Ociperlimab / 8jel

A4DAB185_8jel_C_D | Source PDB: 8jel | Chains: C, D | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6928
Max Score
1.526
Min Score
-3.3974
Total Score
-297.89
Score CDR
-0.4244
Score non-CDR
-0.7249

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVQPGGSLRLSCAASGFTFSDYYMYWVRQAPGKGLEWVAYITKGGGSTYYPDSVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCARQTNYDFTMDYWGQGTLVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCEIVMTQSPATLSVSPGERATLSCKASQDVGTSVAWYQQKPGQAPRLLIYWASARHTGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYSSYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC input.pdb
Selected Chain(s) C (Heavy), D (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.3974
Maximum Score 1.526
Average Score -0.6928
Total Score -297.8889

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E C -2.0054 Soluble
2 V C -1.0689 Soluble
3 Q C -0.8770 Soluble
4 L C 0.0000 Buried
5 V C 1.0381 Aggregation-prone
6 E C 0.0000 Buried
7 S C -0.3961 Soluble
8 G C -0.8355 Soluble
9 G C -0.4646 Soluble
11 G C -0.4086 Soluble
12 L C 0.0248 Aggregation-prone
13 V C -0.5624 Soluble
14 Q C -1.5464 Soluble
15 P C -1.6776 Soluble
16 G C -1.4148 Soluble
17 G C -1.0768 Soluble
18 S C -1.2753 Soluble
19 L C -1.1686 Soluble
20 R C -2.2201 Soluble
21 L C 0.0000 Buried
22 S C -0.5017 Soluble
23 C C 0.0000 Buried
24 A C -0.1359 Soluble
25 A C 0.0000 Buried
26 S C -0.7471 Soluble
27 G C -1.1820 Soluble
28 F C -0.7265 Soluble
29 T C -0.7736 Soluble
30 F C 0.0000 Buried
35 S C -1.5537 Soluble
36 D C -2.2129 Soluble
37 Y C 0.0000 Buried
38 Y C -0.4433 Soluble
39 M C 0.0000 Buried
40 Y C 0.0000 Buried
41 W C 0.0000 Buried
42 V C 0.0000 Buried
43 R C 0.0000 Buried
44 Q C 0.0000 Buried
45 A C -1.1667 Soluble
46 P C -0.9393 Soluble
47 G C -1.4479 Soluble
48 K C -2.2248 Soluble
49 G C -1.3186 Soluble
50 L C 0.0000 Buried
51 E C -0.9106 Soluble
52 W C 0.0000 Buried
53 V C 0.0000 Buried
54 A C 0.0000 Buried
55 Y C 0.0000 Buried
56 I C 0.0000 Buried
57 T C -0.7133 Soluble
58 K C -1.4893 Soluble
59 G C -1.4540 Soluble
62 G C -1.0686 Soluble
63 G C -0.8987 Soluble
64 S C -0.4293 Soluble
65 T C 0.1532 Aggregation-prone
66 Y C 0.4266 Aggregation-prone
67 Y C -0.4852 Soluble
68 P C -1.4124 Soluble
69 D C -2.4518 Soluble
70 S C -1.7750 Soluble
71 V C 0.0000 Buried
72 K C -2.5157 Soluble
74 G C -1.7619 Soluble
75 R C -1.4707 Soluble
76 F C 0.0000 Buried
77 T C -0.8500 Soluble
78 I C 0.0000 Buried
79 S C -0.6492 Soluble
80 R C -1.2014 Soluble
81 D C -1.6480 Soluble
82 N C -1.9123 Soluble
83 A C -1.3660 Soluble
84 K C -2.2687 Soluble
85 N C -1.7466 Soluble
86 T C 0.0000 Buried
87 L C 0.0000 Buried
88 Y C 0.0000 Buried
89 L C 0.0000 Buried
90 Q C -1.4787 Soluble
91 M C 0.0000 Buried
92 N C -1.4124 Soluble
93 S C -1.2405 Soluble
94 L C 0.0000 Buried
95 R C -2.1161 Soluble
96 A C -1.6682 Soluble
97 E C -2.1529 Soluble
98 D C 0.0000 Buried
99 T C -0.6360 Soluble
100 A C 0.0000 Buried
101 V C 0.1604 Aggregation-prone
102 Y C 0.0000 Buried
103 Y C 0.0000 Buried
104 C C 0.0000 Buried
105 A C 0.0000 Buried
106 R C -0.1530 Soluble
107 Q C 0.0000 Buried
108 T C 0.0000 Buried
109 N C -1.1316 Soluble
110 Y C 0.1371 Aggregation-prone
112 D C 0.2418 Aggregation-prone
113 F C 0.6959 Aggregation-prone
114 T C 0.0000 Buried
115 M C 0.0000 Buried
116 D C 0.0000 Buried
117 Y C -0.0423 Soluble
118 W C 0.0000 Buried
119 G C 0.0000 Buried
120 Q C -1.1733 Soluble
121 G C -0.4513 Soluble
122 T C -0.0182 Soluble
123 L C 0.2002 Aggregation-prone
124 V C 0.0000 Buried
125 T C 0.0000 Buried
126 V C 0.0000 Buried
127 S C -0.7217 Soluble
128 S C -0.6105 Soluble
129 A C -0.4687 Soluble
130 S C -0.6537 Soluble
131 T C -0.9049 Soluble
132 K C -1.5465 Soluble
133 G C -1.4657 Soluble
134 P C -0.6533 Soluble
135 S C -0.4879 Soluble
136 V C 0.0000 Buried
137 F C 0.0000 Buried
138 P C -1.2618 Soluble
139 L C 0.0000 Buried
140 A C -1.1685 Soluble
141 P C 0.0000 Buried
142 S C -0.5092 Soluble
143 G C -0.6237 Soluble
144 T C -0.4469 Soluble
145 A C -0.2213 Soluble
146 A C 0.0000 Buried
147 L C 0.0000 Buried
148 G C 0.0000 Buried
149 C C 0.0000 Buried
150 L C 0.0000 Buried
151 V C 0.0000 Buried
152 K C 0.0000 Buried
153 D C -0.4057 Soluble
154 Y C 0.0000 Buried
155 F C 0.0000 Buried
156 P C 0.0000 Buried
157 E C -0.3408 Soluble
158 P C -0.6171 Soluble
159 V C -0.5768 Soluble
160 T C -0.4954 Soluble
161 V C -0.1907 Soluble
162 S C -0.4204 Soluble
163 W C 0.0000 Buried
164 N C -0.8246 Soluble
165 S C -0.7513 Soluble
166 G C -0.6148 Soluble
167 A C -0.2869 Soluble
168 L C -0.0223 Soluble
169 T C -0.1986 Soluble
170 S C -0.1704 Soluble
171 G C -0.1846 Soluble
172 V C 0.1658 Aggregation-prone
173 H C -0.1333 Soluble
174 T C 0.0355 Aggregation-prone
175 F C 0.0000 Buried
176 P C -0.1645 Soluble
177 A C 0.3401 Aggregation-prone
178 V C 0.6939 Aggregation-prone
179 L C 1.5260 Aggregation-prone
180 Q C 0.4986 Aggregation-prone
181 S C 0.0000 Buried
182 S C -0.1643 Soluble
183 G C 0.0839 Aggregation-prone
184 L C 0.2074 Aggregation-prone
185 Y C 0.5594 Aggregation-prone
186 S C 0.0000 Buried
187 L C 0.0000 Buried
188 S C 0.0000 Buried
189 S C 0.0000 Buried
190 V C 0.0000 Buried
191 V C 0.0000 Buried
192 T C -0.1392 Soluble
193 V C 0.0000 Buried
194 P C -0.4516 Soluble
195 S C -0.4795 Soluble
196 S C -0.5823 Soluble
197 S C 0.0000 Buried
198 L C -0.7841 Soluble
199 G C -0.9971 Soluble
200 T C -0.8256 Soluble
201 Q C -1.2931 Soluble
202 T C -1.1720 Soluble
203 Y C 0.0000 Buried
204 I C -1.0833 Soluble
205 C C 0.0000 Buried
206 N C -1.5098 Soluble
207 V C 0.0000 Buried
208 N C -1.7533 Soluble
209 H C 0.0000 Buried
210 K C -2.7217 Soluble
211 P C -1.6574 Soluble
212 S C -1.9114 Soluble
213 N C -2.6144 Soluble
214 T C -2.0852 Soluble
215 K C -2.6509 Soluble
216 V C -1.6884 Soluble
217 D C -2.5731 Soluble
218 K C -2.0226 Soluble
219 K C -2.1055 Soluble
220 V C 0.0000 Buried
221 E C -2.7385 Soluble
222 P C -1.8162 Soluble
223 K C -2.2992 Soluble
224 S C -0.8819 Soluble
225 C C -0.1503 Soluble
1 E D -1.3208 Soluble
2 I D -0.3355 Soluble
3 V D 0.8367 Aggregation-prone
4 M D 0.0000 Buried
5 T D -0.4488 Soluble
6 Q D 0.0000 Buried
7 S D -0.5962 Soluble
8 P D -0.3910 Soluble
9 A D -0.3045 Soluble
10 T D -0.2680 Soluble
11 L D -0.2399 Soluble
12 S D -0.6413 Soluble
13 V D -1.3174 Soluble
14 S D -1.7349 Soluble
15 P D -1.8193 Soluble
16 G D -1.9845 Soluble
17 E D -3.0625 Soluble
18 R D -2.9292 Soluble
19 A D 0.0000 Buried
20 T D -0.6559 Soluble
21 L D 0.0000 Buried
22 S D -0.8655 Soluble
23 C D 0.0000 Buried
24 K D -2.3163 Soluble
25 A D -1.5515 Soluble
26 S D -1.2532 Soluble
27 Q D -2.4467 Soluble
28 D D -2.9331 Soluble
29 V D 0.0000 Buried
36 G D -1.0831 Soluble
37 T D -0.1889 Soluble
38 S D 0.0692 Aggregation-prone
39 V D 0.0000 Buried
40 A D 0.0000 Buried
41 W D 0.0000 Buried
42 Y D 0.0000 Buried
43 Q D 0.0000 Buried
44 Q D -0.8269 Soluble
45 K D -1.2194 Soluble
46 P D -1.1504 Soluble
47 G D -1.2378 Soluble
48 Q D -1.7028 Soluble
49 A D -1.2217 Soluble
50 P D 0.0000 Buried
51 R D -1.0841 Soluble
52 L D 0.0000 Buried
53 L D 0.0000 Buried
54 I D 0.0000 Buried
55 Y D 0.4525 Aggregation-prone
56 W D 0.9257 Aggregation-prone
57 A D 0.0000 Buried
65 S D -0.3316 Soluble
66 A D -0.3946 Soluble
67 R D -1.2468 Soluble
68 H D -0.8781 Soluble
69 T D -0.6903 Soluble
70 G D -0.7337 Soluble
71 I D 0.0000 Buried
72 P D -0.5313 Soluble
74 A D -0.4960 Soluble
75 R D -0.7057 Soluble
76 F D 0.0000 Buried
77 S D -0.6451 Soluble
78 G D -0.4042 Soluble
79 S D -0.5967 Soluble
80 G D -1.0488 Soluble
83 S D -1.2738 Soluble
84 G D -1.9263 Soluble
85 T D -2.4877 Soluble
86 E D -2.9413 Soluble
87 F D 0.0000 Buried
88 T D -0.8613 Soluble
89 L D 0.0000 Buried
90 T D -0.6679 Soluble
91 I D 0.0000 Buried
92 S D -1.6959 Soluble
93 S D -1.7737 Soluble
94 L D 0.0000 Buried
95 Q D -1.8076 Soluble
96 S D -1.6968 Soluble
97 E D -1.3344 Soluble
98 D D 0.0000 Buried
99 F D 0.0000 Buried
100 A D 0.0000 Buried
101 V D -0.2231 Soluble
102 Y D 0.0000 Buried
103 Y D 0.0000 Buried
104 C D 0.0000 Buried
105 Q D 0.0000 Buried
106 Q D 0.0000 Buried
107 Y D 0.0000 Buried
108 S D -0.3612 Soluble
109 S D -0.3085 Soluble
114 Y D 0.3284 Aggregation-prone
115 P D -0.2329 Soluble
116 L D 0.0000 Buried
117 T D 0.0854 Aggregation-prone
118 F D 0.2162 Aggregation-prone
119 G D 0.0000 Buried
120 G D -0.6803 Soluble
121 G D 0.0000 Buried
122 T D 0.0000 Buried
123 K D -0.6115 Soluble
124 V D 0.0000 Buried
125 E D -0.9257 Soluble
126 I D 0.0000 Buried
127 K D -1.5540 Soluble
128 R D -1.0020 Soluble
129 T D -0.0575 Soluble
130 V D 0.3161 Aggregation-prone
131 A D -0.0719 Soluble
132 A D -0.1606 Soluble
133 P D 0.0000 Buried
134 S D -0.1749 Soluble
135 V D 0.0000 Buried
136 F D 0.0820 Aggregation-prone
137 I D 0.0437 Aggregation-prone
138 F D 0.0000 Buried
139 P D -0.5051 Soluble
140 P D -0.8134 Soluble
141 S D -1.8748 Soluble
142 D D -3.1171 Soluble
143 E D -2.9136 Soluble
144 Q D 0.0000 Buried
145 L D -2.2764 Soluble
146 K D -2.7669 Soluble
147 S D -1.6745 Soluble
148 G D -0.9827 Soluble
149 T D -0.7395 Soluble
150 A D 0.0000 Buried
151 S D 0.0000 Buried
152 V D 0.0000 Buried
153 V D 0.0000 Buried
154 C D 0.0000 Buried
155 L D 0.0000 Buried
156 L D 0.0000 Buried
157 N D -0.3571 Soluble
158 N D -0.9724 Soluble
159 F D 0.0000 Buried
160 Y D 0.0000 Buried
161 P D -1.7623 Soluble
162 R D -3.0535 Soluble
163 E D -3.3017 Soluble
164 A D -2.4139 Soluble
165 K D -2.5189 Soluble
166 V D -1.1978 Soluble
167 Q D -0.8313 Soluble
168 W D 0.0000 Buried
169 K D -0.8136 Soluble
170 V D 0.0000 Buried
171 D D -1.7902 Soluble
172 N D -1.4444 Soluble
173 A D -0.5246 Soluble
174 L D 0.2015 Aggregation-prone
175 Q D -0.5399 Soluble
176 S D -0.7576 Soluble
177 G D -1.1243 Soluble
178 N D -1.3162 Soluble
179 S D -1.2763 Soluble
180 Q D -1.2250 Soluble
181 E D -1.7637 Soluble
182 S D -0.7940 Soluble
183 V D -0.5069 Soluble
184 T D -0.8137 Soluble
185 E D -1.6379 Soluble
186 Q D 0.0000 Buried
187 D D -1.8390 Soluble
188 S D -1.8724 Soluble
189 K D -2.4451 Soluble
190 D D -1.9303 Soluble
191 S D 0.0000 Buried
192 T D 0.0000 Buried
193 Y D 0.0000 Buried
194 S D 0.0000 Buried
195 L D 0.0000 Buried
196 S D 0.0000 Buried
197 S D 0.0000 Buried
198 T D -0.6756 Soluble
199 L D 0.0000 Buried
200 T D -0.3695 Soluble
201 L D -0.6251 Soluble
202 S D -1.0495 Soluble
203 K D -1.8550 Soluble
204 A D -1.6735 Soluble
205 D D -2.2327 Soluble
206 Y D 0.0000 Buried
207 E D -3.3172 Soluble
208 K D -3.3974 Soluble
209 H D -2.8415 Soluble
210 K D -2.7842 Soluble
211 V D -1.5210 Soluble
212 Y D 0.0000 Buried
213 A D -0.8179 Soluble
214 C D 0.0000 Buried
215 E D -0.9404 Soluble
216 V D 0.0000 Buried
217 T D -1.2044 Soluble
218 H D 0.0000 Buried
219 Q D -1.7726 Soluble
220 G D -0.4489 Soluble
221 L D -0.2680 Soluble
222 S D -0.4637 Soluble
223 S D -0.4432 Soluble
224 P D -0.5316 Soluble
225 V D -0.0794 Soluble
226 T D -0.5200 Soluble
227 K D -0.7811 Soluble
228 S D -0.7270 Soluble
229 F D -1.0208 Soluble
230 N D -2.1523 Soluble
231 R D -2.4520 Soluble
232 G D -1.9158 Soluble
233 E D -2.0475 Soluble
234 C D -0.7337 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6189 2.5345 CSV PDB
4.5 -0.6636 2.5223 CSV PDB
5.0 -0.7169 2.5106 CSV PDB
5.5 -0.7689 2.5002 CSV PDB
6.0 -0.8075 2.4911 CSV PDB
6.5 -0.8225 2.4817 CSV PDB
7.0 -0.8131 2.4709 CSV PDB
7.5 -0.787 2.4595 CSV PDB
8.0 -0.7517 2.4493 CSV PDB
8.5 -0.7099 2.4419 CSV PDB
9.0 -0.662 2.4376 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH