2890 Soluble
165 V L -0.1227 Soluble
166 T L -0.0958 Soluble
167 V L 0.3378 Aggregation-prone
168 A L -0.4250 Soluble
169 W L 0.0000 Buried
170 K L -0.9486 Soluble
171 A L -0.9673 Soluble
172 D L -1.2749 Soluble
173 S L -0.8666 Soluble
174 S L -0.6101 Soluble
175 P L -0.8563 Soluble
176 V L -0.8595 Soluble
177 K L -1.6248 Soluble
178 A L -0.7508 Soluble
179 G L -0.5356 Soluble
180 V L -0.3671 Soluble
181 E L -0.1920 Soluble
182 T L 0.1045 Aggregation-prone
183 T L 0.0776 Aggregation-prone
184 T L -0.1186 Soluble
185 P L -0.3890 Soluble
186 S L -0.8638 Soluble
187 K L -1.7927 Soluble
188 Q L -1.4639 Soluble
189 S L -1.0448 Soluble
190 N L -1.3468 Soluble
191 N L -1.7068 Soluble
192 K L -1.7857 Soluble
193 Y L -1.1103 Soluble
194 A L 0.0000 Buried
195 A L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 Y L 0.0000 Buried
199 L L 0.0000 Buried
200 S L -0.4392 Soluble
201 L L 0.0000 Buried
202 T L -1.8674 Soluble
203 P L -2.4826 Soluble
204 E L -3.0656 Soluble
205 Q L -2.3367 Soluble
206 W L 0.0000 Buried
207 K L -2.9957 Soluble
208 S L -2.3187 Soluble
209 H L -2.3454 Soluble
210 R L -2.5867 Soluble
211 S L -1.7509 Soluble
212 Y L 0.0000 Buried
213 S L -1.1217 Soluble
214 C L 0.0000 Buried
215 Q L -0.9575 Soluble
216 V L 0.0000 Buried
217 T L -0.6236 Soluble
218 H L 0.0000 Buried
219 E L -2.3258 Soluble
220 G L -1.4225 Soluble
221 S L -0.8446 Soluble
222 T L -0.7149 Soluble
223 V L -0.7891 Soluble
224 E L -2.2068 Soluble
225 K L -1.8691 Soluble
226 T L -1.0974 Soluble
227 V L 0.0000 Buried
228 A L -1.4275 Soluble
229 P L -1.5340 Soluble
230 T L -1.4033 Soluble
231 E L -1.6164 Soluble
232 C L -0.8023 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.62 4.491 CSV PDB
4.5 -0.6523 4.4624 CSV PDB
5.0 -0.6918 4.4221 CSV PDB
5.5 -0.7298 4.3767 CSV PDB
6.0 -0.7559 4.3333 CSV PDB
6.5 -0.7617 4.2991 CSV PDB
7.0 -0.746 4.2788 CSV PDB
7.5 -0.7153 4.2698 CSV PDB
8.0 -0.677 4.2665 CSV PDB
8.5 -0.6343 4.2654 CSV PDB
9.0 -0.5883 4.265 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH