Tralokinumab / 8blq

A4DAB276_8blq_E_C | Source PDB: 8blq | Chains: E, C | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6869
Max Score
1.7599
Min Score
-3.125
Total Score
-298.12
Score CDR
-0.3207
Score non-CDR
-0.7357

Calculation Parameters

Chain Sequence(s) VQLVQSGAEVKKPGASVKVSCKASGYTFTNYGLSWVRQAPGQGLEWMGWISANNGDTNYGQEFQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARDSSSSWARWFFDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKYVLTQPPSVSVAPGKTARITCGGNIIGSKLVHWYQQKPGQAPVLVIYDDGDRPSGIPERFSGSNSGNTATLTISRVEAGDEADYYCQVWDTGSDPVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTEC input.pdb
Selected Chain(s) E (Heavy), C (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.125
Maximum Score 1.7599
Average Score -0.6869
Total Score -298.1176

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V E 1.3005 Aggregation-prone
3 Q E -0.0930 Soluble
4 L E 0.0000 Buried
5 V E -0.3733 Soluble
6 Q E -0.7667 Soluble
7 S E -0.7484 Soluble
8 G E -0.7371 Soluble
9 A E -0.2087 Soluble
11 E E -0.6262 Soluble
12 V E -0.0988 Soluble
13 K E -0.9419 Soluble
14 K E -1.7303 Soluble
15 P E -1.7389 Soluble
16 G E -1.5385 Soluble
17 A E -1.1885 Soluble
18 S E -1.2779 Soluble
19 V E 0.0000 Buried
20 K E -2.1259 Soluble
21 V E 0.0000 Buried
22 S E -0.7427 Soluble
23 C E 0.0000 Buried
24 K E -0.9691 Soluble
25 A E 0.0000 Buried
26 S E -0.1268 Soluble
27 G E 0.2930 Aggregation-prone
28 Y E 0.2276 Aggregation-prone
29 T E -0.2907 Soluble
30 F E -0.5052 Soluble
35 T E -1.0324 Soluble
36 N E -1.3413 Soluble
37 Y E -0.4914 Soluble
38 G E 0.0000 Buried
39 L E 0.0000 Buried
40 S E 0.0000 Buried
41 W E 0.0000 Buried
42 V E 0.0000 Buried
43 R E -0.5098 Soluble
44 Q E -0.7240 Soluble
45 A E -1.0473 Soluble
46 P E -0.9700 Soluble
47 G E -1.2742 Soluble
48 Q E -1.8109 Soluble
49 G E -1.3110 Soluble
50 L E 0.0000 Buried
51 E E -1.1904 Soluble
52 W E 0.0000 Buried
53 M E 0.0000 Buried
54 G E 0.0000 Buried
55 W E 0.0000 Buried
56 I E 0.0000 Buried
57 S E 0.0000 Buried
58 A E 0.0000 Buried
59 N E -2.4797 Soluble
62 N E -2.6129 Soluble
63 G E -2.2296 Soluble
64 D E -2.6111 Soluble
65 T E -1.4352 Soluble
66 N E -1.3982 Soluble
67 Y E -1.3537 Soluble
68 G E 0.0000 Buried
69 Q E -2.7444 Soluble
70 E E -2.9208 Soluble
71 F E 0.0000 Buried
72 Q E -2.5187 Soluble
74 G E -1.6933 Soluble
75 R E -1.5739 Soluble
76 V E 0.0000 Buried
77 T E -0.8938 Soluble
78 M E 0.0000 Buried
79 T E -0.6034 Soluble
80 T E -0.7215 Soluble
81 D E -1.2656 Soluble
82 T E -0.8627 Soluble
83 S E -0.6162 Soluble
84 T E -0.6321 Soluble
85 S E -0.7160 Soluble
86 T E 0.0000 Buried
87 A E 0.0000 Buried
88 Y E -0.7359 Soluble
89 M E 0.0000 Buried
90 E E -1.5242 Soluble
91 L E 0.0000 Buried
92 R E -1.7302 Soluble
93 S E -1.2960 Soluble
94 L E 0.0000 Buried
95 R E -2.9521 Soluble
96 S E -2.2628 Soluble
97 D E -2.5056 Soluble
98 D E 0.0000 Buried
99 T E -0.7925 Soluble
100 A E 0.0000 Buried
101 V E 0.3038 Aggregation-prone
102 Y E 0.0000 Buried
103 Y E 0.0000 Buried
104 C E 0.0000 Buried
105 A E 0.0000 Buried
106 R E 0.0212 Aggregation-prone
107 D E 0.0000 Buried
108 S E 0.2530 Aggregation-prone
109 S E -0.7137 Soluble
110 S E -0.0270 Soluble
111 S E -0.2403 Soluble
111A W E 1.1578 Aggregation-prone
112A A E 0.7987 Aggregation-prone
112 R E 0.0000 Buried
113 W E 1.4330 Aggregation-prone
114 F E 0.8089 Aggregation-prone
115 F E 0.0000 Buried
116 D E -0.1165 Soluble
117 L E 0.0230 Aggregation-prone
118 W E -0.2683 Soluble
119 G E 0.0000 Buried
120 R E -2.0341 Soluble
121 G E -0.8546 Soluble
122 T E 0.0000 Buried
123 L E 0.7155 Aggregation-prone
124 V E 0.0000 Buried
125 T E 0.0000 Buried
126 V E 0.0000 Buried
127 S E -1.0328 Soluble
128 S E -0.8451 Soluble
129 A E -0.7686 Soluble
130 S E -0.9110 Soluble
131 T E -0.8750 Soluble
132 K E -1.6179 Soluble
133 G E -1.6394 Soluble
134 P E 0.0000 Buried
135 S E -0.3022 Soluble
136 V E -0.3728 Soluble
137 F E -0.6425 Soluble
138 P E -1.0296 Soluble
139 L E 0.0000 Buried
140 A E -1.1813 Soluble
141 P E -1.1392 Soluble
142 S E -1.2255 Soluble
143 S E -1.5005 Soluble
144 K E -2.0552 Soluble
145 S E -1.0959 Soluble
146 T E -0.8658 Soluble
147 S E -0.7871 Soluble
148 G E -0.7402 Soluble
149 G E -0.5888 Soluble
150 T E -0.4401 Soluble
151 A E -0.4198 Soluble
152 A E 0.1406 Aggregation-prone
153 L E 0.1420 Aggregation-prone
154 G E 0.0000 Buried
155 C E 0.0000 Buried
156 L E 0.0000 Buried
157 V E 0.0000 Buried
158 K E -0.4252 Soluble
159 D E -0.7476 Soluble
160 Y E 0.0000 Buried
161 F E 0.0000 Buried
162 P E 0.0000 Buried
163 E E -0.8668 Soluble
164 P E -0.9045 Soluble
165 V E 0.0000 Buried
166 T E -0.4948 Soluble
167 V E 0.0519 Aggregation-prone
168 S E -0.2727 Soluble
169 W E 0.0000 Buried
170 N E -0.7582 Soluble
171 S E -0.6691 Soluble
172 G E -0.5683 Soluble
173 A E -0.2001 Soluble
174 L E 0.1242 Aggregation-prone
175 T E 0.0909 Aggregation-prone
176 S E 0.0274 Aggregation-prone
177 G E 0.2276 Aggregation-prone
178 V E 1.0612 Aggregation-prone
179 H E 0.2911 Aggregation-prone
180 T E 0.1037 Aggregation-prone
181 F E 0.0000 Buried
182 P E -0.0333 Soluble
183 A E 0.1978 Aggregation-prone
184 V E 0.0000 Buried
185 L E 1.2532 Aggregation-prone
186 Q E 0.0000 Buried
187 S E 0.0053 Aggregation-prone
188 S E -0.2287 Soluble
189 G E -0.0093 Soluble
190 L E 0.0000 Buried
191 Y E 0.3175 Aggregation-prone
192 S E 0.0000 Buried
193 L E 0.0000 Buried
194 S E 0.0000 Buried
195 S E 0.0000 Buried
196 V E 0.0000 Buried
197 V E 0.0000 Buried
198 T E 0.1519 Aggregation-prone
199 V E 0.0000 Buried
200 P E -0.2758 Soluble
201 S E -0.4638 Soluble
202 S E -0.3557 Soluble
203 S E -0.2851 Soluble
204 L E -0.3204 Soluble
205 G E -0.7546 Soluble
206 T E -0.5840 Soluble
207 Q E -0.9607 Soluble
208 T E -0.9396 Soluble
209 Y E -0.6875 Soluble
210 I E -1.1311 Soluble
211 C E 0.0000 Buried
212 N E -1.4262 Soluble
213 V E 0.0000 Buried
214 N E -1.9130 Soluble
215 H E 0.0000 Buried
216 K E -2.7666 Soluble
217 P E -1.6693 Soluble
218 S E -1.8750 Soluble
219 N E -2.5066 Soluble
220 T E -2.2028 Soluble
221 K E -2.6301 Soluble
222 V E -1.4637 Soluble
223 D E -2.5511 Soluble
224 K E -1.9128 Soluble
225 K E -2.5438 Soluble
226 V E -1.6874 Soluble
227 E E -2.4690 Soluble
228 P E -2.0691 Soluble
229 K E -2.5665 Soluble
2 Y C 1.0627 Aggregation-prone
3 V C 1.7599 Aggregation-prone
4 L C 0.7722 Aggregation-prone
5 T C -0.0773 Soluble
6 Q C 0.0000 Buried
7 P C -0.5987 Soluble
8 P C -0.9485 Soluble
9 S C -0.9183 Soluble
11 V C -0.8165 Soluble
12 S C -0.2569 Soluble
13 V C -0.1604 Soluble
14 A C -0.4290 Soluble
15 P C -1.1958 Soluble
16 G C -2.1762 Soluble
17 K C -2.8351 Soluble
18 T C -1.9834 Soluble
19 A C 0.0000 Buried
20 R C -2.0200 Soluble
21 I C 0.0000 Buried
22 T C -0.6678 Soluble
23 C C 0.0000 Buried
24 G C -0.7056 Soluble
25 G C -0.4370 Soluble
26 N C -0.6798 Soluble
27 I C 0.1334 Aggregation-prone
28 I C 0.0000 Buried
29 G C -0.5998 Soluble
36 S C -0.1952 Soluble
37 K C 0.2748 Aggregation-prone
38 L C 0.8127 Aggregation-prone
39 V C 0.0000 Buried
40 H C 0.0000 Buried
41 W C 0.0000 Buried
42 Y C 0.0000 Buried
43 Q C 0.0000 Buried
44 Q C 0.0000 Buried
45 K C -1.5397 Soluble
46 P C -1.3687 Soluble
47 G C -1.5934 Soluble
48 Q C -1.9554 Soluble
49 A C -1.1291 Soluble
50 P C 0.0000 Buried
51 V C 0.6032 Aggregation-prone
52 L C 0.0000 Buried
53 V C 0.0000 Buried
54 I C 0.0000 Buried
55 Y C -0.8413 Soluble
56 D C -1.4163 Soluble
57 D C -1.3913 Soluble
65 G C -1.7427 Soluble
66 D C -2.3246 Soluble
67 R C -2.1148 Soluble
68 P C -1.0179 Soluble
69 S C -0.6979 Soluble
70 G C -0.7754 Soluble
71 I C -0.6210 Soluble
72 P C -1.3197 Soluble
74 E C -2.3254 Soluble
75 R C -1.9371 Soluble
76 F C 0.0000 Buried
77 S C -1.1489 Soluble
78 G C -1.1514 Soluble
79 S C -0.8157 Soluble
80 N C -1.1897 Soluble
83 S C -0.9668 Soluble
84 G C -1.2850 Soluble
85 N C -1.6746 Soluble
86 T C -1.1623 Soluble
87 A C 0.0000 Buried
88 T C 0.0000 Buried
89 L C 0.0000 Buried
90 T C -0.8242 Soluble
91 I C 0.0000 Buried
92 S C -2.4072 Soluble
93 R C -3.1250 Soluble
94 V C 0.0000 Buried
95 E C -2.7059 Soluble
96 A C -1.5856 Soluble
97 G C -1.4565 Soluble
98 D C -1.5543 Soluble
99 E C -1.4989 Soluble
100 A C 0.0000 Buried
101 D C -1.3580 Soluble
102 Y C 0.0000 Buried
103 Y C 0.0000 Buried
104 C C 0.0000 Buried
105 Q C 0.0000 Buried
106 V C 0.0000 Buried
107 W C 0.6455 Aggregation-prone
108 D C 0.0000 Buried
109 T C -0.1589 Soluble
110 G C -0.5275 Soluble
113 S C -0.6586 Soluble
114 D C -0.8442 Soluble
115 P C 0.0373 Aggregation-prone
116 V C 0.0000 Buried
117 V C 0.3865 Aggregation-prone
118 F C 0.0000 Buried
119 G C -0.1229 Soluble
120 G C -0.6787 Soluble
121 G C -1.2003 Soluble
122 T C 0.0000 Buried
123 K C -2.0827 Soluble
124 L C 0.0000 Buried
125 T C -0.3261 Soluble
126 V C 0.0000 Buried
127 L C 0.7023 Aggregation-prone
128 G C -0.7551 Soluble
129 Q C -1.4726 Soluble
130 P C -1.3091 Soluble
131 K C -2.1061 Soluble
132 A C -1.1186 Soluble
133 A C -0.4221 Soluble
134 P C -0.4027 Soluble
135 S C -0.3369 Soluble
136 V C 0.0000 Buried
137 T C -0.4577 Soluble
138 L C -0.2709 Soluble
139 F C 0.0000 Buried
140 P C 0.0748 Aggregation-prone
141 P C 0.0000 Buried
142 S C -0.9429 Soluble
143 S C -1.6085 Soluble
144 E C -2.5709 Soluble
145 E C 0.0000 Buried
146 L C -2.4239 Soluble
147 Q C -2.4828 Soluble
148 A C -2.0463 Soluble
149 N C -2.9044 Soluble
150 K C -2.8990 Soluble
151 A C 0.0000 Buried
152 T C 0.0000 Buried
153 L C 0.0000 Buried
154 V C 0.0000 Buried
155 C C 0.0000 Buried
156 L C 0.0000 Buried
157 I C 0.0000 Buried
158 S C 0.0000 Buried
159 D C -1.1956 Soluble
160 F C 0.0000 Buried
161 Y C -1.2504 Soluble
162 P C -0.9739 Soluble
163 G C -0.4426 Soluble
164 A C -0.3093 Soluble
165 V C 0.0883 Aggregation-prone
166 T C -0.0076 Soluble
167 V C 0.2593 Aggregation-prone
168 A C -0.4101 Soluble
169 W C 0.0000 Buried
170 K C -1.2876 Soluble
171 A C -0.9293 Soluble
172 D C -1.1533 Soluble
173 S C -0.7260 Soluble
174 S C -0.8205 Soluble
175 P C -0.9352 Soluble
176 V C -0.7660 Soluble
177 K C -1.5481 Soluble
178 A C -0.6305 Soluble
179 G C -0.3765 Soluble
180 V C 0.0172 Aggregation-prone
181 E C 0.0000 Buried
182 T C 0.4094 Aggregation-prone
183 T C 0.2450 Aggregation-prone
184 T C -0.1601 Soluble
185 P C -0.2793 Soluble
186 S C -0.7006 Soluble
187 K C -1.5446 Soluble
188 Q C -1.4764 Soluble
189 S C -1.3567 Soluble
190 N C -1.9907 Soluble
191 N C -2.2059 Soluble
192 K C -1.7924 Soluble
193 Y C -0.9894 Soluble
194 A C 0.0000 Buried
195 A C 0.0000 Buried
196 S C 0.0000 Buried
197 S C 0.0000 Buried
198 Y C 0.0000 Buried
199 L C 0.0000 Buried
200 S C -0.1826 Soluble
201 L C -0.5212 Soluble
202 T C -1.6767 Soluble
203 P C 0.0000 Buried
204 E C -3.0805 Soluble
205 Q C -1.9878 Soluble
206 W C 0.0000 Buried
207 K C -2.9684 Soluble
208 S C -2.3604 Soluble
209 H C -2.3050 Soluble
210 R C -2.4567 Soluble
211 S C -1.4842 Soluble
212 Y C 0.0000 Buried
213 S C -1.0797 Soluble
214 C C 0.0000 Buried
215 Q C -1.0828 Soluble
216 V C 0.0000 Buried
217 T C -0.6608 Soluble
218 H C 0.0000 Buried
219 E C -2.2331 Soluble
220 G C -1.3696 Soluble
221 S C -0.9663 Soluble
222 T C -0.7201 Soluble
223 V C -0.7691 Soluble
224 E C -2.2832 Soluble
225 K C -2.0454 Soluble
226 T C -1.1395 Soluble
227 V C -0.5902 Soluble
228 A C -1.1618 Soluble
229 P C -1.4806 Soluble
230 T C -1.5487 Soluble
231 E C -1.8834 Soluble
232 C C -1.0405 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6205 4.3381 CSV PDB
4.5 -0.6584 4.2896 CSV PDB
5.0 -0.7035 4.2378 CSV PDB
5.5 -0.7459 4.1849 CSV PDB
6.0 -0.7742 4.1317 CSV PDB
6.5 -0.7794 4.0786 CSV PDB
7.0 -0.7609 4.0261 CSV PDB
7.5 -0.727 3.9758 CSV PDB
8.0 -0.6854 3.9306 CSV PDB
8.5 -0.6388 3.8956 CSV PDB
9.0 -0.5877 3.8742 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH